Dacarbazine, also known as imidazole carboxamide and sold under the brand name DTIC-Dome, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. (wikipedia.org)
As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin's lymphoma, and in the MAID regimen for sarcoma. (wikipedia.org)
Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. (wikipedia.org)
The open-label, multicenter, phase III SAR-3007 trial compared trabectedin with dacarbazine in 518 patients with advanced liposarcoma and leiomyosarcoma who previously received an anthracycline-containing regimen followed by at least one additional line of chemotherapy. (targetedonc.com)
Efficacy and safety of trabectedin or dacarbazine for the treatment of patients with uterine leiomyosarcoma after prior chemotherapy: a subgroup analysis of the randomized phase 3 SAR-3007 study. (targetedonc.com)
Interferon and the chemotherapy agents dacarbazine, cisplatin, and vinblastine are approved by the US Food and Drug Administration (FDA) for use as adjuvant therapy in melanoma. (medscape.com)
Dacarbazine injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (navigatingcare.com)
Liver damage may occur more often in people that are receiving other cancer chemotherapy drugs along with dacarbazine treatment. (navigatingcare.com)
The approval was based on recently published clinical efficacy and safety data from the Phase 3, randomized, open-label, controlled study (ET743-SAR-3007), which evaluated YONDELIS versus the chemotherapy agent dacarbazine, in patients with unresectable or metastatic LPS or LMS previously treated with an anthracycline and at least one additional chemotherapy regimen. (prnewswire.com)
Our previous research demonstrated that the cytotoxicity of sulindac against melanoma cells is comparable to dacarbazine, the drug used in chemotherapy. (bvsalud.org)
Melanoma10
Dacarbazine 500mg is used in the treatment of cancers of the lymphatic system and malignant melanoma (a type of skin cancer). (mcareexports.com)
DACARBAZINE 500MG INJECTION is used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. (oceanpharmaproducts.com)
Dacarbazine is used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. (navigatingcare.com)
When dacarbazine is used to treat melanoma, it may be injected once a day for 10 days in a row every 4 weeks or it may be injected once a day for 5 days in a row every 3 weeks. (navigatingcare.com)
Nivolumab improves health-related quality of life (HRQoL) of patients with advanced melanoma , in contrast to dacarbazine, according to a study published in the Annals of Oncology . (cancertherapyadvisor.com)
The authors evaluated the HRQoL of patients enrolled to CheckMate 066, a phase 3 study that contrasted the efficacy of nivolumab with that of dacarbazine, for patients with untreated, unresectable, or metastatic melanoma. (cancertherapyadvisor.com)
The authors concluded that HRQoL of patients with advanced melanoma is superior when nivolumab, rather than dacarbazine, is administered. (cancertherapyadvisor.com)
Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance. (sciencecentral.in)
METHODS: High fat diet (HFD)-induced obese mouse model was used in this study to evaluate the outcome of dacarbazine (DTIC) therapy in melanoma. (sciencecentral.in)
Doxorubicin1
Dacarbazine-Doxorubicin therapy ameliorated an extremely aggressive mesenteric desmoid tumor associated with familial adenomatous polyposis: report of a case. (dtrf.org)
Dacarbazine 500mg is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. (mcareexports.com)
Hodgkin's1
Dacarbazine was proven to be just as efficacious as procarbazine, another drug with similar chemistry, in the German trial for paediatric Hodgkin's lymphoma, without the teratogenic effects. (wikipedia.org)
Purine analog2
Dacarbazine is in the alkylating agent and purine analog families of medication. (wikipedia.org)
Dacarbazine is an anti-cancer agent, which acts by different mechanisms i.e. inhibition of DNA synthesis by acting as a purine analog, action as an alkylating agent and interaction with SH groups. (pediatriconcall.com)
Generic DACARBAZINE / Brand DTIC-DOME 100 mg Injection Vial is used to treat Blood Cancer / Leukemia. (911globalmeds.com)
Liposarcoma2
Patients with uterine leiomyosarcoma who received trabectedin had a median PFS of 4.0 months versus 1.5 months with dacarbazine, almost identical to previously reported results in the overall study population of patients with leiomyosarcoma and liposarcoma. (targetedonc.com)
Overall survival with eribulin was 15.6 versus 8.4 months with dacarbazine in a phase 3 randomized trial of 452 patients with advanced liposarcoma. (the-hospitalist.org)
Injection6
Dacarbazine injection has caused birth defects in animals. (navigatingcare.com)
This medication has not been studied in pregnant women, but it is possible that it may also cause birth defects in babies whose mothers received dacarbazine injection during pregnancy. (navigatingcare.com)
You should not use dacarbazine injection while you are pregnant or plan to become pregnant unless your doctor decides that this is the best treatment for your condition. (navigatingcare.com)
Talk to your doctor about the risks of using dacarbazine injection. (navigatingcare.com)
Dacarbazine injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) over 1 minute or infused intravenously over 15 to 30 minutes by a doctor or nurse in a medical facility. (navigatingcare.com)
tell your doctor and pharmacist if you are allergic to dacarbazine, any other medications, or any of the ingredients in dacarbazine injection. (navigatingcare.com)
Analogs1
Dacarbazine is in a class of medications known as purine analogs. (navigatingcare.com)
Imidazole carboxamide1
Dacarbazine is activated by liver microsomal enzymes to monomethyl triazeno imidazole carboxamide (MTIC), which is an alkylating compound. (wikipedia.org)
Progression-free sur1
Trabectedin (Yondelis) improved progression-free survival (PFS) when compared with dacarbazine in women with advanced uterine leiomyosarcoma, according to a subgroup analysis of the phase III SAR-3007 trial. (targetedonc.com)
DTIC1
Dacarbazine gained FDA approval in May 1975 as DTIC-Dome. (wikipedia.org)
Nivolumab2
Throughout study treatment, 65% of patients receiving dacarbazine and 70% of patients receiving nivolumab completed quality of life questionnaires. (cancertherapyadvisor.com)
HRQoL of patients in the nivolumab group deteriorated later than HRQoL of those who received dacarbazine. (cancertherapyadvisor.com)
Trabectedin4
Patients were randomized in a 2:1 ratio to 1.5 mg/m2 of trabectedin (n = 345) or 1.0 g/m2 of dacarbazine (n = 173) once every 3 weeks until disease progression or unacceptable toxicity. (targetedonc.com)
Trabectedin was administered through a catheter as an IV infusion over 24 hours and patients received dacarbazine as a 20- to 120-minute infusion. (targetedonc.com)
Median time to response was similar, 3.22 months with trabectedin and 2.79 months with dacarbazine. (targetedonc.com)
However, the differences did not translate into less treatment, as 39% of patients in the trabectedin group completed 6 cycles of therapy as compared with 18% of patients in the dacarbazine arm. (targetedonc.com)
Drugs1
Dacarbazine is considered to be highly emetogenic, and most patients will be pre-medicated with dexamethasone and antiemetic drugs like 5-HT3 antagonist (e.g., ondansetron) and/or NK1 receptor antagonist (e.g., aprepitant). (wikipedia.org)
Toxicity1
palifermin increases toxicity of dacarbazine by Other (see comment). (medscape.com)
Mechanism1
Although the mechanism of action for dacarbazine is unknown, possible actions include alkylating agent, purine metabolite, or interaction with sulfhydryl groups. (medscape.com)
Hypersensitivity1
Dacarbazine is contraindicated in patients who have demonstrated a hypersensitivity to it in the past and in patients with hepatic and/or renal insufficiency. (pediatriconcall.com)
Metabolism2
givosiran will increase the level or effect of dacarbazine by affecting hepatic enzyme CYP1A2 metabolism. (medscape.com)
Phenytoin, Phenobarbitone: May induce dacarbazine metabolism. (pediatriconcall.com)
Evaluate1
The aim of this study was to formulate and evaluate Dacarbazine (5-(3, 3-dimethyltriaz-1-en-1-yl)- 1H-imidazole-4-carboxamide implants using hydrophilic polymers. (ijisrt.com)
Interactions1
How Dacarbazine works, side effects, interactions and precautions. (navigatingcare.com)
Liver2
The Swedish National Board of Health and Welfare has sent out a black box warning and suggests avoiding dacarbazine due to liver problems. (wikipedia.org)
Dacarbazine may cause serious or life-threatening liver damage. (navigatingcare.com)
Vaccine2
dacarbazine decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. (medscape.com)
Live vaccines: As dacarbazine may impair the immunological responses, administration of live vaccine may lead to the development of a generalized vaccinia. (pediatriconcall.com)