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Diabetes Mellitus, Type 2Diabetes Mellitus, Type 1Diabetes MellitusHypoglycemic AgentsBlood GlucoseDiabetic NephropathiesDiabetic NeuropathiesHemoglobin A, GlycosylatedInsulinDiabetes Mellitus, ExperimentalCase-Control StudiesDiabetes ComplicationsObesityRisk FactorsDiabetic RetinopathyDiabetic AngiopathiesDiabetes, GestationalPregnancy in DiabeticsDiabetic FootHyperglycemiaStreptozocinGlucose Tolerance TestInsulin ResistanceIslets of LangerhansPrevalenceAlbuminuriaDiabetic DietGlucoseBody Mass IndexHypertensionTime FactorsPrediabetic StateMice, Inbred NODHypoglycemiaDiabetic CardiomyopathiesDiabetic KetoacidosisProspective StudiesFollow-Up StudiesInsulin-Secreting CellsC-PeptideGlucose IntoleranceCardiovascular DiseasesMetforminSulfonylurea CompoundsCohort StudiesRetrospective StudiesIncidenceFastingAlloxanBlood Glucose Self-MonitoringBiological MarkersTreatment OutcomeDiabetes InsipidusBlood PressureCross-Sectional StudiesBody WeightReference ValuesGlutamate DecarboxylaseFructosamineGlycosuriaRisk AssessmentAge FactorsPregnancyComorbidityLipidsTriglyceridesGlycosylation End Products, AdvancedMultivariate AnalysisMetabolic Syndrome XPancreasInsulin Infusion SystemsRats, WistarSex FactorsDipeptidyl-Peptidase IV InhibitorsDisease Models, AnimalHyperlipidemiasCoronary Artery DiseaseDiabetic ComaIslets of Langerhans TransplantationKidney Failure, ChronicUnited StatesGenetic Predisposition to DiseaseJapanLogistic ModelsRegression AnalysisRats, Inbred BBOxidative StressGlucagon-Like Peptide 1ThiazolidinedionesKidneyRats, ZuckerOdds RatioDisease ProgressionDyslipidemiasRats, Sprague-DawleyPredictive Value of TestsGlucagonProportional Hazards ModelsGlucose Clamp TechniqueAsian Continental Ancestry Group
NephropathyKetoacidosisRetinopathyT2DMCardiovascular diseaseGlycemicHyperglycemiaInsulin2016AbstractChronicPrevalencePeripheralMetabolicMethodsComplications of diabeHypertension2020ProgressionMicrovascularDiagnosisMorbidityComplication of diabetes20222021CoronaryIncidence of diabetesNeuropathyGlucoseOnsetLipidOutpatient ClinicObesityT1DMTherapeuticInhibitorsPeople with diabetesPreventionPathogenesisPatients with typeClinicalOccurrence of diabeticAnti-diabeticKidney disease2023ProteinuriaObeseSubjectsTreatmentDyslipidemia
Nephropathy24
  • Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) among type 2 diabetes mellitus patients (DM) in Malaysia. (nih.gov)
  • This study has identified several genes of interest, such as HLA-C, SLC16A3, SLC9A8, SLC12A1 and SLC7A2, that require verification of their roles as susceptibility genes for diabetic nephropathy in ethnic Malays with type 2 DM. (nih.gov)
  • Currently, diabetic nephropathy is the leading cause of chronic kidney disease in the United States and other Western societies. (medscape.com)
  • Generally, diabetic nephropathy is considered after a routine urinalysis and screening for microalbuminuria in the setting of diabetes. (medscape.com)
  • Good evidence suggests that early treatment delays or prevents the onset of diabetic nephropathy or diabetic kidney disease. (medscape.com)
  • Regular outpatient follow-up is key in managing diabetic nephropathy successfully. (medscape.com)
  • Recently, attention has been called to atypical presentations of diabetic nephropathy with dissociation of proteinuria from reduced kidney function. (medscape.com)
  • Also noted is that microalbuminuria is not always predictive of diabetic nephropathy. (medscape.com)
  • [ 3 ] Nevertheless, a majority of the cases of diabetic nephropathy present with proteinuria, which progressively gets worse as the disease progresses, and is almost uniformly associated with hypertension. (medscape.com)
  • Several issues are key in the medical care of patients with diabetic nephropathy. (medscape.com)
  • Diabetes mellitus is known for its complications such as retinopathy, neuropathy and nephropathy. (ijmedicine.com)
  • While not exclusive, the two most common forms are diabetic retinopathy and diabetic nephropathy, whose pathophysiologies are largely identical. (wikipedia.org)
  • The glomeruli of the kidneys are especially sensitive - see diabetic nephropathy - where protein leakage caused by late-stage angiopathy results in diagnostic proteinuria and eventually kidney failure. (wikipedia.org)
  • Background and aims: Oxidative stress contributes to development of diabetic nephropathy. (ewha.ac.kr)
  • We implicated SH3YL1 in oxidative stress-induced inflammation and examined whether SH3YL1 could be used as a new biomarker of diabetic nephropathy. (ewha.ac.kr)
  • Methods and results: In this study, we investigated the relationship between plasma level of SH3YL1 and diabetic nephropathy in patients with type 2 diabetes. (ewha.ac.kr)
  • Conclusion: These findings suggest that plasma level of SH3YL1 offers a promising new biomarker for diabetic nephropathy. (ewha.ac.kr)
  • Nevertheless, significant unmet need remains for products that can offer better glycemic control, as well as the prevention and cure of diabetic complications, such as diabetic nephropathy, retinopathy, and cardiovascular disease. (sbwire.com)
  • Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes. (diabetesjournals.org)
  • Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. (epnet.com)
  • Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). (hindawi.com)
  • The genesis of diabetic nephropathy (DN) in type 2 diabetes mellitus is clearly multifactorial, involving hypertension, hyperglycemia, hyperinsulinemia, and hyperlipidemia [ 1 - 6 ]. (hindawi.com)
  • Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. (academicjournals.org)
  • Previous studies demonstrated the therapeutic potential of Astragalus polysaccharide in treating diabetic nephropathy. (spandidos-publications.com)
Ketoacidosis10
Retinopathy15
  • SAN FRANCISCO ― A large observational registry study of almost 100,000 eyes has found that the diabetes drug semaglutide , a GLP-1 agonist recently approved for weight loss, does not worsen the progression of potentially vision-threatening diabetic retinopathy in the long term in patients taking the drug. (medscape.com)
  • In patients that have either no or early or relatively nonadvanced diabetic retinopathy, the absolute risk of having a worsening in their retinopathy is variable," Zeeshan Haq, MD, a retina specialist at Retinal Consultants of Minnesota, told Medscape Medical News . (medscape.com)
  • But if they're going to be starting this drug and they don't have any existing diabetic retinopathy, the discussion should be had between their doctor and the eye-care provider, and if they do have a history of DR, an evaluation with the eye-care provider should probably happen upon starting the drug. (medscape.com)
  • We know that when patients get rapid control of their diabetes, their diabetic retinopathy can worsen in the short term, although it always ends up doing better in long term anyway," Dedania told Medscape. (medscape.com)
  • We always educate our patients that if they get control of the diabetes to not feel discouraged if their diabetic retinopathy worsens despite getting good control, because we know in the long run it always gets better. (medscape.com)
  • In diabetic retinopathy the end-result is often blindness due to irreversible retinal damage. (wikipedia.org)
  • Diabetic patients with diabetic foot were more likely to have a higher prevalence of cardiovascular risk factors such as hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and microalbuminuria or proteinuria, a higher prevalence of a previous cardiovascular morbidity (coronary artery disease, transient ischemic attack/ischemic stroke, diabetic retinopathy), and a higher prevalence of subclinical cardiovascular disease. (unipa.it)
  • Furthermore, diabetic patients with foot ulceration showed, on a 5-year follow-up, a higher incidence of new-onset vascular events (coronary artery disease, transient ischemic attack/ischemic stroke, diabetic retinopathy). (unipa.it)
  • Controlling diabetes and maintaining the HbA1c level in the 6-7% range are the goals in the optimal management of diabetes and diabetic retinopathy. (medscape.com)
  • If the levels are maintained, then the progression of diabetic retinopathy is reduced substantially, according to The Diabetes Control and Complications Trial. (medscape.com)
  • Two-year results from the Diabetic Retinopathy Clinical Research network (DRCR.net) Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema, known as the Laser-Ranibizumab-Triamcinolone for DME Study, demonstrated that ranibizumab paired with prompt or deferred focal/grid laser treatment achieved superior visual acuity and optical coherence tomography (OCT) outcomes compared with focal/grid laser treatment alone. (medscape.com)
  • The United Kingdom Prospective Diabetes Study (UKPDS), which involved newly diagnosed patients with type 2 diabetes mellitus, revealed that the risk of retinopathy was reduced through both improved glycemic control and improved blood pressure control. (medscape.com)
  • [ 34 ] The ADA recommends that all patients with diabetes (type 2 and type 1) strive to maintain glycated hemoglobin levels of less than 7% (reflecting long-term glucose levels) to prevent or at least minimize the long-term complications of diabetes mellitus, including retinopathy. (medscape.com)
  • The Early Treatment for Diabetic Retinopathy Study found that 650 mg of aspirin daily did not offer any benefit in preventing the progression of diabetes mellitus retinopathy. (medscape.com)
  • More than 70% of subjects in these studies had diabetes, and the most frequent etiology of the vitreous hemorrhage was proliferative diabetic retinopathy. (medscape.com)
T2DM14
  • Eighty-two adult subjects with diagnosed T2DM were recruited from the Diabetes Mellitus Outpatient Clinic of the 3rd Department of Internal Medicine, situated at Papageorgiou General Hospital, Thessaloniki, Greece, and divided into two groups according to the presence or absence of DPN. (springer.com)
  • The management of type 1 and type 2 diabetes mellitus (T1DM, T2DM) has evolved with the availability of various antidiabetic agents. (uspharmacist.com)
  • This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy ( DPN ) in type 2 diabetes mellitus (T2DM) patients . (bvsalud.org)
  • Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). (nih.gov)
  • Objective: In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). (mdpi.com)
  • The vast majority of diabetes mellitus patients can be classified as having either Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM). (sbwire.com)
  • Approximately 90-95% of all diabetics have T2DM. (sbwire.com)
  • Consider market opportunities and potential risks by examining trends in T2DM clinical trial size, duration, and failure rate by stage of development, molecule type, and mechanism of action. (sbwire.com)
  • Background: In China, traditional Chinese medicine (TCM) has been used to treat type 2 diabetes mellitus (T2DM) for centuries. (benthamscience.com)
  • Following reports of increased new-onset diabetes and worse severity of DKA for children with diabetes following SARS-CoV-2 infection, we studied hospitalization rates for children with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in our center during the citywide shutdown. (scienceopen.com)
  • We included 132 patients with 214 hospitalizations: 157 T1DM, 41 T2DM, and 16 others (14 steroid induced, 2 MODY). (scienceopen.com)
  • Despite the overall pediatric admissions declining in 2020 due to the citywide shutdown, overall hospitalization rates in children with T2DM and in new-onset T1DM and T2DM increased, which is not directly associated with active SARS-CoV-2 infection. (scienceopen.com)
  • Globally, about one in eleven adults have diabetes, and 90% of whom are diagnosed as type 2 diabetes mellitus (T2DM). (frontiersin.org)
  • It was concluded that IR is strongly associated with obesity and had an important role in the pathogenesis and increased complication of diabetes which could be used as excellent indicators for early-stage DN in T2DM patients and thus decreasing mortality and morbidity. (academicjournals.org)
Cardiovascular disease6
  • Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. (springer.com)
  • We enrolled 102 consecutive patients with type 2 diabetes mellitus with diabetic foot and 123 patients with type 2 diabetes mellitus without limb lesions to compare the prevalence of main cardiovascular risk factors, subclinical cardiovascular disease, previous cardiovascular morbidity, and incidence of new vascular events on a 5-year follow-up. (unipa.it)
  • Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. (nature.com)
  • In the EMPA-REG OUTCOME trial, a large randomized controlled clinical trial, the highly selective SGLT2 inhibitor empagliflozin significantly reduced the risk of three-point major adverse CV events, cardiovascular death, heart failure hospitalization and composite renal outcomes in patients with type 2 diabetes (T2D) with established cardiovascular disease 2 . (nature.com)
  • BACKGROUND: Type 2 diabetes mellitus is associated with a cluster of lipid and apolipoprotein abnormalities which increase the risk for atherosclerotic cardiovascular disease. (minervamedica.it)
  • In any case, the relationship of high-GI foods and/or a high-CHO diet to the development of obesity, type 2 diabetes, and cardiovascular disease (CVD) remains to be puzzled out. (acsh.org)
Glycemic7
  • Nisar MU, Asad A, Waqas A, Ali N, Nisar A. Association of diabetic neuropathy with duration of type 2 diabetes and glycemic control. (ijmedicine.com)
  • Lorcaserin has been shown to have a moderate effect on weight loss and glycemic control in the diabetic population, although questions remain regarding its long-term safety profile. (medscape.com)
  • Researchers evaluated the impact of low-carbohydrate diets on glycemic regulation among individuals with diabetes mellitus type 2. (news-medical.net)
  • improve glycemic control in adults with type 2 diabetes mellitus ( 1.2 ). (nih.gov)
  • Does Eating High-Glycemic-Index Foods Lead to Obesity, Diabetes, and Heart Disease? (acsh.org)
  • Material and Methods: It was selected scientific articles published between the years 2008 and 2014 were selected from MEDLINE, PUBMED and LILACS databases using as key words: type 2 diabetes, periodontal disease, glycemic control and periodontal treatment. (bvsalud.org)
  • Limited health literacy is associated with low medication adherence for chronic disease (11), heart disease deaths (12), poor glycemic control, and more diabetes-related complications (13). (cdc.gov)
Hyperglycemia7
Insulin8
  • To accomplish ideal glucose control, complex treatment anticipates individuals with type-2 diabetes may include day by day blood glucose testing and checking, fittingly endorsed solutions, for example, oral hypoglycemic agents and/or insulin infusion, nutrition treatment and standard exercise 3 - 5 . (scialert.net)
  • Partanen J, Niskanen L, Lehtinen J, Mervaala E, Siitonen O, Uusitupa M. Natural history of peripheral neuropathy in patients with non-insulin dependent diabetes mellitus. (ijmedicine.com)
  • Fasting C-peptide and insulin levels are usually elevated in type 2 diabetes. (medscape.com)
  • Diabetic patients, especially those on insulin, may not recognize symptoms as DKA because the serum glucose is not elevated. (uspharmacist.com)
  • Type 2 diabetes occurs when your body's cells resist the normal effect of insulin, which is to drive glucose in the blood into the inside of the cells. (harvard.edu)
  • 1998), by H. Leighton Steward and associates diets high in carbohydrate (CHO) are responsible for insulin increases that inhibit fat-burning and lead to obesity, type 2 diabetes (non-insulin-dependent diabetes mellitus), and atherosclerosis (specifically, coronary heart disease, or CHD). (acsh.org)
  • The contention that the quantity or percentage of CHO in a diet, or the relative ability of individual foods or diets to increase plasma glucose concentrations, is the primary determinant in the development of obesity, insulin resistance,* and type 2 diabetes is inconsistent with some observations of human populations. (acsh.org)
  • Scientific findings have positively associated (1) diets high in fat (especially saturated fat) and in refined CHOs (particularly sugars) and (2) the development of insulin resistance. (acsh.org)
20162
  • J Diabetes Res;2016: 4370490, 2016. (bvsalud.org)
  • Methods: A descriptive study that assessed hospital records of all patients diagnosed with AMI over a 2-year period (01 August 2016 to 31 July 2018). (bvsalud.org)
Abstract1
  • abstract = "Aim: Type 2 diabetes is a growing global challenge. (birmingham.ac.uk)
Chronic15
  • Diabetes mellitus is a chronic illness which leads to disability, hospitalization and eventually death. (scialert.net)
  • Uncontrolled diabetes prompts numerous chronic complications such as visual impairment, renal failure and heart failure 7 . (scialert.net)
  • However, chronic dysregulated blood glucose in diabetes is toxic to cells of the vascular endothelium which passively assimilate glucose. (wikipedia.org)
  • Acute and Chronic Complications of Diabetes. (wikipedia.org)
  • Background: Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal disease (ESRD) and cardiovascular morbidity. (uni-wuerzburg.de)
  • Methods: DIACORE is a prospective cohort study aiming to recruit 6000 patients of self-reported Background: Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal disease (ESRD) and cardiovascular morbidity. (uni-wuerzburg.de)
  • Diabetes mellitus (DM) is a chronic, non-communicable disease. (scielo.org.co)
  • One of the chronic complications of diabetes mellitus type 2 (DM2) is diabetic foot (DF) 3 , which can result in amputation if it progresses to an ulcer. (scielo.org.co)
  • The purpose of the NAVIGATOR Study is to evaluate the safety and effectiveness of an investigational drug in patients with chronic nerve pain from diabetic peripheral neuropathy (DPN). (clinicalconnection.com)
  • Type 2 diabetes is a chronic disease. (harvard.edu)
  • We created 8 diabetes categories using gestational diabetes for several adverse maternal and infant outcomes including mellitus (GDM) and chronic diabetes mellitus (CDM) status for cesarean delivery, prolonged labor, maternal birth trauma, macro- the 2 deliveries. (cdc.gov)
  • We identified pregnancies affected by GDM and CDM from hos- obesity, hypertension, and type 2 diabetes, perpetuating a cycle of pital delivery discharge (HD) records and birth certificate (BC) poor health and chronic disease (8,9). (cdc.gov)
  • Diabetes and heart disease are prevalent chronic diseases in the United States. (cdc.gov)
  • As with weight perceptions, many Americans tend to underestimate their risk for obesity-related chronic diseases, including diabetes and heart disease (8). (cdc.gov)
  • Higher health literacy is associated with more knowledge of chronic disease (10) and may play a role in perceived risk for chronic diseases such as diabetes and heart disease. (cdc.gov)
Prevalence9
Peripheral9
  • Diabetic peripheral neuropathy (DPN) is the most prevalent neuropathy in diabetes and a common cause of morbidity. (springer.com)
  • The objective of this study was to detect sensory motor neuropathy in type 2 Diabetes mellitus by clinical examination and nerve conduction study and to correlate clinical features of peripheral neuropathy with nerve conduction study in Type 2 Diabetes mellitus. (ijmedicine.com)
  • This study was undertaken to study types of neuropathy in type 2 diabetes and to correlate clinical features of peripheral neuropathy with nerve conduction study in type 2 diabetes mellitus.100 patients with diabetes whose onset of diabetes mellitus after age of 30 years and duration of diabetes 5 years or more visiting SGRDIMSR, Vallah, Amritsar were subjected to nerve conduction study to find out peripheral neuropathy. (ijmedicine.com)
  • Back to basics: ankle reflex in the evaluation of peripheral neuropathy in type 2 diabetes mellitus. (ijmedicine.com)
  • Validity of the neurological examination in diagnosing diabetic peripheral neuropathy. (ijmedicine.com)
  • Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy. (bvsalud.org)
  • The enzyme, namely aldose reductase, is also expressed in the endothelial and Schwann cells of the peripheral nervous system, contributing to diabetic neuropathy. (wikipedia.org)
  • A clinical research study for individuals 18 to 80 (inclusive) years of age with painful diabetic peripheral neuropathy (DPN). (clinicalconnection.com)
  • The most common type is peripheral neuropathy. (harvard.edu)
Metabolic4
  • Antipsychotic metabolic effects: weight gain, diabetes mellitus, and lipid abnormalities. (jabfm.org)
  • The contribution of altered mitochondrial Ca 2+ handling to metabolic and functional defects in type 2 diabetic (T2D) mouse hearts is not well understood. (diabetesjournals.org)
  • Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
  • Diabetes is a complex metabolic syndrome afflicting a growing number of people globally ( 1 ). (diabetesjournals.org)
Methods1
  • METHODS: One thousand seventy-one diabetic patients at very high cardiovascular risk were enrolled in this prospective study. (minervamedica.it)
Complications of diabe1
  • Among the various complications of diabetes, cardiovascular complications are believed to be the leading causes of disability and death among diabetic patients, particularly for diabetic cardiomyopathy (DCM) ( Cai and Kang, 2003 ). (frontiersin.org)
Hypertension3
  • In the 1930s, Kimmelstiel and Wilson described the classic lesions of nodular glomerulosclerosis in diabetes associated with proteinuria and hypertension. (medscape.com)
  • It is also indicated for the treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus as part of an antihypertensive medicinal product regimen (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
  • Nowadays, therapeutic regimes for diabetes and DCM include several clinical managements, involving lifestyle modifications (diet and exercise), glucose and lipid control (antidiabetic and lipid-lowering drugs), hypertension treatment, and coronary artery diseases intervention. (frontiersin.org)
20203
  • Overall admissions rates for patients with all types of diabetes were 3.08% in 2018 to 3.54% in 2019 ( p = 0.0120) and 4.73% in 2020 ( p = 0.0772). (scienceopen.com)
  • Rates of new-onset diabetes presenting with DKA increased from 0.24% in 2018 to 0.96% in 2020 ( p = 0.0014). (scienceopen.com)
  • 18 years in the United States, by date reported to CDC during February 24-April 2, 2020. (scienceopen.com)
Progression1
Microvascular2
  • Diabetes related microvascular and macrovascular disease in physical therapy setting. (ijmedicine.com)
  • Diabetic kidney disease (DKD) is a microvascular complication resulting from diabetes mellitus and represents the most prevalent cause of kidney failure, and ~30% of DKD cases will develop into renal failure ( 1 ). (spandidos-publications.com)
Diagnosis5
Morbidity3
  • It is also one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes. (medscape.com)
  • Although associated with a variety of pathologies, cardiovascular complications are the major cause of mortality and morbidity in patients with diabetes ( 2 , 3 ). (diabetesjournals.org)
  • As the leading cause of morbidity and mortality in patients with diabetes, diabetic cardiomyopathy (DCM) imposes enormous burden on individuals and public health. (frontiersin.org)
Complication of diabetes1
  • By the 1950s, kidney disease was clearly recognized as a common complication of diabetes, with as many as 50% of patients with diabetes of more than 20 years having this complication. (medscape.com)
20221
  • Researchmoz added Most up-to-date research on 'Type 2 Diabetes Mellitus Therapeutics in South-East Asia Markets to 2022 - Increasing Usage of Newer Therapies and Expanding Treatment Population to Encourage Robust Growth' to its huge collection of research reports. (sbwire.com)
20211
  • Patients had type 2 diabetes and began taking injectable semaglutide between January 2013 and December 2021. (medscape.com)
Coronary1
Incidence of diabetes2
  • [ 86 ] With regards to prevention of diabetes in an at risk population, the XENDOS study, a 4-year RCT, found that orlistat plus lifestyle measures resulted in a lower incidence of diabetes over the 4-year study and a greater weight loss compared with lifestyle changes alone. (medscape.com)
  • In the past decade, the incidence of diabetes mellitus has increased exorbitantly around the world and foot ulcer has become the most serious and costly complication, leading to possible amputation or even death. (scielo.org.co)
Neuropathy7
  • Diabetic neuropathy is one of the devastating complication associated with diabetes mellitus. (ijmedicine.com)
  • NCS helps in early detection of neuropathy and most common form of diabetic neuropathy is distal symmetrical polyneuropathy. (ijmedicine.com)
  • Asad A, Hameed MA, Khan UA, Butt MU, Ahmed N, Nadeem A. Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics. (ijmedicine.com)
  • Diabetic neuropathy: mechanisms to management. (ijmedicine.com)
  • Kalkarni AL, Gokhale VS, Vohra KV, Chaudhary N. Clinical and nerve conduction study correlation in patients of diabetic neuropathy. (ijmedicine.com)
  • Other forms of diabetic angiopathy include diabetic neuropathy and diabetic cardiomyopathy. (wikipedia.org)
  • Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms? (wikipedia.org)
Glucose11
  • A random plasma glucose concentration of 200 mg/dL or greater in association with polyuria, polydipsia, or unexplained weight loss is diagnostic of diabetes. (medscape.com)
  • In an asymptomatic patient, a fasting (ie, no caloric intake for at least 8 h) plasma glucose value of 126 mg/dL or greater or a 2-hour plasma glucose value of 200 mg/dL or greater during an oral glucose tolerance test is also diagnostic of diabetes. (medscape.com)
  • 2 Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the newest class of oral diabetes medications. (uspharmacist.com)
  • 1 Other factors that can contribute to EDKA are 1) the decrease in hepatic glucose production during a fasting state when glycogen stores are already depleted and 2) the increased urinary excretion of glucose. (uspharmacist.com)
  • 10 SGLT2i prevent reabsorption of glucose by blocking sodium-dependent glucose transporter 2 in the proximal convoluted tubule. (uspharmacist.com)
  • Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a unique class of oral antidiabetic medications that reduce glucose reabsorption in the renal proximal tubules, thereby enhancing urinary glucose excretion 1 . (nature.com)
  • In some studies, regular hot tub visits actually reduced blood glucose levels in people with diabetes. (healthgrades.com)
  • In addition to being the most common lipid abnormality in type 2 diabetes mellitus, hypertriglyceridaemia is also a feature of impaired glucose tolerance and impaired fasting glucose. (who.int)
  • Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)
  • Diabetes results in a cardiomyopathy characterized by decreased cardiomyocyte function, increased myocardial fatty acid utilization, decreased glucose utilization, increased myocardial oxygen consumption, and decreased cardiac efficiency ( 4 , 5 ), primarily as the result of changes in metabolism and Ca 2+ handling within the myocyte ( 3 , 6 , 7 ). (diabetesjournals.org)
  • The symptoms of diabetes are related to high blood glucose levels. (harvard.edu)
Onset3
  • Liebzeit KA, Markowitz JS, Caley CF. New onset diabetes and atypical antipsychotics. (jabfm.org)
  • A better understanding of the pharmacological role of curcumin on diabetes and DCM can provide clinical implications for the intervention of the onset and development of diabetes and DCM. (frontiersin.org)
  • Type 2 diabetes is also called type 2 diabetes mellitus and adult-onset diabetes. (harvard.edu)
Lipid3
  • Obtain fasting lipid profile after stable glycemia has been achieved and every 2 years thereafter if normal. (medscape.com)
  • CONCLUSIONS: The results of the study recommend encouraging strategies and appropriate treatments to achieve a targeted lipid profile in diabetic patients at very high cardiovascular risk. (minervamedica.it)
  • A fasting lipid profile is recommended on a yearly basis for patients with diabetes. (who.int)
Outpatient Clinic1
  • Type 2 diabetic patients attending medical outpatient clinic in a Specialist Hospital in Nigeria and apparently healthy controls matched for age and sex were recruited.Socio demographic and clinical data were obtained through a pro forma. (ersjournals.com)
Obesity4
  • Recent studies have further highlighted the role of obesity in the renal damage observed not only in patients with obesity-related glomerulopathy but also in overweight subjects with type 2 diabetes [ 6 - 10 ]. (hindawi.com)
  • Obesity greatly increases the risk of diabetes. (harvard.edu)
  • Epidemiological studies have not lent much credence to the notion that high-CHO diets in general, or those consisting mostly of high-GI foods, lead to obesity, diabetes, and CVD. (acsh.org)
  • Obesity is a contributing risk factor for both diabetes and heart disease (4). (cdc.gov)
T1DM1
  • 10 In Europe, dapagliflozin is approved for use in T1DM patients with a BMI of 27 kg/m 2 or higher. (uspharmacist.com)
Therapeutic2
  • During the last decade, welcome novel classes of antidiabetic drugs have arrived, which have provided remarkable cardiorenal benefits for individuals with type 2 diabetes mellitus, revolutionizing its therapeutic approach. (mdpi.com)
  • However, the incidence and mortality rate of DCM still remains high, it is imperative to develop novel and effective therapeutic strategies for diabetes and DCM. (frontiersin.org)
Inhibitors1
  • SGLT-2 inhibitors have been implicated in causing DKA in both type 1 and type 2 diabetes. (msdmanuals.com)
People with diabetes6
  • Hot tubs also present some added risks for people with diabetes. (healthgrades.com)
  • Meal timing [1] (having to eat regularly) and the matching of nutrients are the two essential factors to consider when planning meals for people with diabetes. (healthcanal.com)
  • Not every meal delivery service can be an excellent option for people with diabetes. (healthcanal.com)
  • The International Diabetes Federation [IDF] (2017) estimates that the number of people with diabetes reaches 425 million worldwide in 2017 and it will rise to 629 million by 2045, indicating a 45% increase throughout the world. (frontiersin.org)
  • People most commonly use alpha-lipoic acid for nerve pain in people with diabetes. (medlineplus.gov)
  • Taking 600-1800 mg of alpha-lipoic acid by mouth or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. (medlineplus.gov)
Prevention2
  • Women with GDM during one of 2 sequential pregnancies had el- ease prevention efforts. (cdc.gov)
  • Intervention 1: Intervention Group: In this study, diabetic prevention shoes will be designed and manufactured based on prototyping from external diabetic prevention shoes. (who.int)
Pathogenesis1
Patients with type4
  • This study used microarray analysis to determine the gene expression profiling in ethnic Malay patients with type 2 DM. (nih.gov)
  • As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events. (springer.com)
  • On this basis, the aim of our study was to evaluate the possible role of diabetic foot as a cardiovascular risk marker in patients with type 2 diabetes mellitus. (unipa.it)
  • Evaluation of heart rate variability (HRV) during cardiovascular autonomic tests and functional capacity of patients with type 1 and type 2 DM. (bvsalud.org)
Clinical9
  • Throughout the years, diabetes mellitus (DM) has risen as an essential clinical and public medical issue throughout the world. (scialert.net)
  • In children who do not meet the criteria described above but in whom diabetes is highly suspected, clinical judgment should be applied. (medscape.com)
  • Conclusion: This review demonstrates that although it appears there may be benefit in using the dental workforce to identify undiagnosed cases of non‐diabetic hyperglycaemia and type 2 diabetes, further high‐quality research in the field is required assessing both the clinical and cost effectiveness of such practice. (birmingham.ac.uk)
  • In a DRCR.net clinical trial comparing Eylea (aflibercept), Lucentis (ranibizumab), and Avastin (bevacizumab) for diabetic macular edema (DME), aflibercept provided greater visual improvement, on average, than did the other 2 drugs for vision of 20/50 or worse at the start of the trial. (medscape.com)
  • The American Diabetes Association (ADA) 'Standards of Medical Care in Diabetes' includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. (scienceopen.com)
  • In clinical trials, the most common (incidence ≥2% and greater than placebo) adverse reactions with WELCHOL included constipation, dyspepsia, and nausea ( 6.1 ). (nih.gov)
  • Recently, clinical trials and preclinical studies have shown that curcumin exerts protective effects against a variety of diseases, including diabetes and its cardiovascular complications. (frontiersin.org)
  • In this review, the clinical trials about curcumin supplementation on diabetes and DCM are presented, and the specific mechanisms by which curcumin might mitigate diabetes and DCM are fully discussed. (frontiersin.org)
  • Results and Conclusion: From the studies reported in this review it can be concluded that diabetic and non-diabetic patients undergoing non-surgical periodontal treatment showed improvement in all clinical periodontal vestments. (bvsalud.org)
Occurrence of diabetic1
  • To know the perception of diabetic patients attached to CESFAM BelarminaParedes, Futrono, Chile, regarding the occurrence of diabetic foot ulcers in 2015. (scielo.org.co)
Anti-diabetic2
  • The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. (nih.gov)
  • Both Cin and Ber display an exciting anti-diabetic efficacy in this study and may be of great value for the treatment of type 2 diabetes. (nih.gov)
Kidney disease1
20231
  • 2023 maj 31 , 2 uppl. (lu.se)
Proteinuria1
Obese6
  • Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). (hindawi.com)
  • But by age 50 more than half of the Arizonan Pimas become obese and develop type 2 diabetes, whereas among the Mexican Pimas type 2 diabetes is rare and occurs mostly among the elderly. (acsh.org)
  • The purpose of this study was to investigate associations between weight perceptions and perceived risk for diabetes and heart disease among overweight or obese women. (cdc.gov)
  • Our findings indicate an association between accurate weight perceptions and perceived risk for diabetes and heart disease in overweight or obese women. (cdc.gov)
  • Our objective was to examine predictors of perceived risk for diabetes and heart disease among overweight and obese women, specifically, perceptions about being overweight. (cdc.gov)
  • Ketosis-prone type 2 diabetes is a variant of type 2 diabetes, which sometimes occurs in obese patients, often those with African (including African-American or Afro-Caribbean) ancestry. (msdmanuals.com)
Subjects3
  • Comparative analysis of electrophysiological parameters of median nerve in normal and diabetic subjects. (ijmedicine.com)
  • More than 60% of type 2 diabetic subjects in the Eastern Mediterranean Region have some degree of dyslipidaemia. (who.int)
  • 25% of non-diabetic subjects are hyperlipidaemic. (who.int)
Treatment6
  • [ 2 ] (See Treatment and Management). (medscape.com)
  • Phase 2 contains how to care for your cause, while Phase 3 will cover treatment protocols for symptoms and other ailments. (kidney-cookbook.com)
  • The aim of this study was to evaluate the adherence to guidelines-oriented dyslipidemia treatment in diabetic patients and to assess the efficacy of a territorial goal-oriented program. (minervamedica.it)
  • In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease. (medicines.org.uk)
  • The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. (epnet.com)
  • The treatment of type 2 diabetes also can produce symptoms. (harvard.edu)
Dyslipidemia1
  • Management of dyslipidemia in children and adolescents with diabetes. (medscape.com)