AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
HLA-C AntigensHLA AntigensHLA-B AntigensFractional PrecipitationHLA-A AntigensAntigensAntigens, BacterialProtein CAntigens, NeoplasmHLA-DR AntigensAntigens, SurfaceHLA-DRB1 ChainsAntibodies, MonoclonalAntigens, ViralHepatitis C AntigensHLA-DQ AntigensAntigens, CD11cHLA-DQ beta-ChainsAntigens, ProtozoanAntigens, Polyomavirus TransformingHistocompatibility Antigens Class IIAntigens, FungalAntigens, CDAntigens, HelminthH-2 AntigensDichlororibofuranosylbenzimidazoleHLA-DRB3 ChainsHistocompatibility TestingHistocompatibility Antigens Class IEpitopesAllelesHLA-D AntigensCarcinoembryonic AntigenAntigens, Viral, TumorHistocompatibility AntigensReceptors, Antigen, T-CellHLA-A2 AntigenGenes, MHC Class IIHLA-DR4 AntigenT-LymphocytesProliferating Cell Nuclear AntigenMolecular Sequence DataReceptors, Antigen, B-CellProstate-Specific AntigenO AntigensHLA-DRB4 ChainsAntigens, CD8Antigens, CD15Enzyme-Linked Immunosorbent AssayHLA-DRB5 ChainsCross ReactionsAntigens, Tumor-Associated, CarbohydrateHaplotypesImmunoglobulin GHLA-DR3 AntigenAmino Acid SequenceLymphocyte ActivationAntigens, CD3Hepatitis B Surface AntigensBlood Group AntigensHLA-DP beta-ChainsAntibody SpecificityHLA-DR2 AntigenHLA-DR Serological SubtypesCell LineMice, Inbred BALB CAntigens, CD4Major Histocompatibility ComplexDNA Probes, HLAAntigens, CD45Gene FrequencyB-LymphocytesReceptors, AntigenAntibody FormationHepatitis B AntigensFluorescent Antibody TechniqueAntigen-Antibody ReactionsAntigens, CD1HLA-B44 AntigenT-Lymphocytes, CytotoxicImmune SeraAntibodies, BacterialImmunizationHLA-B7 AntigenAntigens, DifferentiationEpitopes, T-LymphocyteGenetic Predisposition to DiseaseHLA-B27 AntigenAutoantigensGenes, MHC Class IAutoantibodiesBase SequenceHIV AntigensHLA-DR beta-ChainsHLA-A1 AntigenAntibodiesHistocompatibilityMART-1 AntigenGenotypeFlow Cytometry
AllelesAlleleLocusHistocompatibility antigensGenesLociAntibodiesPeptidesEpitopesHumanPolymorphismDQB1MoleculesAutoimmuneEpithelial cellsTissue AntigensAntibodyImplicated in the pathogenesisClassSusceptibilityProteinGenotypesCohortPolymorphismsFrequencyMoleculeHaplotypePathogenesisSubtypesLeucocytePeripheralProteinsAutoantibodiesMacrophagesAssociationTyping was performedFrequencies
Alleles28
  • The aim of this study was to examine the distribution of HLA Class II DRB1* alleles in a homogeneous cohort of individuals who were infected with HCV-contaminated anti-D immunoglobulin, and to compare frequencies of alleles in individuals with spontaneous viral clearance to those with chronic HCV infection. (nih.gov)
  • No significant association was shown between severity of liver disease and DRB1* alleles. (nih.gov)
  • These results suggest that host HLA-DRB1* alleles are important contributors to disease outcome. (nih.gov)
  • Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles. (ox.ac.uk)
  • BACKGROUND: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles. (ox.ac.uk)
  • OBJECTIVE: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles. (ox.ac.uk)
  • Anti-CCP and anti-citrullinated protein antibodies were associated with HLA-DRB1*04 rather than with HLA-DRB1*01 alleles. (ox.ac.uk)
  • All specific reactivities were primarily associated with the HLA-DRB1*04 alleles, suggesting common pathways of anti-citrulline immunity. (ox.ac.uk)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular number (such as HLA-DRB1 *04:01). (medlineplus.gov)
  • Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. (wikipedia.org)
  • The results support an association of certain HLA class Ib alleles with allo-immunization during pregnancy. (frontiersin.org)
  • AIH usually develops in individuals with a genetic background mainly consisting of some risk alleles of the major histocompatibility complex (HLA). (wjgnet.com)
  • Rationale for the generation of this model is the high prevalence of distinct HLA class II alleles in PV patients, such as HLA-DRB1*04:02, -DRB1*14:01, and -DQB1*05:03. (uni-marburg.de)
  • The occurrence of PV being associated with the presence of specific HLA class II alleles thereby reflects the high relevance of autoreactive CD4+ T cells in disease pathogenesis. (uni-marburg.de)
  • was found in 45% of patients and 35% of them had one or two HLA- em DRB1*04 /em alleles. (exposed-skin-care.net)
  • Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)
  • Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. (thermofisher.com)
  • However, it also appears that different HLA-DRB3 alleles (e.g. (maastrichtuniversity.nl)
  • Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN. (wanfangdata.com.cn)
  • Methods: Thirty-seven patients with histomorphologic findings of inflammatory AAA at operation were genotyped for the polymorphism of the HLA-DR B1 and HLA-DQ B1 alleles and compared to ethnically matched, healthy control subjects (n = 90). (usuhs.edu)
  • Results: Distribution of HLA-DR B1 alleles was nonrandom in patients with inflammatory AAAs versus control subjects. (usuhs.edu)
  • HLA-DR B1 alleles overrepresented in patients with inflammatory AAA express a glutamine substitution at position 70, whereas alleles disfavored in the patient cohort express a negatively charged aspartic acid. (usuhs.edu)
  • Distribution of HLA-DQ B1 alleles were indistinguishable in patients and control subjects. (usuhs.edu)
  • DR4 is one among copious alleles of a gene called DRB1, which itself is one among many in a large complex of genes - called the human lymphocyte antigen complex, or HLA - that's crucial to rendering cells' inner contents visible to the immune system. (alzheimersweekly.com)
  • Genome wide association studies have demonstrated that several HLA and non-HLA alleles are associated with the development of this disease [7]. (encyclopedia.pub)
  • A few studies have been conducted regarding the relationship between HLA alleles and the incidence of recurrent aphthous stomatitis in different human populations especially in the Iranian population (15). (ac.ir)
  • An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. (musc.edu)
  • Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
Allele12
  • The DRB1*01 allele was found significantly more frequently in individuals with viral clearance compared to those with chronic infection (27.4% vs. 7.1% p = 0.001, odds ratio OR = 4.9, pc = 0.01). (nih.gov)
  • We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
  • We have previously shown that Scandinavian sarcoidosis patients expressing the HLA-DR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4+ T cells expressing the TCR AV2S3 gene segment. (jci.org)
  • The maternal HLA-E*01:06 allele was significantly associated with a higher fraction of anti-HLA I immunization (20.0% vs. 4.8%, p = 0.048). (frontiersin.org)
  • For prediction of grade of activity, the impartial predictors were anti-CCP (OR 19.6), and em DRB1*04 /em positive allele (OR 5.1). (exposed-skin-care.net)
  • Human leukocyte antigen (HLA)-DRB3 is a functional HLA class II gene, which has a limited allele diversity in the human population. (maastrichtuniversity.nl)
  • In those cases, where we succeeded at tracing back the induction of these antibodies to the molecular HLA typing of the immunogenic event, we noticed a different frequency of HLA-DRB1 allele groups in the donors as compared to a control group. (maastrichtuniversity.nl)
  • Objective: Human leukocyte antigen (HLA)-B*40:01:35 is a low incidence allele in the HLA-B locus. (tmu.edu.tw)
  • Conclusion: Information on the deduced probable HLA haplotype in association with the low incidence B*40:01:35 allele that we report here is of value for HLA testing laboratories for reference purposes. (tmu.edu.tw)
  • In addition, it can be used by stem cell transplantation donor search coordinators to determine a strategy for finding compatible donors in unrelated bone marrow donor registries when a patient has this uncommon HLA allele. (tmu.edu.tw)
  • whereas that of DRB1*07 allele was lower (2.78% vs 7.75%,OR = 0.340, P = 0.046). (wanfangdata.com.cn)
  • The frequency of HLA-DRB1* 14allele was higher in 11 responders to IFN compared with 24 non-responders (18.18% vs2.08%, OR = 10.444,P = 0.031), whereas that of DQB1*07 allele was inverse (9.09% vs 37.50%, OR = 0.167, P= 0.021).CONCLUSION: The polymorphism of HLA class Ⅱ may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. (wanfangdata.com.cn)
Locus6
  • Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. (rcsb.org)
  • These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA. (rcsb.org)
  • A genetic predisposition has been identified and, in White populations, localized to a shared epitope in the HLA-DRB1 locus of class II histocompatibility antigens. (merckmanuals.com)
  • Polymerase chain reaction was performed to amplify exons 2 and 3 of the HLA-A and HLA-B loci and exon 2 of the HLA-DRB1 locus using group-specific primer sets. (tmu.edu.tw)
  • Conclusion: These data indicate that a genetic risk determinant can be mapped to the HLA-DR B1 locus in patients with inflammatory AAAs. (usuhs.edu)
  • are in linkage disequilibria with the HLA-drb1 locus in a japanese population. (lu.se)
Histocompatibility antigens1
  • This study aimed to determine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in an Iranian population (North East of Iran). (ac.ir)
Genes14
  • HLA-DRB1* genes do not appear to influence severity of liver disease. (nih.gov)
  • Genotyping was performed using an ABI PRISM 7900HT instrument and HLA-SE genes were identified using PCR sequence-specific primers. (nih.gov)
  • The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The HLA-DRB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
  • Further, we attempted to validate our results in another independent cervical cancer GWAS from the East Asian population ( N = 3,314) and re-discovered four genes including WDR19 , HLA-DOB , MICB and OR2B8P . (jcancer.org)
  • The present study is usually a cross-sectional analysis aimed to evaluate the significance of the presence of SE genes, defined as em DRB1*01 /em or em DRB1*04 /em , in relation to anti-CCP antibodies, antikeratin antibody (AKA) and RF in individuals who developed RA. (exposed-skin-care.net)
  • The purpose of this study was to explore whether patients with inflammatory AAAs express disease-relevant genes associated with the HLA-DR region on the short arm of chromosome 6. (usuhs.edu)
  • These specialized proteins are the products of the HLA genes. (alzheimersweekly.com)
  • The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
  • The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
  • Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
  • Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
  • Our research is focused on the role of HLA and non-HLA genes in the etiology and pathogenesis with particular emphasis to uncover the importance of beta cell autoantigens such as GAD65, insulin, IA-2, ZnT8, INS-IGF2 and tetraspanin 7. (lu.se)
  • Overall the research aim at the prediction and prevention primarily of autoimmune (type 1) diabetes by combining screening for HLA and non-HLA genes to identify subjects at risk and to measure and develop tests for beta cell autoimmunity and to carry out primary and secondary prevention trials eventually to prevent and thereby cure autoimmune (type 1) diabetes. (lu.se)
Loci2
  • In a recent meta-analysis using greater than 100 000 subjects, the 100 RA risk loci outside the human leukocyte antigen region explained only 5.5% and 4.7% of heritability in Europeans and Asians, respectively. (nature.com)
  • Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
Antibodies17
  • CONCLUSIONS: Antibodies directed against several citrullinated antigens are present in CCP-positive RA, with many patients displaying multireactivity. (ox.ac.uk)
  • We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)
  • Positive tests for antinuclear antibodies (ANAs) and anti-smooth-muscle antibodies (ASMAs): Tests for antibodies to liver-kidney microsome type 1 (anti-LKM-1), soluble liver antigen (anti-SLA), and liver cytosol type 1 (anti-LC1) may be helpful if ANA and ASMA test results are negative. (medscape.com)
  • DRB1*1502 is associated with systemic lupus erythematosus, systemic sclerosis (SSc) & anti-topoisomerase antibodies. (wikipedia.org)
  • Most patients with primary Sjogren syndrome have two specific antibodies: against Ro (SS-A) and La (SSB) antigens. (medscape.com)
  • During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. (frontiersin.org)
  • Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. (frontiersin.org)
  • Mothers were genotyped for HLA class Ib ( HLA-E, -F and -G ). Anti-HLA class I and II antibodies were identified in 24% of the women. (frontiersin.org)
  • Alloreactive anti-human leukocyte antigen (HLA) antibodies formed during pregnancy are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion, such as febrile non-hemolytic transfusion reactions, immunological platelet refractoriness or transfusion-related acute lung injury (TRALI) ( 1 , 2 ). (frontiersin.org)
  • The discrepancy between studies may be due to screening differences, both in method sensitivity and the sampling time after delivery, as HLA antibodies may persist or become gradually undetectable over time ( 1 - 5 ). (frontiersin.org)
  • The level of anti-HLA antibodies increases with the number of pregnancies and the number of children delivered ( 1 - 5 ). (frontiersin.org)
  • The combination of em DRB1*04 /em + anti-CCP antibodies gave increase in the specificity and positive predictive value to 92% and 90 respectively. (exposed-skin-care.net)
  • Therefore, in organ transplantation, this HLA molecule is frequently mismatched between patient and graft donor and thus antibodies against this mismatched HLA molecule can develop. (maastrichtuniversity.nl)
  • In this study, we aimed to evaluate the prevalence and reactivity of these antibodies and aimed to identify factors that underlie antibody formation against HLA-DRB3. (maastrichtuniversity.nl)
  • We showed in our patient cohort that HLA-DRB3 antibodies are identified in about 7% of all patients that were screened with solid phase assays. (maastrichtuniversity.nl)
  • In conclusion, our study provides information on the immunogenicity and reactivity patterns of antibodies against HLA-DRB3 in kidney transplantation, and it points towards the possibility of HLA expression as a factor underlying antibody formation. (maastrichtuniversity.nl)
  • Autoantibodies (rheumatoid factor, antinuclear antibodies and antibodies against cyclic citrullinated peptides (ACPAs)) and genetic markers (human leucocyte antibody (HLA) shared epitope and protein tyrosine phosphatase nonreceptor type 22 (PTPN22)) were analysed at the time of inclusion. (biomedcentral.com)
Peptides8
  • Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. (rcsb.org)
  • The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
  • HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
  • For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
  • This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
  • peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
  • HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
  • Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
Epitopes4
  • Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. (rcsb.org)
  • Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. (rcsb.org)
  • Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)
  • In these assays, we observed multiple antibody reactivity patterns indicating that HLA-DRB3 harbours multiple epitopes. (maastrichtuniversity.nl)
Human17
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis, multiple sclerosis, systemic lupus erythematosus, cervical cancer (human papillomavirus infection), Sjögren syndrome associated with systemic lupus erythematosus, and intermediate uveitis. (wikipedia.org)
  • DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis, multiple sclerosis, cervical cancer (human papillomavirus infection). (wikipedia.org)
  • Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • GenDx has obtained CE marking for the entire AlleleSEQR product line for human leukocyte antigen (HLA) typing by Sanger sequencing. (aacc.org)
  • In humans, MHCs are also called human leukocyte antigens (HLAs). (neurosciencenews.com)
  • In a separate study published in the same issue of Stem Cell Reports , the researchers saw similar results when they repeated this last experiment with human T cells and HLA-matched or unmatched retinal pigment cells grown from IPSCs. (neurosciencenews.com)
  • Aim of the second part of this doctoral thesis was to investigate Dsg3-specific cellular and humoral immune responses in a novel human leukocyte antigen (HLA)-DRB1*04:02-transgenic (tg) mouse model of PV under the genetic restriction by HLA-DRB1*04:02. (uni-marburg.de)
  • In summary, this experimental study convincingly confirmed that the PV mouse model reproduces the principle mechanisms of HLA-dependent and human Dsg3-specific induction of CD4+ T and B cell responses observed in PV patients. (uni-marburg.de)
  • Patients are eligible for enrollment if they have marrow blast count ≥ 5% or the presence of peripheral blasts, age ≥ 55 years, a Karnofsky score ≥ 70, and related/unrelated donor matching at human leukocyte antigen (HLA)-A, HLA-B, HLA-C, and DRB-1. (onclive.com)
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • It is not clear which factors are responsible for variation in clinical picture of APECED, but human leukocyte antigen (HLA) genotype may be important. (ersjournals.com)
  • The human leukocyte antigen (HLA) genotype may be important, since it was observed that autoimmune conditions in the APECED cohort showed HLA associations that were similar to those found in non‐APECED patients with respective autoimmune disorders 4 . (ersjournals.com)
  • We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. (aacrjournals.org)
  • Major histocompatibility complex (MHC) class I and II molecules which are called human leukocyte antigens (HLA), play an important role in the immune response (16). (ac.ir)
  • HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
Polymorphism1
  • HLA polymorphism can directly affect the bonding capacity of antigens and thus affect antigen-specific T-cell response (17). (ac.ir)
DQB15
  • DQB1*0501 haplotype is associated with systemic lupus erythematosus HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes. (wikipedia.org)
  • This product line consists of reagents for HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1, which are intended for use with SBTengine software for high resolution analysis of HLA sequencing data. (aacc.org)
  • The HLA-A, -B, and -DRB1 product validation files were reviewed by the notified body Dekra, while the kits for HLA-C, -DPB1, and -DQB1 were self-certified by GenDx. (aacc.org)
  • 4 HIX0078231 6p21.32 HLA-DQB1 HLA class II histocompatibility antigen, DQ(W1.1) beta chain precursor (DQB1*0501). (h-invitational.jp)
  • The HLA genotype of the patient (DRB1*01/DRB1*11, DQB1*0301/DQB1*0501) has been previously reported as a predisposing factor to PPH. (ersjournals.com)
Molecules6
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
  • HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
  • These molecules of cell surface play a critical role in antigen processing and T cell activity. (ac.ir)
  • Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
  • Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Autoimmune5
  • Certain variations in the HLA-DRB1 gene have been linked to an increased risk of developing an autoimmune disorder called autoimmune Addison disease. (medlineplus.gov)
  • A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. (medlineplus.gov)
  • It is not clear how HLA-DRB1*04:04 and other HLA-DRB1 variations are involved in the inappropriate immune response that causes autoimmune Addison disease. (medlineplus.gov)
  • The RAS etiology is less described, despite the overall agreement about the role of autoimmune reaction to oral mucosa or cross-reactive antigens. (ac.ir)
  • Major observations suggest that the association between HLA and autoimmune (type 1) diabetes is secondary to the first appearing autoantibody be it against insulin in children with HLA DR4-DQ8 or GAD65 in children with HLA DR3-DQ2. (lu.se)
Epithelial cells4
  • HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
  • In the next clinical trial," continues Sugita, "we plan to use allogeneic iPS-retinal pigment epithelial cells from HLA homozygote donors. (neurosciencenews.com)
  • HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
  • The AIRE protein is a transcriptional regulator expressed mainly in the thymus and plays a central role in the development and maintenance of immunological tolerance by promoting the ectopic expression of peripheral tissue-restricted antigens in medullary epithelial cells of the thymus 2 . (ersjournals.com)
Tissue Antigens1
Antibody2
  • Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)
Implicated in the pathogenesis1
  • The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
Class24
Susceptibility1
  • Many researchers have hypothesized the role of genetic susceptibility, environmental factors, putative antigens, and autoimmunity in the development of this disease, but no single cause has been identified to date. (encyclopedia.pub)
Protein5
  • The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain, which is produced from the HLA-DRA gene. (medlineplus.gov)
  • Together, they form a functional protein complex called the HLA-DR antigen-binding heterodimer. (medlineplus.gov)
  • 18 HIX0058200 6_qbl_hap6 HLA-J Pseudogene candidate (Immunoglobulin C1-set domain containing protein. (h-invitational.jp)
  • The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. (nih.gov)
Genotypes3
  • HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)
  • Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors. (nih.gov)
  • Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. (aacrjournals.org)
Cohort1
  • DRB1*01 is associated with spontaneous viral clearance in an Irish cohort infected with HCV via contaminated anti-D immunoglobulin. (nih.gov)
Polymorphisms3
  • DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. (thermofisher.com)
  • Analysis of functionally relevant amino acid polymorphisms encoded by the HLA-DR B1 gene showed relevance at amino acid position 70. (usuhs.edu)
  • Sometimes additional numbers are added after a colon to identify allelic variants that encode identical proteins, and after another colon, other numbers are added to denote polymorphisms in introns or in 5' or 3' untranslated regions (eg, A*02:101:01:02, DRB1*03:01:01:02). (msdmanuals.com)
Frequency2
  • The frequency of HLA -DRB1 *16 was 0.7% in the healthy subjects, however frequency of HLA -DRB1 *16 in patients with recurrent aphthous stomatitis (RAS) was 42.36%, and this difference was statistically significant (P=0.03). (ac.ir)
  • The frequency of DRB1 * 16 in the patients with RAS were higher than the group. (ac.ir)
Molecule1
  • Familial clustering and other similarities between inflammatory AAAs and giant cell arteritis (GCA), which possesses a genetic risk determinant mapped to the HLA-DR molecule, suggest a role of genetic risk factors in inflammatory AAAs. (usuhs.edu)
Haplotype2
  • The objective of this study is to report the ethnicity of B*40:01:35 and its deduced probable HLA associated haplotype in a Taiwanese unrelated bone marrow hematopoietic stem cell donor. (tmu.edu.tw)
  • We deduced the probable HLA haplotype in association with B*40:01:35 in Taiwanese to be A*24-B*40:01:35-DRB1*11. (tmu.edu.tw)
Pathogenesis2
  • Aim of the first part of this doctoral thesis was to investigate antigen-presenting cells (APC) and APC-derived cytokines, as well as their relation to T helper (Th) cell subsets and the auto-ab response in the pathogenesis of pemphigus. (uni-marburg.de)
  • This association suggests a critical contribution of antigen binding in the pathogenesis of this disease. (usuhs.edu)
Subtypes1
  • According to em DRB1*04 /em subtypes, ( em DRB1* 0405 /em ) was present in of 80% them. (exposed-skin-care.net)
Leucocyte1
  • 21 HIX0058040 6_mann_hap4 Pseudogene candidate (Leucocyte antigen A (Fragment). (h-invitational.jp)
Peripheral1
  • Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. (rcsb.org)
Proteins1
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Autoantibodies1
Macrophages1
  • It is hypothesized that among decidual antigen presenting cell (APC) populations (classical macrophages, classical mature dendritic cells (DC), immature DC and myeloid DC), specialized APCs present fetal antigens to the maternal immune system. (frontiersin.org)
Association1
  • This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
Typing was performed1
  • HLA DRB1* typing was performed on whole blood or serum from 157 females. (nih.gov)
Frequencies1
  • Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. (musc.edu)