Death castration. Medical search. Frequent questions

Cabazitaxel and abiraterone have NCCN category 1 recommendations for management of metastatic castration-resistant and docetaxel-resistant prostate cancer. (medscape.com)
NEW YORK, November 13, 2023 - Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide), for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. (pfizer.com)
The present prospective study aimed to investigate the prevalence of OCT4‑positive (OCT4 + ) CTCs and the potential association with the clinical features and survival of patients with metastatic castration‑resistant prostate cancer (mCRPC) treated with abiraterone + prednisone. (spandidos-publications.com)
Prostate cancer (PC) is the second most common malignancy after lung cancer and one of the leading causes of death in males worldwide. (spandidos-publications.com)
The proposed indication is the treatment - with prednisone or prednisolone - of metastatic castration resistant prostate cancer in adult men whose disease has progressed on or after a docetaxel-based chemotherapy regimen. (jnj.com)
The study demonstrated that abiraterone acetate, in combination with prednisone or prednisolone, improved overall survival (OS) in patients with metastatic castration resistant prostate cancer whose disease had progressed following chemotherapy. (jnj.com)
In April 2011 abiraterone acetate was approved in the US by the Food and Drug Administration (FDA)for use in combination with prednisone or prednisolone for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC) who have received prior chemotherapy containing docetaxel. (jnj.com)
We will continue to work closely with the authorities to ensure abiraterone acetate becomes available as quickly as possible to patients who suffer from metastatic castration resistant prostate cancer that has become resistant to conventional hormone therapies and for whom today there are very few treatment options left," commented Jane Griffiths, Company Group Chairman, Janssen Europe, Middle-East, Africa. (jnj.com)
Metastatic castration resistant prostate cancer occurs when cancer has metastasised (spread into other parts of the body) beyond the prostate and disease progresses despite serum testosterone (androgens) below castrate levels. (jnj.com)
Background Prostate cancer (PCa) is the second most prevalent malignancy and the fifth cause of cancer-related deaths in men. (medrxiv.org)
Prostate cancer at advanced stages including metastatic and castration-resistant cancer remains incurable due to the lack of effective therapies. (oncotarget.com)
Re-expression of CAMK2N1 in prostate cancer cells reduced cellular proliferation, arrested cells in G 0 /G 1 phases, and induced apoptotic cell death accompanied by down-regulation of IGF-1, ErbB2, and VEGF downstream kinases PI 3 K/AKT, as well as the MEK/ERK-mediated signaling pathways. (oncotarget.com)
Prostate cancer is one of the most common malignancies among men and the second most common cause of male cancer-related deaths [ 1 ]. (oncotarget.com)
The usual progression of prostate cancer goes from castration-sensitive to -resistant, inevitably developing highly metastatic properties [ 2 ]. (oncotarget.com)
Prostate cancer (PC) is the most common cancer and the third most common cause of cancer-related deaths in men in developed countries ( 1 ). (snmjournals.org)
Most prostate cancer (PCa) deaths are due to castration-resistant PCa (CRPC), following failure of androgen-deprivation therapy (ADT). (aacrjournals.org)
However, nearly universal progression to castration-resistant prostate cancer (CRPC) occurs 2-3 years after ADT is initiated. (aacrjournals.org)
GnRH agonists provide medical castration in patients with prostate cancer. (medscape.com)
As the fifth most common cause of cancer death in men worldwide, prostate cancer is largely identified in patients who are asymptomatic. (medscape.com)
For the most part, prostate cancer-related deaths occur as a result of advanced disease , which results from any combination of lymphatic, hematogenous, or contiguous local spread. (medscape.com)
In spite of early responses to treatment with androgen deprivation therapy , most patients eventually progress to castration-resistant prostate cancer (CRPC). (medscape.com)
The treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) has seen stepwise improvement since 2002, when it was shown that zoledronic acid could reduce skeletal-related event incidence. (medscape.com)
Non-metastatic castration-resistant prostate cancer (nmCRPC) is only seen in about 4% to 7% of patients with prostate cancer. (medscape.com)
The title of the talk by Celestia S. Higano, MD, New Developments in the Treatment of Hormone Refractory Prostate Cancer, was notable in the use of a term that has been replaced over the past decade with castration resistant. (ajmc.com)
Dr Higano presented a chart showing standard-of-care options for metastatic castration-resistant prostate cancer (mCRPC), which featured 9 different therapies across columns for patients at various points, from those with symptoms to those without, and for those who have already received docetaxel. (ajmc.com)
Today we're going to discuss managing patients with metastatic castration-sensitive prostate cancer, or mCSPC, and highlight the TITAN study results for ERLEADA ® , or apalutamide. (reachmd.com)
ERLEADA ® is an androgen receptor inhibitor indicated for the treatment of patients with mCSPC and non-metastatic castration-resistant prostate cancer, or nmCRPC. (reachmd.com)
The PARP inhibitor olaparib reduced the risk of death by 31% compared with a second hormonal treatment (enzalutamide or abiraterone) in men with metastatic castration-resistant prostate cancer charact. (ascopost.com)
6. Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer. (nih.gov)
8. Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report. (nih.gov)
11. Synergistic antitumor activities of docetaxel and octreotide associated with apoptotic-upregulation in castration-resistant prostate cancer. (nih.gov)
13. Plasma Cell-free DNA Concentration and Outcomes from Taxane Therapy in Metastatic Castration-resistant Prostate Cancer from Two Phase III Trials (FIRSTANA and PROSELICA). (nih.gov)
14. Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer. (nih.gov)
16. Cross-resistance between taxanes and new hormonal agents abiraterone and enzalutamide may affect drug sequence choices in metastatic castration-resistant prostate cancer. (nih.gov)
According to the National Cancer Institute , prostate cancer is the most common cancer and second leading cause of cancer death among men in the United States. (newswise.com)
Castration-resistant prostate cancer, or CRPC, is a late state of prostate cancer that continues to grow despite androgen blockade. (newswise.com)
Prostate cancer is a major cause of male death worldwide and the identification of new and improved treatments is constantly required. (sigmaaldrich.com)
Androgen biosynthesis in castration-resistant prostate cancer. (nih.gov)
Prostate cancer is the second leading cause of death in adult males in the USA. (nih.gov)
Recent advances have revealed that the fatal form of this cancer, known as castration-resistant prostate cancer (CRPC), remains hormonally driven despite castrate levels of circulating androgens. (nih.gov)
JEVTANA is a microtubule inhibitor indicated in combination with prednisone for treatment of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment regimen. (nih.gov)
Prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) has shown encouraging results for treatment of metastatic castration-resistant prostate cancer (mCRPC) in the prospective, multicenter, randomized phase II TheraP study. (bvsalud.org)
Although prostate cancer (PCa) is the second leading cause of cancer death among men worldwide, not all men diagnosed with PCa will die from the disease. (nih.gov)
We used Enhanced Reduced Representation Bisulfite Sequencing, a genome-wide high-coverage single-base resolution DNA methylation method to profile seven localized PCa samples, seven matched benign prostate tissues, and six aggressive castration-resistant prostate cancer (CRPC) samples. (nih.gov)
Association of genetic variation of the six gene prognostic model for castration-resistant prostate cancer with survival. (cdc.gov)
The approach takes advantage of castration-resistant prostate cancer cells' adaptive reliance on androgen signaling. (medscape.com)
Prostate Cancer Death: Race Is Irrelevant Despite a long-held belief that prostate cancer mortality is worse among Black men, in fact, it is similar or even lower than the rate in White men when social factors are equalized, suggests a new analysis. (medscape.com)
Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in American men. (nih.gov)

A crucial challenge is identifying the population at risk of rapid progression from hormone-sensitive PCa (HSPC) to the lethal castration-resistant PCa (CRPC). (medrxiv.org)
However, disease progression usually occurs within a few years despite castrate levels of serum testosterone, defining a state called castration-resistant PC (CRPC). (snmjournals.org)
The response to castration/ADT is tri-phasic: a pro-apoptotic regression phase when tumor shrinks, followed by selection for a residual population of resistant tumor cells and finally recurrent growth as CRPC. (aacrjournals.org)
Statin use at the initiation of ADT prolongs time to castration-resistant PC (CRPC). (urotoday.com)
Although a majority of patients initially respond to ADT well, most of them will eventually develop castration-resistant PCa (CRPC). (nih.gov)

The killer, Saidolim Gayibnazarov, 48, was sentenced in Kazakhstan to chemical castration and life in a harsh penal colony. (dailymail.co.uk)
A call is mounting in Russia to introduce chemical castration for pedophiles. (rt.com)
In a decade, dozens of bills stipulating chemical castration or life imprisonment have been discussed by the State Duma. (rt.com)
Despite his service to his country, Turing was prosecuted and eventually underwent chemical castration to avoid jail time. (space.com)
PAKISTAN'S PRIME MINISTER Imran Khan has said that the worst sex crimes should be punishable by chemical castration, following an arrest in a gang-rape case that has prompted nationwide protests. (thejournal.ie)
What I think is that there should be chemical castration, I have read it is happening in many countries," Khan said in an interview with Pakistani news station Channel 92. (thejournal.ie)
Chemical castration involves using drugs to reduce a person's libido. (thejournal.ie)
In 2012, a bill punishing re-offending child abusers with chemical castration was passed by the Russian State Duma. (ibtimes.co.uk)

Infection with HIV is the effects of male castration on longevi- men, which is similar to patterns of strongest known risk factor for dis- ty (3). (cdc.gov)
Evidence that sex hormones play a role in this loss of resistance is shown by a study on the effects of male castration on longevity ( 3 ). (cdc.gov)

Freud asserts that the removal of the eyes alludes to an infantile fear of castration, but the castration complex is masked by a fear of losing a different sensitive organ: the eyes. (freud.org.uk)
Some judges in India believe that the threat of castration is enough to protect children and women from sex abuse: so deep is the fear of castration in the male psyche. (devdutt.com)

Like other GnRH agonists, goserelin provides a medical castration that deprives hormonally-dependent tumors of testosterone or estrogen. (medscape.com)
It may consist of surgical castration (orchiectomy) or medical castration. (medscape.com)
Agents used for medical castration include luteinizing hormone-releasing hormone (LHRH) analogues or antagonists, antiandrogens, and other androgen suppressants. (medscape.com)

Antiandrogen therapy appears to be less effective than medical or surgical castration, except possibly in patients without overt metastases (M0). (medscape.com)

Although patients with metastatic PC are often treated with androgen deprivation therapy (ADT) and achieve initial treatment response, 10-20% of patients develop metastatic castration-resistant PC (mCRPC) ( 4 - 6 ). (spandidos-publications.com)

The higher incidence of cardiac deaths with cabazitaxel versus mitoxantrone suggests cautious use in patients with cardiac disease. (medscape.com)

Castration caused the tumors to regress, consistent with initial phase of the response that is seen in the human disease. (aacrjournals.org)
Immunohistochemical staining of tumors 5 weeks post-castration revealed an increase in TAMs, and a decrease in CD8 T-cells, consistent with an immunosuppressive or immunoevasive state. (aacrjournals.org)

After the war, deaths due to TB plummeted, falling almost 10-fold between 1945 and 1955, essentially before the advent of effective chemotherapy ( 4 ). (cdc.gov)

Recently, we found that in a PTEN-deficient mouse PCa model, castration induces an immunosuppressive state within the tumor that is concurrent with tumor recurrence. (aacrjournals.org)
At late times post-castration (5-6 weeks), corresponding to the selection phase, we observed a coordinate increase in the stem/progenitor tumor cell population, as well as TNF and CCL2, within the TIME. (aacrjournals.org)
SDX7539 binds to and inhibits MetAP2, which prevents MetAP2-mediated signal transduction pathways and results in tumor cell death. (nih.gov)

Brunei recently introduced a law to make sodomy punishable by stoning to death. (independent.co.uk)
Asked about the case, Khan said the worst sex crimes should be punishable by public hangings, but added this could impact trading deals with partners that oppose the death penalty, such as the European Union. (thejournal.ie)

Most of these patients develop resistance to castration due to a reactivation of the androgen receptor signaling axis. (snmjournals.org)
Among the available options, different non-steroidal androgen receptor (AR) antagonists are approved also to treat castration-resistant forms. (sigmaaldrich.com)

Child sex abusers have been shown on TV telling of their anguish after undergoing forced castration. (dailymail.co.uk)
Atakhov said that his assistant Anna Levchenko monitors websites and and social networks for child pornography and regularly receives death threats from child abusers by email and telephone. (ibtimes.co.uk)

Death penalty to rapists! (newstatesman.com)
The immediate responses to the Hall decision characterized it primarily as a "small but meaningful step" 4 to "chip away at the death penalty. (uclalawreview.org)
This Essay takes the position that the Court's deployment of its consensus-detecting apparatus is not only unexpected in the Hall context but is also striking because it could implicate a broad range of issues related to constitutional claims against harsh punishments like the death penalty. (uclalawreview.org)
But may not a view beyond the courts expose other factors-fulsome hopes and erroneous ideas-referable to anticipated benefits result- ing from enforcement of the death penalty? (nih.gov)

To her, the evidence is clear: In the 2010 study published in the New England Journal of Medicine , at 3 years, the median survival benefit was 4.1 months and, more importantly, a 24.5% reduction on the risk of death. (ajmc.com)

Gayibnazarov was sentenced by judge Dauren Madaliev to castration - routine for all male child sex offenders in Kazakhstan, and carried out by regular chemical injections - and a life term in a grim high security penal colony. (dailymail.co.uk)

Time interval from randomization to PSA progression, clinical progression or death, whichever occurred first, or time from randomization until date last known progression-free. (nih.gov)

Freud emphasized the relation between anxiety and castration, whereas Lacan highlighted the dimension of joy, stemming from the triple structure: real, symbolic and imaginary. (bvsalud.org)

Bone marrow suppression (particularly neutropenia) and its clinical consequences (febrile neutropenia, neutropenic infections, and death): Monitor blood counts frequently to determine if dosage modification or initiation of G-CSF is needed. (nih.gov)

Therefore, apatient who progresses to castration-resistant disease may be exposed tomultiple treatments over several years prior to his death. (renalandurologynews.com)
Patients who died without documented progression and the death occurred more than 3 months after the date of last disease assessment were censored at the date of last disease assessment. (nih.gov)
More Type 2 Diabetes Deaths From Cancer Than Heart Disease In people with type 2 diabetes, cancer screening should get at least as much attention as CVD prevention. (medscape.com)

To date, there is no conclusive study that proves hanging, capital punishment or castration will act as a deterrent to further crimes. (newstatesman.com)
This should also be graded, and for first-degree (sex crimes) there should be castration. (thejournal.ie)

From there we just wrote out a story of a human being losing the self, hence the symbolism of castration, and that human eventually belonging to the sea of people, using suicide and water as the eventual metaphor. (wikipedia.org)

Every cell has DNA repair mechanisms that function to protect DNA from harmful mutations which can cause cancer and cell death. (pcf.org)
So Oedepially-loaded a subconscious also saw "a tempting dish of kidneys au madeve " - her favourite dish, despite the death of her sister from cancer of that organ while a medical student (she could not remember the funeral). (urigeller.com)
To its credit, the FDA does "fast track" many cancer drugs, as even an imperfect drug beats a cancer death. (cancer.org)

OS was defined as the time from randomization to the date of death from any cause. (reachmd.com)

Massachusetts, 1880-1930 (6), show tuberculosis infection is a necessary, mones play a role in this loss of that deaths among women tended to but not sufficient, cause of tuberculo- resistance is shown by a study on the peak at lower ages than deaths among sis (TB). (cdc.gov)
This study found that castrated, mentally handicapped patients, in the first half of the 20th century in Kansas, outlived patients who were not castrated by more than 10 years, mostly due to measurably lower TB death rates. (cdc.gov)

He was put on a (then) new drug for castration-resistant, metastatic PCa in men for whom taxotere (chemo) had failed. (cancer.org)

Ever since Sunday's savage crime, India's political leadership has been loudly engaged in what it appears to believe is advocacy of women's rights - in the main, dramatic but meaningless calls for summary trials, castration and mandatory death penalties. (thehindu.com)

At their core The Castration of The Idiot is about the domestication of the self into human mores and tendencies and traditions such as love. (wikipedia.org)
Waxwork dolls, automata, doubles, ghosts, mirrors, the home and its secrets, madness and severed limbs are mentioned throughout The Uncanny, influencing painters and sculptors to explore these themes and blur the boundaries between animate and inanimate, human and non-human, life and death. (freud.org.uk)

i.e. the sculpture of the life-size man lying down, death). (freud.org.uk)

Kazakhstan has operated a system of forced castration for paedophiles for several years. (dailymail.co.uk)
In the final analysis of TITAN, after a median follow-up of approximately 4 years, ERLEADA ® plus ADT significantly improved OS, with a reduction in the risk of death of 35% compared with ADT alone in a broad population of patients with mCSPC. (reachmd.com)

In the primary analysis, after a median follow-up of 22.7 months, treatment with ERLEADA ® plus ADT reduced the risk of death by 33% compared with placebo plus ADT. (reachmd.com)

Risk factors for tuberculous dis- war, deaths due to TB plummeted, sexual risk factors than those without ease progression itself have also been falling almost 10-fold between 1945 such a history, although confounding studied. (cdc.gov)
The STI hypothesis not only explains the mechanisms behind the lifestyle risk factors discussed above, namely by confounding with sexual behavior, but also why TB has ceased to be a major cause of death in Western societies. (cdc.gov)

not to kill the lowlife means certain death for me and hundreds of others. (techdirt.com)

Anatomy27

Organisms17

Diseases21

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Psychiatry and Psychology7

Phenomena and Processes33

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture2

Information Science5

Named Groups2

Health Care18

Geographicals1

Prostate Cancer48

CRPC5

Chemical castration8

Effects of male castration2

Fear of castration2

Medical castration3

Surgical castration1

Metastatic castration1

Incidence1

Tumors2

Chemotherapy1

Tumor3

Punishable2

Androgen receptor2

Abusers2

Penalty4

Survival1

Routine1

Progression or death1

Freud1

Clinical1

Disease3

Crimes2

Eventually1

Cancer3

Randomization1

Study2

Drug1

Summary1

Human2

Life1

Years2

Placebo1

Risk2

Means1