• A new type of microscope has allowed scientists to map the behaviour and movements of cells during zebrafish ( Danio rerio ) embryonic development, and create a three-dimensional digital movie of the process. (nature.com)
  • E. J. Flynn, C. M. Trent and J. F. Rawls, "Ontogeny and Nutritional Control of Adipogenesis in Zebrafish (Danio rerio)," Journal of LIPID Research, Vol. 50, No. 8, 2009, pp. 1641-1652. (scirp.org)
  • Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. (oregonstate.edu)
  • To address this, we utilized the Danio rerio (zebrafish) model to test the hypothesis that parental zinc deficiency sensitizes the developing embryo to low-concentration arsenic toxicity, leading to altered developmental outcomes. (oregonstate.edu)
  • The zebrafish ( Danio rerio ) is an attractive and versatile model to gain insight into vertebrate brain development and function. (nature.com)
  • The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes. (wikipedia.org)
  • The expression pattern of this gene family has been recently described during zebrafish ( Danio rerio ) embryogenesis, and primarily locates in the nervous system. (frontiersin.org)
  • To this end, the zebrafish ( Danio rerio ) is an established model to study early nervous system development, which combines the complexity of a vertebrate organism with the easy-to-use and high-throughput capabilities of in vitro models ( MacRae and Peterson, 2015 ). (frontiersin.org)
  • Zebrafish (Danio rerio) is a small fish of the Cyprinidae family originating in the streams of India and Myanmar. (weizmann.ac.il)
  • In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale. (scilifelab.se)
  • This study examined the effects thyroid-active compounds during early development on body morphology of Zebrafish ( Danio rerio ). (usgs.gov)
  • Functioning and Gene Expression of Adenosine A 1 Receptor During Zebrafish ( Danio rerio ) Development. (bvsalud.org)
  • Toxicity of three perfluoroalkyl acids (PFAAs) [perfluorooctanoic acid (PFOA), composed of 8 carbon (C8), perfluorohexanoic acid (PFHxA, C6), and perfluorobutanoic acid (PFBA, C4)] was compared in developing zebrafish (Danio rerio). (cdc.gov)
  • Chronic toxicity: There are data for 3 trophic levels, most sensitive fish (zebrafish Danio rerio) NOEC 0.0003 microg/L. (janusinfo.se)
  • Its rapid embryonic development, the transparency of its embryos, the large number of offspring together with several other advantages make it ideal for discovering and understanding the genes that regulate embryonic development as well as the physiology of the adult organism. (nih.gov)
  • These abnormalities were less frequent in transgenic zebrafish embryos expressing rat αA-crystallin suggesting a specific role of α-crystallins in embryonic lens development. (nih.gov)
  • Lxr ligand activation affected the expression of genes involved in lipid metabolism in zebrafish adult brain and eye as well as in zebrafish embryos. (scirp.org)
  • In this study, zebrafish embryos were used to evaluate fetal embryo toxicity of the belladonna mother tincture. (ijpsonline.com)
  • Adult zebrafish were fed defined zinc deficient and zinc adequate diets and were spawned resulting in zinc adequate and zinc deficient embryos. (oregonstate.edu)
  • The method described here allows time-lapse analysis of organ development in zebrafish embryos by using a fluorescence dissecting microscope capable of performing optical sectioning and simple strategies of readjustment to correct focal and planar drift. (jove.com)
  • This method can help answer key questions in the developmental biology field because it allows direct observation of tissues and organ development in living embryos over several hours. (jove.com)
  • The findings could provide new evidences for better understanding the functions of rab11 in the development of zebrafish embryos. (researchsquare.com)
  • In the present study, zili -MO or zili mRNA was microinjected into one-cell embryos to knock down or elevate the expression of zili to study the role of zili during early zebrafish embryogenesis. (bioone.org)
  • The volumetric analysis of cellular expression patterns provides evidence for molecular mechanisms regulating the development of pre-implantation mouse embryos. (zeiss.com)
  • Retinoic acid is a signaling molecule that plays an important role in the development of the brain in animal embryos. (elifesciences.org)
  • exploited the fact that this molecule is weakly fluorescent and used microscopy to directly detect it in zebrafish embryos. (elifesciences.org)
  • Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. (refine.bio)
  • This protocol provides step-by-step instruction on how to generate parabiotic zebrafish embryos of different genetic backgrounds. (jove.com)
  • The overall goal of this method is to generate parabiotic zebrafish embryos, which can be used for studying cell intrinsic versus cell extrinsic functions for candidate genes of interest. (jove.com)
  • The main advantage of this protocol is an improved ability to successfully generate parabiotic zebrafish embryos. (jove.com)
  • Here we provide step-by-step instructions to generate parabiotic zebrafish embryos by surgical fusion of developing blastulas. (jove.com)
  • The antioxidant imbalance and expression of Zebrafish 2, mtnr1ba and pax7 in zebrafish fish embryos decreased. (aclumengine.com)
  • Chick embryos are easily accessible, and their nervous system development is similar to that of human embryos at comparable stages. (lu.se)
  • To complement the in vivo system of chick embryos, we employ patient omics data, single cell RNA sequencing, human and mouse embryos, human cancer cell cultures, human pluripotent stem cells, chick embryo neural crest-derived in vitro crestosphere cultures, and zebrafish and mouse in vivo models. (lu.se)
  • Transparency of the embryo and rapid heart development make zebrafish especially appealing to scientists who research the causes of cardiac birth defects. (upstate.edu)
  • This image, taken by PhD student Yongchang Ji, shows a cross section of a developing heart in a zebrafish embryo only two days after fertilization. (upstate.edu)
  • Though this method can provide insights into spacial and temporal alterations that occur during development of sweeper fish embryo and larvae, it can also be applied to investigate early developmental processes and other model organisms. (jove.com)
  • Our study provides new insight into the rab11 expression and promotes the use of this model organism to tackle future studies on the role of rab11 in embryo development. (researchsquare.com)
  • The transparency of the zebrafish embryo allows real-time visualization of the development and morphogenesis of practically all of its tissues and organs. (weizmann.ac.il)
  • Using fluorescence lifetime imaging microscopy (FLIM) and phasor analysis to measure endogenous retinoic acid (RA) directly in vivo, we have investigated the amplitude of noise in RA signaling, and how modulation of this noise affects patterning of hindbrain segments (rhombomeres) in the zebrafish embryo. (elifesciences.org)
  • When combined with the unparalleled imaging capabilities of the zebrafish embryo, this method provides a uniquely powerful means to investigate cell-autonomous versus non-cell-autonomous functions for candidate genes of interest. (jove.com)
  • Our main model organism is the chick embryo , ideal for functional and translational studies on neural crest development. (lu.se)
  • He studies genes that control positioning of the heart in zebrafish and has found that some of these genes are also critical for normal human heart development through collaborations with clinical geneticists whose patients have family histories of congenital heart defects. (upstate.edu)
  • Conclusions: Our results suggest that rab11 genes play important but distinct roles in the development of the nervous system in zebrafish. (researchsquare.com)
  • In the present project, we showed that zebrafish rab11 genes are conserved in vertebrate evolution by in silicon analysis. (researchsquare.com)
  • These approaches allow the Maves lab to use the zebrafish to understand how specific genes work to properly form the heart. (seattlechildrens.org)
  • Novel cross-regulation interactions between dlx genes in larval zebrafish. (nih.gov)
  • With the available tools of the genomic era and the abundance of disease-associated human genes yet to be explored, the zebrafish model is becoming the preferred choice in basic and applied life sciences. (weizmann.ac.il)
  • Visualize, track and cluster genes based on their expression, intron retention and splicing profile during the Zebrafish development! (inria.fr)
  • I describe the temporal and spatial expression patterns of these genes through embryonic development. (rice.edu)
  • All zebrafish actinin genes have unique expression profiles, indicating specialization of each gene. (rice.edu)
  • The generation of new models will be based on candidate genes identified in WP1 and/or WP2The consortium also aims to use knowledge from genetic and biomarker discovery programmes (in particular, novel pathway information) to support development of novel animal models, and includes European players with a strong track record in this area. (lu.se)
  • PAX6 provides instructions for making proteins that drive tissue development in the fruit fly eye by turning on 'eye' genes and turning off 'non-eye' genes. (medlineplus.gov)
  • 2017). The not-so-long history of zebrafish research in Israel. (weizmann.ac.il)
  • Zebrafish are very visually orientated, and their retina and lens show much the same morphology as other vertebrates including humans. (nih.gov)
  • By in situ hybridization we showed distinct expression of lxr in the brain and the retina in the developing and adult zebrafish. (scirp.org)
  • Our data show that lxr is an important component of the regulatory network governing the lipid homeostasis during zebrafish development, which in turn may support a role of lxr for normal development of the central nervous sytem, including the retina. (scirp.org)
  • The mammalian melatonin receptor MT1 is present in the brain, while MT2, which is the same source as zebrafish, is located in the retina. (aclumengine.com)
  • Tiny zebrafish can also regrow parts of the eye, including neurons in the eye's retina (the light-sensitive tissue at the back of the eyeball). (medlineplus.gov)
  • The zebrafish transcriptome during early development. (scilifelab.se)
  • Furthermore, comparison of altered biological and molecular pathways in zebrafish exposed to PFOA matched findings reported in prior epidemiological studies and other animal models, supporting the predictive value of the transcriptome approach and for predicting adverse health outcomes associated with PFHxA or PFBA exposure. (cdc.gov)
  • Small and large objects activate various circuits in the visual system of zebrafish larvae. (scitechdaily.com)
  • My research focus on whole brain functional calcium imaging in zebrafish larvae using selective plane illumination microscopy (SPIM) for neural activity mapping and to perform cross comparison with behavioral data for evaluation of CNS active drugs. (lu.se)
  • Adult zebrafish. (biologists.com)
  • Melatonin is produced in the pineal gland of the adult zebrafish fish, which is regulated by the circadian rhythm clock of the pineal gland, and by the effect of light on the pineal gland light sensor. (aclumengine.com)
  • However, in adult zebrafish fish, it is mainly expressed in the gray area around the visual disc, as well as in the hills and lower part of the chamber week. (aclumengine.com)
  • Here we show that transient disruption of brain morphogenesis by ethanol exposure results in behavioral hyperactivity in larval zebrafish challenged with changes in lighting conditions. (oregonstate.edu)
  • Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
  • Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. (researchsquare.com)
  • Among various Rab proteins, Rab11 is known to localize to recycling endosome and regulate vesicular recycling and primary ciliogenesis, playing a key role in Kupffer vesicle development in zebrafish [5-7]. (researchsquare.com)
  • The zebrafish Rab11a, Rab11ba and Rab11bb proteins are highly conserved during evolution, especially the GTPase domain, suggesting their important functions. (researchsquare.com)
  • Zebrafish rab11a was clustered in the Rab11a group, and rab11ba and rab11bb in the Rab11b group (Fig.1B) in the phylogenic tree constructed according to amino acid sequences of all the Rab11 proteins above. (researchsquare.com)
  • Adaptor proteins are critical for the development of many tissues and function by tethering upstream signals to downstream molecules to initiate and/or propagate cellular responses (1). (uvm.edu)
  • Piwi proteins are required for germline and stem cell development. (bioone.org)
  • Principal Finding: Using real-time PCR to determine the gene expression pattern of zip7 during zebrafish development, we found that zip7 mRNA is expressed throughout embryonic development and into maturity. (harvard.edu)
  • In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and trigeminal ganglion (Tg), whereas rprml is found primarily in the telencephalon (Tel). At protein level, RPRM is present in a subset of cells in the OP, and neurons in the OE, TeO, hindbrain and sensory peripheral structures. (frontiersin.org)
  • They are taking advantage of CRISPR-Cas9 genome editing technology, and of zebrafish as an animal model system, to identify the genetic causes of congenital heart defects. (seattlechildrens.org)
  • With their expertise in using CRISPR-Cas9 genome editing technology in zebrafish, the Maves lab have the capability to engineer knock-out and precise knock-in zebrafish strains. (seattlechildrens.org)
  • The aquatics facility at Seattle Children's Research Institute is well-equipped with tools for using CRISPR-Cas9 in zebrafish. (seattlechildrens.org)
  • The field took a leap forward in the 1980s, led in part by the work of George Streisinger and others who recognized that zebrafish could be a useful model for genetic screens ( Walker and Streisinger, 1983 ), paving the way to large-scale phenotypic screens in embryogenesis. (biologists.com)
  • In conclusion, our results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish. (bioone.org)
  • Dan Li , Huaqin Sun , Wenqian Deng , Dachang Tao , Yunqiang Liu , and Yongxin Ma "Zili Antagonizes Bmp Signaling to Regulate Dorsal-Ventral Patterning during Zebrafish Early Embryogenesis," Zoological Science 28(6), 397-402, (1 June 2011). (bioone.org)
  • Zebrafish were then exposed to sublethal concentrations (0.4-4000 ppb, µg/L) throughout embryogenesis (1-72 hpf). (cdc.gov)
  • Small-scale marker-based screening for mutations in zebrafish development. (monash.edu)
  • In particular, they are engineering zebrafish to carry DNA mutations that are found in human patients with heart defects. (seattlechildrens.org)
  • Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
  • Zebrafish widely used as an animal model in various fields of biomedical research as a disease model for cancer, metabolic and neurodegenerative diseases, and regenerative medicine. (weizmann.ac.il)
  • Because the function of Zip7 in vivo was unclear, the present study investigated the function of zip7 in vertebrate development and zinc metabolism using zebrafish as a model organism. (harvard.edu)
  • Taken together, our data provide critical insight into a novel function of zip7 in development and zinc homeostasis in vivo in zebrafish. (harvard.edu)
  • however, its role in neural development in vivo remains inconclusive. (curie.fr)
  • Historically, they were used as a model to test the carcinogenic properties of ethyl carbamate (also known as urethane) by examining early development, facilitated by the transparency and ex-vivo development of the organism ( Battle and Hisaoka, 1952 ). (biologists.com)
  • The purpose of this study was to determine whether the extended developmental capability of zebrafish top2a mutants arises from maternal expression of top2a or compensation from its top2b paralogue. (whiterose.ac.uk)
  • Inhibition or poisoning of maternal topoisomerase II delays embryonic development by extending the cell cycle M-phase. (whiterose.ac.uk)
  • Conclusions We conclude that maternal top2a enables zebrafish development before the mid-zygotic transition (MZT) and that zebrafish top2a and top2b are not functionally redundant during development after activation of the zygotic genome. (whiterose.ac.uk)
  • In contrast to mouse Top2a nulls, zebrafish top2a mutants survive to larval stages (4-5 day post fertilization). (whiterose.ac.uk)
  • Finally, we demonstrate a key mammalian BBB regulator Mfsd2a, which inhibits transcytosis, plays a conserved role in zebrafish, as mfsd2aa mutants display increased BBB permeability due to increased transcytosis. (elifesciences.org)
  • This large collection of genetic mutants, still used to this day, was crucial to understand fundamental mechanisms of vertebrate development as well as human Mendelian genetic disease. (biologists.com)
  • We observed miR-137 expression and activity in sensory neurons including Rohon-Beard neurons and dorsal root ganglia, two neuronal cell types that confer touch-sensitivity in normal zebrafish, suggesting a role of these cell types in the observed phenotype. (nature.com)
  • Title : Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers After Cell Ablation Personal Author(s) : McPherson, Adam D.;Barrios, Joshua P.;Luks-Morgan, Sasha J.;Manfredi, John P.;Bonkowsky, Joshua L.;Douglass, Adam D.;Dorsky, Richard I. (cdc.gov)
  • Structural analyses performed on adults showed that repression of miR-153c during development impacts craniofacial skeletal development. (oregonstate.edu)
  • A potential nutritional control of the larval and post-larval skeletal development even in aquaculture species is suggested. (univ-brest.fr)
  • In recent years, the zebrafish has become a favourite model organism for biologists studying developmental processes in vertebrates. (nih.gov)
  • This review describes the advantages of the zebrafish as a model organism as well as giving an overview of eye development in this species. (nih.gov)
  • The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. (wikipedia.org)
  • As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. (elifesciences.org)
  • Expanding our understanding of the zebrafish BBB can thus reveal the mechanistic similarities between the zebrafish and mammalian BBB to further evaluate the position of zebrafish as a model organism for studying the BBB. (elifesciences.org)
  • Zebrafish is an established model organism for studies on health and disease . (bvsalud.org)
  • However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellular and molecular mechanisms governing the zebrafish BBB remain poorly characterized. (elifesciences.org)
  • However, the subcellular and molecular mechanisms governing the formation and maintenance of the zebrafish BBB are only beginning to be characterized. (elifesciences.org)
  • The basic mechanisms of object classification can be studied using zebrafish larva as the model system. (scitechdaily.com)
  • The new faculty member will be part of an interdisciplinary research studying mechanisms of toxicity of chemicals that affect embryonic development and contribute to the onset of chronic disease. (bioblogia.net)
  • I found that pollywog encodes the zebrafish mitogen activated protein kinase kinase kinase 4 ( map3k4 ) gene and that it acts upstream of p38a MAPK in the YSL. (rice.edu)
  • Early heart formation in zebrafish is remarkably similar to what takes place in humans. (upstate.edu)
  • Despite its lack of septation, the tissue patterning of the arterial pole of the zebrafish is remarkably similar to the patterning of pulmonary and aortic arterial poles observed in mouse and chick. (duke.edu)
  • Our previous study demonstrated that Zili, zebrafish Piwil2, inhibits transforming growth factor (TGF)-βsignaling by interacting with Smad4, suggesting a role for zili in Bmp signaling. (bioone.org)
  • We also analyzed the role of Akt, Erk and mechanistic target of rapamycin (mTOR) signaling cascades and showed a requirement for these pathways in motoneurons axon outgrowth and neuronal development. (curie.fr)
  • Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. (nih.gov)
  • Importantly, a precise temporal description of RPRM protein expression during the development of neuronal structures is still missing. (frontiersin.org)
  • Such knowledge is fundamental to advance in our understanding of the possible role of this gene family in neuronal development. (frontiersin.org)
  • Consistent with a role for miRNAs in neurobehavioral development, target prediction analyses identified multiple miRNAs misexpressed in the ethanol-exposed cohorts that were also predicted to target inversely expressed transcripts known to influence brain morphogenesis. (oregonstate.edu)
  • Zebrafish are amenable to genetic manipulation, for which innovative genetic and molecular techniques are constantly being introduced. (weizmann.ac.il)
  • A study in mouse cell lines demonstrated Grb2 was necessary in facilitating cortical neuron growth, which displays the importance of Grb2 in development of neural tissues (4). (uvm.edu)
  • By the 1960s, it was recognized that zebrafish readily developed cancer when exposed to mutagens ( Stanton, 1965 ) and numerous studies explored a wide variety of chemicals that affected tissues of the fish. (biologists.com)
  • A future challenge will be to see if similar retinoic acid gradients and noise control occur in other tissues, and if the noise has any positive role to play in development. (elifesciences.org)
  • Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole. (duke.edu)
  • Morpholino-antisense (MO) gene knockdown assay revealed that downregulation of zip7 expression resulted in several morphological defects in zebrafish including decreased head size, smaller eyes, shorter palates, and shorter and curved spinal cords. (harvard.edu)
  • While miR-137 overexpression was not associated with an observable specific phenotype, downregulation by antisense morpholino and/or transgenic expression of miR-sponge RNA induced significant impairment of both embryonic and larval touch-sensitivity without compromising overall anatomical development. (nature.com)
  • Some molecular pathways required for SHF development in birds and mammals are conserved in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp signaling in the zebrafish heart fields. (duke.edu)
  • In this study, we evaluated the functionality of A1 adenosine receptor through development of zebrafish (6-7-day-, 3-, 8-, and 24-month-old), assessing (I) the effects of the agonist N6-cyclopenthyladenosine (CPA) over locomotor parameters , (II) the anticonvulsant properties of CPA and adenosine per se in the pentylenetetrazol -induced seizure, and (III) the gene expression of adora1b through development. (bvsalud.org)
  • Kao RM, Rurik JG, Farr GH 3rd, Dong XR, Majesky MW, Maves L. Pbx4 is required for the temporal onset of zebrafish myocardial differentiation . (seattlechildrens.org)
  • In this study, we use zebrafish as a model to investigate Grb2's role in the nervous system. (uvm.edu)
  • The following study used the zebrafish developmental model to investigate the responses to endosulfan I and endosulfan sulfate, the major degradation product of endosulfan I and II. (oregonstate.edu)
  • These findings demonstrate that the role of α-crystallins in lens development is conserved from mammals to zebrafish and set the stage for using the embryonic lens as a model system to test mechanistic aspects of α-crystallin chaperone activity and to develop strategies to fine-tune protein-protein interactions in aging and cataracts. (nih.gov)
  • Topoisomerase II alpha is also required for embryonic development in mammals, as mouse Top2a knockouts result in embryonic lethality as early as the 4-8 cell stage. (whiterose.ac.uk)
  • These results suggest that zebrafish has similar responses to CPA as mammals . (bvsalud.org)
  • Most studies address Grb2's role in the vasculature system or in cell culture, and mice deficient in Grb2 die very early in development, therefore little is known about Grb2's role in the nervous system (3, 6, 7, 8). (uvm.edu)
  • These studies highlight the varied role for Grb2 in nervous tissue development in zebrafish. (uvm.edu)
  • Thus, we provide a reference dataset describing the expression patterns of RPRM gene products during zebrafish and mouse development as a first step to approach the physiological role of the RPRM gene family. (frontiersin.org)
  • Herein we examine the temporal and spatial expression patterns of RPRM gene-products (mRNA and protein) during neural development. (frontiersin.org)
  • Duplication of actn3 in the zebrafish indicates that variation in actn3 expression may promote physiological diversity in muscle function among vertebrates. (rice.edu)
  • Pax7 plays an important role in the development of neural processes, especially in the process of yellow Tuan pigmentation. (aclumengine.com)
  • Paragangliomas are on the other hand slow growing tumors and mostly benign, but also these are believed to be primed during development of the neural crest. (lu.se)
  • Electron microscopy studies further reveal high levels of transcytosis in brain endothelium early in development that are suppressed later. (elifesciences.org)
  • When ZEISS Lattice Lightsheet 7 was presented to the research community in 2020, it marked a milestone in the development of microscopy techniques for the study of life. (zeiss.com)
  • 2016). Zebrafish reel in phenotypic suppressors of autism. (weizmann.ac.il)
  • This paper investigates the spatial dynamics of a zebrafish model with cross-diffusions. (aimsciences.org)
  • Farr GH 3rd, Imani K, Pouv D, Maves L. Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects . (seattlechildrens.org)
  • 2018) In: Development and function of the zebrafish neuroendocrine system. (weizmann.ac.il)
  • It has a particular focus on morphological as well as molecular aspects of the development of the lens. (nih.gov)
  • Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFOA, PFHxA, and PFBA using the zebrafish model system. (cdc.gov)
  • Significance: Our data suggest that zip7 is required for eye, brain, and skeleton formation during early embryonic development in zebrafish. (harvard.edu)
  • Because the zebrafish genome and early heart development are very similar to that in humans, work in the Maves lab will have direct relevance for understanding human heart development and congenital heart defects. (seattlechildrens.org)
  • The YSL undergoes dramatic reorganization during early development through processes that mirror the morphogenetic movements of the blastoderm. (rice.edu)
  • These data show that the p38 MAPK pathway is essential for maintaining normal yolk cell equilibrium during early development and that without proper cues from the YSL, the blastoderm cannot complete its morphogenetic movements. (rice.edu)
  • Alterations in the length and position of paired fins caused by exposure to thyroid-disrupting chemicals during early development, as shown here for Zebrafish, could affect physical aspects of locomotion and consequently other important organismal functions such as foraging, predator avoidance, and ultimately survival and recruitment into the adult population. (usgs.gov)
  • The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. (oregonstate.edu)
  • In this study I demonstrate that the population that gives rise to the arterial pole of the zebrafish can be traced from the epiblast, is a discrete part of the mesodermal heart field. (duke.edu)
  • Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. (ucdenver.edu)
  • We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. (biologists.com)
  • Integrating zebrafish toxicology and nanoscience for safer product development. (oregonstate.edu)
  • The objective of this study was to determine the role of LXR during development using the zebrafish model. (scirp.org)
  • In 2015, a study was published about zebrafishes' capacity for episodic memory. (wikipedia.org)
  • A new study from the Max Planck Institute for Medical Research reveals how the eye of a zebrafish larva can already distinguish between prey and predator. (scitechdaily.com)
  • Due to its circadian nature, the zebrafish fish provides a special opportunity to study the circadian rhythm of melatonin regulation. (aclumengine.com)
  • NIH-supported researchers continue to study fruit fly development, asking questions like, "What makes an eye an eye? (medlineplus.gov)
  • Results indicate that, in such experimental conditions, C. auratus has a significant preference for a dark environment, a feature that might be relevant for the development of an experimental model of anxiety for the study of this species. (bvsalud.org)
  • Barrier properties of brain endothelial cells are induced by extrinsic signals from other cells in the surrounding microenvironment during development ( Stewart and Wiley, 1981 ). (elifesciences.org)
  • This molecule is highly conserved in vertebrates enabling the investigation of its function in the developing zebrafish. (nature.com)