The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. (wikipedia.org)
Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis. (nih.gov)
Through a unique combination of computer simulations and laboratory experiments, researchers at the Paul Scherrer Institute PSI have discovered new binding sites for active agents - against cancer, for example - on a vital protein of the cell cytoskeleton. (psi.ch)
The protein tubulin is an essential building block of the so-called cell cytoskeleton. (psi.ch)
Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction. (wikipathways.org)
Collectively, this network of protein fibers is known as the cytoskeleton . (lumenlearning.com)
Of the three types of protein fibers in the cytoskeleton, microfilaments are the narrowest. (lumenlearning.com)
Sushmita Chatterjee and a research team in nanomedicine, materials science, nanotechnology and biology at the Tel Aviv University in Israel studied the therapeutic capacity of cytoskeleton-associated protein 5 , hitherto abbreviated as CKAP5. (medicalxpress.com)
One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)
Plant cytoskeleton consists of two major networks of protein polymers, actin microfilaments (AFs) and microtubules (MTs). (cas.cz)
These results show that in mesenteric arteries an intact cytoskeleton and force development are not prerequisites for G-protein-coupled receptor-induced activation of PYK2 and paxillin, by tyrosinephosphorylation, in vascular tissue, but are necessary for the translocation of PYK2 and paxillin to the membrane. (manchester.ac.uk)
Ohanian, V, Gatfield, K & Ohanian, J 2005, ' Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle ', Hypertension , vol. 46, no. 1, pp. 93-99. (manchester.ac.uk)
Design origin: actin cytoskeleton and protein complexes in human fibroblast. (scicanvas.com)
Description: A sandwich quantitative ELISA assay kit for detection of Rat Activity Regulated Cytoskeleton Associated Protein (ARC) in samples from tissue homogenates or other biological fluids. (diastrip.com)
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
Proteins6
Even within one cell, the cytoskeleton can change through association with other proteins and the previous history of the network. (wikipedia.org)
notably, integration of proteomics data with in situ subcellular microscopic analyses showed a high abundance of cytoskeletonproteins associated with acidified PBs at the early development stages. (nature.com)
Microtubules form the most rigid part of the cytoskeleton and are responsible for the intracellular movement of organelles or proteins. (ptglab.com)
The cytoskeleton is an interconnected network of filamentous polymers and regulatory proteins that help cells sustain their shape and internal arrangement. (aatbio.com)
These elements of the cytoskeleton get their name from the fact that their diameter, 8 to 10 nm, is between those of microfilaments and microtubules. (lumenlearning.com)
One constituent of the cytoskeleton are microfilaments, also known as actin. (aatbio.com)
the main components of the eukaryotic cytoskeleton. (wikipedia.org)
As a card-carrying cell biologist, Goley was next drawn to the fledgling field of bacterial cell biology and brought her expertise in eukaryotic cytoskeletal biochemistry to studying the cytoskeleton of Caulobacter crescentus as a postdoctoral researcher with Lucy Shapiro at Stanford University. (rupress.org)
We knew, and still know, far less than for eukaryotic cytoskeletons about what these bacterial polymers really do, how their structures relate to their functions, or how they are regulated by interacting partners. (rupress.org)
Microtubule1
Research has shown that microtubule assembly and stability in the cytoskeleton is compromised causing the neurons to degrade over time. (wikipedia.org)
Cytoskeletal2
Cytoskeleton, Inc. offers a wide range of kits and products for drug screening, signal transduction and cytoskeletal research. (cytoskeleton.com)
In this review , we briefly summarize the functions of some prominent viruses in inducing or hijacking cytoskeletal structures and the related antiviral responses in order to provide new insights into the crosstalk between the cytoskeleton and viruses , which may contribute to the design of novel antivirals targeting the cytoskeleton . (bvsalud.org)
Bacterial6
The bacterial cytoskeleton guides the synthesis of cell wall and thus regulates cell shape. (aps.org)
Since spatial patterning of the bacterial cytoskeleton is critical to the proper control of cell shape, it is important to ask how the cytoskeleton spatially self-organizes in the first place. (aps.org)
What first drew you to study the bacterial cytoskeleton? (rupress.org)
At the time I was considering fields for postdoctoral study, in 2005, the bacterial cytoskeleton was a really new thing. (rupress.org)
I thought studying the bacterial cytoskeleton would marry my long-term interest in microbiology with the love for the cytoskeleton I acquired in graduate school, and I felt that the field was replete with fundamental mechanistic, and even phenomenological, questions. (rupress.org)
Each illustrates how bacterial pathogens can exert dramatic effects on the host cytoskeleton. (cdc.gov)
Cells11
The cytoskeleton can also contract, thereby deforming the cell and the cell's environment and allowing cells to migrate. (wikipedia.org)
In 1903, Nikolai K. Koltsov proposed that the shape of cells was determined by a network of tubules that he termed the cytoskeleton. (wikipedia.org)
All cells, even bacteria, have a type of cytoskeleton. (ptglab.com)
The results suggest that p230 is part of a cell surface- and cytoskeleton-associated subplasmalemmal structure that may play an important role in cell surface-cytoskeleton interaction in various cells both in vitro and in vivo. (rupress.org)
The actin cytoskeleton is a potentially vulnerable property of cancer cells, yet chemotherapeutic targeting attempts have been hampered by unacceptable toxicity. (edu.au)
A novel class of anti-tropomyosin compounds has been developed that preferentially disrupts the actin cytoskeleton of tumor cells, impairing both tumor cell motility and viability. (edu.au)
studying the actin cytoskeleton in single cells in culture, tissues, and multicellular organisms including various neurodevelopmental model systems. (uu.nl)
Because they control cell shape and movement, these structures are a major component of the structural elements called the cytoskeleton, which participates in the movement of entire cells. (pediagenosis.com)
The cytoskeleton provides mechanical support that allows cells to conduct essential functions like cell division and movement. (aatbio.com)
The cytoskeleton has several critical functions, including determining cell shape, participating in cell division, and allowing cells to move. (medlineplus.gov)
1996). This paper shows that macrophage-like cells align their cytoskeleton along grooves 44 nm in depth. (cdc.gov)
Fibers2
These fibers have a diameter of ca. 5-9 nm and form the thinnest of all cytoskeleton fibers. (ptglab.com)
The cytoskeleton is a network of long fibers that make up the cell's structural framework. (medlineplus.gov)
Regulation1
The Host Cytoskeleton Functions as a Pleiotropic Scaffold: Orchestrating Regulation of the Viral Life Cycle and Mediating Host Antiviral Innate Immune Responses. (bvsalud.org)
Muscle contraction3
A large-scale example of an action performed by the cytoskeleton is muscle contraction. (wikipedia.org)
A main component in the cytoskeleton that helps show the true function of this muscle contraction is the microfilament. (wikipedia.org)
abstract = "Dynamic remodeling of the actin cytoskeleton occurs during agonist-induced smooth muscle contraction. (manchester.ac.uk)
Modulates1
L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. (ox.ac.uk)
Cell17
The structure, function and dynamic behavior of the cytoskeleton can be very different, depending on organism and cell type. (wikipedia.org)
The cytoskeleton provides the cell with structure and shape, and by excluding macromolecules from some of the cytosol, it adds to the level of macromolecular crowding in this compartment. (wikipedia.org)
The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. (cshlpress.com)
Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
The cytoskeleton is a three-dimensional network supporting and stabilizing the cell. (ptglab.com)
Many dynamic cellular processes cooperate with the cytoskeleton, such as cell motion, cell division, intracellular transport, and cell signaling. (ptglab.com)
Erin Goley investigates how the microbial cytoskeleton controls cell growth and division. (rupress.org)
The actin cytoskeleton is essential for many fundamental biological processes, but tools for directly manipulating actin dynamics are limited to cell-permeable drugs that preclude single-cell perturbations. (uu.nl)
The cytoskeleton serves a variety of purposes: provides rigidity and shape to the cell, facilitates cellular movement, anchors the nucleus and other organelles in place, moves vesicles through the cell, and pulls replicated chromosomes to the poles of a dividing cell. (cloudaccess.net)
The Actin Cytoskeleton Kegg reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (diastrip.com)
The cytoskeleton also offers the cell the ability to resist deformation from extrinsic forces and aid in the transport of intracellular cargo. (aatbio.com)
The cytoskeleton is made up of three main components, tubulin, actin , and intermediate filaments, that each work to support the shape of the cell and have specifically associated morphologies and functions. (aatbio.com)
The cytoskeleton is often one of the first components to be hijacked as it provides a convenient transport system for viruses to enter the cell and reach the site of replication. (bvsalud.org)
The host cytoskeleton has complex interactions with viruses during the viral life cycle , as well as cell -to- cell transmission once the life cycle is completed. (bvsalud.org)
The cytoskeleton provides a flexible framework for the cell and is involved in mediating numerous cellular functions, from cell shape and structure to programmed cell death. (cdc.gov)
Cell's1
They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. (ptglab.com)
Cellular2
This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. (cshlpress.com)
Both internal and external stimuli can act with and alongside the cytoskeleton to affect local mechanical properties and cellular behavior. (aatbio.com)
Eukaryotes1
Initially, it was thought that the cytoskeleton was exclusive to eukaryotes but in 1992 it was discovered to be present in prokaryotes as well. (wikipedia.org)
Inhibition1
The cytoskeleton also influences binding or inhibition to phospholipids, membrane trafficking, ion transport, and spatial localization of signaling. (aatbio.com)
Functions1
A multitude of functions can be performed by the cytoskeleton. (wikipedia.org)
Antibodies1
Antibodies were raised against a cytoskeleton-associated, nonphosphorylated, 230,000-dalton bovine lens polypeptide (designated p230), and rendered monospecific by using a novel immunoaffinity technique. (rupress.org)
Phosphorylation3
We have investigated the role of the actin cytoskeleton in noradrenaline (NA)-induced and endothelin (ET)-induced activation of the calcium-dependent nonreceptor tyrosine kinase PYK2 and subsequent phosphorylation of paxillin in rat small mesenteric arteries. (manchester.ac.uk)
NA and ET induced a rapid and prolonged activation of PYK2, as shown by increased phosphorylation at Y402 and Y881, and a concomitant association of the kinase with a Triton X-100 insoluble membrane (cytoskeleton) compartment. (manchester.ac.uk)
Here we show that phosphorylation of the human L1-CD at S1152, Y1176, S1181, and S1248 renders L1 sensitive to ethanol by promoting L1 coupling with ankyrin-G and the spectrin-actin cytoskeleton. (ox.ac.uk)
Organelles1
When the cytoskeleton was first introduced, it was thought to be an uninteresting gel-like substance that helped organelles stay in place. (wikipedia.org)
Products1
To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Cytoskeleton Inc. Other Actin products are available in stock. (diastrip.com)
Diseases1
Research into neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS) indicate that the cytoskeleton is affected in these diseases. (wikipedia.org)
Dynamics1
In this review, we will focus on how comprehensive and adaptable modeling allows investigators to explain experimental observations and develop testable hypotheses on the intracellular dynamics of the actin cytoskeleton. (nih.gov)