Dendritic antigens cd80. Medical search. Frequent questions

In addition to CTLA-4 CD80/CD86 interaction fascin dependent polarization of cytoskeleton towards dendritic cell Treg immune synapse play a pivotal role. (wikipedia.org)
Functional activation of lymphocytes requires a second costimulatory signal via interaction between CD28 and B7-1 (CD80) or B7-2 (CD86) in addition to the interaction between peptide-bound MHC molecules and their cognate TCR. (medscape.com)
The ability of BECs to express either of the CD28 ligands, CD80, or CD86, or a combination of these, would allow them to act as APCs and thereby provoke and maintain a T cell-mediated response. (medscape.com)
Immunohistochemical studies showed expression of B7-1 and B7-2 on BECs in PBC, [ 38 , 42 ] but comprehensive studies have failed to demonstrate CD80 or CD86 protein and mRNA level in cultured BECs. (medscape.com)
Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells (APC). (biolegend.com)
2. Cross-regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen-activated dendritic cell subsets. (nih.gov)
4. Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. (nih.gov)
18. Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. (nih.gov)
Expression of costimulatory molecules such as CD80 and CD86 are required for efficient priming of T cells via activation of CD28. (nih.gov)
Behrens L, Kerschensteiner M, Misgeld T, Goebels N, Wekerle H, Hohlfeld R. Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions. (bdbiosciences.com)
The CD28 antigen, a disulfide-linked homodimeric glycoprotein, Mr 44 kilodaltons (kd), is a cell-adhesion molecule (CAM) and functions as the ligand for CD80 (B7-1) and CD86 (B7-2) antigens, which are present on activated B lymphocytes, monocytes, and dendritic cells. (bdbiosciences.com)
Interaction of the CD28 antigen with CD80 or CD86 antigens, or both, co-stimulates CD2 and CD3 antigen/T-cell antigen receptor (TCR)-dependent T-cell-mediated proliferation and cytotoxicity. (bdbiosciences.com)
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. (bdbiosciences.com)
Fleischer J, Soeth E, Reiling N, Grage-Griebenow E, Flad HD, Ernst M. Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes. (bdbiosciences.com)
Ligation of CD40 expressed by DCs is especially important for mediating the maturation and functional activation of these cells, the subsequent up-regulation of co-stimulation molecules, such as CD80 or CD86, and the amplified production of IFN-γ ( 6 , 7 ). (iiarjournals.org)
The MutuDC1940 cell line retains response to TLR ligands such as CpG (TLR9-L) and PolyIC (TLR3-L) and to a lesser extent LPS (TLR4-L) stimulation by up-regulation of co-stimulatory molecules CD40, CD80 and CD86. (topsan.org)
In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on dendritic cells as evidenced by increased levels of the cell surface costimulatory molecules, CD80/CD86. (nih.gov)
The second signal or "costimulation signal" is delivered when B7-1/CD80 and B7-2/CD86 on the surface of APCs engage CD28 on T-cells. (shu.edu)
The expression of costimulatory molecules (both CD80 and CD86) on DCs was decreased when graded numbers of CD4 + CD25 + T cells were added to the coculture, even if DCs were first stimulated with anti-CD40 antibody. (biomedcentral.com)
Surprisingly, CD4 + CD25 + cells downregulate CD80 mRNA levels on DCs, whereas levels of CD86 mRNA were not significantly decreased. (biomedcentral.com)
The down regulation of CD80 and CD86 molecules on DCs depends on direct interaction between CD4 + CD25 + T cells and DC interaction, and no decreased expression was observed when DC were separated from CD4 + CD25 + cells by a cell permeable membrane. (biomedcentral.com)
In this study, the authors show that the CD4 + CD25 + regulatory T cells can directly act on APCs (B and dendritic cells[DCs]), and can influence their presentation functions by downregulating costimulatory molecules such as CD80 and CD86. (biomedcentral.com)
mRNA levels for CD80 and CD86 were determined by RT-PCR with specific primers for CD80, CD86, and hypoxanthine guanine phosphoribosyltransferase (HPRT) as internal control. (biomedcentral.com)
Cross-linking of MHC class II molecules on human monocyte-derived DC results in the up-regulation of the surface expression of CD83, CD80, CD86, CD54, CD1a and CD40 molecules, the typical DC maturation-associated markers. (nih.gov)
As judged by CD80, CD83, and CD86 expression dendrimer, AMC6 and gag peptide did not significantly induce DC maturation, which is required for antigen presentation to T-cells. (biobanking.com)
Northern analysis was used to measure CD80 or CD86 mRNA concentrations in luteal tissue samples. (biomedcentral.com)
Mixed luteal parenchymal cell cultures and purified luteal endothelial cell cultures were prepared, and real-time RT-PCR was used to examine the presence of CD80 and CD86 mRNA in each culture type. (biomedcentral.com)
Monoclonal antibodies to CD80 and CD86 were added to a mixed luteal parenchymal cell-T cell co-culture in vitro T cell proliferation assay to assess the functional significance of costimulatory molecules on activation of T lymphocytes by luteal parenchymal cells. (biomedcentral.com)
Northern analysis revealed CD80 and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle. (biomedcentral.com)
CD80 and CD86 mRNAs were detected in mixed luteal parenchymal cell cultures, but only slight amounts of CD80 (and not CD86) mRNA were detected in cultures of luteal endothelial cells. (biomedcentral.com)
Luteinizing hormone, PGF2alpha and TNF-alpha were without effect on concentrations of CD80 or CD86 mRNA in mixed luteal parenchymal cells cultures. (biomedcentral.com)
Anti-CD80 or anti-CD86 monoclonal antibodies inhibited T cell proliferation in the in vitro T cell proliferation assay. (biomedcentral.com)
The transition of DCs from Ag-processing to Ag-presenting cells is accompanied by increased expression of class I and II major histocompatibility (MHC) proteins, CD80 and CD86 co-stimulatory molecules and CD40 adhesion molecules. (biomedcentral.com)
DCs were derived from mouse bone marrow cells and exposed to of 2.5 μg/mL of naked M278 or encapsulated M278 for 24 hours to determine the expressions of costimulatory molecules (CD80, CD86, and CD40) and the MHC complex. (techconnect.org)
L.E.M. extract enhanced the expression of MHC-I, MHC-II, CD86, CD80, and CD40 in bone marrow-derived dendritic cells (DCs) and strongly induced the production of IL-12. (bvsalud.org)
RTDCs isolated by enzyme digestion, Percoll density gradient centrifugation and overnight GM-CSF culture followed by MACS separation retain an archetypical immature dendritic cell phenotype, characterised by MHCIIlow CD40(neg) CD86(neg) CD80(neg) CD11c(low) cell surface expression. (elsevierpure.com)
MHCIIlow CD40(neg) CD86(low) CD80(neg) CD11c(low) but can further mature phenotypically in vitro. (elsevierpure.com)
Results: Treatment of DCs with Sta56 induced cell surface expression of CD80, CD83, CD86 and MHC Class II increased the production of interleukin-12 (IL-12) p40, IL-12 p70 and IL-10 and decreased DC phagocytic capacity. (bvsalud.org)
Maturation of DC was determined by the expression of surface markers CD40, CD80, CD86 and MHCII. (biomedcentral.com)
Ts Pmy was able to activate mouse bone marrow-derived DCs to semi-mature status characterized by expressing surface CD40 and CD86, but not CD80 and MHCII. (biomedcentral.com)
The next mAbs were utilized: FITC-anti-CD40 PE-anti-CD80 PE-anti-CD86 allophycocyanin-anti-CD11c FITC-anti-CD11b FITC-anti-B220 FITC-anti-CD4 and PE-anti-CD8α (Pharmingen). (biotech-angels.com)

T regulatory cell adhesion to antigen presenting dendritic cell causes sequestration of Fascin-1, an actin-bundling protein essential for immunological synapse formation, and skews Fascin-1-dependent actin polarization in antigen presenting dendritic cells toward the T reg cell adhesion zone. (wikipedia.org)
Although it is reversible upon T regulatory cell disengagement, this sequestration of essential cytoskeletal components causes a lethargic state of dendritic cells, leading to reduced T cell priming. (wikipedia.org)
This suggests Treg-mediated suppression of antigen presenting cells is a multi-step process. (wikipedia.org)
However, recent understanding of the relationship between structure and function of MHC molecules favors the hypothesis that the upregulation of MHC antigens in presenting peptide antigens to the autoreactive T cells is important in disease susceptibility. (medscape.com)
[ 43 ] The fact that memory CD4 + T cells are less dependent on the interaction between CD28 and CD80/86 supports the view that although initial priming at early PBC stage may require such costimulation, the latter events may not. (medscape.com)
Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
1. The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells. (nih.gov)
3. Splenic dendritic cells pulsed with Ixodes ricinus tick saliva prime naive CD4+T to induce Th2 cell differentiation in vitro and in vivo. (nih.gov)
5. Ketamine inhibits maturation of bone marrow-derived dendritic cells and priming of the Th1-type immune response. (nih.gov)
6. CD40 is necessary for activation of naïve T cells by a dendritic cell line in vivo but not in vitro. (nih.gov)
8. UVB-irradiated dendritic cells are impaired in their APC function and tolerize primed Th1 cells but not naive CD4+ T cells. (nih.gov)
9. Dendritic type, accessory cells within the mammalian thymic microenvironment. (nih.gov)
11. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy. (nih.gov)
12. Early activation markers of human peripheral dendritic cells. (nih.gov)
14. Comparison of DNA- and mRNA-transfected mouse dendritic cells as potential vaccines against the human papillomavirus type 16 associated oncoprotein E7. (nih.gov)
15. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. (nih.gov)
16. Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells. (nih.gov)
17. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. (nih.gov)
19. Dendritic cells lentivirally engineered to overexpress interleukin-10 inhibit contact hypersensitivity responses, despite their partial activation induced by transduction-associated physical stress. (nih.gov)
Intravenous immunization with 5x105 dendritic cells (DCs) pulsed with the peptide-2-induced specific CTLs. (who.int)
In the present study, Induction of dendritic cells we employed a single 9-amino acid (a.a. (who.int)
Tumor antigens are endo-cytosed by immature dendritic cells, processed by proteases, and presented as peptides by MHC molecules to T cells. (nih.gov)
CD80 is also expressed on activated CD4-positive and CD8-positive T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. (bdbiosciences.com)
We hypothesized that CD40 plays an important role in dendritic cells (DC) pulsed with αGalCer (DCGs) in the treatment of lung metastases. (iiarjournals.org)
The TCRs of iNKT cells are selected for the recognition of a variety of lipid antigens when bound to a major histocompatibility class I-like molecule, CD1d ( 1 , 2 ). (iiarjournals.org)
Ongoing progress in research on a specific ligand of iNKT cells, alpha-galactosylceramide (αGalCer), and treatment with dendritic cells (DCs) pulsed with αGalCer (DCG) has led to diverse approaches for modulating immune responses, including those involved in vaccination against various types of cancers ( 3 - 5 ). (iiarjournals.org)
Following encounters with CD1d/αGalCer complexes displayed by antigen-presenting cells (APCs), iNKT cells not only produce a large amount of interferon (IFN)-γ, but also up-regulate surface expression of CD40 ligand (CD40L). (iiarjournals.org)
In coexistence with a tumor antigen, mature DCs also support the priming of CD8 + T cells and, eventually, the formation of effector and memory cells ( 10 ). (iiarjournals.org)
subset (CD11c high ,B220 - ,DEC205 + ,CD24 high ,CD11b - ) of conventional dendritic cells derived from the CD11c:SV40LgT transgenic mice. (topsan.org)
In addition to responding to PAMP stimulation and producing Th1 cytokines such as IL-12, these cells are also capable of presenting antigen in the context of both MHC-I and MHC-II, including direct antigen presentation and cross-presentation of cell-associated antigens. (topsan.org)
In addition to its direct oncolytic action, the virus also induces the expression of CD80 on the surface of infected cancer cells, thereby enhancing interaction with T-cells by binding with CD28, thereby activating T-cells. (shu.edu)
Engagement of T-cells via CD28 binding of CD80 and TCR via binding with and activating accessory molecule CD3. (shu.edu)
The first involves T-cell receptor (TCR) triggering by donor antigen on APCs (antigen presenting cells). (shu.edu)
It remains unclear whether this suppression mechanism is mediated by direct T cell-T cell interactions or requires antigen presenting cells (APCs) as well. (biomedcentral.com)
Cederbom L, Hall H, Ivars F: CD4 + CD25 + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. (biomedcentral.com)
Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. (nih.gov)
Antigen-driven interaction of dendritic cells (DC) with CD4(+) T(h) cells results in the exchange of bidirectional activating signals. (nih.gov)
Cross-linking of TCR by MHC class II-bound antigen activates T(h) cells, resulting in their up-regulation of CD40 ligand. (nih.gov)
María Angeles Muñoz-Fernández of the Spanish HIV HGM BioBank, Hospital General Universitario Gregorio Marañón, Madrid, and colleagues used nanoparticles to deliver HIV gag-derived peptides to antigen presenting cells (APCs), namely human dendritic cells (DCs), in an attempt to elicit a therapeutic response. (biobanking.com)
Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization. (cdc.gov)
The objective of this study was to explore the role of the aryl hydrocarbon receptor (AhR) in ambient particulate matter (PM)-mediated activation of dendritic cells (DCs) and Th17-immune responses in vitro. (cdc.gov)
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. (abeomics.com)
As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. (abeomics.com)
Macrophages and dendritic cells have implications in uveitis pathogenesis. (nih.gov)
We investigated the antigen uptake and cytokine production profile of monocyte-derived dendritic cells (MoDCs) in 10 uveitis patients and 10 healthy controls. (nih.gov)
The ability of a class II MHC-expressing cell type to elicit a response from T cells in vivo is also dependent on expression of costimulatory molecules by the antigen presenting cell and delivery of a costimulatory signal to the T cell. (biomedcentral.com)
It can be concluded from this study that parenchymal cells within the bovine CL express functional costimulatory molecules that facilitate interactions between with T cells, and these components of the antigen presentation pathway are expressed maximally in the midcycle CL. (biomedcentral.com)
Bovine luteal parenchymal cells also stimulate class II MHC-dependent proliferation of T lymphocytes in vitro [ 21 , 22 ], indicating that the class II MHC molecules expressed by luteal parenchymal cells are functional and that these cells can act as antigen presenting cells. (biomedcentral.com)
Class II-dependent presentation of antigen to T cells occurs via interaction of class II MHC molecules on the antigen presenting cell surface with the T cell receptor for antigen (TCR) on the T lymphocyte surface. (biomedcentral.com)
The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. (biomedcentral.com)
Here, we discuss how the principles of antigen presentation favor the presentation of peptides that are derived from newly synthesized proteins in irradiated cells. (biomedcentral.com)
T cells can recognize differentiation antigens and other non-mutated self-antigens that are overexpressed by cancer cells in the context of sufficient inflammatory signals, which result from the release of damage-associated molecular pattern (DAMP) molecules [ 1 , 2 ]. (biomedcentral.com)
Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer cells, and a series of adjuvants and co-stimulatory molecules have been proposed to enhance the immune response against weak self-antigens expressed on cancer cells. (biomedcentral.com)
Circulating and intratumoral NK and H-2Kb/OVA-specific CD8 responses are monitored, as well as the state of activation of dendritic cells (DC) with regard to activation markers and IL-12 secretion. (biomedcentral.com)
For instance, the development of tolerogenic DCs will lead to antigen tolerance in particular through the expansion of T regulatory cells (Tregs). (biomedcentral.com)
In addition to TLR ligands, CD1d-restricted invariant NKT (iNKT) cells have been shown to efficiently promote the transactivation of DCs through the CD40L-CD40 interaction upon recognition of the CD1d-glycolipid antigen complex by their semi-invariant TCR. (biomedcentral.com)
Induction of an effective anti-tumour response requires the active and integrated participation of host dendritic cells (DCs), taking up tumour-associated antigens (TAAgs) and generating Ag-specific T cells[ 1 ]. (biomedcentral.com)
Acute graft versus host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation (AHSCT) caused by cellular and inflammatory factors, including those arising from monocytes and dendritic cells as integral parts of the immune system. (brieflands.com)
As an intergenic lncRNA, the lnc-DC was shown to regulate the human monocytes differentiation and antigen presenting cells (APCs) activation during immune responses. (brieflands.com)
On the other hand, immune cells such as monocytes, dendritic cells, and T cells are considered as important players during the aGVHD initiation ( 3 , 4 ). (brieflands.com)
PLA-PEG can facilitate passive uptake of antigens by dendritic cells (DCs) by increasing the influx of DCs in to the injection site. (techconnect.org)
In this study, we focused on antigen-presenting cells (APCs) located upstream of the immune system, induced a T-cell response, then examined the impact of L.E.M. extract on the APCs. (bvsalud.org)
Respiratory tract dendritic cells (RTDC) form a contiguous subepithelial network within the nasorespiratory tract bridging innate and acquired immunity and have been implicated in nasal mucosal tolerance induction. (elsevierpure.com)
Both RTDC and SDC processed and presented antigen efficiently to T cells in vitro. (elsevierpure.com)
CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. (thermofisher.com)
CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. (thermofisher.com)
In this study, we investigated the response of dendritic cells (DCs) to a major 56-kDa scrub typhus antigen Sta56. (bvsalud.org)
Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells . (relationship983.cfd)
Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen . (relationship983.cfd)
An antigen is a molecule capable of stimulating an immune response and is often produced by cancer cells , viruses, bacteria or intracellular signals. (relationship983.cfd)
Instead, the DNA in millions of white blood cells in the bone marrow is shuffled to create cells with unique receptors, each of which can bind to a different antigen. (relationship983.cfd)
The vast majority of T cells express alpha-beta TCRs (αβ T cells), but some T cells in epithelial tissues (like the gut) express gamma-delta TCRs ( gamma delta T cells ), which recognize non-protein antigens. (relationship983.cfd)
B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. (rndsystems.com)
The macrophage inflammatory protein-3α (MIP-3α) is a specific chemokine for dendritic cells (DCs). (bmj.com)
4-7 In addition, increasing evidence shows that OVs can induce the immunogenic cell death (ICD) of cancer and stromal cells through the release of damage-associated molecular patterns (DAMPs) and tumor-associated antigens. (bmj.com)
d CD8 T-cell proliferation, e CD44 manifestation on CD8 T cells, and f CD80 manifestation on NOD.PI2tg DCs. (cancerhugs.com)
Exposure of immature dendritic cells to probiotics induced their maturation toward an immunomodulatory phenotype, and secretion of TGFβ. (oncotarget.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
Dendritic cells (DCs) are antigen-presenting cells that regulate T cell responses for many infectious diseases. (biomedcentral.com)
Dendritic cells (DCs) are antigen presenting cells that play a pivotal role in the control and modulation of immune responses by initiating T cell responses and producing cytokines and other molecules that regulate adaptive immunity [ 21 ]. (biomedcentral.com)
Current methods for preparing dendritic cells (DCs) for cancer vaccine immunotherapy, utilizing antigen-loaded monocyte-derived DCs (MoDCs) that are activated via a complex process, result in DCs that are difficult to maintain in culture, have low growth potential, and require repeated preparations for several rounds of vaccine delivery. (acir.org)
Aiming to enhance antigen presentation of a desirable target epitope, the team transduced ihv-DC2 cells with a fusion construct encoding pTERT, which consisted of a fragment from human telomerase reverse transcriptase (hTERT) linked to a proteasomal target sequence of IκBα. (acir.org)
monocytes ( CL:0000576 ) - Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. (guidetoimmunopharmacology.org)
however, its expression is restricted to DENDRITIC CELLS and activated MACROPHAGES . (nih.gov)
Generation of antitumor T cells for adoptive cell therapy with artificial antigen presenting cells. (celljournal.org)
elements (IRF)-1 IRF-3 and IRF-7 towards the RANTES separately of myeloid differentiation principal response gene-88 (administration of Bryo-1 triggered a TLR-4-reliant T helper cell 2 (Th2) cytokine response and extended a subset of myeloid dendritic cells that portrayed a Compact disc11chighCD8α? (biotech-angels.com)
Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. (thermofisher.com)
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. (thermofisher.com)

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. (thermofisher.com)

These findings suggest that L.E.M. extract may exhibit an antitumor immune response by regulating the function of APCs to induce cytotoxic T lymphocytes, as well as by suppressing the decline in antigen-presenting cell activity caused by the presence of cancer. (bvsalud.org)

[ 37 ] BECs also express high levels of several other adhesion molecules, such as vascular cell adhesion molecule (VCAM)-1 and leukocyte function associated antigen (LFA)-3, that are also important for mediating adhesion to lymphocytes. (medscape.com)
has been shown to induce the expression of MHC class II, adhesion molecules, and a variety of other antigens on the bile ducts. (medscape.com)
What is the importance of CD80 and CD3 accessory molecules? (shu.edu)
Costimulation is dependent on binding of costimulatory molecules present on the antigen-presenting cell to the lymphocyte receptor CD28. (biomedcentral.com)
Antigens inside a cell are bound to class I MHC molecules, and brought to the surface of the cell by the class I MHC molecule, where they can be recognized by the T cell. (relationship983.cfd)

The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production. (bdbiosciences.com)
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. (bdbiosciences.com)

Monoclonal antibodies identifying a novel T-cell antigen and Ia antigens of human lymphocytes. (bdbiosciences.com)

Additional factors likely to affect the measured potency include antigen purity, formulation excipients, and the interaction between one or more components in a combined vaccine product. (nih.gov)
Interpretation & conclusions: Our results showed that the surface antigen of O. tsutsugamushi activated DCs through interaction with TLR4 and activation of MAPK and NF-?B signalling, suggesting Sta56 as a potential candidate molecule for the development of vaccine against scrub typhus. (bvsalud.org)

If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (relationship983.cfd)
The affinity between CD8 and the MHC molecule keeps the T C cell and the target cell bound closely together during antigen-specific activation. (relationship983.cfd)
Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)
These modified DCs were also transduced with the HLA-A2.1 molecule and made to overexpress the testis antigen MAGEA3, which is present in many cancer types. (acir.org)

We previously reported that oral ingestion of Lentinula Edodes Mycelia (L.E.M.) extract enhances the tumor antigen-specific T-cell response and exerts an antitumor effect in a tumor-bearing mouse model. (bvsalud.org)

A better knowledge of the interactions of the polycationic carriers with the molecular mechanisms involved in antigen presentation from uptake into DC to HLA-socket presentation would help to design much more efficient nanocompounds that would facilitate efficient antigen presentation and, accordingly, an efficient immune response," concluded the authors. (biobanking.com)
Collectively, these data suggests that our nano-encapsulated M278 vaccine drives maturation of DCs and efficient antigen presentation for elicitation of enhanced Th1 adaptive immune responses. (techconnect.org)

No. T3036) MutuDC, these dendritic cell lines provide a powerful tool in vaccine science and immunotherapy, particularly in strategizing target antigens to CD8α + subset. (topsan.org)
For HCC, as well as other tumors, antigen-specific immunotherapy remains a viable approach that is dependent on the definition of tumor-associated antigens. (aacrjournals.org)

NY-ESO-1, a member of the cancer testis antigen family, is one possible candidate for a tumor-specific antigen in HCC. (aacrjournals.org)

Extraordinary advances in molecular immunology have led to a detailed understanding of tumor antigens, antigen presentation, innate immunity, cytokine and chemokine pathways, and immunoregulation. (nih.gov)

The L307 monoclonal antibody specifically binds to B7/BB1, a 60 kDa transmembrane glycoprotein that was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)

Antigen presentation in the dendritic neuro-endocrine-immune cellular network. (nih.gov)
13. Increased antigen presentation and T(h)1 polarization in genetically histamine-free mice. (nih.gov)
Therefore, in this study, we investigated the potential of PLA-PEG-encapsulated M278 NPs to induce maturation and activation of DCs for effective antigen presentation to bolster immune responses. (techconnect.org)

We found that the antigen uptake of MoDCs was time dependent. (nih.gov)
Compared to healthy controls, MoDCs from uveitis patients showed elevated antigen uptake. (nih.gov)
Furthermore, we identified two subpopulations from MoDCs based on their antigen uptake capacity. (nih.gov)
In conclusion, MoDCs from uveitis patients demonstrate greater antigen uptake but have impaired cytokine production. (nih.gov)

Induction of anergy is one means by which tolerance to antigens in peripheral tissues is induced, thus avoiding an autoimmune response [ 26 ]. (biomedcentral.com)

CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. (biolegend.com)

Figure-1: Human CD80/hFc recombinant protein. (abeomics.com)

A costimulatory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 RECEPTOR . (nih.gov)

However, there is some controversy concerning the expression of CD80/ 86 by BECs. (medscape.com)

Consistency of production is recognised as an important feature of vaccine quality control and antigen and adjuvant are critical factors that should be evaluated as part of in vitro consistency testing. (nih.gov)

The receptor for antigens on the T cell surface comprises eight proteins. (shu.edu)

The primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). (nih.gov)
Notably, however, the establishment of fundamental immunological concepts and paradigms, such as B and T cell collaboration or tolerance, was based on a reductionist (or analytical) approach that departed from a classical "host-pathogen" view of immunology, by putting much emphasis on self/non-self discrimination concepts explored with simpler protein antigens such as ovalbumin or keyhole limpet hemocyanin (KLH). (frontiersin.org)

This is the first report of a spontaneous immune response in HCC patients to a known tumor-specific antigen, NY-ESO-1 protein. (aacrjournals.org)
The NG-348 virus uses PsiOxus' proprietary Tumor-Specific Immuno-gene Therapy (T-SIGn) platform to "arm" adenovirus with two additional immuno-therapeutic transgenes: (1) full-length human CD80 and (2) a membrane-anchored antibody fragment specific for the T-cell receptor CD3 protein. (shu.edu)
Human extracellular domain CD80 (B7-1) Fc fusion protein. (abeomics.com)
However, except for virus-induced cancers, tumor antigens are mostly self or near-self protein epitopes that are often poorly immunogenic and submitted to central and peripheral tolerance. (biomedcentral.com)
developed a method for establishing immortalized and constitutively activated human primary blood dendritic cell lines (ihv-DCs) that utilizes the viral protein Tax, a transcriptional regulator from human T cell leukemia virus type 2 (HTLV-2), which is not known to be pathogenic in humans. (acir.org)

There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. (relationship983.cfd)
Using bioinformatics analyzes, integrated and regular genes were selected as common genes CD80, LST1, ATM and ITM2B 4-1BBL, Akt inhibitor, interleukin 7 and 15 expansion media. (celljournal.org)

Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naïve populations. (hokudai.ac.jp)

Using such modified isolation procedures for RTDCs, we have developed a consistent method of RTDC enrichment, which maintains the immature phenotype and functional antigen presenting capability. (elsevierpure.com)

Antigen and adjuvant are the major components contributing to vaccine potency, although their precise contribution to the measured potency of a vaccine is difficult to predict and will be influenced by other factors in addition to the amount of antigen and degree of adsorption. (nih.gov)
We have developed a simple and sensitive enzyme-linked immunosorbent assay (ELISA) to quantify diphtheria and tetanus antigens in combined vaccine products and measure the degree of adsorption to adjuvant. (nih.gov)

Human T-cell activation, II: A new activation pathway used by a major T-cell population via a disulfide-bonded dimer of a 44-kilodalton polypeptide (9-3 antigen). (bdbiosciences.com)
Detects human B7‑1/CD80 in ELISAs. (rndsystems.com)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care3

CD8641

Cells90

CD401

APCs1

Molecules5

CD282

Lymphocytes1

Interaction2

Molecule4

Tumor antigen-specific1

Efficient antigen presentation2

Immunotherapy2

Testis antigen1

Understanding of tumor1

Differentiation antigens2

Presentation3

Uptake4

Tissues1

Cytotoxic1

Recombinant1

Specificity1

Expression1

Vitro1

Proteins1

Ovalbumin2

Protein5

Genes2

Populations1

Functional1

Adjuvant2

Human2