Dendritic cell sarcoma follicular. Medical search. Frequent questions

Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
e The pattern listed is for the spindled cell component of the tumor. (basicmedicalkey.com)
Hemangioendothelioma is a vascular tumor with several different morphologic patterns that can include a component of ovoid or spindled cells, but generally lacks an inflammatory component. (neoplasiaresearch.com)
We present a challenging lymphocyte-rich soft tissue lesion that was not recognized to be an unusual hemangioendothelioma until after several recurrences in the arm of a 63 year-old male, which was originally diagnosed as a follicular dendritic cell tumor instead. (neoplasiaresearch.com)
The most recent tumor consisted predominantly of epithelioid spindled cells with moderate amounts of bubbly pale to eosinophilic cytoplasm with rare discrete cytoplasmic vacuoles, admixed with a prominent lymphoid infiltrate and occasional erythrocytes. (neoplasiaresearch.com)
The tumor cells were positive for keratin and vascular markers (CD31, CD34, and Factor VIII), but negative for follicular dendritic cell markers (CD21, CD23, CD35). (neoplasiaresearch.com)
Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site. (nih.gov)
Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. (nih.gov)
Angiomyolipoma (AML) is a rare mesenchymal neoplasm of the tumor, composed of a varying heterogeneous mixture of three tissue components: blood vessels, smooth muscle and adipose cells. (biomedcentral.com)
The tumor cells were spindled and histiocytoid in shape, with slightly eosinophilic cytoplasm, and arranged along the vessels or scattered among the inflammatory background. (biomedcentral.com)
The tumor cells were positive immunostaining for HMB-45, Melan-A, and smooth muscle actin. (biomedcentral.com)
The inflammatory AML should be distinguished from other tumors with inflammatory background such as inflammatory myofibroblastic tumor and follicular dendritic cell tumor and deserves wider recognition for its occurrence as a primary hepatic tumor. (biomedcentral.com)
Of these, inflammatory or pelioid pattern usually presents as a focal finding within the tumor, but very rarely, they become the predominant pattern [ 4 ], creating great diagnostic confusion with other tumors such as inflammatory myofibroblastic tumor (IMT), follicular dendritc cell (FDC) tumor and other hepatic mesenchymal neoplasms. (biomedcentral.com)
Her study explores the link between Tumor microenvironment and topics such as Immunotherapy that cross with problems in Cell biology. (research.com)
This classification attempts to classify lymphomas by cell type (i.e. the normal cell type that most closely resembles the tumor). (newworldencyclopedia.org)
This review examines the cytohistological features of various nonepithelial and nonlymphoid tumors of the thyroid, including vascular lesions, neural tumors (including granular cell tumor and paraganglioma), smooth muscle tumors, solitary fibrous tumor, histiocytic neoplasms (eg, Langerhans cell histiocytosis and Rosai-Dorfman disease), and follicular dendritic cell sarcoma. (unicatt.it)
cell histiocytosis and giant cell tumor. (neobiotechnologies.com)

1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
Langerhans cell histiocytosis (LCH) is a rare haematological neoplasm characterized by the accumulation of CD1a + , CD207/Langerin + histiocytes within inflammatory lesions. (biomedcentral.com)
Recently, transformation of CLL into histiocytic/dendritic/Langerhans cell sarcoma (all are myeloid origin), dubbed as "transdifferentiation", has also been reported. (najms.com)

Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm. (wikipedia.org)
Clusterin can be stained to help distinguish FDCS and is involved in the many important cancer hallmarks, including resistance to cell death and evading growth suppressors. (wikipedia.org)
Follicular dendritic cell sarcoma (FDCS) is a rare intermediate grade sarcoma involving a variety of nodal and extra nodal sites. (elsevierpure.com)
Metastatic or recurrent follicular dendritic cell sarcoma (FDCS) is a disabling condition on the Compassionate Allowance List, which qualifies an individual for an expedited approval process. (callfred.com)
FDCS is a rare, malignant cancer that affects the body's follicular dendritic cells, which are cells that help sustain the functions of the body's immune system. (callfred.com)
EBV + inflammatory follicular dendritic cell (FDC) sarcoma is an indolent malignant neoplasm of spindled FDCs with a rich lymphoplasmacytic infiltrate and a consistent association with Epstein-Barr virus (EBV). (lww.com)
Follicular dendritic cell sarcoma (FDCS) is an uncommon low-grade malignant sarcoma . (bvsalud.org)
Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
We describe a case of a 44 year-old woman diagnosed with follicular dendritic cell sarcoma (FDCS). (deepdyve.com)
FDCS is a very rare disease affecting the dendritic antigen presenting cells and is often misdiagnosed. (deepdyve.com)

citation needed] Proliferation of FDC cells is characteristic of many neoplastic conditions including follicular hyperplasia, follicular lymphoma, nodular lymphocyte predominate Hodgkin's disease and angioimmunoblastic T-cell lymphoma. (wikipedia.org)
Chemotherapy regimens that have documented responses include lymphoma protocols with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and rituximab with CHOP (R-CHOP) as well as sarcoma protocols of doxorubicin and ifosfamide or gemcitabine and a taxane [ 6 ]. (biomedcentral.com)
Follicular lymphoma regardless of grade is CD19 positive in 48-79% of the cases while around 6% of the cases are reported negative. (nordiqc.org)
Large B-cell lymphoma is positive in 24-50% of the cases, another 14% are negative. (nordiqc.org)
CD19 is generally weakly expressed in B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma. (nordiqc.org)
Hodgkin and Reed-Sternberg cells in classical Hodgkin Lymphoma are generally CD19 negative, while around 40% are positive for CD20. (nordiqc.org)
Lymphocytic-Histiocytic (L&H) cells of nodular lymphocytic predominant Hodgkin lymphoma are negative, while staining for CD20 is positive as a rule. (nordiqc.org)
CD20 is strongly expressed in T-cell rich B-cell lymphoma, B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma as opposed to a weaker CD19 reaction mentioned above. (nordiqc.org)
Hertzberg MS, Schifter M, Sullivan J, Stapleton K. Paraneoplastic pemphigus in two patients with B-cell non-Hodgkin's lymphoma: significant responses to cyclophosphamide and prednisolone. (medscape.com)
Martinez De Pablo MI, Iranzo P, Mascaro JM, Llambrich A, Baradad M, Herrero C. Paraneoplastic pemphigus associated with non-Hodgkin B-cell lymphoma and good response to prednisone. (medscape.com)
Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. (najms.com)
Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A. Histiocytic sarcoma arising in indolent small b-cell lymphoma: Report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (najms.com)
Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature. (najms.com)
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma. (uams.edu)
In lymphoma, the cells in the lymphatic system grow abnormally, dividing too rapidly and growing without any order or control (Longe 2005). (newworldencyclopedia.org)
DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. (newworldencyclopedia.org)
green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells. (newworldencyclopedia.org)
CD21 is also useful for distinguishing marginal zone lymphoma with follicular involvement from follicular lymphoma with marginal zone differentiation. (genomeme.ca)
When used in concert with other B- and T-cell markers, CD21 is valuable for differentiating between nodular lymphocyte-predominant Hodgkin's lymphoma, T-cell/histiocyte-rich B-cell lymphoma, and lymphocyte-rich classic Hodgkin's lymphoma. (genomeme.ca)
CD21 staining is useful for recognizing abnormal follicular dendritic cell patterns in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma. (genomeme.ca)
Tru cut biopsy from omental deposit- IHC results confirm Non Hodgkin Lymphoma - Diffuse large B cell Lymphoma- non GCB type. (iriakerala.org)
The pathogenesis of PTLDs seems to be multifactorial-EBV is main one .Antigenic stimulation Plasmacytoid dendritic cells (PDCs) , regulatory T cells are other factors .Whilst most are high-grade B-cell non-Hodgkin's lymphoma (NHLs), a few are classical Hodgkin's lymphomas. (iriakerala.org)
38= Cutaneous T-cell lymphoma, NOS (C44. (cancercentrum.se)

Hematologic malignancies are most commonly associated with paraneoplastic pemphigus, although it can also be associated with carcinomas, sarcomas, and benign neoplasms. (medscape.com)
It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
CD19 is found on majority of B-cell neoplasms with some exceptions. (nordiqc.org)
The CD19 reactivity patterns differ from those of CD20 in several B-cell lesions: In plasma cells neoplasms with t(11;14) the expression of CD19 and CD20 is mutually exclusive, the majority of cases are CD20+ while only a small fraction of these tumours expresses CD19. (nordiqc.org)
CD19 is useful in identification of B-cell lineage of majority of B-cell neoplasms but appears to be less useful in subclassifying of B-cell neoplasms in histological material. (nordiqc.org)

Myeloid Sarcoma: Presentation, Diagnosis, and Treatment. (nih.gov)

These cells are best visualized with immunostaining using the FDC markers CD21, CD35, R4/23, clusterin, and KiM4p. (wikipedia.org)
It has wide morphological spectrum on light microscopy and has characteristic immune-reactivity for dendritic cell markers (CD21, CD23, and CD35). (elsevierpure.com)
It is a part of B-cell Receptor Complexes (BCR) on the cell surface together with CD21, CD81 and CD225. (nordiqc.org)
Cluster of Differentiation 21 (CD21) is a glycoprotein on the surface of B-cells that is bound by Epstein-Barr virus (EBV) during infection of these cells. (genomeme.ca)
CD21 staining is useful for recognizing follicular dendritic cell matrices in normal tonsillar and lymph tissue, and can also stain dendritic cell sarcomas. (genomeme.ca)

Chan JKC, Fletcher CDM, Nayler SJ, Cooper K. Follicular Dendritic Cell Sarcoma: Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (neoplasiaresearch.com)
Baer MR, Krantz SB, Cousar JB, Glick AD, Collins RD. Malignant histiocytoses developing in patients with b-cell lymphomas. (najms.com)

Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
Vascular tumors should be included in the differential diagnosis of suspected dendritic cell tumors, even if a lymphocyte-rich infiltrate is present. (neoplasiaresearch.com)
Tumors of histiocytes and dendritic cells: Follicular Dendritic Cell Sarcoma. (neoplasiaresearch.com)
According to the predominant component, growth pattern, cell type, and other features, the tumors were subcategorized into trabecular, pelioid and inflammatory variants. (biomedcentral.com)
B-cell heavy chain rearrangement study on blood sample (pure CLL) and liver metastatic NEC (pure NEC, no contamination from CLL) revealed that these two tumors shared similar monoclonal peaks. (najms.com)
Dendritic cell tumors associated with low-grade b-cell malignancies. (najms.com)
Radiation Therapy for Young Children Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant for Primary Brain Tumors. (ucdenver.edu)
They play a major role in defending the host from both tumors and virally infected cells. (newworldencyclopedia.org)

It accounts for only 0.4% of soft tissue sarcomas, but has significant recurrent and metastatic potential and is considered an intermediate grade malignancy. (wikipedia.org)
Favorable response to PD-1 inhibitor plus chemotherapy as first-line treatment for metastatic follicular dendritic cell sarcoma of the spleen: a case report. (bvsalud.org)

Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
Proliferative Lesions of Follicular Dendritic Cells: An Overview, Including a Detailed Account of Follicular Dendritic Cell Sarcoma, of a Neoplasm with Many Faces and Uncommon Etiologic Associations. (neoplasiaresearch.com)

Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)

In cultures, a subpopulation of Kaposi sarcoma cells express CD14. (neobiotechnologies.com)

Follicular dendritic cell tumours are reported CD19 positive. (nordiqc.org)
It appears to be potentially useful additional marker of follicular dendritic cell tumours. (nordiqc.org)

The development of B-cells is not influenced by CD19, but CD19 deficient mice show decrease in lymphocyte number and impairment of lymphocyte function as well as reduction in formation of germinal centres. (nordiqc.org)
Specially, B cells play the major role in the humoral immune response , as opposed to the cell-mediated immune response that is governed by T cells , another type of lymphocyte. (newworldencyclopedia.org)
Lymphocyte-like natural killer (NK) cells also are involved in the immune system , albeit part of the innate immune system . (newworldencyclopedia.org)

At the time of the follicular dendritic cell sarcoma discovery, information on the effect of chemotherapy and radiation on it was nonexistent. (wikipedia.org)
Intraperitoneal Follicular Dendritic Cell Sarcoma: Role of Chemotherapy and Bone Marrow Allotransplantation in Locally Advanced Disease? (deepdyve.com)

Spindled to oval neoplastic cells with ill-defined cell borders were dispersed or formed loose whorled fascicles in a dense lymphoplasmacytic background. (lww.com)
The neoplastic cells showed variable expression of FDC markers and were labeled for Epstein-Barr virus-encoded RNA on in situ hybridization. (lww.com)
Typically, neoplastic cells lack CD1a, desmin and CD45 staining. (biomedcentral.com)
These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)

summarize the increasing role of cellular immunity in paraneoplastic pemphigus, evidenced by lesional mononuclear cells and elevated IL-6 levels in sera from paraneoplastic pemphigus patients. (medscape.com)
Marzano AV, Vezzoli P, Mariotti F, Boneschi V, Caputo R, Berti E. Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (medscape.com)
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (medscape.com)

These 9 cases thus broaden the clinicopathologic scenarios of EBV + inflammatory FDC sarcoma. (lww.com)

Histologically, EBV + inflammatory FDC sarcomas arising from these anatomic sites were similar to their hepatosplenic counterparts. (lww.com)
We herein present one case of hepatic AML exhibiting prominent inflammatory cells in the background, which happened in a 61-year-old Chinese female patient, without signs of tuberous sclerosis. (biomedcentral.com)
Histologically, the striking feature was the infiltration of numerous inflammatory cells in the background, including small lymphocytes, plasma cells, and eosnophils. (biomedcentral.com)
The extensive involvement of the mononuclear phagocytic system, including tissue macrophages and endothelial cells suggests participation of inflammatory mediators from this lineage with the resulting vascular dilatation and increasing permeability. (cdc.gov)

Transgenic mice over-expressing CD19 show reciprocal phenotype with increase in peritoneal B-1 lymphocytes, increase B-cell proliferation, reduction of number of B-cells exiting bone marrow, reduced surface IgM, and elevated humoral immune responses. (nordiqc.org)

Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)

The histopathogenetic classification distinguishes hyaline vascular Castleman disease, plasma cell Castleman disease, human herpesvirus 8 (HHV-8)-associated Castleman disease, and multicentric Castleman disease not otherwise specified. (iriakerala.org)

citation needed] Follicular dendritic cells are localized in germinal centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B cells. (wikipedia.org)
Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
Tonsil and appendix are both appropriate controls: The mantle zone B-cells, the germinal centre B-cells and the follicular dendritic cells must show a strong staining reaction. (nordiqc.org)
Scattered follicles showing onion skinning of the mantle zones and hyalinised atrophic germinal centres with predominance of follicular dendritic cells and "lolipop"shaped blood vessels were noted. (iriakerala.org)

Her work deals with themes such as Neuroscience and Cytokine, which intersect with Dendritic cell. (research.com)
Her research integrates issues of In vitro, Cytokine and Follicular dendritic cells in her study of Cell biology. (research.com)

Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)

Histologically similar to those in the kidney, hepatic AML consists of a mixture of myoid cells, adipose tissue and thick-walled vessels. (biomedcentral.com)

Vascular as well as dendritic cell markers should be included in the immunohistochemical panel employed in their evaluation. (neoplasiaresearch.com)

Direct immunofluorescence microscopy performed on epithelial biopsy specimen obtained from a patient with pemphigus vulgaris detects immunoglobulin G deposits at the epithelial cell surfaces. (medscape.com)

Innate lymphoid cell is closely connected to Antigen-presenting cell in her research, which is encompassed under the umbrella topic of Dendritic cell. (research.com)
The concepts of her Cancer cell study are interwoven with issues in Acquired immune system, Antigen, T cell immunity, Immunity and Blockade. (research.com)
Her Immunity study combines topics in areas such as Cancer cell, Blockade, Antigen, Cell biology and Immunotherapy. (research.com)
Her study in Acquired immune system and T cell immunity are all subfields of Antigen. (research.com)

The most common type is the mixed type which comprises sheets of epithelioid muscle cells admixed with islands of adipocytes and abnormal vessels. (biomedcentral.com)

It is a specific and sensitive marker of B-cells widely expressed from early pre-B stages, normal B-cells and normal plasma cells (staining is weaker than normal B-cells and a subpopulation may lack expression). (nordiqc.org)

Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)

Taking Forsythia extracts or nutritional supplements may benefit Primary Follicular Dendritic Cell Sarcoma patients on Radiation treatment over Folic Acid nutritional supplements. (addon.life)
Should you take it when diagnosed with Primary Follicular Dendritic Cell Sarcoma? (addon.life)

13 ] have reported v-Raf murine sarcoma viral oncogene homolog B (BRAF) V600E mutations in 5 from 27 (18.5 %) cases tested. (biomedcentral.com)
RESULTS: Lassa fever virus antigens and viral particles were observed in multiple organ systems and cells, including cells in the mononuclear phagocytic system and other specialized cells where it had not been described previously. (cdc.gov)

Only 13% of marginal zone B-cell lymphomas are positive. (nordiqc.org)

Anatomy2

Organisms1

Diseases16

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Disciplines and Occupations1

Information Science1

Tumor17

Langerhans11

FDCS10

Lymphoma28

Neoplasms5

Myeloid sarcoma1

CD215

Malignant2

Tumors8

Metastatic2

Neoplasm2

Interdigitating1

Kaposi1

Tumours2

Lymphocyte3

Chemotherapy2

Neoplastic cells4

Paraneoplastic pemphigus3

Clinicopathologic1

Inflammatory4

Proliferation1

Indolent1

Castleman1

Germinal4

Cytokine2

Lymph nodes1

Tissue1

Markers1

Epithelial1

Antigen4

Epithelioid1

Subpopulation1

Carcinoma1

Primary2

Viral2

Marginal zone1