• Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for vascular diseases, and is often regarded as a key early event in the development of atherosclerosis. (wikipedia.org)
  • Therefore, increased ADAMs-mediated shedding can induce inflammation, tissue remodeling and dysfunction associated with various cardiovascular diseases such as hypertension and atherosclerosis, and ADAMs can be a potential therapeutic target in these diseases. (nih.gov)
  • 2010 ). Results from cav-1 (caveolin-1, the key structural protein of caveolae)-deficient mice indicated that cav-1 in endothelium is essential in the translocation of LDL-derived cholesterol into the vessel wall and in the development of atherosclerosis, and this result was further confirmed in apoE-/- mice (Fernandez-Hernando et al. (springer.com)
  • It was reported there was an adverse link between moderate drinking of red wine and risk of heart disease (Szmitko and Verma 2005 ), and further the anti-atherosclerosis effect of RSV had been found (Fan et al. (springer.com)
  • Atherosclerosis is initiated by endothelium dysfunction, followed by immune cell (including monocytes) infiltration into the vascular intima to induce forming of plaques. (ki.se)
  • Atherosclerosis begins when lipoproteins infiltrate the vascular intima, drawing monocytes across the endothelium. (mayoclinic.org)
  • Injury to vascular endothelium, such as that induced by aging, high cholesterol, diabetes or hypertension, is considered a key initiating event in the development of atherosclerosis, leading to impairment of brain blood flow. (mayo.edu)
  • Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. (imperial.ac.uk)
  • Excessive or prolonged increases in permeability of the endothelium, as in cases of chronic inflammation, may lead to tissue swelling (edema). (wikipedia.org)
  • Inflammation and endothelial injury were assessed in selected samples by immunostaining for CD8 T cells, activated cytotoxic T lymphocytes, and vascular endothelial cells. (nih.gov)
  • Vascular endothelial cells normally provide an efficient barrier against thrombosis, lipid uptake, and inflammation. (nature.com)
  • Many disease conditions-including obesity, arthritis and heart disease-- are affected by an ongoing inflammation even when there is no infection. (ohsu.edu)
  • 3) Vascular dysfunction within adipose tissue leads to inflammation and metabolic dysfunction. (bu.edu)
  • The latter is commonly reported as a noninfectious acute inflammation of the anterior uveal tract and its adjacent structures, which may affect more than 20% of SpA patients representing the most common EAM of the disease [ 3 ]. (hindawi.com)
  • iii) infection of vascular endothelium/ heart pericytes with subsequent local inflammation (vasculitis) and clot formation [ 9 ]. (springer.com)
  • Surface associated glycoproteins of endothelial origin, or derived from pericytes, intravascular leukocytes, and plasma, are other important components of the glycocalyx, constituting a vascular cell surface proteome that is dynamic, tissue-specific, and sensitive to changes in vascular homeostasis, blood infection, and inflammation. (lu.se)
  • This method facilitates the identification of markers of vascular activation and provides a molecular framework to understand the contribution of vascular dysfunction to the organ pathology of systemic inflammation. (lu.se)
  • Some authors think that it begins with some minor trauma to the ear that then incites chronic inflammation of the perichondrium, resulting in local vascular compromise. (medscape.com)
  • Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • I'm Nikki Grimsley and I'm representing the Clinician Outreach and Communication Activity, or COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • Countermeasures Team Lead for the 2023 Malaria Response at the Centers for Disease Control and Prevention. (cdc.gov)
  • 4 Due to the historically low rates of syphilitic disease in 1999, the Centers for Disease Control and Prevention (CDC) launched the National Plan to Eliminate Syphilis in 1999. (glowm.com)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • On September 15, 2020, the Centers for Disease Control and Prevention (CDC) notified ADHS that the mother tested positive for hantavirus, and the son was confirmed to be co-infected with both hantavirus and SARS-CoV-2. (cdc.gov)
  • The pathogenesis of arterial hypertension often involves a rise in systemic vascular resistance (vasoconstriction and vascular remodeling) and impairment of salt excretion in the kidney (inappropriate salt retention despite elevated blood pressure). (nature.com)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
  • Scholars@Duke publication: Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner. (duke.edu)
  • Obesity and its comorbidities, including hypertension, hyperlipidemia and type 2 diabetes mellitus, have a devastating impact on vascular function leading to conditions that promote cardiovascular disease. (bu.edu)
  • In human subjects, studies have shown that endothelial dysfunction, recognized as impairments in flow-mediated dilation or endothelial-dependent vasodilation in response to acetylcholine, is predictive of cardiovascular events in patients with hypertension, coronary artery disease, peripheral artery disease, etc. (bu.edu)
  • A malfunction of the vascular endothelium arises at an early stage in the development of pulmonary arterial hypertension. (medicalnewstoday.com)
  • With pulmonary arterial hypertension, the malfunctioning of the vascular epithelium results in the contraction and narrowing of the blood vessels. (medicalnewstoday.com)
  • The focus of the Pulmonary Vascular Biology Lab, led by Dr. Jason Elinoff, is the interplay between lung vascular endothelium and immune effector cells and their contributions to the development and progression of pulmonary arterial hypertension (PAH). (nih.gov)
  • Vascular endothelium actively participates in inflammatory reactions in the majority of chronic respiratory diseases. (intechopen.com)
  • We hypothesised that MTX specifically protects the vascular endothelium against inflammatory injury via induction of AMPK-regulated protective genes. (bmj.com)
  • Premature cardiovascular disease (CVD) is a serious long-term complication of chronic systemic inflammatory diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). (bmj.com)
  • 3, 5- 8 Animal models of inflammatory bowel disease (IBD), using knockout or transgenic mice, only acquire characteristic lesions when their colon is populated with normal commensal bacteria, 9- 15 while germ free mice with genetic susceptibility do not develop disease. (bmj.com)
  • We have shown that chronic inflammatory disease impacts endothelial progenitor cell (EPC) biology, through reducing their circulating numbers and by impairing their function. (rug.nl)
  • Obesity promotes a chronic inflammatory state, which contributes to the development of insulin resistance and cardiovascular disease. (bu.edu)
  • Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
  • Spondyloarthropathies (SpA) embrace different chronic inflammatory diseases sharing common genetic (association with HLA-B27 antigen) and clinical features. (hindawi.com)
  • The disease course is usually complicated by extra-articular manifestations (EAMs), such as psoriasis, inflammatory bowel disease (IBD), and acute anterior uveitis (AAU) [ 2 ]. (hindawi.com)
  • Unlike selective pulmonary vasodilators alone, approaches directed at inflammatory vascular remodeling have the potential to arrest or even reverse the disease. (nih.gov)
  • [ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)
  • Vascular dysfunction is a hallmark of systemic inflammatory responses such as bacterial sepsis. (lu.se)
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
  • the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
  • Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)
  • 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
  • Caveolae-mediated permeability plays a major role in the transport of large molecules across endothelium (Komarova and Malik 2010 ). (springer.com)
  • peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. (bvsalud.org)
  • Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
  • vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
  • These responses were preserved when HUVECs were pretreated with tumour necrosis factor-α to mimic dysfunctional endothelium. (bmj.com)
  • Dr. Katusic's research is designed to define mechanisms linking dysfunctional endothelium with progression of cognitive decline. (mayo.edu)
  • and group 4 comprised the six patients with congenital heart disease as controls, with a total of 27 normal coronary angiography sites. (bmj.com)
  • CONCLUSIONS There is evidence of persisting abnormal vascular wall morphology and vascular dysfunction at the site of regressed coronary aneurysms in patients with previous Kawasaki disease. (bmj.com)
  • 1 , 2 Approximately 50% of coronary aneurysms occurring in the acute stage of this disease were shown to regress within several years, and normal angiographic findings were demonstrated. (bmj.com)
  • However, the long term prognosis and natural history of Kawasaki disease, particularly in patients with regressed coronary aneurysms or with normal coronary arteries, remain uncertain. (bmj.com)
  • On the basis of our own 3-11 and other 12-14 previous studies, we felt there was a need to examine prospectively the long term consequences of regressed coronary aneurysms and normal coronary arteries after Kawasaki disease. (bmj.com)
  • Intravascular ultrasound imaging of coronary arteries now allows detailed visualisation of coronary wall morphology and the healing process in patients with Kawasaki disease. (bmj.com)
  • When anaesthetising patients with coronary artery disease, maintain coronary perfusion pressure and avoid tachycardia. (onteenstoday.com)
  • Myocardial perfusion scans help us diagnose: Coronary artery disease. (onteenstoday.com)
  • Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. (duke.edu)
  • Numerous established studies have confirmed that an impaired endothelial function (within the lining of the arteries) is linked to all major coronary heart diseases. (detoxamin.com)
  • The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)
  • therefore, the association between certain periodontal pathogens and coronary artery disease or stroke is gaining more importance. (medscape.com)
  • For this purpose, we used a mammalian infection model, the ferret, in which NiV causes fulminating systemic disease, with fever and neurologic and/or respiratory signs, similar to those in humans ( 15 ). (cdc.gov)
  • Tickborne rickettsial diseases in humans often share similar clinical features yet are epidemiologically and etiologically distinct. (cdc.gov)
  • Thus, the public health response to halt local malaria transmission targets the mosquito vector in humans with the disease. (cdc.gov)
  • By creating a new mouse model of Alzheimer's disease that better recapitulated how the disease plays out in humans, investigators at KU Leuven have gained new. (bioworld.com)
  • VSPB, Viral Special Pathogens Branch, CDC (National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology). (cdc.gov)
  • In this review, we focus on the role of ADAMs in cardiovascular pathophysiology and cardiovascular diseases. (nih.gov)
  • The funds from this ARC will be used to 1) initiate collaborative studies in mouse models on mechanisms of obesity-linked cardiovascular diseases and 2) support research where basic science and clinical research labs perform molecular analyses on tissues and cell samples isolated from patient populations. (bu.edu)
  • Non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) are emerging as major threats to modern societies. (ki.se)
  • Central role of metabolism in endothelial cell function and vascular disease. (koreamed.org)
  • Thus, the overall objective of this group includes defining how abnormalities in maternal nutrition and metabolism affect critical developmental processes that lead to later disease. (ohsu.edu)
  • Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
  • Human studies show that vitamin D reduces arterial stiffness and blood pressure, directly reducing the risk of heart disease and stroke. (lifeextension.com)
  • However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger arterial disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. (imperial.ac.uk)
  • Improved understanding of vascular biology is crucial for all cardiologists, and particularly interventional cardiologists, as maintenance of a competently functioning endothelium is critical for long-term vascular health. (nature.com)
  • Vascular biology. (nih.gov)
  • Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. (hindawi.com)
  • Cerebral endothelium is probably one of the most specific types since it is the crucial element of the well-known blood-brain barrier. (hindawi.com)
  • Cerebral endothelial dysfunction is mentioned in the pathophysiology of several neurological diseases. (hindawi.com)
  • Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
  • Dr. Katusic's team is interested in the development of optimal therapeutic interventions designed to exert a protective effect on vascular endothelium in the cerebral circulation. (mayo.edu)
  • Evidence continues to substantiate the importance of healthy cerebral blood vessels in the prevention of Alzheimer's disease. (mayo.edu)
  • These insights open new horizons for vascular regenerative medicine and challenge current dogmas on the pathophysiology of fibro-proliferative vascular disease. (rug.nl)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
  • My research in Hematology addresses three areas of investigation: disorders associated with sickle cell disease pathophysiology, venous thrombosis/thromboembolism (VT/E) associated with aging, and cerebrovascular injury. (duke.edu)
  • Vascular injury has been seen in patients with acute graft versus host disease (GVHD) in the skin. (nih.gov)
  • Studying the mechanisms of endothelial dysfunction in brain blood vessels of patients with smoking habits and COPD can be very important for preventing acute vascular events. (intechopen.com)
  • In sickle cell disease, vaso-occlusion leads to serious life-threatening complications, including acute pain crises and irreversible organ damage. (duke.edu)
  • Overall, there was a non-significant trend towards increased endothelium-dependent vasodilation following both acute and chronic FVPD consumption. (cambridge.org)
  • Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)
  • If the local vascular homeostasis is disturbed, it will result in platelet deposition, aggregation and a release of factors that promote smooth muscle proliferation. (detoxamin.com)
  • The aim of this review is to explore the role of glucosinolates derived isothiocyanates in various molecular mechanisms involved in the progression of Alzheimer's disease and their potential in the prevention and treatment of Alzheimer's disease. (frontiersin.org)
  • This chapter describes endothelium-related and neuro-mediated mechanisms of emphysema development in chronic obstructive pulmonary disease (COPD) and smoking on the basis of previously completed studies, literature data, and own researches. (intechopen.com)
  • This research team is determined to find the mechanisms in the fetus that lead to adult cardiovascular disease. (ohsu.edu)
  • We propose projects to define the molecular mechanisms by which metabolic disease impacts vascular function and vice versa . (bu.edu)
  • Dr. Katusic's studies are focused on understanding mechanisms responsible for normal endothelial function and repair of injured endothelium. (mayo.edu)
  • Flowchart showing the possible mechanisms linking oral/dental infections to systemic diseases. (medscape.com)
  • Epidemiological evidence from systematic research findings and clinical trials suggests that nutritional and functional dietary isothiocyanates interfere with the molecular cascades of Alzheimer's disease pathogenesis and prevent neurons from functional loss. (frontiersin.org)
  • So far there is no clinically approved pharmaceutic therapy to reverse the process, largely due to limited understanding of the molecular events underlying the disease development. (ki.se)
  • This ARC will coordinate activities of basic science labs and clinical research labs to assess the interrelationship between metabolic dysfunction and vascular disease. (bu.edu)
  • The group's studies are performed on experimental models of stroke and Alzheimer's disease. (mayo.edu)
  • Dr. Katusic's research will help to alleviate suffering and improve quality of life for patients with stroke and Alzheimer's disease. (mayo.edu)
  • It is important to understand how a mother's diet or diabetes will affect the endothelium's ability to sense changes in disease states. (ohsu.edu)
  • Resveratrol also down-regulated the increased expressions of vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR, or VEGF receptor-2) induced by high glucose. (springer.com)
  • On the other side, vascular endothelial growth factor (VEGF), one of the strongest hyperpermeability inducers (Senger et al. (springer.com)
  • This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply. (portlandpress.com)
  • The absence of a change in plasma VEGF may reflect altered VEGF binding at the endothelium, although this cannot be confirmed by the present data. (portlandpress.com)
  • even 1 in 3 people die from Alzheimer's disease, and it is a growing epidemic across the globe fruits and vegetables rich in glucosinolates (GLCs), the precursors of isothiocyanates (ITCs), have long been known for their pharmacological properties and recently attracted increased interest for the possible prevention and treatment of neurodegenerative diseases. (frontiersin.org)
  • The aggregation of misfolded proteins, such as α-synuclein in Parkinson's disease (PD), occurs intracellularly or extracellularly in the majority of neurodegenerative diseases. (bvsalud.org)
  • Herein, we aimed to determine if novel compound, 11-Hydroxy-1-(8-methoxy-5-(trifluoromethyl)quinolin-2-yl)undecan-1-one oxime (named as J24335), is a promising candidate for disease-modifying therapy to prevent the pathological progression of neurodegenerative diseases, such as PD. (bvsalud.org)
  • Our research aims to understand how metabolic stress signals reprogram hepatocytes and immune cells to promote the progression of these diseases. (ki.se)
  • Monocytes and liver-resident macrophages are activated by stimuli from the microenvironment and communicate with metabolic tissues to affect disease progression. (ki.se)
  • Scientists from the Max Planck Institute for Heart and Lung Research and Giessen University have now succeeded for the first time in an animal model in not only halting the progression of the disease, but also in reversing it with the help of an inhalation therapy. (medicalnewstoday.com)
  • Not only was the disease progression halted, we were also able to observe a clear improvement in all areas,' explains Soni Pullamsetti, first author of the study. (medicalnewstoday.com)
  • Werner Seeger, Director of the Department of Lung Development and Remodelling at the MPI and Director of the Department of Internal Medicine at University Hospital Giessen sees the potential of the study as relating to the fact that 'for the first time, the progression of the disease was not only halted but the structural changes in the blood vessels were also reversed using a locally administered substance. (medicalnewstoday.com)
  • We aimed to see whether vascular injury mediated by cytotoxic T lymphocytes and microvessel loss arises in patients with chronic GVHD. (nih.gov)
  • Heart Disease is the end result of injury that started at the extremely thin layer of endothelial cells that line the inside surface of the heart and blood vessel walls. (detoxamin.com)
  • later, vascular injury was noted during the Each sample was divided into 2 × 5 mL por- annual medical examination. (who.int)
  • the blood in the second vascular injury. (who.int)
  • The incidence of cardiac injury is much greater in patients with severe disease presentation and those in intensive care. (springer.com)
  • This report updates the 2006 CDC recommendations on the diagnosis and management of tickborne rickettsial diseases in the United States and includes information on the practical aspects of epidemiology, clinical assessment, treatment, laboratory diagnosis, and prevention of tickborne rickettsial diseases. (cdc.gov)
  • Learn about clinical trials that address specific scientific questions about human health and disease. (mayo.edu)
  • This vascular disruption then creates the observed clinical sequelae of painful nodules. (medscape.com)
  • Since then, this disease can be classified into four different clinical forms that have identical histologicalfeatures, but affecting specific populations. (bvsalud.org)
  • Many considered the endothelium a specialized epithelial tissue. (wikipedia.org)
  • The different transmission characteristics of NiV-Malaysia and NiV-Bangladesh might be attributable to differences in infectivity and pathogenicity of virus strains and in tissue tropism, reflected by higher incidence of respiratory disease in NiV-Bangladesh-infected patients ( 14 , 21 ). (cdc.gov)
  • 1993) A kallikrein-like enzyme in human vascular tissue. (nature.com)
  • Originally regarded as a passive barrier, the endothelium has become appreciated as a complex tissue with multiple functions and critical for shaping health. (rug.nl)
  • Therefore, it is of utmost importance to establish the frequency of infection of heart tissue in COVID-19 patients with multiple presentations of the disease. (springer.com)
  • Oral microorganisms may also enter the deeper tissue after trauma or surgery, which contributes to the disease process, particularly when they cause BE. (medscape.com)
  • This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
  • The general outline of angiogenesis is activating signals binding to surface receptors of vascular endothelial cells. (wikipedia.org)
  • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. (koreamed.org)
  • In this contest of very heterogeneous disease phenotype, the importance of personalised multidisciplinary management of the disease is mandatory. (hindawi.com)
  • The management of SpA has dramatically improved over the last decades due to the development of new treat-to-target strategies and to the introduction of biologic disease modifying antirheumatic drugs (bDMARDs), particularly tumor necrosis factor alpha inhibitors (TNFis), currently used for the treatment of nonresponder patients to conventional synthetic agents. (hindawi.com)
  • Among biologic disease modifying antirheumatic drugs (bDMARDs), tumor necrosis factor alpha inhibitors (TNFis) are currently widely used for the treatment of SpA. (hindawi.com)
  • Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low-cost, effective antibacterial therapy. (cdc.gov)
  • Despite population-wide improvements in lipid levels, heart disease remains the No. 1 cause of death both within the U.S. and globally. (mayoclinic.org)
  • In contrast, infectious diseases and environmental/occupational exposures reflected much higher proportions of early phase research. (cdc.gov)
  • Emerging Infectious Diseases is a publication of the U.S. Government. (cdc.gov)
  • Depending on their nature and function, ECs form either a continuous or porous endothelium, allowing various levels of passage of fluids and nutrients between the lumen and surrounding tissues. (beckman.com)
  • Background: Reduced plasma vitamin C concentrations in chronic diseases may result from abnormal urinary excretion of vitamin C: a renal leak. (researchgate.net)
  • however, the prominent upward shift in age distribution has increased the prevalence of chronic diseases, including Alzheimer's disease (AD). (frontiersin.org)
  • During fetal development, maternal under-nutrition and over-nutrition are associated with an elevated risk of chronic diseases later in life. (ohsu.edu)
  • This includes studies of germ cell development and epigenetic effects that persist following fertilization, the uterine environment during implantation, as well as placental and organ formation and function and related development of chronic diseases after birth. (ohsu.edu)
  • The average UK adult consumes less than three portions of fruit and vegetables daily, despite evidence to suggest that consuming five portions daily could help prevent chronic diseases. (cambridge.org)
  • This was followed by birth defects and developmental disabilities, cardiovascular disease, genetic testing, and cancer, which all showed relatively high proportions of later phase translational studies. (cdc.gov)
  • The vascular endothelium and human diseases. (koreamed.org)
  • The aims of this unit are to provide a knowledge base of recent developments in understanding the cardivascular system and its role in human diseases, and to examine how such understanding can lead to identification and exploitation of novel drug targets for future therapy. (bath.ac.uk)
  • Importantly, the ARC is translational, and it strives to meaningfully involve mechanistic studies in experimental systems with measures of vascular cell function in patients. (bu.edu)
  • The disease caused by SARS-CoV-2 is now being understood as a multisystem infection and harms other organs besides the lungs. (springer.com)
  • Although syphilis rates have seen an overall decline since syphilis was first reported in the 1940s, only a few decades ago this disease was as widespread as chlamydial infection is today. (glowm.com)
  • The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)
  • Kaposi sarcoma is one of the first recognized opportunistic diseases in HIV infection and is still the most common malignancy associated with AIDS 32 . (bvsalud.org)
  • Several systemic diseases, such as diabetes mellitus, may increase the prevalence, incidence, or severity of gingivitis and periodontitis. (medscape.com)