Chronic kidneyDigital twinsDiscordantAlzheimer'sEpidemiologyMonozygotic and dizygotic twin pairsGeneticSickle-cell diDizygotic TwinsMusculoskeletal diseasesMultiple BirthsTripletsPrematureInfectious diseases1999Congenital heart d2019SymptomsCardiovascularAppeared in 19942021CentersProgression of the diseaseHumansCeliac DiseaseMonochorionicPregnanciesInfantsIdenticalFindingsResearchersMeSHDisordersCoronaryPropensityVirtual TwinsCohortInflammatorySusceptibilityKawasaki DiseaseIncidenceClinical TrialsOnsetSeverityEbolaRegistryDifferencesBabiesHereditaryInfectionsComplex diseaseVaccination
Chronic kidney1
- Alaska Airlines flight attendant Jenny Stansel, 38, has been battling chronic kidney disease for more than 15 years. (insideedition.com)
Digital twins13
- Digital twins have inexhaustible applications in the healthcare industry, from helping researchers to test new scenarios in real-life environments with improved safety and cost-effectiveness to allowing the creation of useful virtual models and medical simulations based on the gathered data from patient records, wearable devices, device manufacturers, drugs and pharmaceutical companies, and other healthcare departments. (med-tech.world)
- Using digital twins, cardiothoracic surgeons and neurosurgeons can run a virtual simulation of surgical procedures before executing complex surgeries. (med-tech.world)
- Digital twins can simulate how molecules and proteins interact to identify the right therapeutics and enlist digital cohorts of patients testing new drugs with optimal dosage to reduce the number of clinical trials needed. (med-tech.world)
- Digital twins also provide an avenue for the digital design of medical devices to be tested with different patients under different conditions in virtual worlds where there's a low cost of failure. (med-tech.world)
- Digital twins in health care have begun to help practitioners understand patient conditions, even novel ones such as COVID-19's impact on the lungs. (advmfg.org)
- WDCC Meetup: How to use Digital Twins in green life sciences? (wur.nl)
- Digital Twins are one of the key enabling technologies that can help us improve quality of life. (wur.nl)
- Digital Twins offer opportunities to make timely data driven decisions for a better future. (wur.nl)
- In recent years, WUR has carried out an investment programme to discover how we can use Digital Twins in green life sciences. (wur.nl)
- That is why we continue to do research and to develop Digital Twins together with partners. (wur.nl)
- In the future, we will be able to create digital twins that simulate various processes in our body. (medicalxpress.com)
- Digital twins are virtual representations of devices and processes that capture the physical properties of the environment and operational algorithms/techniques in the context of medical devices and technologies. (medicalxpress.com)
- An international team of researchers have developed advanced computer models, or "digital twins," of diseases, with the goal of improving diagnosis and treatment. (medicalxpress.com)
Discordant5
- Concordant and discordant locations of stenoses were found with similar frequency in monozygotic and dizygotic twin pairs. (bmj.com)
- Uneven X inactivation in a female monozygotic twin pair with Fabry disease and discordant expression of a novel mutation in the alpha-galactosidase A gene. (bmj.com)
- Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. (nature.com)
- Here we conducted an in-depth pairwise analysis of the systemic immune compartment of 61 monozygotic twin pairs discordant for MS, in which both siblings carry the same genetic and early-life environmental risk for the disease, yet only one is affected by MS. This approach thus eliminated the majority of bias attributed to variable genetic and early environmental influences in a heterogenous population 17 , 18 . (nature.com)
- In MZ pairs discordant for IWL, co-twins with at least one IWL were 0.4 kg m −2 ( P =0.041) heavier at 25 years than their non-dieting co-twins (no differences in baseline BMIs). (nature.com)
Alzheimer's15
- The investigational anti-amyloid monoclonal antibody gantenerumab (Genentech/Roche) showed no clear benefit for patients with early Alzheimer's disease (AD) in the phase 3 GRADUATE I and II trials, the company has announced. (medscape.com)
- It plans to present topline data from the trials in a presentation scheduled for November 30 during the upcoming Clinical Trials on Alzheimer's Disease conference. (medscape.com)
- We know that current anti-amyloid approaches are not a cure, nor will they stop the disease on their own, but they are the first wave of effective treatments for Alzheimer's, with more to come," the Alzheimer's Association said. (medscape.com)
- The results we've seen from drugs in this class point to the urgent need to bring a range of amyloid and nonamyloid therapies to market to slow the course of Alzheimer's disease," said Fillit. (medscape.com)
- Successes and disappointments are an expected part of the scientific process, but we are unmistakably in a modern era of Alzheimer's research, on the cusp of a new generation of therapies that will take a more holistic approach to treating the disease by targeting all of its underlying causes," Fillit said. (medscape.com)
- Parkinson's disease is the world's second most common neurodegenerative disorder, behind Alzheimer's disease . (yahoo.com)
- The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. (medicalxpress.com)
- The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. (medicalxpress.com)
- Suddenly getting lost, failing to recognize family members, or forgetting words and names are well-known symptoms of Alzheimer's disease. (medicalxpress.com)
- Mild cognitive impairment (MCI) is a form of cognitive ability loss that can precede Alzheimer's disease or other types of dementia. (medicalxpress.com)
- Alzheimer's disease is a progressive neurodegenerative disease estimated to affect 6 million Americans and 33 million people worldwide. (medicalxpress.com)
- Could something as basic as a good night's sleep protect African Americans who have a gene variant linked to Alzheimer's Disease? (medicalxpress.com)
- The three common alleles at the APOE locus influence the onset and lifetime risk of typical late-onset Alzheimer's disease (AD). (johnshopkins.edu)
- Meyer, JM & Breitner, JCS 1998, ' Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel ', American Journal of Medical Genetics - Neuropsychiatric Genetics , vol. 81, no. 1, pp. 92-97. (johnshopkins.edu)
- Breitner, John C.S. / Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel . (johnshopkins.edu)
Epidemiology3
- Our disease models leverage from the leading data networks/platforms and combine the best from AI/ML, predictive modeling, and pharmaco-epidemiology. (technologynetworks.com)
- Given this changing epidemiology, U.S. surveillance data were reviewed to investigate secondary cases of invasive disease caused by Hi. (cdc.gov)
- The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease ( Twin Res hum Genet. (lu.se)
Monozygotic and dizygotic twin pairs3
- OBJECTIVE To compare the coronary anatomy and the location of coronary lesions in monozygotic and dizygotic twin pairs affected with coronary artery disease. (bmj.com)
- RESULTS The lumen diameters of the left main coronary artery, the left anterior descending coronary artery, the circumflex artery, and the right coronary artery, as well as the lengths of the left main coronary artery, showed similar variability within monozygotic and dizygotic twin pairs. (bmj.com)
- By integrating data on the immune profiles of healthy monozygotic and dizygotic twin pairs, we estimated the variance in CD25 expression by helper T cells displaying a naive phenotype to be largely driven by genetic and shared early environmental influences. (nature.com)
Genetic13
- There are genetic and environmental factors involved in the onset of gum disease, and in many cases the risk of developing periodontitis can be significantly lowered by taking preventative measures. (elisondentistry.com)
- Genetic predisposition - Despite practicing rigorous oral hygiene routines, as much as 30% of the population may have a strong genetic predisposition to gum disease. (elisondentistry.com)
- These individuals are six times more likely to develop periodontal disease than individuals with no genetic predisposition. (elisondentistry.com)
- Nonetheless, the expanding helper T cells of twins with MS, which were also elevated in non-twin patients with MS, emerged independent of the individual genetic makeup. (nature.com)
- Hence, investigating how genetic predisposition and environmental triggers shape the interactions of individual immune cells is vital to understand the pathophysiology of autoimmune diseases including MS. (nature.com)
- The Swedish Twin Registry (STR), which today has developed into a unique resource, was first established in the late 1950s to study the importance of smoking and alcohol consumption on cancer and cardiovascular diseases whilst controlling for genetic propensity to disease. (nih.gov)
- Huntington's disease (HD) is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. (hdsa.org)
- The heritability was 0.57 (95% CI, 0.45-0.69) amongst male twins, and 0.38 (0.26-0.50) amongst female twins.The genetic contribution to the variation in CHD-mortality was moderate both in females and males. (duke.edu)
- Given the limited numbers of AD cases now available, models containing only additive genetic or shared environmental effects (explaining 75% and 65% of individual differences in disease onset, respectively) cannot be rejected in favor of a model that retains both influences. (johnshopkins.edu)
- What's more, the discovery of the Lupski family mutation, a genetic variant that hadn't previously been connected to CMT disease, may allow for new directions in medical research, and could potentially lead to new treatments for the disease down the line. (discovermagazine.com)
- In 2011, whole-genome sequencing revealed not only the genetic variants responsible, it also revealed which neurotransmitters were affected, and suggested a new drug regimen that worked remarkably well to control the twins' symptoms. (discovermagazine.com)
- The Australian Twin Registry as a resource for genetic studies into ophthalmic traits (Twin Res Hum Genet. (lu.se)
- Chinese National Twin Registry as a resource for genetic epidemiologic studies of common and complex diseases in China ( Twin Res. (lu.se)
Sickle-cell di16
- Blood donors exist for patients with sickle-cell disease, but the donors must be a perfect match. (wafb.com)
- He was born with sickle-cell disease and undergoes monthly blood transfusions. (wafb.com)
- According to doctors, sickle-cell disease affects 100,000 Americans, whose blood cell shape resembles a crescent, instead of being round and healthy. (wafb.com)
- Over the weekend, Jason and Devin McCourty announced sad news that that their aunt, Winifred, passed away after a battle with sickle cell disease. (patsfans.com)
- As many people know, the Tackle Sickle Cell Campaign began from watching our Aunt Winnie fight the sickle cell disease. (patsfans.com)
- The Sickle Cell Disease Association of America, Inc. (SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding of individuals, families those who are impacted by sickle cell disease. (wikipedia.org)
- To advocate for and enhance our membership's ability to improve the quality of health, life and services for individuals, families and communities affected by sickle cell disease and related conditions, while promoting the search for a cure for all people in the world with sickle cell disease. (wikipedia.org)
- The Sickle Cell Disease Association of America, Inc. originated in Racine, Wisconsin. (wikipedia.org)
- There was a common belief that there was a need for national attention to sickle cell disease. (wikipedia.org)
- The name was changed in 1994 to the Sickle Cell Disease Association of America, Inc. Over the course of several years, the organization has grown into over 40 different branches. (wikipedia.org)
- Research Public Health Education Professional Health Education Patient Services Community Services Support to Global Organizations and Practitioners The Sickle Cell Disease Association of America, Inc. hosts several events throughout each year. (wikipedia.org)
- The Sickle Cell Disease National Convention is held annually during the first weekend of October in Baltimore's Inner Harbor. (wikipedia.org)
- Tiki Barber - The former NFL running back has sickle cell disease and does his part educating others. (wikipedia.org)
- Devin McCourty and Ryan McCourty - Twins fight Sickle Cell Disease with Tackle Sickle Cell Organization. (wikipedia.org)
- Santonio Holmes - Runs benefit for son with sickle cell disease. (wikipedia.org)
- Sickle Cell Disease Association of America Inc. "Premium Domain Names at already Discounted Prices - sicklecellnationalwalk.com is available for sale! (wikipedia.org)
Dizygotic Twins1
Musculoskeletal diseases2
- Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. (europa.eu)
- Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. (europa.eu)
Multiple Births1
- I. 'Street of twins': multiple births in Cuba II. (lu.se)
Premature2
- The high concordance of premature coronary artery disease found in monozygotic twin pairs may largely be related to factors that are independent of the macroanatomic distribution of the coronary blood supply. (bmj.com)
- [ 3 ] After birth, premature infants may need to undergo transcranial ultrasonography, as premature twins are susceptible to intraventricular hemorrhage and periventricular leukomalacia. (medscape.com)
Infectious diseases1
- The topics covered include infectious diseases, many cancers, chronic and acute physical and psychological conditions, newly emerging and reemerging diseases, public health issues, and issues of interest to the young adult audience (eating disorders, sports injuries, growth, and puberty). (gale.com)
19992
- We are building reference 'virtual twin' simulators in high priority diseases to accelerate drug development and patient access to the drugs they really need" commented Dr Billy Amzal, CEO of QUINTEN HEALTH and a pioneer expert in disease modeling since 1999. (technologynetworks.com)
- Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. (hdsa.org)
Congenital heart d2
- The SMFM also recommends fetal echocardiography in monochorionic diamniotic (MCDA) twin gestations due to increased risk of congenital heart disease in this population, especially in gestations with TTTS, which negatively affects the recipient twin's heart. (medscape.com)
- AIBODY , a Physiology-as-a-Service platform, and German Heart Centre Berlin (DHZB), a medical research institute specializing in cardiovascular disease, have signed a collaboration agreement which focuses on the development of a suite of solutions to improve the diagnosis and treatment of congenital heart disease. (med-tech.world)
20194
- Following an average annual decline of 2% from 2014 to 2019, the number of twin births fell by 7% from 2019 to 2020 and increased by 2% from 2020 to 2021. (cdc.gov)
- The report " Changes in Twin Births in the United States, 2019-2021 " examines changes in the number and rate of twin births from 2019 to 2021 by month and year of birth and age and race and Hispanic origin of the mother. (cdc.gov)
- The number of twin births in the United States fell by 7% from 2019 to 2020, compared with a 3% decline in the number of singleton births. (cdc.gov)
- The twin birth rate from 2019 to 2020 declined by 11% for women aged 40 and over, 5% for those aged 30-39, and 1% for females under age 30. (cdc.gov)
Symptoms8
- What are the symptoms of Parkinson's disease and how can it be treated? (yahoo.com)
- So what are the symptoms of Parkinson's disease and how can it be treated? (yahoo.com)
- The main symptoms of Parkinson's disease include involuntary shaking (otherwise known as tremors), movement that's slower than usual and stiffness in the muscles, the NHS outlines . (yahoo.com)
- For more information about the symptoms of Parkinson's disease, visit the NHS here . (yahoo.com)
- However, for every one in 20 people affected by the disease, symptoms may appear when they're under the age of 40. (yahoo.com)
- While there is no known cure for Parkinson's disease, symptoms may be controlled through treatment. (yahoo.com)
- While drug treatment may help to manage Parkinson's symptoms, it cannot slow the progression of the disease. (yahoo.com)
- With no symptoms, he was shocked to learn that the disease had advanced to stage-4, the tumours had spread in his lungs, his adrenal gland, kidney, and pancreas. (albertacancer.ca)
Cardiovascular1
- Oral contraceptives (OC) modulate the risk for developing cardiovascular (CV) diseases. (maastrichtuniversity.nl)
Appeared in 19941
- It is therefore not surprising that the earliest use of the term 'digital twin' appeared in 1994 in the field of medical imaging. (med-tech.world)
20211
- By month, the twin birth rate declined by 7% in January 2021 compared with the year before and generally remained stable until the end of the year, when rates increased by 7% in November and 14% in December. (cdc.gov)
Centers3
- Centers for Disease Control and Prevention. (cdc.gov)
- Some of the organization's partnerships include: National Association for the Advancement of Colored People (NAACP), National Institutes of Health (NIH), Health Resources and Services Administration (HRSA), Centers for Disease Control (CDC), United Way of America, and the Robert Johnson Foundation. (wikipedia.org)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Progression of the disease2
- When an individual is suffering from gum disease, the additional destruction of gingival tissue due to grinding can accelerate the progression of the disease. (elisondentistry.com)
- A periodontist can perform effective cleaning procedures in deep pockets such as scaling and root planing, and also prescribe antibiotic and antifungal medications to treat infection and halt the progression of the disease. (elisondentistry.com)
Humans1
- Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (bmj.com)
Celiac Disease1
- Celiac Disease. (gale.com)
Monochorionic4
- Twin-to-twin transfusion syndrome (TTTS) is a common complication that typically presents in the second trimester of pregnancy in 10-15% of monochorionic (MC) twins due to net transfer of volume and hormonal substances from 1 twin to the other across vascular anastomoses on the placenta. (medscape.com)
- In uncomplicated dichorionic twin pregnancies, delivery should be considered at 37 weeks' gestation to minimize perinatal death, and no clear evidence supports delivery of monochorionic twins before 36 weeks, according to a meta-analysis published online September 6 in the BMJ . (medscape.com)
- Then they performed a meta-analysis to evaluate the risk for stillbirth and neonatal complications in weekly intervals for monochorionic and dichorionic twin pregnancies, starting from 34 weeks' gestation. (medscape.com)
- Timing of delivery for multiple pregnancies should be always be individualised, however, the current evidence-base suggests that in uncomplicated dichorionic twin pregnancies delivery should be considered at 37 weeks' gestation and in monochorionic pregnancies delivery should be considered from 36 weeks," he continued. (medscape.com)
Pregnancies11
- A retrospective cohort study of MCDA twin pregnancies complicated by TTTS that underwent laser coagulation of vascular anastomoses or fetal reduction by umbilical cord occlusion found that the prevalence of brain lesions detected by third-trimester MRI is higher than that of prenatal ultrasonography alone, making MRI a useful adjunct to detect antenatal brain lesions in twin pregnancies after in utero treatment for TTTS. (medscape.com)
- Our study provides comprehensive estimates comparing risks of stillbirth and neonatal mortality at various gestational ages, which is required for the planning of delivery in uncomplicated twin pregnancies," write Fiona Cheong-See, MBBS, from Queen Mary University of London, United Kingdom, and colleagues with the Global Obstetrics Network Collaboration. (medscape.com)
- The study is the largest to date to evaluate stillbirths and neonatal outcomes in twin pregnancies, and the first to estimate neonatal morbidity for specific gestational ages. (medscape.com)
- Twin pregnancies carry a higher risk for stillbirth than singleton pregnancies, and the risk increases with gestational age. (medscape.com)
- Although uncomplicated twin pregnancies are often scheduled for early delivery to prevent stillbirth, preterm birth can increase neonatal complications. (medscape.com)
- Yet, the optimal age for delivery of twin pregnancies has not been established. (medscape.com)
- Our estimates of fetal and neonatal outcomes at various gestational ages in twin pregnancies should be taken into account when decisions are made on timing of delivery," the authors conclude. (medscape.com)
- The information on risks provided in twin pregnancies will complement the ongoing national and international efforts to reduce the rates of stillbirths and unexpected neonatal complications in babies born near term. (medscape.com)
- We welcome this robust systematic review which provides us with a comprehensive picture on stillbirths and neonatal outcomes in twin pregnancies," said Mark Kilby, MD, professor of Fetal Medicine and spokesperson for the Royal College of Obstetricians and Gynaecologists, in a related press release. (medscape.com)
- The study confirms existing findings of previous studies and adds further objectivity to the NICE guidelines on the management of twin pregnancies. (medscape.com)
- Because twin pregnancies are risky pregnancies. (nutritionfacts.org)
Infants3
- Background: Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract disease and hospitalization in infants and young children. (tau.ac.il)
- results: Twins comprised 7.6% (66/875) of hospitalized infants with RSV bronchiolitis during the study period. (tau.ac.il)
- Infants who have GBS disease can require prolonged hospitalization and expensive supportive therapy, and survivors may suffer permanent disability (e.g., hearing or visual loss or mental retardation). (cdc.gov)
Identical8
- The aim of this study was to determine whether the use of third-generation OC has an impact on markers of CV disease in genetically identical women. (maastrichtuniversity.nl)
- Use of third-generation OC impacts on CV disease markers in young-adult genetically identical women. (maastrichtuniversity.nl)
- Real-life identical twins, not the kind they make movies about. (latimes.com)
- Naturally, it was the same surgical team that had performed the same operation on the same bone of the same hand of identical twin Ozzie, in the same hospital. (latimes.com)
- except identical twins. (cdc.gov)
- In studies of identical twins, researchers from Lund University have identified mechanisms that could be behind the development of type 2 diabetes. (lu.se)
- This could explain cases where one identical twin develops type 2 diabetes while the other remains healthy. (lu.se)
- The study involved 14 pairs of identical twins in Sweden and. (lu.se)
Findings3
- conclusions: Our findings suggest that twins hospitalized with RSV bronchiolitis do not have an increased risk for severe infection as compared to singletons. (tau.ac.il)
- Despite this triad of clinical findings, patients with anti-GBM disease may present with a spectrum of conditions ranging from pulmonary hemorrhage with minimal or no renal involvement to full-blown renal failure with limited or no pulmonary involvement. (medscape.com)
- The Cuban Twin Registry: initial findings and perspectives ( Twin Res Hum Genet. (lu.se)
Researchers1
- For instance, when an AI-powered anatomical analysis is combined with the virtual model of a patient's heart, it enables researchers to understand the progression of heart diseases over time and to identify how the patient will respond to new drugs. (med-tech.world)
MeSH1
- 359 disease terms (MeSH) has been reported with BDNF gene. (cdc.gov)
Disorders1
- Disorders affecting TWINS, one or both, at any age. (bvsalud.org)
Coronary7
- With respect to the dominance pattern of coronary blood supply, two of three monozygotic twin pairs differed, while all dizygotic twin pairs were concordant. (bmj.com)
- The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
- The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)
- The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)
- The early epidemiological studies that pointed to the possible importance of programming in coronary heart disease were based on the simple strategy of examining men and women in middle and late life whose body measurements at birth were recorded. (bmj.com)
- Scholars@Duke publication: Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. (duke.edu)
- BACKGROUND: Kawasaki disease is a systemic vasculitis that affects small and medium-sized vessels, primarily the coronary arteries. (bvsalud.org)
Propensity1
- The aim of this study was to investigate the role of genes and environment in susceptibility to breast cancer and to give an estimate of heritability in the propensity to develop the disease. (nih.gov)
Virtual Twins1
- QUINTEN HEALTH has announced that it has closed its financing round to advance disease modeling platforms and virtual twins in real-world, as part of the Quinten Group's €14 million growth equity investment from TECHLIFE CAPITAL and MACSF, essentially dedicated to the healthcare activities of the Quinten group. (technologynetworks.com)
Cohort2
- The funds will be used to advance QUINTEN HEALTH's in silico disease and care simulation platform, turning a decade of experience in disease modeling and real-world data analytics into regulatory-grade disease cohort simulators to accelerate, de-risk and maximize the value of pharmaceutical R&D. QUINTEN HEALTH's disease models are developed from the global federation of best-in-class real-world and trial data sources. (technologynetworks.com)
- Coding of occupation for the "young cohort" of the Danish twin register. (lu.se)
Inflammatory2
- Using complementary multimodal high-throughput and high-dimensional single-cell technologies in conjunction with data-driven computational tools, we identified an inflammatory shift in a monocyte cluster of twins with MS, coupled with the emergence of a population of IL-2 hyper-responsive transitional naive helper T cells as MS-related immune alterations. (nature.com)
- Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. (medicalxpress.com)
Susceptibility1
- Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. (bcu.ac.uk)
Kawasaki Disease3
- OBJECTIVE: Kawasaki Disease (KD) is the leading cause of acquired heart disease in children in developed countries (e.g. (bvsalud.org)
- CASE REPORT: A 5-year-old female was diagnosed with classic Kawasaki disease. (bvsalud.org)
- CONCLUSIONS: The use of etanercept in Kawasaki disease has demonstrated a clinically favorable response. (bvsalud.org)
Incidence4
- Widespread vaccination has reduced invasive disease caused by Haemophilus influenzae (Hi) type b in the United States by approximately 99%, but incidence of disease caused by non-type b Hi has been increasing. (cdc.gov)
- Since licensure and recommendation for Hib vaccines were implemented, the incidence of invasive Hib disease in the United States has declined by approximately 99%, accounting for only 1.3% of invasive Hi disease in 2018. (cdc.gov)
- However, despite clinical trials that demonstrate the effectiveness of intrapartum antibiotic prophylaxis, prevention strategies have not been implemented widely or consistently, and the incidence of neonatal GBS disease has not declined. (cdc.gov)
- Armenia has very high cancer incidence and mortality rates relative to other countries, as well as a very high prevalence of rare malignant diseases. (who.int)
Clinical Trials1
- This report provides the epidemiologic basis for prevention protocols, summarizes results of clinical trials demonstrating the efficacy of intrapartum antimicrobial agents, examines limitations of different approaches to prevention, and presents guidelines for the prevention of GBS disease. (cdc.gov)
Onset3
- For this purpose we need to understand the early events of disease onset and progression. (europa.eu)
- Diabetes and underlying medical issues - Many medical conditions can intensify or accelerate the onset and progression of gum disease including respiratory disease, heart disease, arthritis and osteoporosis. (elisondentistry.com)
- Traditional methods are not appropriate for this estimation since they do not consider right-censoring (incomplete expression of the genotype owing to death) nor do they model the relation of onset age and disease liability. (johnshopkins.edu)
Severity2
- Prognosis varies depending on disease stage and severity and gestational age at diagnosis. (medscape.com)
- In contrast, the mere fact of a child being a twin was not found to be a significant risk factor for disease severity. (tau.ac.il)
Ebola1
- Field clinicians working during the unprecedented Ebola virus disease (EVD) outbreak in West Africa, which began in December 2013, have been confronted with complex situations concerning mothers and breast-fed children in which one or both in a pair have tested positive for Ebola virus (EBOV) ( 1 ). (cdc.gov)
Registry25
- Conversely, a registry-based study investigated the familial recurrence rate of MS and revealed that monozygotic twin pairs displayed the highest familial risk (17% age-adjusted risk for the unaffected twin) of developing MS, indicating a strong heritable effect 8 . (nature.com)
- Since that time, the Registry has been expanded and updated on several occasions, and the focus has similarly broadened to most common complex diseases. (nih.gov)
- The model is fitted to the occurrence of AD among 9,786 members of the National Academy of Sciences-National Research Council Registry of aging veteran twins. (johnshopkins.edu)
- Australian Twin Registry: 30 years of progress (Twin Res Hum Genet. (lu.se)
- The introduction of the Australian twin registry (in Chinese) ( Zhonghua Liu Xing Bing Xue Za Zhi. (lu.se)
- Australian Twin Registry: a nationally funded resource for medical and scientific research, incorporating match and WATCH (Twin Res Hum Genet. (lu.se)
- The Australian Twin Registry (Twin Res. (lu.se)
- Australian NHMRC Twin Registry: a resource for pediatric research (Pediatr Cardiol. (lu.se)
- Australian N.H. & M.R.C. Twin Registry (Aust N Z J Med. (lu.se)
- Australian NHMRC twin registry (Med J Aust. (lu.se)
- The Brazilian Twin Registry (Twin Res Hum Genet. (lu.se)
- Brazilian Twin Registry: A Bright Future for Twin Studies/Twin Research (Twin Res Hum Genet. (lu.se)
- Chilean school-age children twin registry: planning, sampling and implications ( Twin Res Hum Genet. (lu.se)
- The Chinese National Twin Registry: a 'gold mine' for scientific research ( J Intern Med. (lu.se)
- The Chinese National Twin Registry: an update ( Twin Res hum Genet. (lu.se)
- Current status of the Chinese National Twin Registry ( Twin Res Hum Genet. (lu.se)
- The Qingdao Twin Registry: a status update ( Twin Res hum Genet. (lu.se)
- The Qingdao Twin Registry: a focus on chronic disease research ( Twin Res Hum Genet. (lu.se)
- The Danish Twin Registry: An Updated Overview ( Twin Res Hum Genet. (lu.se)
- The Danish Twin Registry: linking surveys, national registers, and biological information ( Twin Res Hum Genet. (lu.se)
- The Danish Twin Registry (Scand J Public Health. (lu.se)
- The Danish Twin Registry in the new millennium ( Twin Res Hum Genet. (lu.se)
- The danish twin registry: past and present ( Twin Res. (lu.se)
- The Danish Twin Registry: 127 birth cohorts of twins ( Twin Res. (lu.se)
- The early history of the Danish twin registry (in Danish) ( Dan Medicinhist Arbog. (lu.se)
Differences1
- Analysis of monozygotic twin pairs from the National Longitudinal Study of Adolescent Health (Add Health) revealed that between-twin differences in IQ have little effect on the majority of the examined outcome measures. (bvsalud.org)
Babies3
- We report the case of a lactating EBOV-positive mother and her twin babies. (cdc.gov)
- This footage posted to Facebook by the zoo shows twin babies Yaad and Tukada vying for the tasty carbs. (yahoo.com)
- Twin babies may be ten times more likely to die at birth. (nutritionfacts.org)
Hereditary1
- mRNA-based vaccines and gene/cell therapeutics open up new possibilities for medical practitioners in the fight against cancer and infectious or hereditary diseases. (medicalxpress.com)
Infections1
- Chronic stress and poor diet - Stress lowers the ability of the immune system to fight off disease, which means bacterial infections may possibly beat the body's defense system. (elisondentistry.com)
Complex disease1
- Diabetes is a complex disease. (lu.se)
Vaccination1
- High Hib vaccination coverage since the 1990s has substantially reduced Hib disease, and other serotypes now account for most Hi-associated invasive disease in the United States ( 3 ). (cdc.gov)