Dehydrogenase. Medical search. Frequent questions

Currently, the only serological marker used in the staging and monitoring of melanoma is serum lactate dehydrogenase, which is not sufficiently specific or sensitive, and is not used routinely in all centers. (nih.gov)
The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. (antibodies-online.com)
Find Lactate Dehydrogenase A ELISA Kits for a variety of species such as anti-Human Lactate Dehydrogenase A, anti-Rat Lactate Dehydrogenase A, anti-Mouse Lactate Dehydrogenase A. The species listed below are among those available. (antibodies-online.com)
Find Lactate Dehydrogenase A ELISA Kits with a specific Detection Method. (antibodies-online.com)
Find Lactate Dehydrogenase A ELISA Kits with a specific Sample. (antibodies-online.com)
The present study was undertaken to investigate total lactate dehydrogenase (LDH) activity in blood samples of silica-exposed agate workers as a non-invasive way to measure silica-induced toxicity. (bmj.com)
We read with great interest the study of Junewar et al 1 in the September issue of the American Journal of Neuroradiology , which justified the statements that higher serum lactate dehydrogenase (LDH) levels were possible predictors of poor outcome ( P = .009) but were not correlated with the severity of posterior reversible encephalopathy syndrome (PRES). (ajnr.org)
The phase IV clinical study analyzes which people take Amoxicillin and have Blood lactate dehydrogenase increased. (ehealthme.com)
Among them, 233 people (0.26%) have Blood lactate dehydrogenase increased. (ehealthme.com)
What is Blood lactate dehydrogenase increased? (ehealthme.com)
Blood lactate dehydrogenase increased is found to be associated with 2,212 drugs and 1,956 conditions by eHealthMe. (ehealthme.com)
Currently, we are studying 27,181 people who have Blood lactate dehydrogenase increased. (ehealthme.com)
Do you take Amoxicillin and have Blood lactate dehydrogenase increased? (ehealthme.com)

A glucose-6-phosphate dehydrogenase (G6PD) deficient strain of mouse (GPDX) which was developed using the ethylating agent ethylnitrosourea (ENU) has been used to study clonality in epithelial tissues. (nih.gov)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder most commonly associated with hemolytic anemia. (health.mil)
Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme for the pentose phosphate pathway in the erythrocyte because it converts glucose-6-phosphate to 6-phosphoglucono-d-lactone. (health.mil)
Glucose-6-phosphate dehydrogenase in western Islamic Republic of Iran) to [G6PD] deficiency is a common X-linked find the prevalence of G6PD deficiency. (who.int)
6-phosphate dehydrogenase (G6PD) of Physicians and Surgeons Pakistan , deficiency. (who.int)
Objective Glucose- 6- phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathic disease which causes neonatal jaundice in most cases, and in association with intake of drugs or certain foods (for example fava) can cause haemolytic crises. (bmj.com)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of certain drugs. (msdmanuals.com)

A double bond is normally formed in between the two atoms that the hydrogens were taken from, as in the case of succinate dehydrogenase. (wikipedia.org)
Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma (RCC). (medscape.com)
Succinate dehydrogenase (SDH) is a mitochondrial enzyme complex composed of four protein subunits (SDHA, SDHB, SDHC, and SDHD) that functions as a member of the Krebs cycle and electron transport chain. (medscape.com)
Learning Objectives Succinate dehydrogenase deficiency (type B) is associated with Pheochromocytoma-Paraganglioma syndrome, which can result in wide metastatic extra-adrenal paragangliomas. (snmjournals.org)
Pheocromocytoma-Paraganglioma syndromes are associated with mutations in 3 different genes that encode subunits B, C, and D of the mitochondrial enzyme succinate dehydrogenase (SDH), which catalyzes the oxidation of succinate to fumarate in the Krebs cycle [1-2]. (snmjournals.org)
Succinate dehydrogenase deficiency contributes to the predisposition to metastatic paragangliomas. (snmjournals.org)
The patient was identified with succinate dehydrogenase deficiency (type B), which is associated with Pheochromocytoma-Paraganglioma syndrome, Type 4, and can result in extra-adrenal paragangliomas which tend to metastasize widely. (snmjournals.org)

Dihydropyrimidine dehydrogenase (DPD) deficiency is a condition in which the body cannot break down the nucleotides, thymine and uracil. (nih.gov)
When Do Symptoms of Dihydropyrimidine dehydrogenase deficiency Begin? (nih.gov)
Dihydropyrimidine dehydrogenase deficiency is a disorder characterized by a wide range of severity, with neurological problems in some individuals and no signs or symptoms in others. (medlineplus.gov)
In people with severe dihydropyrimidine dehydrogenase deficiency, the disorder becomes apparent in infancy. (medlineplus.gov)
Individuals with asymptomatic dihydropyrimidine dehydrogenase deficiency may be identified only by laboratory testing. (medlineplus.gov)
People with dihydropyrimidine dehydrogenase deficiency, including those who otherwise exhibit no symptoms, are vulnerable to severe, potentially life-threatening toxic reactions to certain drugs called fluoropyrimidines that are used to treat cancer. (medlineplus.gov)
These drugs are not broken down efficiently by people with dihydropyrimidine dehydrogenase deficiency and build up to toxic levels in the body (fluoropyrimidine toxicity). (medlineplus.gov)
Severe dihydropyrimidine dehydrogenase deficiency, with its early-onset neurological symptoms, is a rare disorder. (medlineplus.gov)
However, between 2 and 8 percent of the general population may be vulnerable to toxic reactions to fluoropyrimidine drugs caused by otherwise asymptomatic dihydropyrimidine dehydrogenase deficiency. (medlineplus.gov)
Dihydropyrimidine dehydrogenase deficiency is caused by mutations in the DPYD gene. (medlineplus.gov)
Mutations in the DPYD gene result in a lack (deficiency) of functional dihydropyrimidine dehydrogenase. (medlineplus.gov)
Dihydropyrimidine dehydrogenase deficiency interferes with the breakdown of uracil and thymine, and results in excess quantities of these molecules in the blood, urine, and the fluid that surrounds the brain and spinal cord ( cerebrospinal fluid ). (medlineplus.gov)
It is unclear how the excess uracil and thymine are related to the specific signs and symptoms of dihydropyrimidine dehydrogenase deficiency. (medlineplus.gov)
Mutations that result in the absence (complete deficiency) of dihydropyrimidine dehydrogenase generally lead to more severe signs and symptoms than do mutations that lead to a partial deficiency of this enzyme. (medlineplus.gov)
Because fluoropyrimidine drugs are also broken down by the dihydropyrimidine dehydrogenase enzyme, deficiency of this enzyme leads to the drug buildup that causes fluoropyrimidine toxicity. (medlineplus.gov)
Pyruvate carboxylase deficiency presents with similar chemical and central nervous system findings as pyruvate dehydrogenase complex deficiency. (medscape.com)
Four novel PDHA1 mutations in pyruvate dehydrogenase deficiency. (medscape.com)
Mild phenotype in a male with pyruvate dehydrogenase complex deficiency associated with novel hemizygous in-frame duplication of the E1a subunit gene (PDHA1). (medscape.com)
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients. (medscape.com)
Caveats when considering ketogenic diets for the treatment of pyruvate dehydrogenase complex deficiency. (medscape.com)
Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility. (medscape.com)
Pyruvate dehydrogenase complex deficiency due ubiquitination and proteasome-mediated degradation of the E1beta subunit. (medscape.com)
Neonatal pyruvate dehydrogenase deficiency with lipoate responsive lactic acidaemia and hyperammonaemia. (medscape.com)
Debray FG, Lambert M, Vanasse M, Decarie JC, Cameron J, Levandovskiy V. Intermittent peripheral weakness as the presenting feature of pyruvate dehydrogenase deficiency. (medscape.com)
Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. (medscape.com)
The most common fatty acid oxidation disorder, medium chain acyl-CoA dehydrogenase deficiency (MCADD), has become the focal point for the adoption of tandem mass spectrometry to detect it and related inborn errors of metabolism. (cdc.gov)
Despite the increase in screening, understanding of the nat dehydrogenase deficiency" or "tandem mass spectrometry" to ural history of unscreened MCADD remains limited.1,3,4 gether with "newborn screening. (cdc.gov)
Pyruvate dehydrogenase deficiency is characterized by the buildup of a chemical called lactic acid in the body and a variety of neurological problems. (nih.gov)
People with pyruvate dehydrogenase deficiency usually have neurological problems as well. (nih.gov)
Because of the severe health effects, many individuals with pyruvate dehydrogenase deficiency do not survive past childhood, although some may live into adolescence or adulthood. (nih.gov)
The genes involved in pyruvate dehydrogenase deficiency each provide instructions for making a protein that is a component of a group of proteins called the pyruvate dehydrogenase complex. (nih.gov)
Mutations in the gene that provides instructions for making E1 alpha, the PDHA1 gene, are the most common cause of pyruvate dehydrogenase deficiency, accounting for approximately 80 percent of cases. (nih.gov)
Other components of the pyruvate dehydrogenase complex are also involved in pyruvate dehydrogenase deficiency. (nih.gov)
The brain, which requires especially large amounts of energy, is severely affected, resulting in the neurological problems associated with pyruvate dehydrogenase deficiency. (nih.gov)
Dichloroacetate (DCA) is a structural analog of pyruvate that has been recommended for the treatment of primary lactic acidemia, particularly in patients with pyruvate dehydrogenase (PDHC) deficiency. (nature.com)
Genetic of glucose-6-phosphate dehydrogenase blood disorders survey in the Sultanate deficiency in the Fars province of Iran. (who.int)
dehydrogenase deficiency in some ethnic recommended screening test for glucose- groups of Pakistan. (who.int)
3-Beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare form of congenital adrenal hyperplasia that results in decreased production of all 3 groups of adrenal steroids: mineralocorticoids, glucocorticoids, and sex steroids. (medscape.com)
A variety of mutations in the HSD3B2 gene affect the activity of this enzyme, resulting in the extremely variable, phenotypic presentations of 3-beta-hydroxysteroid dehydrogenase deficiency. (medscape.com)
The need for replacement therapy varies in late-onset (nonclassic) 3-beta-hydroxysteroid dehydrogenase deficiency and depends on the severity of the defect. (medscape.com)
Although first described in male infants with ambiguous genitalia and severe salt wasting, 3-beta-hydroxysteroid dehydrogenase deficiency also occurs in 46,XX female infants (who may have mild clitoromegaly), as well as in older patients who present with a milder or so-called late-onset variant. (medscape.com)
Results of search for 'su:{Glucosephosphate dehydrogenase deficiency. (who.int)

Estimation of risk of glucose 6-phosphate dehydrogenase deficient red cells to ozone and nitrogen dioxide : investigator's final report / by Marie A. Amoruso. (who.int)

Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. (proteopedia.org)
2014). A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. (proteopedia.org)
In rodent SNpc, DA neurons can be divided into two subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH1A1). (nih.gov)
Finally, the sniff-cam could visualize the individual difference of alcohol metabolism capacity originating from aldehyde dehydrogenase phenotype by imaging transcutaneous EtOH. (rsc.org)

The pyruvate dehydrogenase complex (PDC) is one of the alpha-ketoacid dehydrogenase complexes, which are involved in energy and amino acid metabolism. (gla.ac.uk)

Mutations in the genes that provide instructions for E1 beta (the PDHB gene), the E2 enzyme (the DLAT gene), E3 binding protein (the PDHX gene), and pyruvate dehydrogenase phosphatase (the PDP1 gene) have been identified in people with this condition. (nih.gov)
As with PDHA1 gene mutations, changes in these other genes lead to a reduction of pyruvate dehydrogenase complex activity. (nih.gov)

Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH. (unboundmedicine.com)
Costello LC, Franklin R, Stacey R. Mitochondrial isocitrate dehydrogenase and isocitrate oxidation of rat ventral prostate. (unboundmedicine.com)
TY - JOUR T1 - Mitochondrial isocitrate dehydrogenase and isocitrate oxidation of rat ventral prostate. (unboundmedicine.com)
AU - Costello,L C, AU - Franklin,R, AU - Stacey,R, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 495 EP - 506 JF - Enzyme JO - Enzyme VL - 21 IS - 6 N2 - Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH. (unboundmedicine.com)

E3 is a dihydrolipoamide dehydrogenase, and E3BP or protein X mediates the interaction between E2 and E3. (nature.com)
pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). (gla.ac.uk)

Like all catalysts, they catalyze reverse as well as forward reactions, and in some cases this has physiological significance: for example, alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde in animals, but in yeast it catalyzes the production of ethanol from acetaldehyde. (wikipedia.org)
when the proton on the oxygen leaves, the free electrons on the oxygen will be used to create a double bond, as seen in the oxidation of ethanol to acetaldehyde carried out by alcohol dehydrogenase in the image on the right. (wikipedia.org)
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al. (nih.gov)
In this study, we developed a biofluorometric gas-imaging system (sniff-cam) based on nicotinamide adenine dinucleotide (NAD)-dependent alcohol dehydrogenase (ADH) to visualize transcutaneous ethanol (EtOH) distribution. (rsc.org)
The coordination number of the catalytic zinc ion in alcohol dehydrogenase has been studied by integrated ab initio quantum chemical and molecular mechanical geometry optimisations involving the whole enzyme. (lu.se)
Thus, the results give no support to proposals attributing an important role to five-coordinate zinc complexes in the catalytic mechanism of alcohol dehydrogenase. (lu.se)

Any of these may be called dehydrogenases, especially those in which NAD+ is the electron acceptor (oxidant), but reductase is also used when the physiological emphasis on reduction of the substrate, and oxidase is used only when O2 is the electron acceptor. (wikipedia.org)
Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties. (nih.gov)

In enzymology, a mannitol dehydrogenase (EC 1.1.1.255) is an enzyme that catalyzes the chemical reaction D-mannitol + NAD+ ⇌ {\displaystyle \rightleftharpoons } D-mannose + NADH + H+ Thus, the two substrates of this enzyme are D-mannitol and NAD+, whereas its 3 products are D-mannose, NADH, and H+. (wikipedia.org)
The enzyme prephenate dehydrogenase catalyzes the oxidative decarboxylation of prephenate to 4-hydroxyphenylpyruvate for the biosynthesis of tyrosine. (rcsb.org)
Dysregulation of glutamate dehydrogenase (GDH), an enzyme that catalyzes the oxydative deamination of glutamate, leads to a variety of metabolic and neurological disorders. (nih.gov)

The pyruvate dehydrogenase complex is made up of multiple copies of several enzymes called E1, E2, and E3, each of which performs part of the chemical reaction that converts pyruvate to acetyl-CoA. (nih.gov)
Prephenate dehydrogenases exist as either monofunctional or bifunctional enzymes. (rcsb.org)
Analysis of the structure further reveals that two secondary structure elements, beta3 and beta7, are missing in the prephenate dehydrogenase domain of the bifunctional chorismate mutase-prephenate dehydrogenase enzymes. (rcsb.org)

This gene provides instructions for making an enzyme called dihydropyrimidine dehydrogenase, which is involved in the breakdown of molecules called uracil and thymine. (medlineplus.gov)

This is seen for example in the oxidation of acetaldehyde to acetic acid by acetaldehyde dehydrogenase, a step in the metabolism of ethanol and in the production of vinegar. (wikipedia.org)

The NADP + -dependent dehydrogenase activity of a predominant isoenzyme of human liver 3α-hydroxysteroid dehydrogenase was activated by antihyperlipidemic drugs, such as bezafibrate and clinofibrate, and by clofibric acid and fenofibric acid (active metabolites of clofibrate and fenofibrate, respectively). (aspetjournals.org)

acyl-CoA dehydrogenase (MCAD) protein. (cdc.gov)
The 21-amino acid sequence from the bovine protein exhibited 90.5% identity with the human sequence of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). (nih.gov)
Photoreceptor retinol dehydrogenase (prRDH) is a membrane-associated cytosolic protein that localizes to the outer segments (OS) of rods and cones. (jneurosci.org)

Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11. (nih.gov)

Isocitrate dehydrogenases (IDHs) act in the tricarboxylic acid (TCA) cycle to catalyse the conversion of isocitrate to 2-oxoglutarate (2-OG) with concomitant production of NADH and/or NADPH. (bl.uk)

The pyruvate dehydrogenase complex converts a molecule called pyruvate, which is formed from the breakdown of carbohydrates, into another molecule called acetyl-CoA. (nih.gov)
RALDH class 1A 1 is retinal dehydrogenase which converts retinalaldehyde to retinoic acid. (proteopedia.org)
RALDH class 1A 2 is retinal dehydrogenase which converts retinal to retinoate. (proteopedia.org)

A dehydrogenase is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. (wikipedia.org)
Dehydrogenases oxidize a substrate by transferring hydrogen to an electron acceptor, common electron acceptors being NAD+ or FAD. (wikipedia.org)

A decrease in functional E1 alpha leads to reduced activity of the pyruvate dehydrogenase complex. (nih.gov)
This observation suggests that the two functional domains of chorismate mutase-prephenate dehydrogenase are interdependent and explains why these domains cannot be separated. (rcsb.org)

Fetoplacental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) inactivates cortisol to cortisone, protecting the fetus from high glucocorticoids. (uni-muenchen.de)
Patients with classic salt-losing 3-beta-hydroxysteroid dehydrogenase require initial replacement of glucocorticoids and mineralocorticoid, plus the addition of sex steroids at appropriate, pubertal age. (medscape.com)

Older patients with mild defects in 3-beta-hydroxysteroid dehydrogenase activity (late-onset or nonclassic variant) may present with premature pubic hair development, hirsutism, irregular menstrual cycles or primary amenorrhea. (medscape.com)

Other associated proteins control the activity of the complex: pyruvate dehydrogenase phosphatase turns on (activates) the complex, while pyruvate dehydrogenase kinase turns off (inhibits) the complex. (nih.gov)
The results suggest that pyruvate dehydrogenase (PDH) activity in the cerebrum is 4.4-fold higher when neuronal firing is unperturbed. (nature.com)
1. The activity of pyruvate dehydrogenase (PDH) was measured in samples of triceps muscle obtained in 15 males, before and after immobilization for 5 weeks and 5 months of strength training carried out in random order with cross-over of treatment. (portlandpress.com)

We report the first crystal structure of a monofunctional prephenate dehydrogenase enzyme from the hyper-thermophile Aquifex aeolicus in complex with NAD+. (rcsb.org)

Sometimes a dehydrogenase catalyzed reaction will look like this: AH + B+ ↔ A+ + BH when a hydride is transferred. (wikipedia.org)
The result of a dehydrogenase catalyzed reaction is not always the acquisition of a positive charge. (wikipedia.org)

Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells. (nih.gov)
17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. (nih.gov)
17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. (uni-marburg.de)
This condition is due to defects in type II 3-beta-hydroxysteroid dehydrogenase, an enzyme that occurs almost exclusively in the gonads and adrenal glands. (medscape.com)

Effects of arsenic on pyruvate dehydrogenase activation. (nih.gov)

Anatomy8

Organisms12

Diseases5

Chemicals and Drugs170

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Health Care2

Lactate13

G6PD7

Succinate dehydrogenase7

Deficiency42

Glucose-6-Phosphate Dehydrogena1

Aldehyde dehydrogenase4

Alpha-ketoacid dehydrogenase1

Mutations2

Isocitrate dehydrogenase4

Dihydrolipoamide dehydrogenase2

Alcohol6

Reductase2

Catalyzes3

Enzymes3

Gene1

Oxidation1

NADP1

Protein3

Characterization1

NADH1

Converts3

Substrate2

Functional2

Glucocorticoids2

Patients1

Activity3

Crystal Structure1

Reaction2

Type4

Activation1