TranssphenoidalInsulinHyperadrenocorticismHypertensionAcromegalyCentral diabetesClinicalPrecursorSurgeryTreatmentCatsGrantResultDogsUrineDaysPatientsYOUNGTranssphenoidal hypophysectomyHypothyroidismGlucoseRadiotherapyGrowth hormonePituitary hormoneRegulateSevereSecondaryDiabeticAntidiuretic hormoneTypeVasopressinIncreasesDevelop
Transsphenoidal5
- Transsphenoidal hypophysectomy is a technically challenging surgery to perform, whereby a tumour affecting the pituitary gland is removed from the base of the brain through the soft palate in the mouth. (rvc.ac.uk)
- Transsphenoidal Hypophysectomy -- Part IV: The Neuromuscular System -- 20. (osu.cz)
- OBJECTIVES: To evaluate the efficacy and safety of transsphenoidal hypophysectomy in treating HST and DM in cats. (bvsalud.org)
- ANIMALS: Sixty-eight client-owned cats with HST and DM treated by transsphenoidal hypophysectomy. (bvsalud.org)
- Transsphenoidal hypophysectomy however, has the potential to become the treatment of choice for dogs (and cats) with PDH. (vin.com)
Insulin6
- Insulin had only recently been made available for the treatment of human diabetes mellitus, as the result of the investigations in Canada of Banting, Best, MacLeod and Collip. (animalresearch.info)
- In 1956, S. M. Rabson and E. N. Mendenhall described this familial syndrome comprising insulin-resistant diabetes, pineal hyperplasia, and various somatic anomalies. (mhmedical.com)
- The severely impaired insulin-binding capacity results in highly insulin-resistant diabetes mellitus. (mhmedical.com)
- It is highly insulin-resistant diabetes mellitus. (mhmedical.com)
- Hypophysectomy has been of short-term benefit, but the problems of insulin resistance persist. (mhmedical.com)
- Overt diabetes mellitus may result from the insulin antagonism caused by hypercortisolemia in about 85% of cats with hyperadrenocorticism. (dvm360.com)
Hyperadrenocorticism1
- The RVC team was the first in the UK to treat cats with acromegaly (hypersomatotropism) and is now also routinely performing hypophysectomy in dogs (and the occasional cat) with pituitary-dependent Cushing's syndrome (hyperadrenocorticism). (rvc.ac.uk)
Hypertension1
- The drug should be used with caution in patients with diabetes mellitus, hypertension, angina pectoris, hypertrophy of the present gland and hyperthyroidism. (myphages.com)
Acromegaly1
- We consider surgical hypophysectomy to be the optimal treatment option for acromegaly. (rvc.ac.uk)
Central diabetes1
- Arginine vasopressin deficiency (central diabetes insipidus) results from a deficiency of vasopressin (antidiuretic hormone [ADH]) due to a hypothalamic-pituitary disorder. (msdmanuals.com)
Clinical2
- At the Garvan Institute he led a joint laboratory and clinical research team studying diabetes and pituitary hormone secretions, in particular the secretion and clinical uses of human growth hormone. (wikipedia.org)
- Photographs demonstrating the improvement in clinical signs for Poppy, a six-year-old miniature schnauzer following hypophysectomy for her Cushing's syndrome. (rvc.ac.uk)
Precursor1
- In latent diabetes, a precursor to diabetes, blood sugar level may be normal. (diabetestalk.net)
Surgery2
- The RVC's highly experienced team was the first veterinary centre in the UK to offer hypophysectomy surgery and have since performed the procedure on more than 100 pets. (rvc.ac.uk)
- Fifty-five cats (95% of 58 surviving cats [81% of all cats undergoing surgery]) had improved control of diabetes. (bvsalud.org)
Treatment4
- Alternative treatment options are limited, since medical treatment is currently cost prohibitive and medical management of the diabetes mellitus alone is often extremely challenging and unrewarding. (rvc.ac.uk)
- Hypophysectomy is an excellent treatment option for pituitary dependent Cushing's syndrome. (rvc.ac.uk)
- Through offering surgical hypophysectomy as a treatment option, the RVC team have since successfully cured many diabetic acromegalic cats and cushingoid dogs. (rvc.ac.uk)
- 1 diabetes or high dose GH treatment) the diabetogenic actions of GH become apparent. (diabetestalk.net)
Cats2
- Cats typically stay in the hospital for 7-10 days post-operatively whilst we stabilise their diabetes mellitus. (rvc.ac.uk)
- BACKGROUND: Hypersomatotropism (HST) is an increasingly recognized endocrinopathy in cats and is mostly described associated with diabetes mellitus (DM). (bvsalud.org)
Grant1
- In 1982, the National Health and Medical Research Council (NHMRC) awarded the Garvan Institute its first Program Grant for research into diabetes. (wikipedia.org)
Result2
- If Cushing's syndrome is a result of a pituitary tumor, a transsphe-noidal hypophysectomy may be performed. (brainkart.com)
- Diabetes manifests during childhood or adolescence and may result in ketoacidosis and intercurrent infections. (mhmedical.com)
Dogs1
- In dogs hypophysectomy is only rarely performed, it is currently possible only in very few specialized veterinary centers and requires a team approach, involving a neurosurgeon, an endocrinologist and a radiologist. (vin.com)
Urine1
- Нефрогенний нецукровий діабет Nephrogenic diabetes insipidus (NDI) is an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine. (msdmanuals.com)
Days1
- In a second series rats were pre-treated for a period of 22 days, beginning 14 days after hypophysectomy, and then injected with doses of PZI (0.4 units 1.6 units/day) that induced convulsions in unprotected (saline and prolactin-treated) rats run concurrently. (diabetestalk.net)
Patients2
- Diabetes mellitus (DM) has a heterogenous cause, and the exact pathogenesis differs between patients. (bvsalud.org)
- Patients who have undergone hypophysectomy and/or other surgeries on the brain are contraindicated. (myphages.com)
YOUNG1
- and endocrine dysfunction (hypothyroidism, 'maturity-onset diabetes of the young', repeated abortions or infertility). (litfl.com)
Transsphenoidal hypophysectomy2
- 12. Gigantism associated with a pituitary tumour secreting growth hormone and prolactin and cured by transsphenoidal hypophysectomy. (nih.gov)
- If pituitary-dependent Cushing disease is confirmed, consultation with a neurosurgeon experienced in transsphenoidal hypophysectomy is indicated. (medscape.com)
Hypothyroidism1
- Hypothyroidism and diabetes usually do not mandate a consultation. (medscape.com)
Glucose1
- Diabetes: Glucose-induced collagen modifications and microvascular disease may play an important role in limited joint mobility syndromes. (medscape.com)
Radiotherapy1
- The owners were informed about our findings and the therapeutic options, however, they decided against radiotherapy as well as against hypophysectomy. (vet-magazin.ro)
Growth hormone1
- At the Garvan Institute he led a joint laboratory and clinical research team studying diabetes and pituitary hormone secretions, in particular the secretion and clinical uses of human growth hormone. (wikipedia.org)
Pituitary hormone1
- In patients with radiologic evidence of hyperplasia without a pituitary tumor: first-line treatment with GH receptor antagonist should be considered as surgery (which is not usually recommended) can lead to disease remission only by means of a total hypophysectomy, invariably resulting in the need for lifelong pituitary hormone replacement treatment. (nih.gov)
Regulate2
- However, clinical signs may also be mild and HAC is often not suspected until it becomes evident that the diabetes is difficult to regulate. (vin.com)
- A 10 year old Domestic Shorthair cat (male castrated, 5.3 kg) was referred because of difficulties to regulate diabetes mellitus which had been diagnosed 3 months previously. (vet-magazin.ro)
Severe1
- 6 The Diabetic Retinopathy Vitrectomy Study (DRVS) showed that in eyes with severe vitreous hemorrhage, early intervention with pars plana vitrectomy resulted in better visual outcomes than deferral of surgery in patients with type I diabetes mellitus. (entokey.com)
Secondary1
- Other specific types (formerly called secondary diabetes mellitus) may occur in approximately 20% of diabetic cats. (vin.com)
Diabetic5
- 2. A case of pituitary gigantism who had two episodes of diabetic ketoacidosis followed by complete recovery of diabetes. (nih.gov)
- 1 Although diabetic retinopathy is still the leading cause of vision loss in the working age population of many developed countries such as the United States, visual outcomes in diabetic patients continue to improve with substantial advancements in systemic diabetes control and more effective retinopathy therapy. (entokey.com)
- In 1952, Luft and associates 2 performed a hypophysectomy in the hope of ameliorating the vascular complications of diabetes, and in 1960, photocoagulation for the treatment of diabetic retinopathy was first reported by Meyer-Schwickerath, 3 who used a xenon arc photocoagulator to directly treat new vessels on the surface of the retina. (entokey.com)
- This chapter reviews the clinical manifestations and pathophysiologic mechanisms underlying the visual complications of diabetes mellitus, as well as the current appropriate management of diabetic retinopathy based on the results of major clinical studies. (entokey.com)
- 11 The strongest risk factors for development of diabetic retinopathy are longer duration of diabetes and worse glycemic control. (entokey.com)
Antidiuretic hormone2
- Demeclocycline Prolonged administration of demeclocycline may cause diabetes insipidus, as this drug decreases the production of antidiuretic hormone by the kidneys. (studymoose.com)
- Arginine vasopressin deficiency (central diabetes insipidus) results from a deficiency of vasopressin (antidiuretic hormone [ADH]) due to a hypothalamic-pituitary disorder. (msdmanuals.com)
Type4
- While type-1-like diabetes seems to be rare it is currently assumed that up to 80% of cats suffer from a type-2-like diabetes. (vin.com)
- in adults, 90% to 95% of cases consisted of type 2 diabetes mellitus, and at current rates, at least one in three people in the US will develop the disease in their lifetime. (medscape.com)
- A client newly diagnosed with type 1 diabetes is taught to exercise on a regular basis. (studymoose.com)
- 6. Management of type 2 diabetes mellitus associated with pituitary gigantism. (nih.gov)
Vasopressin3
- Marked increase in the volume of urine output is a sign of diabetes insipidus caused by vasopressin deficiency. (studymoose.com)
- vasopressin levels and response to exogenous vasopressin help distinguish arginine vasopressin deficiency from arginine vasopressin resistance (nephrogenic diabetes insipidus). (msdmanuals.com)
- Nephrogenic Diabetes Insipidus Nephrogenic diabetes insipidus (NDI) is an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine. (msdmanuals.com)
Increases1
- The prevalence of all types of retinopathy increases with the duration of diabetes, probably reflecting the consequences of prolonged hyperglycemia. (entokey.com)
Develop1
- However, clinical signs are identical to those of hypercortisolism, and diabetes mellitus may develop as well. (vin.com)