Diseases human airway asthma airway resistance. Medical search. Frequent questions

The aim of this study was to compare air-trapping as quantified by high-resolution computed tomography (HRCT) of the chest with measures of lung function and airway inflammation in children with mild to moderate asthma. (nih.gov)
It is a mediator of allergic inflammation and different diseases including asthma. (wikipedia.org)
In COPD, there is epithelial mucous metaplasia, airway wall fibrosis, and inflammation associated with loss of surrounding alveolar attachments to the outer wall of small airways: bronchiolar smooth muscle is increased also. (nih.gov)
LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
GCs, usually in the form of prednisolone, supposedly reduce airway inflammation and prevent fibrosis. (ingridking.com)
Chronic inflammation may play a role in numerous diseases, including arthritis, heart disease and diabetes. (asknestle.in)
Piperine can also reduce airway inflammation caused by asthma and recurrent allergies. (asknestle.in)
Quantitative CT Evidence of Airway Inflammation in WTC Workers and Volunteers with Low FVC Spirometric Pattern. (omicsdi.org)
We used quantitative CT (QCT) to investigate proximal and distal airway inflammation and emphysema in participants with stable low FVC pattern. (omicsdi.org)
Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. (ersjournals.com)
Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
Airway inflammation is a central feature of bronchial asthma. (ersjournals.com)
Corticosteroids are the most effective drugs to suppress airway inflammation, mainly by downregulation of pro-inflammatory proteins 22 , 23 . (ersjournals.com)
Inhaled corticosteroids suppress airway inflammation, which is responsible for asthma-associated changes of the airway vasculature. (ersjournals.com)
Inflammation leads to excessive uptake of calcium by cells, and is a factor in obesity, depression, and the degenerative diseases. (raypeat.com)
However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. (mdpi.com)
Asthma is a common chronic disease characterized by bronchial inflammation, reversible airway obstruction, and airway hyperresponsiveness (AHR). (blogspot.com)
In the present study, we examined the capacity of phospholipase A2 (PLA2), one of the major components of bee venom (BV), to reduce airway inflammation and improve lung function in an experimental model of asthma. (blogspot.com)
We showed that the intratracheal administration of bvPLA2 markedly suppressed the OVA-induced allergic airway inflammation by reducing AHR, overall area of inflammation, and goblet cell hyperplasia. (blogspot.com)
There are probably dozens of laboratories in the world that study asthma, allergic asthma, and allergic inflammation and its various iterations. (scireq.com)
The pathophysiology of asthma is complex and involves airway inflammation, intermittent airflow obstruction, and bronchial hyperresponsiveness. (medscape.com)
Antigen presentation by the dendritic cell with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)
The mechanism of inflammation in asthma may be acute, subacute, or chronic, and the presence of airway edema and mucus secretion also contributes to airflow obstruction and bronchial reactivity. (medscape.com)
Asthma is characterized by a narrowing and inflammation of the bronchi, with symptoms of dyspnea, fatigue and exercise limitation. (bvsalud.org)
The Global Initiative for Asthma defines asthma as a heterogeneous disease characterized by chronic inflammation of the airways, with a history of respiratory symptoms, such as wheezing, dyspnea, chest tightness, cough and variable airflow limitation 1 . (bvsalud.org)

15-Lipoxygenase-1 (15LO1) which is an enzyme in the fatty acid metabolism and its metabolite, 15-HETE, are highly expressed in asthma (which lead to the overexpression of MUC5AC) and are induced by IL-13 in human airway epithelial cells. (wikipedia.org)
Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)
Previous work in our group has demonstrated that a physiologically relevant dose of TGF-β1 is capable of driving EMT in primary human bronchial epithelial cells (PBEC) isolated from lung-transplant recipients, an effect that was accentuated by TNFα. (ndltd.org)
PDGF is expressed in the airway by a variety of cells contribute to the pathogenesis of asthma-mast cells, eosinophils and airway epithelial cells. (il-10.com)
http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)

This data suggest that quantitative HRCT may be a useful tool in the evaluation of peripheral airflow obstruction in children with asthma. (nih.gov)
Exposures of 50 to 100 ppm may be tolerated for more than 30 to 60 minutes, but higher or longer exposures can cause death from airway obstruction. (cdc.gov)
This reflects isolated detection of small airways obstruction and/or emphysema. (omicsdi.org)
This study confirms our earlier observations that detection of small airways obstruction and/or emphysema, in symptomatic smokers with normal routine spirometry, requires analysis of expiratory airflow at low lung volumes, including FEF 75 . (omicsdi.org)
Dependence upon normal routine spirometry may result in clinical and physiologic delay in the diagnosis and treatment in symptomatic smokers with emphysema and small airways obstruction. (omicsdi.org)
Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction? (nationaljewish.org)
Asthma, which occurs in adult and pediatric patients, is a chronic inflammatory disorder of the airways characterized by an obstruction of airflow. (medscape.com)

Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. (wikipedia.org)
IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown. (ox.ac.uk)
airway hyperresponsiveness was only partially reduced. (ox.ac.uk)
These vascular components seem to have significant clinical implications because of their correlations to asthma severity, including airflow limitation 10 - 13 and bronchial hyperresponsiveness 7 , 11 , 14 - 18 . (ersjournals.com)
Airway hyperresponsiveness or bronchial hyperreactivity in asthma is an exaggerated response to numerous exogenous and endogenous stimuli. (medscape.com)
The degree of airway hyperresponsiveness generally correlates with the clinical severity of asthma. (medscape.com)

iv) The effect of hypoxia on the proliferation of cultured human airway smooth muscle cells. (gla.ac.uk)
The proliferative response of cultured human airway smooth muscle cells was examined under different environmental oxygen tensions. (gla.ac.uk)

They evaluated markers of induced diabetes, levels of eosinophils and airway resistance ( PMC7747657 ). (ingridking.com)

Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. (wikipedia.org)
These enzymes are required to induce aggression of parenchymal inflammatory cells into the airway lumen, where they are then cleared. (wikipedia.org)
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. (nih.gov)
The clinically observed distinctions between asthma and COPD are reflected by differences in the remodeling process, the patterns of inflammatory cells and cytokines, and also the predominant anatomic site at which these alterations occur. (nih.gov)
In COPD the changes begin later in life and the associated inflammatory response differs from that in asthma. (nih.gov)
In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). (ersjournals.com)
In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. (ersjournals.com)
In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
19 published his findings on cortisone causing dramatic improvements in patients with rheumatoid arthritis, corticosteroids have become established as the most potent anti-inflammatory agents in the pharmacotherapy of various chronic inflammatory diseases, including asthma 20 . (ersjournals.com)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
and 3) the interactions of corticosteroids and airway blood vessels by which inflammatory changes of the airway vasculature can be reversed in patients with asthma. (ersjournals.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-kappaB inflammatory signaling pathway in human skin cells. (nationaljewish.org)
Just some of the lowest rates of obesity, heart disease, depression, inflammatory diseases, and autoimmune diseases in the entire world .¹ Not to mention, some of the oldest and healthiest people on the planet. (greensmoothiegirl.com)
The underlying pathology, the chronic inflammatory process and airway remodeling (AR), mediated by cells and cytokines. (il-10.com)
[ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)

Research has shown that cell-surface expression of IL-13Rα2 on human asthmatic airway fibroblasts was reduced compared with expression on normal control airway fibroblasts. (wikipedia.org)
In asthma the epithelium appears to be more fragile than that of COPD, the epithelial reticular basement membrane (RBM) is significantly thicker, there is marked enlargement of the mass of bronchial smooth muscle, and emphysema does not occur in the asthmatic nonsmoker. (nih.gov)
If you are highly allergic, or asthmatic, you probably know that the drugs in asthma can inhibit the enzyme called phosphodiesterase . (ocfaq.com)

A recent comparative clinical trial looked at a small cohort of asthma affected cats treated with oral prednisolone (n=4) or an inhaled GC, fluticasone (n=5). (ingridking.com)
The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. (ersjournals.com)
In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed. (ersjournals.com)
This comprehensive volume presents overviews as well as in depth reviews of many aspects of the clinical presentation, pathophysiology, and treatment of Pulmonary Hypertension (PH) especially PH related to thromboembolic disease. (e-booksdirectory.com)
Dr Sayers has maintained his research interest in the molecular basis of asthma and allergy spending time with the Asthma Genetics Group in Southampton, UK (1998-2001) and in pre-clinical drug development in New Zealand at Genesis Research and Development Corporation and the Malaghan Institute (2001-2003). (nottingham.ac.uk)
Pre-clinical drug development in asthma. (nottingham.ac.uk)
This document provides clinical recommendations for the management of severe asthma. (ersjournals.com)
including these clinical airways, the Jigglers way Just helps a Converted alternative creation as a insight of underlying the piece for human browser that has same to sonochemistry. (cdseidel.de)
There are also existing clinical studies on humans. (ocfaq.com)
Currently, the diagnosis and treatment of respiratory disease are reliant on specialist clinical testing which is conducted in specialist clinical settings [3]. (physionet.org)
However, the frequent occurrence of therapy resistance is a major challenge in the clinical management of the patient, as well as the molecular mechanisms behind resistance therapy is not yet fully understood. (il-10.com)
All inpatient encounters from patients aged ≤18 years with a primary or secondary discharge diagnosis of International Classification of Diseases, Tenth Revision, Clinical Modification code G06.0 (intracranial abscess and granuloma) or G06.2 (extradural and subdural abscess, unspecified) during the study period were included. (medscape.com)
Chronic bronchitis (49.1%) and asthma (36.1%) were the most common clinical diagnoses. (bvsalud.org)
epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (bvsalud.org)

Drug-resistant bacterial infections have caused serious threats to human health and call for effective antibacterial agents that have low propensity to induce antimicrobial resistance. (bvsalud.org)
Introducing ß-homo-glycine into poly-ß-lysine effectively reduces the toxicity of resulting poly-ß-peptides and affords the optimal poly-ß-peptide, ßLys50HG50, which shows potent antibacterial activity against clinically isolated methicillin-resistant Staphylococcus aureus (MRSA) and MRSA persister cells, excellent biosafety, no antimicrobial resistance, and strong therapeutic potential in both local and systemic MRSA infections. (bvsalud.org)
A longitudinal study reveals persistence of antimicrobial resistance on livestock farms is not due to antimicrobial usage alone. (ox.ac.uk)
Sarah Gregory] Antimicrobial resistance has become, as we all know, a huge problem in recent years. (cdc.gov)
After the increase in summer 2021, no evidence of higher levels of intensive care unit (ICU) admission, mortality, genetic relatedness of isolates from different patients, or increased antimicrobial resistance of isolates was observed. (medscape.com)
Background Prior studies indicated increased antimicrobial resistance in Ethiopia, with related health, economic, and environmental costs. (bvsalud.org)
Antimicrobial resistance to ceftriaxone and azithromycin has not been reported. (cdc.gov)

The year had just begun when the initial diagnosis of feline asthma blindsided my family. (ingridking.com)
Asthma in cats is still a relatively rare diagnosis. (ingridking.com)
Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination, and Drug Susceptibility Prediction. (ox.ac.uk)
Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction. (omicsdi.org)
Concurrent COVID-19 diagnosis was defined as having International Classification of Diseases, Tenth Revision codes U07.1 or B97.29 on the discharge diagnosis list. (medscape.com)
Spirometry with postbronchodilator response should be obtained as the primary test to establish the asthma diagnosis. (medscape.com)

Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance. (nationaljewish.org)
Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. (nationaljewish.org)
Abbreviations used characterized by TH2 cytokine production and associated with AHR: Airway hyperreactivity allergen sensitization and adaptive immunity. (cdc.gov)

Nevertheless, the study of bronchial small airways is much less common. (e-booksdirectory.com)
The main target of this book is to provide a bronchial small airways original research from different experts in the field. (e-booksdirectory.com)

The hypertrophy of submucosal mucus-secreting glands is similar in extent in asthma and COPD. (nih.gov)
Varying degrees of mononuclear cell and eosinophil infiltration, mucus hypersecretion, desquamation of the epithelium, smooth muscle hyperplasia, and airway remodeling are present. (medscape.com)

IL-33 expression was quantified in endobronchial biopsy (EB) specimens from children with STRA and related to remodeling, and collagen production by airway fibroblasts from pediatric patients stimulated with IL-33 and budesonide was quantified. (ox.ac.uk)

There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. (nottingham.ac.uk)
GLA can shape immune responses and interfere with the course of respiratory diseases. (frontiersin.org)
In this review, we aim to analyze how the lung and gut microbiota influence each other and may impact on respiratory diseases. (frontiersin.org)
Viruses are also known to be key players in numerous respiratory diseases and to interact with the human immune system, but technical issues still limit the amount of data regarding virobiota ( Mitchell and Glanville, 2018 ). (frontiersin.org)
While GLA mycobiota also influences chronic gut diseases such as IBD, we will not address this key role in the present review: we aimed at analyzing how lung and gut bacteriobiota and mycobiota influence each other, how they interact with the human immune system, and their role in respiratory diseases. (frontiersin.org)
Respiratory diseases are of increasing burden to modern society [1, 2]. (physionet.org)
Introduction: Chronic respiratory diseases (CRDs) are diseases of the lung airways and parenchyma. (bvsalud.org)

Resistance to airflow in the respiratory tract is largely determined by the degree of tone in the smooth muscle layer surrounding the airways. (gla.ac.uk)
Wheezing: A musical, high-pitched whistling sound produced by airflow turbulence is one of the most common symptoms of asthma. (medscape.com)

Data was collected at zero end-expiratory pressure (ZEEP) and with continuous positive airway pressure (CPAP) ventilation, at positive end-expiratory pressure (PEEP) settings of 4 and 8 cmH2O. (physionet.org)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)

CONCLUSION: IL-33 is a relatively steroid-resistant mediator that promotes airway remodeling in patients with STRA and is an important therapeutic target. (ox.ac.uk)
TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. (springer.com)
The mechanisms involved include direct stimulation of airway smooth muscle and indirect stimulation by pharmacologically active substances from mediator-secreting cells such as mast cells or nonmyelinated sensory neurons. (medscape.com)

IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. (ox.ac.uk)
OBJECTIVE: We sought to investigate the relationship between IL-33 and airway remodeling in pediatric patients with STRA. (ox.ac.uk)
The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. (nationaljewish.org)
Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an immunoregulatory Factor Mediates Airway Remodeling and Possible Pharmacological Target. (il-10.com)

IL-13 induces a class of protein-degrading enzymes, known as matrix metalloproteinases (MMPs), in the airways. (wikipedia.org)
Importantly, dual targeting cholesterol and steroid biosynthesis with simvastatin, commonly prescribed cholesterol synthesis inhibitors, and inhibitors to have the strongest growth inhibitory AKR1C3 effect.From our results we conclude that the CAFS induces upregulation of cholesterol and steroid biosynthesis in PCa cells, driving them to AR targeted therapy resistance. (il-10.com)

Not surprisingly, our vet concurred with the radiology specialist that Uli showed classic asthma pathology related to restricted airways and defined bronchial, interstitial cell and alveolar disruption. (ingridking.com)

These are real-life experiments that have shown over and over again, with an amazing reproducibility, how powerful these environmental influences are in conferring protection against asthma and allergies. (scireq.com)

BACKGROUND: TH2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). (ox.ac.uk)

The vicious cycle between climate change and air pollution is associated with reproductive, respiratory, and cardiovascular diseases, as well as public health problems such as diabetes, cancer, premature aging, and psychiatric diseases. (fountainmagazine.com)

When these muscle cells enlarge and lose their inherent flexibility or are restricted from contracting or relaxing by surrounding fibrotic cells, the airways thicken and make breathing more difficult. (ingridking.com)
Obliterative Bronchiolitis (OB) is the pathological correlate of Bronchiolitis Obliterans Syndrome (BOS) a progressive disease that results in the fibrotic obliteration and blockage of the airways. (ndltd.org)
TAK1 was also shown to be more strongly activated in fibrotic human airway sections compared to control, suggesting that the findings have direct disease relevance. (ndltd.org)

Furthermore, IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells. (wikipedia.org)
The results exacerbate the airway resistance and simply induce asthma. (hzhongtai.com)
Sensitive triggering factors such as dust, dust mites, mold, mold, pollen and smoke can diffuse in the air and easily induce asthma. (hzhongtai.com)

Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)

Allergic asthma was induced in female BALB/c mice by intraperitoneal administration of ovalbumin (OVA) on days 0 and 14, followed by intratracheal challenge with 1% OVA six times between days 22 and 30. (blogspot.com)

Human and cat airways are lined with muscle cells that allow for flexibility of the long bronchial tubes. (ingridking.com)
Moreover, it assists in building a strong resistance against invading microorganisms and sarcoma cells within the body. (asknestle.in)
The majority of genes (99%) amplified in human stools are from bacteria, which are as numerous as human cells and comprise 150 distinct bacterial species, belonging mainly to Firmicutes and Bacteroidetes phyla. (frontiersin.org)
Furthermore, the suppression was associated with a significant decrease in the production of Th2 cytokines, such as IL-4, IL-5, and IL-13, and a reduction in the number of total cells, including eosinophils, macrophages, and neutrophils in the airway. (blogspot.com)
CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)

Asthma is a chronic disease of the respiratory system and heterogeneous, one of the most common lung diseases worldwide. (il-10.com)
Learn what Dr. Vercelli, a scientist at the forefront of complex lung diseases, has to say about the field and her work! (scireq.com)
Dr. Vercelli's group research the complex interactions between genetics, epigenetics and the environment that control the susceptibility to complex lung diseases, such as allergy and asthma. (scireq.com)

Corticosteroids are now known to exert their effects on the airway vasculature through genomic and nongenomic mechanisms. (ersjournals.com)
In addition, corticosteroids seem to reverse components of the asthma-induced structural changes (airway remodelling), including the increased vascularity of the bronchial wall 24 . (ersjournals.com)
The rapid effects of corticosteroids have also been demonstrated in the airway vasculature in recent years 29 , 30 . (ersjournals.com)
Measuring safety of inhaled corticosteroids in asthma. (nationaljewish.org)
Current therapeutic options for the management of asthma include inhaled corticosteroids and β2 agonists, which elicit harmful side effects. (blogspot.com)

WTC workers with spirometric low FVC have higher QCT-measured WAP compared to those with normal spirometries, but did not differ in distal airway and emphysema measurements, independently of obesity, smoking, and other covariates. (omicsdi.org)
COPD is a composite term encompassing several diseases including chronic bronchitis and emphysema. (nottingham.ac.uk)

Overview and Understanding of Human Circadian Immunology -- 5. (nshealth.ca)
you didn't start out in a completely independent field within hematology or immunology and then find your way to airway defense? (scireq.com)
American Academy of Allergy, Asthma & Immunology (AAAAI) is ac- port from the National Institutes of Health (NIH). (cdc.gov)

The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma: it is likely that these increases also occur in severe COPD as they do in bronchiectasis. (nih.gov)
Recent studies have emphasized the difficulty of early detection of chronic obstructive pulmonary disease (COPD) in symptomatic smokers with normal routine spirometry. (omicsdi.org)
In 2004, Dr Sayers joined the University of Nottingham as a Lecturer and has developed a research group focussed to understanding the cellular and molecular mechanisms underlying asthma and COPD. (nottingham.ac.uk)
Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression. (nottingham.ac.uk)

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma. (cdc.gov)
Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. (nationaljewish.org)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
09/24/1993 SUGGESTED CITATION Centers for Disease Control and Prevention. (cdc.gov)

This document provides guidance for follow-up and antiviral chemoprophylaxis of close contacts of cases of human infection with novel influenza A viruses associated with severe human disease or with the potential to cause severe human disease . (cdc.gov)
Novel influenza A viruses have caused sporadic infections resulting in severe human disease and substantial mortality among detected cases to date . (cdc.gov)
Limited, non-sustained human-to-human transmission of some novel influenza A viruses associated with severe human disease likely occurred or cannot be excluded in some case clusters that have occurred worldwide . (cdc.gov)
The public health goal of this interim guidance is to prevent further spread of novel influenza A viruses associated with severe human disease if there are infected persons in the United States. (cdc.gov)
In general, decisions to initiate antiviral chemoprophylaxis should be guided by the risk stratification described below, 3 based on observational data for reported cases of human infections with avian influenza A(H7N9) and A(H5N1) viruses, and on data from seasonal influenza studies. (cdc.gov)
Persons with an unprotected exposure to novel influenza A virus associated with severe human disease in a laboratory setting may have a high-risk or moderate-risk exposure, and need to be evaluated case by case. (cdc.gov)
Public health personnel should attempt to identify as soon as possible and monitor all close contacts of confirmed or probable cases of human infection with novel influenza A viruses associated with severe human disease for new illness. (cdc.gov)
Influenza, one of the most common infectious diseases, is a highly contagious airborne disease that occurs in seasonal epidemics and manifests as an acute febrile illness with variable degrees of systemic symptoms, ranging from mild fatigue to respiratory failure and death. (medscape.com)
Influenza causes significant loss of workdays, human suffering, and mortality. (medscape.com)
Avian influenza (H5N1) is rare in humans in developed countries. (medscape.com)
however, 2009 influenza A (H1N1) and influenza B viruses also circulated, and the predominant virus varied by U.S. Department of Health and Human Service (HHS) region and week. (cdc.gov)
Five cases of human infection with a novel influenza A virus were reported during the 2010--11 influenza season from three states. (cdc.gov)
Influenza viruses cause disease among all age groups ( 2--4 ). (cdc.gov)
Influenza B viruses may cause milder disease but often cause epidemics with moderate or severe disease, either as the predominant circulating virus or along with influenza A. (msdmanuals.com)
A weekly surveillance report of seasonal influenza in the US is available at the Centers for Disease Control and Prevention's FluView . (msdmanuals.com)

Background Hospital admissions with acute exacerbations of chronic obstructive pulmonary disease are common and associated with high mortality rates, frequent readmission and worse quality of life. (ndltd.org)
In an acute episode of asthma, symptoms vary according to the episode's severity. (medscape.com)
Environmental factors are the primary factors leading to the recurrence or acute occurrence of asthma. (hzhongtai.com)
Pulse oximetry measurement is desirable in all patients with acute asthma to exclude hypoxemia. (medscape.com)
COVID-19 (coronavirus disease 2019) is the disease resulting from infection by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus. (bvsalud.org)

Pathogenesis of asthma. (medscape.com)

Dr. Denning] Antibacterial resistance is caused by many different things, but one of them, for example, is using antibacterials in food for animals to improve the growth of animals, which is clearly unhelpful if they're antimicrobials that lead to resistance of human pathogens. (cdc.gov)
There are 18 H types and 11 NA types, giving 198 possible combinations, but only a few are human pathogens. (msdmanuals.com)
therefore, the association between certain periodontal pathogens and coronary artery disease or stroke is gaining more importance. (medscape.com)

The aim of this review is to examine the current literature for the most recent updates on health effects of specific air pollutants and their impact on asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infection. (cdc.gov)
Considerable past evidence suggests that air pollution is an important factor that enhances pulmonary disease, while also causing greater harm in susceptible populations, such as children, the elderly, and those of low socio-economic status worldwide. (cdc.gov)
Asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infections all seem to be exacerbated because of exposure to a variety of environmental air pollutants with the greatest effects because of particulate matter, ozone, and nitrogen oxides. (cdc.gov)
Summary: Continued vigilance will be essential to lessen the effects of air pollution on human health and pulmonary disease. (cdc.gov)
Since hypoxia can be a feature of respiratory disorders, such as asthma and chronic obstructive pulmonary disease, it may be of importance to determine if airway smooth muscle function is altered under hypoxic conditions. (gla.ac.uk)
Exposure to metalworking fluid aerosols can lead to hypersensitivity pneumonitis and chronic obstructive pulmonary disease ( 1 , 6 , 12 - 14 ). (cdc.gov)
Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. (cdc.gov)
A machine learning approach to triaging patients with chronic obstructive pulmonary disease. (nationaljewish.org)

This leads to malnutrition and water-borne diseases and contributes to 12.6 million preventable deaths in the world each year. (fountainmagazine.com)

The tone of the airway smooth muscle in vivo is regulated by neural control mechanisms, locally released mediators as well as humoral factors. (gla.ac.uk)
Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease. (nottingham.ac.uk)
Flowchart showing the possible mechanisms linking oral/dental infections to systemic diseases. (medscape.com)

Plethysmography indices, respiratory resistance, and reactance before and after bronchodilator with impulse oscillation (IOS), exhaled nitric oxide (eNO), total eosinophil count (TEC), and serum eosinophil cationic protein (ECP) levels were measured in 21 subjects. (nih.gov)
In chronically hypoxic rats, however, the airway smooth muscle appears to be more sensitive to nitric oxide than control rats, which may explain why contractile responses are significantly smaller in the chronically hypoxic rats. (gla.ac.uk)

Respiratory tract infection (RTI) is defined as any infectious disease of the respiratory tract. (e-booksdirectory.com)
It may cause infectious disease that can be passed from one person to another by direct contact, water or food or aerosolization of infected particles in the environment and through the insects like mosquitoes and other insects. (topwellnesshealth.com)
It is an infectious disease. (topwellnesshealth.com)
I'm an infectious disease physician and I've been looking after patients for over thirty years with many different sorts of infections, including fungal diseases, which is my area of interest and specialty. (cdc.gov)

Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. (nationaljewish.org)
Differentiating Upper Airways Resistance in Adenoid Hypertrophy, Allergic Rhinitis, and Obstructive Sleep Apnea: Imaging and Approaches -- 21. (nshealth.ca)

The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)
In summary, we demonstrate a role of motile cilia in TGF-β1 sensing and showed that TGF-β1 disturbs TJ permeability of conductive airway epithelia by redistributing CLDN3 from TJs into cell nuclei. (springer.com)

Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. (nih.gov)
The chest radiograph remains the initial imaging evaluation in most individuals with symptoms of asthma, but in most patients with asthma, chest radiography findings are normal or may indicate hyperinflation. (medscape.com)

We'll be talking about antibiotic resistance and fungal infections. (cdc.gov)

The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. (wikipedia.org)

In the UK the prevalence of asthma is particularly high, a recent report showed that in Scotland more than 18% of people experienced asthma symptoms and in England and Wales similar figures were reported, 17% and 15.3% respectively (Global Initiative for Asthma 2004). (nottingham.ac.uk)
4 found a high prevalence of asthma symptoms among schoolchildren. (bvsalud.org)

Also, people with diabetes who eat more lycopene don't seem to have a lower risk of dying from heart disease. (medlineplus.gov)
Las personas que consumen más licopeno en su dieta no parecen tener un riesgo menor de desarrollar diabetes. (medlineplus.gov)

Anatomy35

Organisms9

Diseases42

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology5

Phenomena and Processes63

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science4

Named Groups1

Health Care12

Inflammation25

Epithelial cells6

Obstruction7

Hyperresponsiveness6

Cultured human airway smooth2

Eosinophils and airway1

Inflammatory16

Asthmatic3

Clinical14

Antimicrobial resistance7

Diagnosis6

Cytokine3

Small airways2

Mucus2

Fibroblasts1

Respiratory diseases7

Airflow2

Continuous positive2

Mediator3

Remodeling4

Induces2

Alveolar1

Allergies1

Pathology1

Cardiovascular1

Fibrotic3

Induce3

Bronchial epithelial1

Allergic Asthma1

Cells6

Lung Diseases3

Corticosteroids5

Emphysema2

Immunology3

COPD4

Severe asthma2

Centers for Diseas5

Influenza15

Acute5

Pathogenesis1

Pathogens3

Pulmonary disease9

Contributes1

Mechanisms4

Nitric2

Infectious disease4

Hypertrophy2

Permeability2

Patients with asthma2

Antibiotic Resistance1

Peripheral1

Interleukin1

Prevalence of asthma2

Diabetes2