Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. (wikipedia.org)
A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, chemical mechanisms, and biological functions. (wikipedia.org)
The two main types of DNase found in animals are known as deoxyribonuclease I (DNase I) and deoxyribonuclease II (DNase II). (wikipedia.org)
Deoxyribonuclease I (DNase I) is an endonuclease isolated from bovine pancreas that digests double and single stranded DNA into oligo and mononucleotides. (sigmaaldrich.com)
A deoxyribonuclease ( DNase , for short) is any enzyme that catalyzes the hydrolytic cleavage of phosphodiester linkages in the DNA backbone. (wikidoc.org)
It can block RNase and deoxyribonuclease (DNase) activity. (sigmaaldrich.com)
Deoxyribonuclease (DNase) I Solution (1 mg/mL) is useful to reduce or prevent the clumping of concentrated and/or cryopreserved cell suspensions following thawing. (stemcell.com)
LongLife™ DNase (Deoxyribonuclease) is a ready to use DNase I preparation provided with a co-factor bivalent metal ion. (gbiosciences.com)
I personally believe that the work helps to raise awareness for the potential use of deoxyribonuclease (DNase), an enzyme that acts to clear NETs by dissolving the DNA strands, in the acute treatment of STEMI. (the-hospitalist.org)
Recombinant3
0.001) and was apparent by 6 weeks, irrespective of concomitant recombinant human deoxyribonuclease (rhDNase) use. (nih.gov)
A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis. (nih.gov)
Using a strategy previously tested in patients with CF, they treated a small group of patients with severe COVID-19 symptoms with enzyme recombinant human deoxyribonuclease I, or rhDNase, which degrades extracellular DNA in the sputum. (asbmb.org)
Pancreatic1
Part of this material was treated with pancreatic deoxyribonuclease. (duke.edu)
Enzyme2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Deoxyribonuclease I (DNASE1) in serum, plasma, urine, saliva, seminal plasma and other biological fluids. (tissue-cell-culture.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Deoxyribonuclease I (DNASE1) in samples from Serum, plasma, urine, saliva, seminal plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (tissue-cell-culture.com)
Human1
Description: A sandwich ELISA kit for detection of Deoxyribonuclease I from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tissue-cell-culture.com)
Biological1
A wide variety of deoxyribonucleases are known, which differ in their substrate specificities, chemical mechanisms, and biological functions. (wikidoc.org)
Activity1
Two deoxyribonuclease I gene polymorphisms and correlation between genotype and its activity in Japanese population. (cdc.gov)
Type1
Deoxyribonucleases are thus one type of nuclease . (wikidoc.org)
Year2
We report the case of a 77-year-old Caucasian man with severe dementia and behavioral disturbance secondary to Alzheimer's disease treated with memantine who began adjunct treatment with deoxyribonuclease I. Prior to initiation of deoxyribonuclease I treatment, our patient appeared to be in a stuporous state, with a Mini-Mental State Examination score of 3 and a Functional Assessment Staging Test score of 7. (medscape.com)
This graph shows the total number of publications written about "Deoxyribonuclease I" by people in this website by year, and whether "Deoxyribonuclease I" was a major or minor topic of these publications. (umassmed.edu)
Treatment2
After obtaining informed consent from family members, we started administration of 120 mg of deoxyribonuclease I per day (1500 KU/mg) for treatment of severe cognitive impairment. (medscape.com)
Our patient began to demonstrate rapid, considerable improvement in cognitive function 2 days following initiation of deoxyribonuclease I treatment. (medscape.com)
Group1
Deoxyribonuclease and competence factor activities of transformable and nontransformable group H streptococci. (cornell.edu)