Development membrane proteins. Medical search. Frequent questions

This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
However, only a small fraction of membrane proteins, such as G-protein coupled receptors (GPCRs) and ion channels, have been considered as drug targets. (biophysics.org)
A Closer Look at Membrane Proteins opens with a description of the insulin-like growth factor system, with focus on the insulin-like growth factor receptors and functions associated with them. (novapublishers.com)
The data on membrane proteins, their N-glycome and oxidation status id related to the authors' findings on the receptors in different physiological and pathological conditions, such as normal and abnormal tissue growth and development. (novapublishers.com)
Ephrins, also known as ephrin ligands, and Eph receptors (Ephs), which are RTKs, are key regulators of physiological and pathological processes involved in development and disease, such as cellular motility, cell repulsion, and cell adhesion [ 4 ]. (hindawi.com)
Both receptors and ligands are membrane-bound proteins that require direct cell-cell interaction for activation. (hindawi.com)
A further chapter discusses how surface membrane G-protein receptors in C. albicans and other fungi transmit external stimuli through 2 major protein kinase cascades. (cdc.gov)

Our research centers around studying membrane proteins involved in disease, using X-ray crystallography and other biophysical techniques, to reveal structural, functional and mechanistic details of membrane proteins that could one day aid in the development of new drugs and vaccines targeted towards membrane proteins. (ualberta.ca)
Facilities include those for protein-sequence analysis, peptide and oligonucleotide synthesis, access to the synchrotron at Lawrence Berkeley National Lab for X-ray crystallography, and NMR spectrometry. (berkeley.edu)
took the in situ approach one step further and showed the applicability of room temperature data collection for in meso / in situ crystallization (IMISX) and its use for high-throughput crystallography of membrane proteins crystallized in meso using the LCP technology. (iucr.org)
In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)

Subtypes, defined by variation in the outer membrane protein PorA, are an integral part of the characterization scheme for Neisseria meningitidis . (cdc.gov)
In the absence of a comprehensive vaccine against this organism, the characterization of its variable surface antigens is important for epidemiologic monitoring and vaccine development ( 2 ). (cdc.gov)
We describe the design and synthesis of a novel set of iso-baric tags for quantitative glycan profiling, which will have broad applications in carbohydrate based biomarker dis-covery, therapeutic protein characterization, and vaccine development. (nist.gov)
Among the bacterial systems available, the Gram-positive lactic bacterium, Lactococcus lactis , traditionally used in food fermentations, is nowadays widely used for large-scale production and functional characterization of bacterial and eukaryotic membrane proteins. (springer.com)
The aim of this chapter is to describe the different possibilities for the functional characterization of peripheral or intrinsic membrane proteins expressed in Lactococcus lactis . (springer.com)
The main focus of our research is the development and optimization for High-Performing-Computing (HPC) of computational methodology for the structural and energetic characterization of protein interactions at molecular level. (bsc.es)

It is estimated that about 30-35 percent of proteins in the human proteome are integral membrane proteins. (biophysics.org)

Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
Methylenediphenyl diisocyanate binds membrane and intracellular proteins of intact THP-1 cells. (cdc.gov)
Because of this low prevalence, we propose that methylenediphenyl diisocyanate (MDI) may adduct to cell membrane and intracellular proteins, contributing to the development of non-IgE asthma. (cdc.gov)
Proteins identified in the soluble fraction were all of intracellular origin suggesting that reactive MDI can cross the cell membrane and subsequently haptenate intracellular proteins. (cdc.gov)
The results of the present study support the potential involvement of dNCO haptenated membrane and intracellular proteins in development of asthma. (cdc.gov)

Some INM proteins contain common protein domain structures, and can thus be categorised into known protein domain families. (wikipedia.org)
Native and redesigned proteins exhibited highly similar characteristics, predicted structures and binding pockets, and slightly different docking poses against known ligands, although task-specific designs are still required for proteins more susceptible to internal hydrogen bond formations. (mit.edu)
Scientists discovered a protein that modifies a microbe's membrane and helps it survive in hot, acidic environments, proving a long-standing hypothesis that these structures have a protective effect. (stanford.edu)
The structures of some organisms' membranes are retained in the fossil record and can serve as molecular fossils or biomarkers, leaving hints of what lived in the environment long ago. (stanford.edu)
Our crystal structures of this novel type of protease are providing information on how the rhomboid protease acts to cleave protein targets in the membrane. (ualberta.ca)
which moves proteins and other molecules within cells in sac-like structures called vesicles. (medlineplus.gov)
In closing, commandments surrounding integral membrane protein expression and purification, integral membrane protein biochemistry, integral membrane protein functionality studies and integral membrane protein high-resolution structures are described. (novapublishers.com)
This study therefore provides a proof of principle that membrane protein structures can be determined at a synchrotron using in situ room temperature data collection strategies. (iucr.org)

Defining the core proteome of the chloroplast envelope membranes. (uni-frankfurt.de)

Once INM:chromatin interactions have been established following formation of the nuclear envelope, soluble nuclear proteins may bind to exposed chromosomal segments. (wikipedia.org)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
Glycophorin A was the most affected protein in sickle RBCs by this ERK1/2 pathway, which contained 12 unique phosphorylated peptides, suggesting that in addition to its effect on sickle RBC adhesion, increased glycophorin A phosphorylation via the ERK1/2 pathway may also affect glycophorin A interactions with band 3, which could result in decreases in both anion transport by band 3 and band 3 trafficking. (duke.edu)
Specifically, we are interested in post-translational modifications, changes to a protein after it's produced, which add an incredible level of diversity to the underlying proteins within a cell and can control a diverse array of processes, including protein stability, interactions, and activity. (upenn.edu)
We aim to develop and optimize computational algorithms for characterizing and understanding protein-protein interactions, which remains one of the most important challenges in Structural Biology. (bsc.es)
More efficient identification of correct docking poses, especially in difficult cases such as weak interactions, multi-protein complexes or membrane proteins. (bsc.es)

Since the outer nuclear membrane is continuous with the endoplasmic reticulum it is possible that the inner nuclear membrane proteins are translated on the rough endoplasmic reticulum, whereby the proteins move into the nucleus by lateral diffusion through a nuclear pore. (wikipedia.org)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)

Abstract The 90 kD heat shock proteins (Hsp90) are molecular chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. (sbir.gov)

Membrane receptor proteins serve as connection between the cell's internal and external environments. (phys.org)
Approximately half of the most common drugs today are directed at membrane receptor proteins. (expertsvar.se)

INM proteins also aid in organization of nuclear pore complexes (NPCs). (wikipedia.org)
Current opinion is that INM proteins synthesised in the cytoplasm are transported to the INM through nuclear pore complexes (NPC). (wikipedia.org)
We have also made available our software through different web servers, such as pyDockWeb for protein-protein docking, pyDockSAXS for the structural prediction of protein complexes using Small-Angle X-ray Scattering (SAXS) data in collaboration with Pau Bernadó (CBS, Montpellier), or OPRA for the identification of RNA-binding residues in proteins. (bsc.es)
Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)

and, regulation of biological processes such as chromosomal folding, protein secretion and intracellular signaling. (berkeley.edu)
Biological membranes consist of a phospholipid bilayer and a variety of proteins that accomplish vital biological functions. (phys.org)
Protein is one of the central biomolecules that is involved in almost all biological events and thus its quantitative analysis has been actively conducted for many years. (nii.ac.jp)
Dr. Thompson's research focuses on the development and deployment of proteomics and metabolomics mass spectrometry techniques for the analysis of biological systems. (duke.edu)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
One-third of all our proteins have the cell membrane as their natural environment, where they perform several of the most basic life-preserving biological processes. (expertsvar.se)
Understanding certain key scientific concepts behind the battle against COVID-19 and how SARS-CoV-2's biological mechanisms actually work will allow us to navigate in the sea of information to better gauge the scope of the problem and the prospects concerning the development of potential treatments. (bbva.com)
Expanded polytetrafluoroethylene (e-PTFE) membranes have been the standard materials for clinical treatment with guided bone regeneration (GBR), achieving good results when used as mechanical barriers covering sites of extraction e- PTFE is a polymer with high stability in biological systems, which provides better tissue organization, infection resistance and no induction of inflammatory reactions 1 . (bvsalud.org)

Adsorption of plasma proteins on uncoated PLGA nanoparticles. (uni-frankfurt.de)

For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
Structural and biophysical data show that ASTN-2 (but not ASTN-1) binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. (ox.ac.uk)
These findings also identify additional protein targets of this pathway other than the RBC adhesion molecule ICAM-4 and enhance the understanding of the mechanism of small molecule inhibitors of MEK/1/2/ERK1/2, which could be effective in ameliorating RBC hemorheology and adhesion, the hallmarks of SCD. (duke.edu)
For example, some favorite modifications can lead to the protein being degraded which provides a mechanism to get rid of proteins which cause disease. (upenn.edu)

Stanford University researchers have identified a protein that helps these organisms form a protective, lipid-linked cellular membrane - a key to withstanding extremely highly acidic habitats. (stanford.edu)
These proteins provide a selective conduction of ions across cellular membranes, which is crucial for cell survival. (surrey.ac.uk)
Maintaining the structure of intracellular membranes is essential for preserving normal cellular function. (phys.org)
Membrane proteins play a pivotal role in various cellular functions and are key targets for pharmaceutical interventions. (phys.org)
These sessions, providing diverse perspectives using different systems, are "Protein machines and disorder," "Organelles, mechanisms and phase properties of cellular quality control," and "Cell signaling - new tools and emerging concepts. (asbmb.org)

Critical biomolecules of the cell are identified, engineered and harnessed for myriad applications in sessions on "Frontiers in carbohydrate synthesis and recognition," "Lipid dynamics and signals in membrane and protein structure," and "Regulation of RNA. (asbmb.org)
Sickle RBC treatment with U0126 decreased thirty-six phosphopeptides from twenty-one phosphoproteins involved in regulation of not only RBC shape, flexibility, cell morphology maintenance and adhesion, but also glucose and glutamate transport, cAMP production, degradation of misfolded proteins and receptor ubiquitination. (duke.edu)
We employed a comprehensive approach for global and dynamic profiling of the surfaceome and endocytosed (endocytome) proteins and their regulation by hypoxia in patient-derived GBM cultures. (lu.se)
We provide a quantitative ranking of more than 600 surface resident and endocytosed proteins, and their regulation by hypoxia, serving as a resource to the cancer research community. (lu.se)

Because VIA1 contains a predicted winged-helix domain, a hallmark feature of ESCRT-II proteins that mediates the interaction with ESCRT-III proteins, our data support the hypothesis that universal, mechanistic principles govern membrane remodeling across all living organisms. (biorxiv.org)
My postdoctoral work identified mechanistic principles of protein self-assembly, membrane remodeling, and RNA scaffolding that collectively regulate viral morphogenesis. (aiche.org)

They then mutated those genes one-by-one, eliminating any proteins the genes made. (stanford.edu)
Genes controlling hyphal development include ones that are upregulated during cell elongation and adherence to epithelia. (cdc.gov)

In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)

Finally, transport proteins play an important role in the maintenance of concentrations of ions. (phys.org)
These transport proteins come in two forms: carrier proteins and channel proteins. (phys.org)

including improvements in membrane protein overexpression, stabilization of proteins using antibodies or thermostabilizing mutations, and the enhancement of crystallization technologies such as crystallization in lipidic cubic phase (LCP, in meso crystallization). (iucr.org)

Cell recognition proteins allow cells to identify each other and interact. (phys.org)
Chemical Tailoring of Aptamer Glues with Significantly Enhanced Recognition Ability for Targeted Membrane Protein Degradation. (bvsalud.org)
However, the application of aptamers in cell membrane protein -based biomedical research is limited by their inherent drawbacks, such as sensitivity to the recognition environment and susceptibility to enzymatic degradation, which leads to the loss of recognition ability . (bvsalud.org)
To address these challenges, this study presents a subzero- temperature -enabled molecule stacking strategy for the on-demand tailoring of aptamer glues for the precision recognition and efficient degradation of membrane protein . (bvsalud.org)

Proteins from the bands were identified using proteomic mass spectrometry. (cdc.gov)
Importantly, we highlight the limited correlation between transcriptomics and proteomics, emphasizing the critical role of membrane protein enrichment strategies and quantitative mass spectrometry. (lu.se)

CrMP-Sol also presents QTY-enabled water-soluble designs to facilitate native membrane protein studies despite natural hydrophobicity. (mit.edu)
This protein can be a membrane-bound or soluble protein. (nih.gov)
After exposure, cells were processed into soluble and membrane fractions, dialyzed, and analyzed for extent of MDI protein binding, following acid hydrolysis, by quantification of the MDI hydrolysis product, methylenedianiline (MDA). (cdc.gov)
Protein bound MDI was detected in a dose-dependent manner and quantified from the membrane and soluble fractions of MDI exposed THP-1 cells. (cdc.gov)
Eleven bands from the soluble fraction and 2 bands from the membrane fraction were identified as containing MDI bound proteins. (cdc.gov)

The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. (nih.gov)
Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. (nih.gov)
The ligands can have a glycosylphosphatidylinositol anchor (A type) or a membrane-spanning protein domain (B type). (hindawi.com)

From previous research in archaea, Welander and her team knew that the organisms produce a membrane containing a ringed molecule called a calditol. (stanford.edu)
A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. (phys.org)
The photosystems have the unique capacity to perform and fix energy in a process where water splitting and oxygen evolution takes place, providing planet Earth with an essential molecule for development of life, i.e. (rug.nl)

Membrane proteins are critical mediators for tumor progression and present enormous therapeutic potentials. (mit.edu)
Although gene profiling can identify their cancer-specific signatures, systematic correlations between protein functions and tumor-related mechanisms are still unclear. (mit.edu)

Development of a topical fixed-dose combination drug for peripheral neuropathic pain. (sbir.gov)

BPS member Martin Picard, along with a few colleagues, organized the symposium which brought together scientists from the Great Paris area to discuss the recent advances in the field of structural and functional analysis of membrane proteins. (biophysics.org)
Machine learning was used to extract key functional descriptions for protein visualization in the 3D-space, where spatial distributions provide function-based predictive connections between proteins and cancer types. (mit.edu)
Kunji ERS, Slotboom DJ, Poolman B (2003) Lactococcus lactis as host for overproduction of functional membrane proteins. (springer.com)
Monné M, Chan KW, Slotboom DJ, Kunji ERS (2005) Functional expression of eukaryotic membrane proteins in Lactococcus lactis. (springer.com)

Such proteins could include enzymes that modify histones-such as methylases and acetylases-which act to alter the three-dimensional conformation of chromatin, as well as DNA binding proteins-such as helicases, gyrases, and transcription factors-that are involved in unwinding/looping DNA and/or recruiting RNAP holoenzyme. (wikipedia.org)
Membrane enzymes produce a variety of substances essential for cell function. (phys.org)

Being able to show how this protective membrane is created could help researchers understand other molecular fossils in the future, offering new evidence about the evolution of life on Earth. (stanford.edu)
To understand the molecular role of polarity proteins in plant development, it is important to characterize their interactome, including their protein-protein interaction partners. (oeaw.ac.at)
Following up on the top hits obtained by proximity labeling, I study co-localization, protein-protein interaction, and genetics to expand our knowledge on the molecular networks that regulate stomatal development. (oeaw.ac.at)
8-9 An integral aspect of these past studies was the development and use of hierarchical (or multiscale) computer simulations that rigorously bridge insights from quantum mechanical (QM), molecular, and coarse-grained (CG) resolutions to connect with experiments. (aiche.org)

Kingsley's group uses genetics to study the development of bones and joints in vertebrates, or animals with backbones. (stanford.edu)

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. (ox.ac.uk)
Several studies have suggested distinct roles for synapsin I and synapsin II during neuronal development. (jneurosci.org)
Whether synapsin III plays a role similar to those described for synapsin I and synapsin II during neuronal development was the subject of the present study. (jneurosci.org)

These changes can promote mitochondrial biogenesis and membrane dynamics that in turn support mitochondrial respiration. (nature.com)
Fig. 4: Post-translational mechanisms governing respiratory control and the role of mitochondrial membrane dynamics. (nature.com)
Using genetic tools and confocal microscopy, I study the role and protein dynamics of this novel polarity domain in stomatal development (and beyond). (oeaw.ac.at)
Finally, we have basic theory projects relating to the experimental work just described, as well as in transport and structure in complex colloidal or zeolite systems, protein dynamics, and fundamental issues in quantum and statistical mechanics. (mcgill.ca)
The diversity of the photosynthesis proteins due to evolution upon adaptation and exploitability is intriguing for researchers from all fields of science to understand aspects of structural diversity, function and dynamics. (rug.nl)

The increasing interest in extracellular vesicles (EVs) research is fueled by reports indicating their unique role in intercellular communication and potential connection to the development of common human diseases. (nist.gov)
Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signaling cell death. (phys.org)
The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)

Some may interact directly with the nuclear lamina, and some may be associated with it through scaffold proteins. (wikipedia.org)
The nucleoplasmic domains of such proteins can interact with chromatin to create a scaffold and restrict the conformation of chromosomes within three dimensions. (wikipedia.org)
Nonhuman primates provide a powerful model to unravel the mechanisms by which early stress and genetic makeup interact to produce long-term changes in brain development, stress reactivity, and risk for psychiatric disorders. (nih.gov)
Based on its structure, the Megf8 protein may be involved in cell processes such as sticking cells together (cell adhesion) and helping proteins interact with each other. (medlineplus.gov)
More than half of all proteins interact with membranes. (phys.org)
Here, we used an affinity purification approach in two distantly related photosynthetic eukaryotes, the green alga Chlamydomonas reinhardtii and the plant Arabidopsis thaliana , to discover proteins that interact with VIPP1. (biorxiv.org)

Development in the area of structural biology methods combined with new computational possibilities has highlighted the importance of combining different methods in order to maximize the output. (lu.se)

Of the few known proteins involved in these processes, VIPP1 stands out due to its similarity to ESCRT-III, an integral component of the ESCRT machinery that is responsible for membrane remodeling and trafficking in the cytoplasm of eukaryotes. (biorxiv.org)
The colour changes can be attributed to the local chemical environment on the nanostructured metal surface and provide information about different processes in which the proteins being studied are involved. (expertsvar.se)

During my postdoc, I characterize novel mechanisms and polarity proteins in the development of stomata, the major drivers of gas exchange and carbon fixation in the leaf epidermis of vascular plants. (oeaw.ac.at)
However, the mechanisms behind their selectivity - e.g. how these proteins can perfectly discriminate between ions - is not entirely understood. (surrey.ac.uk)

Development of a non-fibrillic amyloid-beta oligomer selective positron emission tomography imaging diagnostic for Alzheimer. (sbir.gov)
In this research project, we successfully developed several original methods (or synthetic small molecules) based on chemistry that allow for selective labeling and imaging target proteins under nearly natural conditions. (nii.ac.jp)

There are about 60 INM proteins, most of which are poorly characterized with respect to structure and function. (wikipedia.org)
Several integral nuclear membrane proteins of different size and structure have been identified. (wikipedia.org)
Overall, our structure provides the first atomic-resolution description of a MACPF protein involved in development, while highlighting distinctive features of ASTN-2 responsible for its activity. (ox.ac.uk)
The team directly proved this idea by identifying the protein that creates the unusual membrane structure in the species Sulfolobus acidocaldarius . (stanford.edu)
Does this membrane structure really do what we're saying it does? (stanford.edu)
These methods may contribute to analyzing protein structure and functions in living cells. (nii.ac.jp)
Among others, we have developed software for prediction of protein-protein complex structure by docking simulations, identification of binding sites on protein surfaces, or prediction of hot-spot residues from energy calculations. (bsc.es)

I discovered a novel polarity protein in Arabidopsis thaliana that polarizes at distinct developmental stages in stomatal precursors. (oeaw.ac.at)
The absence of VIA1 causes thylakoid swelling upon exposure to high light in Chlamydomonas and defective thylakoid biogenesis in the newly emerging leaf tissue in Arabidopsis, thereby delaying chloroplast development in this tissue. (biorxiv.org)

The ion-transporting activities of many membrane proteins, such as the Na+,K+-pump (or Na+,K+-ATPase), and Na+- and K+-channels, are sensitive to the transmembrane electrical potential difference. (biophysics.org)
These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. (nih.gov)

Heat shock proteins are emphasized because of the temperature-sensitive morphogenesis to the tissue form. (cdc.gov)

Finding preserved membrane lipids, for example, could suggest when an organism evolved and how that may have been the circumstance of its environment. (stanford.edu)

Once all regulatory proteins, etc. have been synthesized and the scaffold has been established, the cell has attained its own specific expression profile. (wikipedia.org)
The vertebrate-specific proteins astrotactin-1 and 2 (ASTN-1 and ASTN-2) are integral membrane perforin-like proteins known to play critical roles in neurodevelopment, while ASTN-2 has been linked to the planar cell polarity pathway in hair cells. (ox.ac.uk)
The Rab23 protein transports vesicles from the cell membrane to their proper location inside the cell. (medlineplus.gov)
For example, the Rab23 protein regulates a developmental pathway called the hedgehog signaling pathway that is critical in cell growth (proliferation), cell specialization, and the normal shaping (patterning) of many parts of the body. (medlineplus.gov)
Structural proteins are attached to microfilaments in the cytoskeleton which ensures stability of the cell. (phys.org)
Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation. (duke.edu)
UNLABELLED: BACKGROUND: In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBCs). (duke.edu)
The RMT2-26 monoclonal antibody specifically recognizes T cell immunoglobulin and mucin domain-2 (TIM-2) which is also known as T-cell membrane protein 2, TIMD-2, or Tim2. (bdbiosciences.com)
Cell membrane proteins play a crucial role in the development of early cancer diagnosis strategies and precision medicine techniques . (bvsalud.org)

The experiments revealed one gene that, when mutated, produced S. acidocaldarius that lacked calditol in the membrane. (stanford.edu)
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
The MEGF8 gene provides instructions for making a protein whose function is unclear. (medlineplus.gov)
The ank gene that the team found produces a protein that spans the membrane surrounding cells. (stanford.edu)
His group is the first to pinpoint the ank gene, identify the protein encoded by it and construct a model explaining how the ank protein may be involved in arthritis. (stanford.edu)

It has been proposed that chromatin-binding/modifying proteins embedded within the inner nuclear membrane may be central in determining the identity of newly differentiated cells. (wikipedia.org)
He loved microscopes and watching the proteins and molecules that make up cells move around. (biophysics.org)
Polarity proteins orient divisions in stomatal precursor cells to determine stomatal fate and patterning. (oeaw.ac.at)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
These viruses are spherical in shape and covered in protein spikes that help them bind to and infect healthy cells. (bbva.com)
If that membrane is destroyed, proteins can no longer infect or communicate with healthy cells. (bbva.com)
This protein is believed to shuttle pyrophosphate - a strong inhibitor of calcification and bone mineralization - into and out of cells. (stanford.edu)
The extent of MDI intracellular protein binding was not affected by cytochalasin D, a chemical which binds actin filaments and inhibits active uptake into cells. (cdc.gov)
e-PTFE membranes are used as mechanical barriers to protect the blood clot and allow bone cells to be selected to repopulate the bone defect, preventing the epithelial tissue to migrate into the defect 1 . (bvsalud.org)

Significance Statement Thylakoid membranes are essential for photosynthesis, yet their biogenesis and maintenance are poorly understood. (biorxiv.org)

I adapted the biotin ligase (BirA)-based proximity labeling method for polarity proteins in the stomatal lineage and identified the respective plasma membrane proteomes. (oeaw.ac.at)

Improving the precision of quantitative bottom-up proteomics based on stable isotope-labeled proteins. (uni-frankfurt.de)
RESULTS: To further characterize global ERK1/2-induced changes in membrane protein phosphorylation within human RBCs, a label-free quantitative phosphoproteomic analysis was applied to sickle and normal RBC membrane ghosts pre-treated with U0126, a specific inhibitor of MEK1/2, the upstream kinase of ERK1/2, in the presence or absence of recombinant active ERK2. (duke.edu)

When applied to membrane proteins, the contribution to the scattering signal of the detergent molecules present in the sample is significant and needs to be dealt with. (biophysics.org)

Development of human membrane transporters: Drug disposition and pharmacogenetics. (msdmanuals.com)

New insight into the role of PTCH1 protein in serous ovarian carcinomas. (nih.gov)
We propose that VIA1 is part of a previously unrecognized chloroplast ESCRT-like system that plays a critical role in forming, remodeling, and repairing photosynthetic membranes. (biorxiv.org)
Furthermore, it plays a key role in protecting public health and can provide valuable inputs for the development of new medicines and protection systems against particular diseases, such as COVID-19. (bbva.com)
It is possible to find different techniques using physical barriers 2-7 and the characteristics of the biomaterial and the design of the membrane used in guided tissue regeneration play an important role in obtaining good results 8 . (bvsalud.org)

VIA1 is predicted to contain a winged-helix domain, a characteristic feature of ESCRT-II proteins that mediates the interaction with ESCRT-III proteins. (biorxiv.org)

In the last decade, a new line of versatile detergent-free methods have emerged, increasing the production of membrane proteins. (biophysics.org)
Next, a review of the current methods used to prepare and study membrane proteins is presented, with focus on large scale simulations and special emphasis on scalable parallel methods. (novapublishers.com)
We are continuously validating our docking methods in CAPRI , a world-wide community experiment that aims to evaluate the current state of protein-protein docking prediction. (bsc.es)
New methods for protein-RNA and protein-DNA binding. (bsc.es)

These govern multiple functions, including hyphal development and the secretion of pathogenic factors. (cdc.gov)

Understanding membrane proteins is therefore vital in modern drug development. (expertsvar.se)
Greater knowledge of the reactions in membrane proteins will lead to a greater understanding of how a drug functions, which will ultimately contribute to our ability to develop several drugs more rapidly," says Andreas Dahlin. (expertsvar.se)

Membrane proteins are difficult to produce due to their hydrophobic nature, usually resulting in poor yields of stable proteins. (biophysics.org)
These findings hold great potential for advancing cancer diagnosis and targeted therapy through the development of more stable and reliable aptamer probes. (bvsalud.org)

Unlike plants and fungi, archaeal organisms do not produce protective outer walls of cellulose and their membranes do not contain the same chemicals as bacteria. (stanford.edu)
Here we report the discovery of VIA1, a conserved protein that interacts with VIPP1 and participates in thylakoid biogenesis and remodeling in two distantly related photosynthetic organisms. (biorxiv.org)

In experimental electrophysiological studies, this can be relatively easily controlled via electrodes in the aqueous solutions on each side of the membrane. (biophysics.org)

This membrane can be disrupted by detergents and alcohols, which is why soap and alcohol hand sanitiser gels are effective against the virus. (bbva.com)

Welander became interested in studying this microbe because of its rare chemistry, including its unusual lipid membranes. (stanford.edu)
as well as the development and application of state-of-the-art numerical models of the chemistry of the regional and global atmosphere. (mcgill.ca)

One of the few known critical regulators of this process, VIPP1 (Vesicle-Inducing Protein in Plastids 1), was recently shown to be structurally similar to ESCRT-III proteins - the first evidence for ESCRT-like (Endosomal Sorting Complex Required for Transport) machinery in chloroplasts. (biorxiv.org)

Anatomy45

Organisms13

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes58

Disciplines and Occupations2

Technology, Industry, Agriculture7

Information Science3

Health Care1

Receptors7

Crystallography4

Characterization6

Integral membrane1

Intracellular proteins5

Structures8

Proteome1

Interactions6

Endoplasmic reticulum2

ABSTRACT1

Receptor proteins2

Complexes4

Biological8

Plasma proteins1

Mechanism4

Cellular5

Regulation4

Mechanistic principles2

Genes2

Pivotal role1

Transport proteins2

Stabilization1

Recognition4

Mass spectrometry2

Soluble5

Ligands3

Molecule3

Tumor2

Peripheral1

Functional4

Enzymes2

Molecular4

Genetics1

Neuronal development3

Dynamics5

Extracellular3

Interact6

Structural biology1

Processes2

Mechanisms2

Selective2

Structure7

Arabidopsis2

Transmembrane3

Morphogenesis1

Lipids1

Cell9

Gene5

Cells9

Photosynthesis1

Polarity1

Quantitative2

Molecules1

Transporters1

Role4

Mediates1

Methods4

Secretion1

Understanding2

Stable2

Organisms2

Aqueous1

Detergents1

Chemistry2

Regulators1