Diabetes glucose uptake adipose tissue fatty acids. Medical search. Frequent questions

The impairment of glucose metabolism by fatty acid oxidation is mediated by the short-term inhibition of several glycolytic processes. (wikipedia.org)
Hemodynamic stress overrides fatty acid inhibition of glucose metabolism. (wikipedia.org)
In addition, CD11c + ATMs were enriched for mitochondria and for RNA transcripts encoding mitochondrial, proteasomal, and lysosomal proteins, fatty acid metabolism enzymes, and T-cell chemoattractants, whereas CD11c − ATMs were enriched for transcripts involved in tissue maintenance and repair. (diabetesjournals.org)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
PPARs do a bunch of things, including regulating fatty acid storage and glucose metabolism. (stumptuous.com)
The adipose tissue significantly affects the whole-body metabolism of carbohydrates and lipids, which also involves fatty acid esters of hydroxy fatty acids (FAHFA), lipid mediators that affect glucose uptake and insulin sensitivity in target tissues. (cas.cz)
In contrast to the negative effects of many adipokines, our study identified transforming growth factor beta 2 (TGF-beta 2) as an adipokine released from adipose tissue (fat) in response to exercise that actually improves glucose tolerance," says Laurie J. Goodyear, PhD, Head of Joslin's Section on Integrative Physiology and Metabolism and study co-author. (newswise.com)
Not only did exercise-stimulated TGF-beta 2 improve glucose tolerance, treating obese mice with TGF beta 2 lowered blood lipid levels and improved many other aspects of metabolism. (newswise.com)
TGF-B2 is an Exercise-Induced Adipokine that Regulates Glucose and Fatty Acid Metabolism. (newswise.com)
The aim of this review was to summarize and discuss current knowledge on the impact of dietary fibre as modulator of the relationship between glucose metabolism and microbiota composition in humans. (springer.com)
More specifically, we analysed evidence from observational studies and randomized nutritional intervention investigating the relationship between gut microbiota, short-chain fatty acids and glucose metabolism. (springer.com)
Indeed, it may influence multiple physiological mechanisms related to human health, i.e. synthesis of micronutrients, defence against pathogens, regulation of glucose and lipid metabolism, and immune function [ 1 ]. (springer.com)
Therefore, in this review, we summarized current evidence from observational and intervention studies performed in humans investigating the relationship between the composition of the gut microbiota, concentration of SCFA and glucose metabolism. (springer.com)
The physiological functions of the Igf 1 receptor signaling pathway include regulation of growth and development, metabolism, tissue repair, and immune function. (ebiwinner.com)
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. (nature.com)
The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism. (nature.com)
c Somatostatin's effects on metabolism are indirect via suppression of secretion of insulin, glucagon, growth hormone, and thyroid hormone and by effects on gastric acid secretion, gastric emptying time, and pancreatic exocrine secretion (see text). (basicmedicalkey.com)
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. (scienceopen.com)
In the basal state, the effects of GH on protein metabolism are modest and include increased protein synthesis and decreased breakdown at the whole body level and in muscle together with decreased amino acid degradation/oxidation and decreased hepatic urea formation. (scienceopen.com)
GH is a counterregulatory hormone that antagonizes the hepatic and peripheral effects of insulin on glucose metabolism via mechanisms involving the concomitant increase in FFA flux and uptake. (scienceopen.com)
Impaired insulin secretion and free radical formation are the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and fatty acids metabolism. (wiley.com)
When activated, PPAR-γ up-regulates the transcription of genes mainly involved in fatty acid metabolism and triglyceride storage, promoting adipogenesis and lipids uptake to the adipose tissue [ 17 , 18 ] improving whole body insulin sensitivity. (biomedcentral.com)
However, beta-cell dysfunction and IR induce impaired glucose metabolism, thus leading to the progression to T2D. (e-apem.org)
Insulin resistance (IR) has been identified as a cardinal trigger of impaired glucose metabolism, T2D, and cardiovascular diseases [ 3 , 4 ]. (e-apem.org)
2010). Senp2 also regulates fatty acid metabolism in skeletal Downloaded from https://academic.oup.com/jmcb/article-abstract/10/3/258/4763638 by Ed 'DeepDyve' Gillespie user on 26 June 2018 Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 j 259 muscle (Koo et al. (deepdyve.com)
which, when activated, stimulate expression of genes involved in energy homeostasis, specifically the metabolism of glucose and fatty acids (Blaschke et al. (bodybuilding.com)
The insulin signaling pathway is a central regulator of energy metabolism, particularly in the context of glucose homeostasis. (alliedacademies.org)
The functions of FGF21 are mainly manifested in glucose metabolism, lipid metabolism, and insulin resistance. (cyagen.com)
PPAR-γ also induces FGF21 expression in white adipose tissue, indicating that it also regulates metabolism in the feeding state. (cyagen.com)
To our knowledge this is the first report on identification of a short peptidefrom adiponectin with positive effects on glucose or fatty acid metabolism. (phoenixpeptide.com)
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
After conducting several cross-sectional surveys with schoolchildren and observing their high prevalence of overweight and other risk factors , supported with scientific evidence, it was decided to carry out intervention programs with this population and evaluate their effects on health parameters, including those associated with glucose metabolism. (bvsalud.org)

[ 2 ] However, it is known that millions of US individuals have obesity and type 2 diabetes mellitus . (medscape.com)
ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
Gaps exist in our information about diabetes and obesity in Arabpopulations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)
Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. (diabetesjournals.org)
We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity. (diabetesjournals.org)
Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
Type 2 diabetes is increasingly common primarily because of increases in the prevalence of a sedentary lifestyle and obesity. (justia.com)
Obesity is associated with an increased risk of developing metabolic syndrome, type 2 diabetes and cardiovascular disease. (cas.cz)
Objective: β-adrenoceptor mediated activation of brown adipose tissue (BAT) has been associated with improvements in metabolic health in models of type 2 diabetes and obesity due to its unique ability to increase whole body energy expenditure, and rate of glucose and free fatty acid disposal. (monash.edu)
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. (jci.org)
We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. (jci.org)
Obesity is a prominent risk factor for Non-insulin Dependent Diabetes Mellitus, (NIDDM), which is also called diabetes mellitus type II. (heraldopenaccess.us)
Ectopic obesity is defined as the accumulation of triglycerides in non-adipose tissues [6]. (heraldopenaccess.us)
Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. (springer.com)
In particular, animal studies support a causal role between the composition of the gut microbiota and development of obesity, insulin resistance and type 2 diabetes (T2D). (springer.com)
Clinical diagnosis is made on the basis of the presence of 3 of 5 conditions: 1) high triglyceride level, 2) low high-density lipoprotein (HDL) cholesterol level, 3) high fasting blood glucose level, 4) presence of central obesity (ie, high waist circumference), and 5) high blood pressure ( 1 ). (cdc.gov)
Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. (nature.com)
In response to the impaired glucose uptake associated with obesity, fat cells will increase their production and release of RBP4. (linbioscience.com)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
Obesity often increases the risk of lifestyle diseases, such as cardiovascular disease, diabetes, and cancer. (frontiersin.org)
In this study, we observed the overexpression of SUMO-speci﫿c protease 2 (Senp2) in adipose tissues during obesity. (deepdyve.com)
The FGF21 gene plays a significant role in the pathogenesis of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD), obesity, and insulin resistance. (cyagen.com)
We previously hypothesized that apoCIII overexpression would compromise fatty acid delivery to adipose tissues and would thus contribute to resistance to diet-induced obesity, similarly to what was described for overexpression of apoCI [ 15 ]. (biomedcentral.com)
Obesity element binding protein 1 and fatty acid synthase. (cdc.gov)
Obesity was defi ned expression chronically in tissues. (cdc.gov)
Elevated levels of uric acid (hyperuricemia) also have implications for the pathogenesis of obesity and have been linked to deteriorated glucose tolerance, impaired fasting glucose and type 2 diabetes 5 . (bvsalud.org)

In the liver β-oxidation of fatty acids fulfills the local energy needs and may lead to ketogenesis (creating ketone bodies out of fatty acids. (wikipedia.org)
The ketone bodies are then used to meet the demands of tissues other than the liver. (wikipedia.org)
Circulating glucose in the liver stimulates its uptake. (wikipedia.org)
This in turn decreases malonyl-CoA concentrations which stimulates fatty acid oxidation and ketogenesis by glucagon in the liver. (wikipedia.org)
AMPK phosphorylates and inactivates ACC in the liver and other tissues. (wikipedia.org)
Patients suffering from lipodystrophies experience reduced body fat, severe insulin resistance, hypertriglyceridemia, and hypoleptinemia, and nonalcoholic fatty liver disease. (medscape.com)
This basal glucose uptake is precisely matched by the release of glucose from the liver. (justia.com)
It follows, therefore, that defects at the level of the β-cell, muscle and liver can lead to the development of glucose intolerance and diabetes mellitus. (justia.com)
Mice lacking lipin-1 ( fld or fatty liver dystrophy) develop fatty livers and hypertriglyceridemia in the pre-weaning period, and are also devoid of mature adipose tissue [reviewed in 1]. (aocs.org)
Insulin resistance is defined as an inadequate response by insulin target tissues, such as skeletal muscle, liver, and adipose tissue, to the physiologic effects of circulating insulin. (jci.org)
The hallmarks of impaired insulin sensitivity in these three tissues are decreased insulin-stimulated glucose uptake into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue. (jci.org)
The brain integrates metabolic signals from peripheral tissues such as the liver, pancreas, adipose tissue, gut and muscle. (nature.com)
It promotes the storage of nutrients as glycogen in liver and muscle, and as triacylglycerols in adipose tissue. (basicmedicalkey.com)
LBS-009, developed by Belite Bio™, a subsidiary company of Lin BioScience, is a first-in-class anti-RBP4 oral therapy targeting liver disease and type 2 diabetes, two age-related metabolic diseases. (linbioscience.com)
Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and type cumulatively impact more than 1.89 billion patients worldwide. (linbioscience.com)
Non-alcoholic fatty liver disease (NAFLD) occurs when an excess accumulation of fat damages the liver. (linbioscience.com)
Increased RBP4 production in enlarged adipocytes also instigates a cascade of responses that result in a redistribution of free fatty acids from adipose tissue to the liver, leading to excessive accumulation of hepatic fat. (linbioscience.com)
The major factor that can increase the blood glucose levels and the production of new glucose molecules is the liver cells. (myprojectwriters.com)
In the present study, a high-fructose diet fed rat model of hypertriglyceridemia, dyslipidemia, insulin resistance and hepatic steatosis was employed to investigate the global transcriptional changes in the lipid metabolizing pathways in three insulin sensitive tissues: liver, skeletal muscle and adipose tissue in response to chronic dietary administration of NDGA. (biomedcentral.com)
DNA microarray expression profiling indicated that dietary administration of NDGA upregulated the expression of certain genes involved in fatty acid oxidation and their transcription regulator, PPARα, decreased the expression of a number of lipogenic genes and relevant transcription factors, and differentially impacted the genes of fatty acid transporters, acetyl CoA synthetases, elongases, fatty acid desaturases and lipid clearance proteins in liver, skeletal muscle and adipose tissues. (biomedcentral.com)
When ursodeoxycholic acid is hydrolyzed in the liver and stored adipose tissue, some of the carboxyl groups may be retained and released in the blood as proatherogenic metabolites, which might be related to a possible increase in HDL-cholesterol concentrations, which are also increased in obese patients with T2DM. (wsicycling.com)
Additionally, insulin signaling inhibits gluconeogenesis, the process of glucose production from non-carbohydrate sources, in the liver. (alliedacademies.org)
In mice, prolonged fasting of PPAR-α strongly induces FGF21 expression in the liver, which induces the transcriptional coactivator PGC-1α, and stimulates liver gluconeogenesis, fatty acid oxidation, and ketogenesis. (cyagen.com)
After a specific knockout of FGF21 in the liver, mice developed fatty liver and hyperlipidemia, reducing serum ketone body levels. (cyagen.com)

The Randle cycle is a biochemical mechanism involving the competition between glucose and fatty acids for their oxidation and uptake in muscle and adipose tissue. (wikipedia.org)
This inhibition of glucose oxidation at the level of pyruvate dehydrogenase preserves pyruvate and lactate, both of which are gluconeogenic precursors. (wikipedia.org)
Malonyl-CoA signals glucose utilization and it controls the entry and oxidation of long-chain fatty acids (LCFA) in the mitochondria. (wikipedia.org)
Glucose oxidation produces citrate which can be converted to malonyl-CoA by acetyl-CoA carboxylase. (wikipedia.org)
The glucose-derived malonyl-CoA prevents the oxidation of fatty acids and favors fatty acid esterification. (wikipedia.org)
Inhibition of fatty acid oxidation requires that ACC is active. (wikipedia.org)
The inhibition of MCD suppresses the oxidation of fatty acids and stimulates glucose oxidation. (wikipedia.org)
In a study on MCD deficient mice there was no difference in the oxidation of fatty acids and glucose in the heart under aerobic conditions. (wikipedia.org)
Lipins also act in the nucleus as transcriptional co-activators with peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) and peroxisome proliferator-activated receptor α to regulate target genes involved in fatty acid oxidation. (aocs.org)
PGC-1α and PPARα are both master regulators of genes involved in mitochondrial biogenesis and fatty acid oxidation, respectively [reviewed in 6]. (aocs.org)
The functions of the lipins in co-regulating the effects of PGC-1α and PPARα and also acting as a PAP demonstrate the unique abilities of lipins to regulate both glycerolipid synthesis and fatty acid oxidation. (aocs.org)
Some studies suggest that an increase in plasma fatty acid concentration reduces glucose uptake and phosphorylation, and this leads to reduced glycogen synthesis and glucose oxidation. (heraldopenaccess.us)
Carnitine plays a role in the transfer of long chain fatty acids from cytoplasm to mitochondria for beta-oxidation. (heraldopenaccess.us)
L-carnitine supplementation decreases serum glucose but has no effect on glucose oxidation [11]. (heraldopenaccess.us)
BAIBA is one of the myokines, affectionately known as "exercise factors", which play a powerful role behind the benefits of regular exercise-increased glucose uptake, increased free fatty acid oxidation, and reduced fat mass. (naturalscience.com)
During fasting and other catabolic states, GH predominantly stimulates the release and oxidation of FFA, which leads to decreased glucose and protein oxidation and preservation of LBM and glycogen stores. (scienceopen.com)
These findings suggest that NDGA ameliorates hypertriglyceridemia and steatosis primarily by inhibiting lipogenesis and enhancing fatty acid catabolism in three major insulin responsive tissues by altering the expression of key enzyme genes and transcription factors involved in de novo lipogenesis and fatty acid oxidation. (biomedcentral.com)
Conversely, it activates enzymes involved in ATP-generating processes, such as fatty acid oxidation (e.g., carnitine palmitoyltransferase 1, CPT1) and glucose uptake (e.g., translocation of GLUT4). (alliedacademies.org)

What I mean is that in a healthy body, our system knows what to do with fatty acids and triglycerides . (stumptuous.com)

In response to hyperglycemia after a meal, pancreatic insulin secretion is stimulated and the combination of hyperinsulinemia plus hyperglycemia promotes glucose uptake (by splanchnic and peripheral, primarily muscle, tissues) and suppresses hepatic glucose production. (justia.com)
The action of antidiabetic plants of the Canadian James Bay Cree traditional pharmacopeia on key enzymes of hepatic glucose homeostasis ") report the antidiabetic action of seven Canadian plants as evidenced by glucose-6-phosphatase and glycogen synthase, two key enzymes, respectively, involved in gluconeogenesis and glycogenesis in hepatocytes. (hindawi.com)
It reduces hepatic glucose output, may decrease intestinal absorption of glucose, and may increase glucose uptake in peripheral tissues. (medscape.com)

Tissue culture medium conditioned by CD11c + ATMs, but not CD11c − ATMs or other stromovascular cells, impaired insulin-stimulated glucose uptake by human adipocytes. (diabetesjournals.org)
Methods: Using a specific inhibitor of phosphoinositide 3-kinase α (PI3Kα), which effectively inhibits the insulin signaling pathway, we examined the effects of various β-adrenoceptor agonists, including the physiological endogenous agonist norepinephrine on glucose uptake and respiration in mouse brown adipocytes in vitro and on glucose clearance in mice in vivo. (monash.edu)
Results: PI3Kα inhibition in mouse primary brown adipocytes in vitro, did not inhibit β-adrenoceptor stimulated glucose uptake, GLUT1 synthesis, GLUT1 translocation or respiration. (monash.edu)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)
Stimulates glucose uptake by differentiated adipocytes by inducing the glucose transporter SLC2A1/GLUT1 (instead of SLC2A4/GLUT4). (cyagen.com)

Aside from blood glucose, this fraction reduced blood triglyceride and free fatty acids. (hindawi.com)
GH exerts anabolic effects directly and through stimulation of IGF-I, insulin, and free fatty acids (FFA). (scienceopen.com)
It helps in the reduced breakdown of fats to free fatty acids. (rxlist.com)
Nordihydroguaiaretic acid (NDGA), the main metabolite of Creosote Bush, has been shown to have profound effects on the core components of metabolic syndrome, including lowering of blood glucose, free fatty acids and triglyceride levels, attenuating elevated blood pressure in several rodent models of dyslipidemia, and improving body weight, insulin resistance, diabetes and hypertension. (biomedcentral.com)

DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)
The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. (spandidos-publications.com)
and blood glucose levels (variable). (myprojectwriters.com)
Glucose molecules are delivered to cells by the circulating blood and therefore, to ensure a constant supply of glucose to the cells, it is important that blood glucose levels be maintained at relatively constant levels. (myprojectwriters.com)
The major factor that can decrease the blood glucose levels including the transport of glucose into cells and the loss of glucose is through urine. (myprojectwriters.com)
Normally, in a healthy person, the blood glucose levels can easily be restored to normal levels through the actions of two pancreatic hormones: Insulin and glucagon. (myprojectwriters.com)
If blood glucose levels rise after the digestion of food then the beta-insulin cells of the pancreas respond by secreting insulin. (myprojectwriters.com)
Of note, ADP-1 decreased blood glucose levels and enhanced insulin production in pancreatic β cells in db/db mice. (phoenixpeptide.com)
Nateglinide is an amino acid derivative that stimulates insulin secretion from the pancreas (within 20 minutes of oral administration), which, in turn, reduces blood glucose levels. (medscape.com)

Furthermore, two intermediates in this pathway, phosphatidic acid and diacylglycerol, serve as essential precursors for the synthesis of phospholipids. (aocs.org)
It also stimulates the synthesis of proteins in tissues such as muscle. (basicmedicalkey.com)
When activated, AMPK phosphorylates and inhibits enzymes involved in ATP-consuming processes, such as fatty acid synthesis (e.g., acetyl-CoA carboxylase, ACC) and protein synthesis (e.g., mammalian target of rapamycin, mTOR). (alliedacademies.org)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

By contrast, type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM) is characterized by insulin-resistance and inadequate insulin secretion. (justia.com)
All the abnormalities in diabetes basically result from an imbalance between insulin sensitivity and insulin secretion. (justia.com)
Because the pancreas is able to appropriately augment its secretion of insulin to offset the insulin resistance, glucose tolerance remains normal. (justia.com)
With time, however, the beta-cell fails to maintain its high rate of insulin secretion and the insulin resistance leads to the development of impaired glucose tolerance and eventually overt diabetes mellitus. (justia.com)
The pharmacological properties of herbal remedies, including the amelioration of insulin sensitivity, the promotion of insulin secretion, the increase of glucose uptake by adipose and muscle tissues, the inhibition of sugar absorption in intestines and the generation of sugar by hepatocytes, have been demonstrated in several studies ( 15 , 16 ). (spandidos-publications.com)
Prostaglandins are hormone-like compounds produced in body tissue that help control blood pressure, smooth muscle activity, inflammation, glandular secretion, calcium movement, hormone regulation, and cell growth control. (bodybuilding.com)
Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)

Hormones that control adipose tissue lipolysis affect circulating concentrations of fatty acids, these in turn control the fuel selection in muscle. (wikipedia.org)
When fasting, the activation of lipolysis provides fatty acids as the preferred fuel source for respiration. (wikipedia.org)
Under physiological conditions, the main- PPARγ mutation has been shown to link to familial partial lipody- tenance of normal adipose tissue mass is mainly the result of a strophy, a clinical disorder characterized by the loss of adipose balance of lipid storage and lipolysis (Bouchard et al. (deepdyve.com)
We measured body energy balance, tissue capacity to store exogenous lipids, lipogenesis and lipolysis rates in non-transgenic and apoCIII overexpressing mice fed a HFD during two months. (biomedcentral.com)
Thus, apoCIII overexpression resulted in increased NEFA availability to adipose uptake and decreased adipocyte lipolysis, favoring lipid enlargement of adipose depots. (biomedcentral.com)

The invention relates to combinations of (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridine-2-ol with other active compounds for the treatment of diabetes mellitus type 2 and/or type 1. (justia.com)
the invention also relates to pharmaceutical compositions, combination products and kits containing these combinations as well as uses of such combinations in the treatment of diabetes mellitus type 2 and/or diabetes mellitus type 1. (justia.com)
Diabetes mellitus is on the rise worldwide and is considered to be at an epidemic level by the World Health Organization. (justia.com)
Type 1 (insulin-dependent diabetes mellitus, IDDM) is due primarily to autoimmune-mediated destruction of pancreatic β-cells, resulting in absolute insulin deficiency. (justia.com)
Streptozotocin (STZ) is widely used to study the pathology of diabetes mellitus and diabetic complications in most strains of rodents [15]. (researchgate.net)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
Diabetes mellitus (DM) is a metabolic disease in patients with high blood glucose over prolonged period ( 1 ). (spandidos-publications.com)
Proteinuria was first recognized in diabetes mellitus in the late 18th century. (medscape.com)
Patients may have physical findings associated with long-standing diabetes mellitus. (medscape.com)
Go to Diabetes Mellitus, Type 1 and Diabetes Mellitus, Type 2 for more complete information on these topics. (medscape.com)
Hyperglycemia is the hallmark of diabetes mellitus . (rxlist.com)
What Is Diabetes Mellitus? (rxlist.com)
Diabetes mellitus is a metabolic disease characterized by constantly high blood sugar levels. (rxlist.com)
This is an abnormal event that also occurs in diabetes mellitus. (myprojectwriters.com)
These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. (phoenixpeptide.com)
heart disease remains the leading cause of mortality in diabetes mellitus. (msdmanuals.com)
Complications of Diabetes Mellitus In patients with diabetes mellitus, years of poorly controlled hyperglycemia lead to multiple, primarily vascular, complications that affect small vessels (microvascular), large vessels (macrovascular). (msdmanuals.com)
Kooy et al found improved body weight, glycemic control, and insulin requirements when metformin was added to insulin in type 2 diabetes mellitus. (medscape.com)
Because of these sustained beneficial effects, the policy to continue metformin treatment after the introduction of insulin in type 2 diabetes mellitus should be followed unless contraindicated. (medscape.com)

BAIBA also instigates the "browning" of white adipose tissue, which increases energy expenditure, improves insulin sensitivity and helps regulate weight management. (naturalscience.com)
The mRNA expression levels of peroxisome proliferator-activated receptor (PPAR)-γ and lipocalin-2 in white adipose tissue were, respectively, down- and up-regulated. (biomedcentral.com)
Reduction of PPAR-γ expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. (biomedcentral.com)
This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
Edward W. Kraegen regularly ties together related areas like White adipose tissue in his Endocrinology studies. (research.com)
He merges Insulin resistance with White adipose tissue in his study. (research.com)

The glucose that is not oxidized is then rerouted to glycogen. (wikipedia.org)
This rerouting to glycogen explains the rapid resynthesis of muscle glycogen after exercise as well as the increased glycogen content in muscles found in starvation or diabetes. (wikipedia.org)
When subjects are well nourished, the GH-induced stimulation of IGF-I and insulin is important for anabolic storage and growth of lean body mass (LBM), adipose tissue, and glycogen reserves. (scienceopen.com)
In conclusion, AEG enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen. (wiley.com)
His Glycogen investigation overlaps with other areas such as Glucose uptake and Glycogen synthase. (research.com)
Glycogen overlaps with fields such as Glucose uptake and Glycogen synthase in his research. (research.com)
Edward W. Kraegen performs integrative study on Glucose uptake and Glycogen in his works. (research.com)
It helps convert glucose to a storage product called 'glycogen. (rxlist.com)

The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)
Conclusions: We conclude that the β-adrenergic pathway is still functionally intact upon the inhibition of PI3Kα, showing that the activation of downstream insulin effectors is not required for the acute effects of β-adrenoceptor agonists on glucose homeostasis or thermogenesis. (monash.edu)
Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. (nature.com)
Level constancy is accomplished primarily through negative feedback systems, which ensures that blood glucose concentration is maintained within the normal range (3.6 - 5.8 mmol/L). Negative feedback systems are extremely important in homeostasis as it sense changes in the body and activate mechanisms that reverse the changes in order to restore conditions to their normal levels. (myprojectwriters.com)
Insulin resistance (IR), i.e., whole-body decreased glucose uptake in response to physiological insulin levels, determines impaired glucose homeostasis and it is recognized as cardinal trigger of T2D and cardiovascular disease in both adults and children. (e-apem.org)
Excess or insuf﫿cient lipid storage in generation of the intermediate species of diacylglycerol (DAG) adipose tissues would impair nutrient homeostasis, which is and monoacylglycerol (MAG) (Young and Zechner, 2013). (deepdyve.com)

The initial stage of diabetes is characterised by impaired glucose tolerance and postprandial hyperglycemia. (justia.com)
In addition, following CUS, fasting insulin levels were increased and were accompanied by signs of impaired glucose tolerance and elevated serum corticosteroid levels. (biomedcentral.com)

Adipose tissue was obtained from lean and obese women undergoing bariatric surgery. (diabetesjournals.org)
In obese women, CD11c + ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. (diabetesjournals.org)
The number of obese patients undergoing cardiac and noncardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular disorders. (benthamscience.com)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Zhu's study found that diet and exercise therapy for obese postmenopausal women can significantly improve blood lipid levels, improve insulin resistance, reduce plasma insulin levels and effectively prevent type 2 diabetes ( 4 ). (frontiersin.org)
Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. (e-apem.org)
It is a major drug used in obese patients with type 2 diabetes. (medscape.com)

S. H. Kim and coworkers (" Citrus junos Tanaka peel extract exerts antidiabetic effects via AMPK and PPAR- both in vitro and in vivo in mice fed a high-fat diet ") indicate that the ethanol extract of the peel of Citrus junos in vitro stimulates glucose uptake in C2C12 myotube cells. (hindawi.com)
We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). (phoenixpeptide.com)

This polarization and proliferation of CD4 T cells further amplifies inflammation, primarily in visceral adipose tissue, and is currently thought to be the driving force in RBP4-mediated insulin resistance. (linbioscience.com)
In addition, estrogen regulates fat distribution and adipocyte differentiation and increases visceral fat, leading to increased risk of chronic diseases such as coronary heart disease and diabetes ( 3 ). (frontiersin.org)
Adv 36 DNA persists in multiple tissues of infected sition of visceral fat disproportional to total fat deposition animals for long periods after initial infection ( 3 ). (cdc.gov)

It has been proposed that these changes lead to an accumulation of cytosolic citrate, which in turn inhibits PFK-1, followed by an increase in glucose 6-phosphate, which eventually inhibits hexokinase. (wikipedia.org)
Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
Dietary administration of NDGA decreased plasma levels of TG, glucose, and insulin, and attenuated hepatic TG accumulation. (biomedcentral.com)
Overweight youth are more susceptible to metabolic disorders, since the accumulation of body fat, especially in the abdominal region, generates an increase in fatty acids circulating in the bloodstream, which consequently impairs insulin signaling and leads to a reduction in sensitivity of receptors and tissue response to cellular actions that are mediated by this hormone 1,3,4 . (bvsalud.org)

Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)
In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. (cambridge.org)
These agents lower postprandial glucose by slowing glucose absorption and delaying the hydrolysis of ingested complex carbohydrates and disaccharide. (medscape.com)

Glucose transporter 4 translocation was confirmed by determining the uptake of glucose in the presence of insulin receptor tyrosine kinase and PI3K inhibitors. (wiley.com)
Insulin signaling pathway activates phosphatidylinositol 3-kinase (PI3K), which phosphorylates and activates Akt (also known as protein kinase B). Akt regulates glucose transport by promoting the translocation of glucose transporters, such as GLUT4, to the plasma membrane. (alliedacademies.org)
ADP-1-induced glucose transport coincided with ADP-1-induced biosynthesis of glucose transporter 4 and its translocation to the plasma membrane. (phoenixpeptide.com)

The metabolic syndrome classification is of interest in epidemiologic studies because of its ability to predict the development of cardiovascular disease (CVD) and type 2 diabetes in adults ( 2 ). (cdc.gov)
In developed countries, cardiovascular disease is the main complication causing death resulted from diabetes ( 5 , 6 ). (spandidos-publications.com)

For example, lipin-1 is the major PAP in adipose tissue, and cardiac and skeletal muscle since lipin-1-deficient mice had little if any detectable PAP activity [2]. (aocs.org)
The experiment showed a number of positive metabolic effects in the mice, including improved glucose tolerance and increased fatty acid uptake. (newswise.com)
Next, they fed the mice a high fat diet, causing the animals to develop diabetes. (newswise.com)
In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
However, the adipose tissue mass (45 %) and leptin plasma levels (2-fold) were significantly greater in apoCIII mice. (biomedcentral.com)
Lipogenesis rates were similar, while exogenous lipid retention was increased in perigonadal (2-fold) and brown adipose tissues (40 %) of apoCIII mice. (biomedcentral.com)
A fat tolerance test evidenced delayed plasma triglyceride clearance and greater transient availability of non-esterified fatty acids (NEFA) during the post-prandial state in the apoCIII mice plasma. (biomedcentral.com)
Transgenic mice overexpressing human apoCIII have marked elevated TG and non-esterified fatty acid (NEFA) levels [ 21 ]. (biomedcentral.com)

As β-adrenoceptor agonist administration results in increased hepatic gluconeogenesis that can consequently result in secondary pancreatic insulin release, there is uncertainty regarding the importance of insulin and the subsequent activation of its downstream effectors in mediating β-adrenoceptor stimulated glucose uptake in BAT. (monash.edu)

Both AMPK and MCD are inactive and glucose uptake is stimulated. (wikipedia.org)
These conditions exist in tissues rich in oxygen, in which AMPK is inactive and glucose inactivates the AMPK (researched in skeletal muscle). (wikipedia.org)
These results indicate that the AMPK signaling activation, combined with oxidative damage markers, could act as sentinel biomarkers, reflecting the threshold of redox balance that is linked to effective glucose control in diabetes. (elifesciences.org)
A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. (phoenixpeptide.com)

They can affect lipid uptake (how we use fat) and adipogenesis (the creation of new fat cells). (stumptuous.com)

Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)

Cardiovascular exercise and low-moderate carbohydrate diets containing essential fatty acids are recommended for reducing triglyceride levels. (bodybuilding.com)

Insulin-dependent tissues, adipose tissue and primarily skeletal muscles, are responsible for the remaining 25% of glucose utilization. (justia.com)

Prolonged periods of high blood sugar can result in complications such as diabetes , heart disease, and damage to various organs. (diabetescompass.com)
In this special issue, we aimed to gather together updated information reflecting the considerable progress in basic and clinical research into CAM for diabetes and its complications. (hindawi.com)
Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. (spandidos-publications.com)
Diabetes leads to numerous complications associated with the heart, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease ( 3 ). (spandidos-publications.com)
Chronically, microvascular and macrovascular complications are the major reasons for increasing morbidity and mortality in patients with diabetes. (spandidos-publications.com)
Normoglycemia is the key to attenuate the microvascular and neurological complications of type 1 diabetes. (spandidos-publications.com)
Herbal and traditional Chinese medicine have also exhibited a strong impact on treatment of cardiovascular complications in diabetes ( 17 ). (spandidos-publications.com)
It is also one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes. (medscape.com)
Even excess level of glucose can lead to further complications such as diabetes or damage to organs. (myprojectwriters.com)
Intensive control of plasma glucose can prevent or delay many of these complications but will not reverse them once established. (msdmanuals.com)

The extent of inhibition increases along the glycolytic pathway, being most severe at the level of pyruvate dehydrogenase and less severe at the level of glucose uptake and 6-phosphofructo-1-kinase (PFK-1). (wikipedia.org)
Therefore, in this study, we made an effort to discriminate between the two pathways and address whether the insulin signaling pathway is dispensable for the effects of β-adrenoceptor activation on glucose uptake in BAT. (monash.edu)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
This article explores the components and regulation of the pathway, as well as its implications in various diseases such as cancer and diabetes. (ebiwinner.com)
Dysregulation of the Igf 1 receptor signaling pathway has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. (ebiwinner.com)

Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). (aacrjournals.org)
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. (research.com)
FGF21 is induced in rodents and humans on a low protein diet and reduces dietary methionine levels of the essential amino acid. (cyagen.com)

Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
Increased plasma free fatty acid concentration is associated with insulin resistance. (heraldopenaccess.us)

This is when plasma concentrations of fatty acids or ketone bodies are increased. (wikipedia.org)
Plasma glucose concentrations are normally maintained within a fairly narrow range despite wide fluctuations in the body's supply (e.g. meals) and demand (e.g. exercise) for nutrients. (justia.com)
Elevated concentrations of RBP4 in adipose tissue have been shown to activate antigen presenting cells (APC), resulting in an influx of immune cells. (linbioscience.com)
Candesartan 4 mg and ibuprofen 25 once daily (200 mg as acetaminophen) for four months were significantly different from the control group (Figs. 3A,B). Patients treated with aspirin and ibuprofen for four months had significantly increased LDL-cholesterol concentrations but similar HbA1c or fasting plasma glucose measurements. (wsicycling.com)
Insulin-dependent glucose-dependent insulinotropic polypeptide stimulates muscle glucose uptake and is released in response to insulin stimulation at glucose concentrations significantly higher than in normoglycemic healthy individuals. (wsicycling.com)
Insulin-dependent glucose-dependent insulinotropic polypeptide is the most potent activator of adiponectin, which is synthesized from VLDL, and it has recently been shown that adiponectin is a better biomarker online pharmacy uk generic of insulin resistance in T2DM than fasting serum glucose concentrations have become (1). (wsicycling.com)

Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. (spandidos-publications.com)
Massive adipose tissue depositions in the abdomen and increased, which results in noninsulin-mediated increases thorax suffi cient to interfere with respiration developed in a patient with multiple medical problems. (cdc.gov)

In fact, PPAR agonists - which help activate PPARs - are one class of new diabetes drugs. (stumptuous.com)
In addition to the change in plasma fatty acid levels, hepatic apoA-I andapoA-II are increased by PPAR-alpha activation, which improves cholesterol levels by increasing HDL levels (Chinetti et al. (bodybuilding.com)

The Fibroblast Growth Factor ( FGF ) gene family is involved in a wide range of mitogenic and cell survival activities and participates in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (cyagen.com)
Total adiponectin levels increased by approximately twofold in P+ in association with increased adipose tissue gene expression. (elsevierpure.com)

Gymnemic Acid blocks the sugar receptors on your tastebuds, which makes eating sweets less appealing. (naturalscience.com)

In the presence of a robust compensatory insulin secretory response to insulin resistance, glucose levels can remain relatively normal. (jci.org)
Additional investigation confirmed that levels of this one adipokine actually increased in the fat tissue as well as in the bloodstream with exercise, in both cases. (newswise.com)
Type 2 diabetes (T2D) is a chronic disease that occurs when the body cannot effectively use insulin, the hormone that regulates blood sugar levels. (linbioscience.com)
There are many methods of maintaining normal blood sugar levels, including treatment with insulin focus to a therapy area by external pumps, blood glucose monitoring and physical exercise. (spandidos-publications.com)
Persistent high glucose levels damage the inner lining of the blood vessels and nerve fibers and increase the risk of heart attack , stroke , kidney failure, and vision loss. (rxlist.com)
Aim:- To measure blood sugar levels in human subjects following the ingestion of different volume of glucose , sucrose depending on the subject's body weight and pure water (control). (myprojectwriters.com)
Overall, our results illustrate that both exercise and antioxidant intervention improve blood glucose control in diabetes by promoting redox balance, despite different levels of redox state(s). (elifesciences.org)
Indeed, diabetes, high blood pressure and many other chronic diseases are associated with imbalances in the levels of ROS in the body. (elifesciences.org)
The term 'insulin resistance' refers to a reduced glucose uptake in response to physiological insulin levels. (e-apem.org)
However, plasma free fatty acid and glucose levels were unchanged, and there were only minimal changes in other "adipokines. (elsevierpure.com)
Glucose fluxes ([3- 3 H]glucose infusion) were measured during 6-h euglycemic (5 mmol/l) "pancreatic clamp" studies (somatostatin/glucagon/growth hormone) with stepped insulin levels. (elsevierpure.com)
Treatment is diet, exercise, and medications that reduce glucose levels, including insulin , oral antihyperglycemic medications, and non- insulin injectable medications. (msdmanuals.com)
The intervention program proved to be efficient in reducing waist circumference, HOMA-IR and uric acid levels of overweight adolescents. (bvsalud.org)
Some lifestyle changes, including weight reduction, increased levels of physical activity and changes in eating habits can prevent, or at least delay, the onset of type 2 diabetes 2 . (bvsalud.org)

It is theorized to play a role in explaining type 2 diabetes and insulin resistance. (wikipedia.org)
RÉSUMÉ Le monde arabe connait une épidémie d'obésité et de diabète de type 2. (who.int)
Les données relatives à l'augmentation de la prévalence de l'obésité et du diabète de type 2 chez les enfants appartenant à un groupe ethnique arabe sont alarmantes. (who.int)
Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
A significant fraction of individuals originally diagnosed with type 2 diabetes evolve with time to a type 1 state, which is defined as exhibiting anti-β-cell autoimmunity. (justia.com)
These findings suggest that TGF beta 2 may be a potential therapy for treatment of high blood sugar, and eventually a potential therapy for type 2 diabetes. (newswise.com)
In addition, there is evidence that fatty acids interfere with very early stages of Glucose Transporter Type 4 (GLUT4) and hexokinase II activity [8]. (heraldopenaccess.us)
Yes, C.U.T.S. along with a HEALTHY DIET can help prevent or reverse early stage Type II diabetes. (naturalscience.com)
Type 2 diabetes is on the rise, with approximately 422 million patients globally ( Source: WHO ). (linbioscience.com)
Insulin resistance is a key pathophysiological feature of type 2 diabetes. (wiley.com)
The American Diabetes Association (ADA) has issued guidelines on which type is the best suited for your situation. (rxlist.com)
Type 2 diabetes (T2D) is a major health problem that has reached epidemic proportions around the world. (e-apem.org)
Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
Thus, only 21 days of pioglitazone therapy improved insulin action in humans with type 2 diabetes. (elsevierpure.com)
In general, the treatment of type 2 diabetes in children follows the same rationale as does treatment for the disease in adults. (medscape.com)
Among all of the noninsulin drugs currently in use to treat type 2 diabetes in adults, the US Food and Drug Administration (FDA) has approved metformin, liraglutide, and exenatide extended-release for use in children with type 2 DM. (medscape.com)
Insulin resistance (IR) and type 2 diabetes are becoming common among children and adolescents, are related to cardiometabolic risk and have been presented as a public health problem, requiring attention from the early stages of life 1,2 . (bvsalud.org)

Lipodystrophies are categorized based on etiology (genetic or acquired) and distribution of lost adipose tissue, affecting the entire body (generalized) or only regions (partial). (medscape.com)
One of the major arguments for the role of behavioural factors in the etiology of diabetes has been the rapid increase in the prevalence and incidence of the disease in populations undergoing rapid westernization. (justia.com)

Otto S. , now a third-year medical student, was assigned to do a history and physical examination on a newly admitted 47-year-old patient named Chet S. had consulted his physician for increasing weakness and fatigue and was found to have a severely elevated serum glucose level. (basicmedicalkey.com)

Diagnosis is by measuring plasma glucose. (msdmanuals.com)

Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)

Participants were designated as having metabolic syndrome if they met criteria for 3 of 5 variables: 1) high blood pressure, 2) low high-density lipoprotein cholesterol level, 3) high fasting blood glucose level, 4) high waist circumference, and 5) high triglyceride level. (cdc.gov)

This mechanism replenishes the intermediates of the citric acid cycle. (wikipedia.org)

Glucose uptake connects with themes related to GLUT4 in his study. (research.com)
His research on GLUT4 frequently connects to adjacent areas such as Glucose uptake. (research.com)

Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. (biomedcentral.com)

Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. (wiley.com)

Anatomy29

Organisms10

Diseases25

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology2

Phenomena and Processes53

Technology, Industry, Agriculture6

Information Science2

Health Care5

Metabolism33

Obesity32

Liver24

Oxidation18

Triglycerides1

Hepatic glucose3

Adipocytes8

Free fatty4

Blood glucose levels9

Synthesis4

Secretion7

Lipolysis5

Mellitus20

White adipos6

Glycogen8

Homeostasis6

Impaired glucose t2

Obese8

Stimulates glucose uptake2

Visceral3

Accumulation4

Postprandial3

Translocation3

Cardiovascular disease2

Mice9

Gluconeogenesis1

AMPK4

Adipogenesis1

High blood glucose1

Triglyceride levels1

Utilization1

Complications10

Pathway5

Protein3

Associated With Insulin Resistance2

Concentrations6

Increases3

PPAR2

Gene2

Receptors1

Levels14

Type17

Etiology2

Serum glucose1

Plasma glucose1

Excess1

Metabolic syndrome1

Citric acid1

GLUT42

Intolerance1

Increase in glucose1