Determine suramin. Medical search. Frequent questions

NF449, a sulfated compound produced from the antiparasitic medication suramin, once was reported to inhibit infection by enterovirus A71 (EV-A71). (mindunwindart.com)
2000) demonstrated that TIMP-3 could possibly be solubilized from extracellular matrices by suramin, a historic antihelminthic and antiparasitic medication. (rue2011.com)

After the patient received 2 treatment doses of suramin and analysis of repeat blood films confirmed that parasitemia had cleared, a lumbar puncture was performed. (cdc.gov)
Urinary VEGF was affected by Suramin at doses above 50 mg ml(-1), corresponding to the estimated threshold of saturation of Suramin binding to urine albumin. (ox.ac.uk)

OBJECTIVES: I. Determine the maximum tolerated dose of interleukin-12 (IL-12) in patients with AIDS-associated Kaposi's sarcoma. (knowcancer.com)

The patient received a full course of suramin for early-stage disease, (regimen in Table 1 ), which resulted in full recovery. (cdc.gov)
JYNNEOS™ is a vaccine indicated for prevention of smallpox and mpox disease in adults 18 years of age and older determined to be at occupational risk for smallpox or mpox infection. (cdc.gov)

however, the first full treatment dose was complicated by circulatory collapse and bronchoconstriction, which required administration of hydrocortisone and chlorphenamine and immediate discontinuation of the suramin infusion. (cdc.gov)
Subsequent investigation showed that the suramin dose had been infused more rapidly than prescribed. (cdc.gov)
We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. (ox.ac.uk)
Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml(-1). (ox.ac.uk)

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. (ox.ac.uk)
Intravesical Suramin shows lack of toxicity and low systemic absorption. (ox.ac.uk)

Although much work has focused on little chemical productive website inhibitors, recent quest for BACE1 hang-up by proteins as well as antibodies features Suramin cost revealed exosites that could control enzymatic task. (cd31-signal.com)

Both 6h and 7h displayed trypanocidal activities within a similar mid-nanomolar concentration range as the commercially used trypanocides suramin and ethidium bromide. (uea.ac.uk)

Objective: The study's objective ended up being determine whether the chronic dietary ingestion that will stimulates wide spread alkalinity leads to increased RER, through assessment. (aktsignal.com)

PPADS (100 mM), a P 2X and P 2Y1,4,6 receptor antagonist, was ineffective using either low or high concentrations of ATP and ADPbS, which combined with the suramin data hints at a P 2Y receptor effect of the compounds. (edu.pk)

Lomeguatrib is used to treat melanoma, suramin is a treatment for African sleeping sickness and river blindness and trifluperidol is used in cases of mania and schizophrenia. (drugtargetreview.com)

Only few research have utilized recombinant enzymes to obviously determine the isoform looked into [33, 34]. (bioinf.org)
To determine how the latter mutation impaired b subunit synthesis, recombinant b subunit bearing the mutation was expressed in BHK cells. (embl.de)

We thus suggest that suramin is really a guaranteeing scaffold that to develop a fresh type H3FL of healing inhibitor to take care of OA. (rue2011.com)
Results from a small clinical trial suggest that the anti-parasitic drug suramin can diminish autism spectrum disorder symptoms, but more rigorous research is needed. (medicalrewind.com)

In addition, a study of the Cerebrospinal Fluid (Central Nervous System) should be done to determine the presence or not of the parasite in the brain. (fastlyheal.com)
The presence of suramin and prazosin were not significantly increase the inhibition caused by the FE extract, while Ca 2+ and ATP significantly increased the inhibition by the FE extract. (arccjournals.com)

It may also be used to treat certain conditions as determined by your doctor, which may not be listed in the professional package insert. (1bestpillsforhealth.com)

Using the optimized circumstances, Michaelis-Menten constants (ideals for NTPDase1, 2 and 3 acquired for reactive blue 2, PPADS, suramin, and "type":"entrez-protein","attrs":"text message":"ARL67156″,"term_id":"1186396857″,"term_text message":"ARL67156″ARL67156, using the in-capillary electrophoresis technique. (bioinf.org)

Determine the antitumor activity of IL-12 in these patients. (knowcancer.com)

PPADS, a specific purinergic receptor antagonist, was used to determine whether suramin acts via purinergic receptors. (nih.gov)
We next tested the role of purinergic signaling in the generation of SAH-induced eHACSs by recording endfoot activity before and after treatment with the broad-spectrum purinergic receptor antagonist, suramin. (uvm.edu)

The effect of suramin on epidermal growth factor receptor (EGFR) was determined by analyzing receptor phosphorylation and dimerization. (nih.gov)
however suramin treatment resulted in rapid phosphorylation and dimerization of EGFR. (nih.gov)
To determine whether protein tyrosine phosphorylation by ROS regulates endothelial cell (EC) metabolism and function, we exposed vascular ECs to H2O2 or H2O2 plus vanadate. (nih.gov)
This resulted in a time- and dose-dependent increase in protein tyrosine phosphorylation of several proteins (M(r) 21-200 kDa), as determined by immunoprecipitation and Western blot analysis with antiphosphotyrosine antibody. (nih.gov)
An immediate signaling response to increased protein tyrosine phosphorylation by ROS was activation of phospholipases such as A2, C, and D. Suramin pretreatment inhibited ROS stimulation of phospholipase D (PLD), suggesting a role for growth factor receptors in this activation. (nih.gov)

13. Suramin and hydrocortisone: determining drug efficacy in androgen-independent prostate cancer. (nih.gov)
however, the first full treatment dose was complicated by circulatory collapse and bronchoconstriction, which required administration of hydrocortisone and chlorphenamine and immediate discontinuation of the suramin infusion. (cdc.gov)

Greatest endothelial cell inhibition was observed with suramin alone and steroid alone (U-24067 or testosterone) at their highest respective doses tested. (kzoo.edu)

4. Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer. (nih.gov)
10. A phase I/II study of continuous infusion suramin in patients with hormone-refractory prostate cancer: toxicity and response. (nih.gov)
15. Phase I study of suramin administered by intermittent infusion without adaptive control to cancer patients: update of two expanded dose levels near the maximally tolerated dose. (nih.gov)
19. Evaluation of continuous infusion suramin in metastatic breast cancer: impact on plasma levels of insulin-like growth factors (IGFs) and IGF-binding proteins. (nih.gov)

XAMR 0721, a suramin analogue containing only one of the two polysulfonated arms, was also analyzed for its effects on growth and EGFR activation. (nih.gov)
Rather, it appears that suramin acts via an interaction with EGFR, but not with purinergic receptors. (nih.gov)

The antiparasitic and cytotoxic activities of the newly synthesized derivatives were determined in vitro with the bloodstream form of Trypanosoma brucei brucei, the hepatic stage of Plasmodium berghei, and human leukemia HL-60 cells. (uea.ac.uk)

3. Phase I and clinical evaluation of a pharmacologically guided regimen of suramin in patients with hormone-refractory prostate cancer. (nih.gov)
The patient received a full course of suramin for early-stage disease, (regimen in Table 1 ), which resulted in full recovery. (cdc.gov)

Melarsoprol, a relatively toxic drug, is used either alone or in combination with suramin when infection has progressed to involve the CNS (2). (cdc.gov)
In addition, it is of interest to further explore the activity of EIDD-1931 and its orally bioavailable pro-drug molnupiravir in animal infection models to determine whether it offers promise for the treatment of MAYV infection . (bvsalud.org)
XBP 1 deletion in intestinal epithelial cells triggered natural enteritis and enhanced susceptibility to induced colitis, and an association of XBP 1 variants with both kinds of human inflammatory bowel infection was determined. (plapathway.com)
The Egg hatch assay can be used to determine whether a parasite causing an infection has become resistant to standard drug treatments. (mdwiki.org)

citation.page_first 10317 _citation.page_last 10317 _citation.title 'Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism. (rcsb.org)
Further consistent white rock with this structural hypothesis is the knowledge that suramin - a polysulfated drug with substantial corresponding negative charge has been found kentucky to inhibit sperm-zona pellucida tonawanda binding. (hoselito.com)

Suramin need not enter NCI-H596 cells to exert its growth-stimulatory effect, nor is this effect mediated by an interaction with soluble growth factors. (nih.gov)

Methods: The aim of this review was to summarize the present knowledge in the innovative field of bile acids pharmacology, to reveal the novel mechanisms of their action, particularly focusing on clinically relevant aspects, and to evaluate the role of both genetic and epigenetic variation in genes encoding bile acid-activated receptors in determining the therapy outcome. (eurekaselect.com)

2. Suramin: development of a population pharmacokinetic model and its use with intermittent short infusions to control plasma drug concentration in patients with prostate cancer. (nih.gov)
6. Suramin, an active drug for prostate cancer: interim observations in a phase I trial. (nih.gov)
18. Suramin in hormone-refractory metastatic prostate cancer: a drug with limited efficacy. (nih.gov)
In addition, the anti-proliferative effects of suramin, an antitrypanosomal drug (Stein et ai. (kzoo.edu)

With suramin, the Ki value for rat liver PFK was 40 times higher than PFK from S. cervi . (biomedcentral.com)

The purpose of this study was to examine the mechanisms by which suramin exerts this growth-stimulatory effect in NSCLC cells. (nih.gov)
11. A phase I study of suramin with once- or twice-monthly dosing in patients with advanced cancer. (nih.gov)
Glenn Yiu, study author and an associate professor in the Department of Ophthalmology and Vision Sciences at UC Davis , said that continued study can help determine the benefits of goji berries in patients with early-stage AMD. (chinesemedicine.news)
The overall goal of this study was to determine whether halothane affects the function of the α subunit of heterotrimeric G proteins. (asahq.org)
Our outcomes may well partly clarify the elevated cardio events in sufferers along with myocardial bridge.The aim of this study ended up being determine belowground occurrence, endurance along with achievable impact with the biocontrol agent Phlebiopsis gigantea (Fr. (7-cl-o-nec1inhibitor.com)

He suggested that results in complete recovery in suramin may also be used as vehicle, or the ema the use of radiofrequency fields, and once satisfied that it risk is attributed to three times daily (qid) instead to accommodate british and german demands to help determine the adequacy of the degradation products. (stonecottagegardens.com)

When the suramin-conjugated beads were added to the cells on cell culture inserts, which preclude an interaction with the cell surface but allow interaction with the culture medium, there was no effect on proliferation. (nih.gov)
16. Pharmacometric analysis of the effect of furosemide on suramin pharmacokinetics. (nih.gov)

To determine how the latter mutation impaired b subunit synthesis, recombinant b subunit bearing the mutation was expressed in BHK cells. (embl.de)

12. Suramin: rapid loading and weekly maintenance regimens for cancer patients. (nih.gov)

NCI-H596 cells were treated with agarose-immobilized suramin, directly or by addition on cell culture inserts, after which growth was determined by [3H]thymidine incorporation. (nih.gov)

9. Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin. (nih.gov)
14. Nontoxic suramin as a chemosensitizer in patients: dosing nomogram development. (nih.gov)
The most important task is determining if patients in endemic areas have been exposed to O volvulus via the black fly vector. (medscape.com)

Agarose-immobilized suramin stimulated NCI-H596 cell growth, but only when added directly to the cells. (nih.gov)
Suramin and angiostatic steroid U-24067 did not yield the expected synergistic inhibition of BACE and TEn cell growth as was shown in the chorioallantoic membrane (CAM) assay on tumor growth (Wilks et al. (kzoo.edu)

Relatively, 40 times higher sensitivity of filarial PFK towards suramin as compared to the analogous enzyme from the mammalian system indicates that this enzyme could be exploited as a potential chemotherapeutic target against filariasis. (biomedcentral.com)

In this project, it was determined that endothelial cells, along with a mixed population of cells, could be harvested from angiogenesis chambers (developed by Dvorak et aI. (kzoo.edu)

We first evaluated different cell lines and virus inputs to determine the best conditions for a reliable and reproducible antiviral assay. (bvsalud.org)

The patient described here illustrates the difficulty a physician may encounter in determining whether CNS invasion has occurred. (cdc.gov)

It may also be used to treat certain conditions as determined by your doctor, which may not be listed in the professional package insert. (thecityclub.in)

In the second aim of this dissertation we determined the role of purinergic signaling in the generation of high-amplitude spontaneous endfoot Ca2+ events after SAH. (uvm.edu)

The 2.9 A resolution crystal structure of the N-terminal domain of one variant, MITat 1.2, has been determined. (nih.gov)
The solution structure of the 16th CCP module from human complement factor H has been determined by a combination of 2-dimensional nuclear magnetic resonance spectroscopy and restrained simulated annealing. (embl.de)
In one case where the prediction differed from the reported co-crystal structure, the researchers re-determined the co-crystal structure at high resolution and found that DOCKovalent was actually correct. (blogspot.com)
The structure of the minor cis isomer has also been determined using a smaller constraint set. (lookformedical.com)

Antiparasitic medication2

Doses2

Maximum Tolerated Dose1

Disease2

Dose4

Systemic2

Proteins1

Concentration1

Chronic1

Receptor1

Treatment1

Recombinant2

Suggest2

Presence2

Treat1

Text1

Activity1

Purinergic receptor a2

Phosphorylation5

Hydrocortisone2

Endothelial cell1

Infusion4

EGFR2

Vitro1

Regimen2

Infection4

Structural2

Soluble1

Receptors1

Drug4

Liver1

Study5

Results1

Effect2

Subunit1

Rapid1

Addition1

Patients3

Growth2

Higher1

Population1

Cell lines1

Patient1

Conditions1

Role1

Structure4