MutagenesisMutagenesis, Site-DirectedDrug DiscoveryMutagenesis, InsertionalMolecular Sequence DataAmino Acid SequenceMutationBase SequenceBinding SitesModels, MolecularEscherichia coliStructure-Activity RelationshipSequence Homology, Amino AcidProtein Structure, TertiaryAmino Acid SubstitutionProtein BindingRecombinant ProteinsDNA Transposable ElementsBacterial ProteinsSequence AlignmentCloning, MolecularPlasmidsProtein ConformationKineticsSequence Analysis, DNADrug DesignSubstrate SpecificityProtein Structure, SecondaryGenes, BacterialCysteineCell LineCatalysisDNA PrimersPoint MutationEthylnitrosoureaMutagensConserved SequenceCrystallography, X-RayPhenotypeComputational BiologyAlanineCatalytic DomainDNA Mutational AnalysisAmino Acid MotifsMolecular StructureEscherichia coli ProteinsHigh-Throughput Screening AssaysSmall Molecule LibrariesDNAAlgorithmsHistidineDrug Evaluation, PreclinicalHistory, 20th CenturyGenetic Complementation TestTransfectionSOS Response (Genetics)LigandsTranscription, GeneticDNA, BacterialProtein EngineeringGene Expression ProfilingPromoter Regions, GeneticGene LibraryRestriction MappingRecombinant Fusion ProteinsGenomicsSequence DeletionSaccharomyces cerevisiaePolymerase Chain ReactionEthyl MethanesulfonateTranscription FactorsProteomicsModels, BiologicalChromosome MappingDirected Molecular EvolutionLysineMutant ProteinsOligodeoxyribonucleotidesNobel PrizeSoftwareDNA-Binding ProteinsModels, GeneticEnzyme StabilityCricetinaeAspartic AcidGene Expression Regulation, BacterialUltraviolet RaysGenetic VectorsPhylogenySignal TransductionMass SpectrometryCombinatorial Chemistry TechniquesBiological ProductsCOS CellsProteinsAsparagineOligonucleotide Array Sequence AnalysisDNA RepairPeptidesHistory, 19th Century