Cytoplasm neoplasm proteins. Medical search. Frequent questions

The p53 (phospho-)protein (p53), 53 kDa, is expressed in the nuclei of all normal cells, but usually not immunohistochemically detectable due to a very short half-life (10-20 min. (nordiqc.org)
In such cases the protein may be immunohistochemically stainable not only in the nuclei but also in the cytoplasm. (nordiqc.org)
All tumors were composed of a proliferation of bland intradermal fibroblastic/myofibroblastic cells with indistinct palely eosinophilic cytoplasm and tapering nuclei, with no significant cytologic atypia or pleomorphism, arranged in short-intersecting fascicles and entrapping appendages. (lww.com)
Tumors showed a multinodular growth pattern, nested architecture separated by a delicate, arborizing vascular network, monotonous round to ovoid nuclei, and clear cytoplasm. (johnshopkins.edu)
Neoplastic cells were typically characterized by irregularly shaped nuclei with vesicular chromatin and small nucleoli not visible with a 10x objective, and cytoplasm that ranged from clear to densely granular and eosinophilic. (elsevierpure.com)
The plasma cells were large with eccentrically placed nuclei and basophilic cytoplasm. (microscopic-haematology.com)
In addition,the western blot was used to detect the protein expression of NF-κB signaling pathway associated protein NF-κB p65 in cytoplasm and nuclei. (cnki.net)
Squamous cells with clear cytoplasm, dense dark nuclei and occasionally bi-nuclei are called koilocytic cells, which indicate an infection of the cells by HPV. (illnessee.com)

Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
Lysyl oxidase?like 2 (LOXL2), which is involved in invasive growth and metastasis of malignant neoplasms, has recently been reported to serve a key role in hepatic and pulmonary fibrosis. (omicsdi.org)

It can be a benign tumor such as thyroid adenoma, or it can be a malignant neoplasm (thyroid cancer), such as papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
citation needed] Thyroid neoplasm might be classified as benign or malignant. (wikipedia.org)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
The concern with a breast schwannoma is that medics make a correct differential diagnosis because they can resemble a malignant neoplasm (breast cancer) mammographically. (breast-cancer.ca)
A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)

It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
Neoplastic cells were positive for S-100 protein and epithelial membrane antigen, but negative for carcinoembryonic antigen. (biomedcentral.com)
However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. (omicsdi.org)
The protein expression of transcription factor Snail and EMT( epithelial to mesenchymal transition) molecule markers E-cadherin,N-cadherin,and Vinmentin were also detected. (cnki.net)
In addition,overexpression of ECRG4 could up-regulate the expression of E-cadherin protein of EMT epithelial marker and down-regulate the expression of Vimentin and N-cadherin protein of Snail and EMT interstitial markers. (cnki.net)
It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
Because of this, one should be comfortable using immunohistochemistry or other methods with the diagnosis of these lesions, and to help exclude epithelial or melanocytic neoplasms ( Table 11.1 ). (basicmedicalkey.com)
Immunohistochemistry for epithelial markers, such as cytokeratin can highlight a papilloma, rather than a neuroma, since the latter is negative for cytokeratin but is positive for S100 protein. (illnessee.com)

Neoplastic cells showed a range of sebaceous differentiation with finely vacuolated rather than clear cytoplasm. (biomedcentral.com)

The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
Tumors were commonly positive for S100 protein and CD56. (johnshopkins.edu)

Ultrastructurally, all of the six neoplasms examined showed features consistent with conventional-type (clear cell) renal carcinoma, although two demonstrated distinctive intracisternal microtubules. (elsevierpure.com)
The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma with sebaceous differentiation, and salivary gland neoplasms. (biomedcentral.com)
Sebaceous carcinoma (SC) is a rare neoplasm. (biomedcentral.com)
It seems that these intraoral sebaceous glands can rarely give rise to a variety of sebaceous neoplasms, such as sebaceous carcinoma [ 7 ]. (biomedcentral.com)
To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
External ear canal papillomas should be distinguished from other skin lesions including an irritated seborrheic keratosis , carcinoma in situ and invasive SCC , cholesteatoma , skin appendage, and/or other soft tissue neoplasms. (illnessee.com)

Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)
Histological sections revealed presence of mucosal fragments with atrophic squamous stratified epithelium, and fibrous connective tissue composed of cells with granular and eosinophilic cytoplasm. (bvsalud.org)

The cytoplasmic and often nuclear expression of S100 protein is present in nearly all tumor cells, and vimentin typically stains tumor cell cytoplasm adjacent to vessel walls. (wikipedia.org)
No case stained positively for desmin or S100 protein. (lww.com)

These cells have proteins that make up the characteristics of the tumor. (wikipedia.org)
These proteins arise from blood vessels, nerve cells and muscle cells. (wikipedia.org)
The cells of this tumor usually show a columnar to cuboidal cytoplasm with a well-defined cytoplasmic membrane. (wikipedia.org)
Hairy Cell Leukemia (HCL) is is an uncommon lymphoid neoplasm characterized by the accumulation of small mature B cell lymphoid cells with abundant cytoplasm and "hairy" projections within the peripheral blood, bone marrow, and splenic red pulp. (lls.org)
BAFF is a protein which can bind to this receptor and helps the survival of mature B cells. (lls.org)
Normal (wild type - WT) p53 is accumulated in damages cells, e.g., in virus infections, where the protein is bound (e.g., to protein E6 of human papilloma virus) and prevented from break down. (nordiqc.org)
The CRM1 inhibitor KPT-330 accumulated nuclear TRP53 and NFKB1A (also known as IκBα), which is thought to capture TRP53 in the cytoplasm, and induced apoptosis in the hematopoietic cells expressing SEPT9-ABL1. (elsevierpure.com)
Laminin 5 β3 and γ2 chains were expressed in the cytoplasm of tumor cells. (elsevierpure.com)
Furthermore, strong expressions of these two proteins were observed in cancer cells invading in a scattered manner. (elsevierpure.com)
They prevent the synthesis of a virus's proteins in infected cells and help block the virus from reproducing (replicating itself). (clicksold.com)
Interferons are species-specific proteins that induce antiviral and antiproliferative responses in animal cells. (clicksold.com)
Interferons block viral reproduction in healthy cells through the production of antiviral proteins. (clicksold.com)
Here, it is determined that in normal prostate cells, histone deacetylase 6 (HDAC6), the known regulator of androgen receptor (AR) signaling, localizes in the cytoplasm and nucleus, while its kinase, glycogen synthase kinase b (GSK3b), primarily resides in the Golgi. (nebraska.edu)
Schwannoma is a rare and benign neoplasm which develops out of 'Schwann' cells or nerve sheath cells. (breast-cancer.ca)
Analysis of a breast schwannoma will typically show several clusters of elongated 'spindle cells', indicative of a neoplasm of mesenchymal origin, in a palisading pattern. (breast-cancer.ca)
These spindle-shaped cells may have irregular contours with curved cores and the background cytoplasm might be slightly colored. (breast-cancer.ca)
Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK?2 human proximal tubular cells. (omicsdi.org)
18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
When the number of plasma cells in the peripheral blood exceeds 2 x 10 9 L the neoplasm is referred to as plasma cell leukaemia. (microscopic-haematology.com)
Results: The mRNA and protein expression level of ECRG4 increased significantly after overexpression of ECRG4 in Hep-2 cells. (cnki.net)
Antibody -- Any of the protein molecules produced by specialized immune system cells (B cells) that can recognize and bind to a particular foreign antigen. (nih.gov)
Cell-free system -- A mixture of cytoplasmic and/or nuclear components from cells used for in vitro protein synthesis, transcription, DNA replication, or other purposes. (nih.gov)

Redistribution of GSK3b to the cytoplasm results in phosphorylation of HDAC6 and its retention in the cytoplasm, which, in turn, stimulates deacetylation of HSP90, AR import into the nucleus, and secretion of prostate-specific antigen (PSA). (nebraska.edu)

Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)

citation needed] Thyroid adenoma is a benign neoplasm of the thyroid. (wikipedia.org)
it is entirely benign and should not be confused with dermatofibrosarcoma protuberans or other neoplasms such as dermatomyofibroma. (lww.com)

Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

Progression of prostate cancer is accompanied by Golgi scattering, translocation of GSK3b from the Golgi to the cytoplasm, and the cytoplasmic shift in HDAC6 localization. (nebraska.edu)
Stathmin1 ( STMN1) is a cytoplasmic phosphoprotein known as oncoprotein 18 involved in the regulation of the cell cycle as the protein that destabilizes microtubules. (biomedcentral.com)
15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)

Amino acids link together by peptide bonds to form proteins, or function as chemical messengers and as intermediates in metabolism. (nih.gov)

FnipL/Fnip2 and Flcn were located together in the cytoplasm in a reticular pattern, although solely expressed Flcn was found mainly in the nucleus. (nih.gov)
Estrogen binding to this protein, whether first in the cytoplasm followed by translocation of this complex to the nucleus, or initially in the nucleus where it interacts with the chromatin of the target cell, causes an immediate raise in RNA production (Jensen, 1965. (llu.edu)
They are distributed in both the cytoplasm and the nucleus. (nih.gov)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
At the same time,overexpression of ECRG4 could down-regulate the protein expression of NF-κB p65 in nucleus and up-regulate the protein expression of NF-κB p65 in cytoplasm. (cnki.net)

Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)

The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm. (nih.gov)

Substances that increase the risk of NEOPLASMS in humans or animals. (lookformedical.com)
Enzyme -- A protein molecule that catalyzes chemical reactions of other substances without itself being destroyed or altered by the reactions. (nih.gov)

Protein expression analysis revealed aggregation of the mutated, truncated protein in the perinuclear region, whereas the normal protein was distributed diffusely in the cytoplasm with a homogenous or fine granular pattern. (nih.gov)

This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
These gene methods are typically organized as fol lows terminase portal protease scaffold main head shell protein click here head tail joining proteins tail shaft protein tape measure protein tail tip base plate proteins tail fiber. (jak1inhibitor.com)
ORF33 is the probably candidate to get a portal protein determined by the observation that the portal protein is usually situated straight away downstream with the terminase gene. (jak1inhibitor.com)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
What pathways are this gene/protein implicaed in? (cancer-genetics.org)
The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. (cancerindex.org)
The CALR gene provides instructions for making a multi-functional protein called calreticulin. (medlineplus.gov)

All interferons act as secreted ligands of specific cell surface receptors, eliciting the transcription of hundreds of interferon-stimulated genes whose protein products hav … How Does Interferon Therapy Work. (clicksold.com)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Previous studies have indicated that KIN17 is involved in global genome repair, DNA replication, transcription and regulation of the cell cycle as part of a multi-protein complex. (spandidos-publications.com)

The most distinctive immunohistochemical feature of these neoplasms was moderate to intense nuclear labeling for TFE3 protein. (elsevierpure.com)
Rabbit polyclonal to Parp.Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-bindingzinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure,and apoptosis. (2011globalhealth.org)

Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)

Non-hyperfunctioning adenomas with papillary hyperplasia usually show a more predominantly papillary pattern without vacuolated cytoplasm and scalloping colloid (b). (wikipedia.org)

Chymotrypsin -- An enzyme that catalyses the hydrolysis (the breakdown) of proteins into peptides or amino acids in the small intestine. (nih.gov)
These genetic changes lead to production of an altered calreticulin protein with a different sequence of building blocks (amino acids) at one end. (medlineplus.gov)

Stat1 mRNA and STAT1 protein expression were decreased before disease onset in Tn, even in their thymic precursors, whereas Stat3/STAT3 expression increased upon disease establishment. (bvsalud.org)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
In addition, the mRNA and protein expression levels of LOXL2 were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice. (omicsdi.org)
Then the expression of ECRG4 mRNA and protein by Real-time PCR and Western blot were detected. (cnki.net)

We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

The estrogen mediate their cellular activities through a specific protein known as an estrogen receptor. (llu.edu)
Induction of a neoplasm in response to estrogen may involve this pathway of action. (llu.edu)

DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)

Multiple alternatively spliced transcript variants have been found for this protein. (cancerindex.org)
Multiple alternatively spliced variants, encoding the same protein, have been identified. (cancerindex.org)

This RNA production eventually results in the production of cellular proteins required for cell proliferation. (llu.edu)
Plasma cell myeloma is a neoplasm occurring more commonly in males. (microscopic-haematology.com)
KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
This protein is found in several parts of the cell, including inside a structure called the endoplasmic reticulum (ER), in the fluid-filled space inside the cell (the cytoplasm), and at the outer surface of the cell. (medlineplus.gov)

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Comparison of head morphogenesis and structural proteins Genome sequencing of tailed phages and prophages has revealed a prevalent genetic organization on the genes encoding head morphogenesis and head structural proteins. (jak1inhibitor.com)
This indicates that these E. ictaluri phages, similarly to most dsDNA viruses, use a DNA packaging motor consisting of two nonstructural proteins encoded by adjacent genes. (jak1inhibitor.com)

The consecutive ORFs 14 to 32 have considerable sequence similarity with phage head morphogenesis and structural proteins, with putative perform in tail assem bly, tail fiber protein, phage host specificity, selleck chemicals minor tail proteins, important tail proteins, significant capsid proteins, structural proteins, as well as a phage head morphogenesis protein. (jak1inhibitor.com)
We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

Regardless of the localization, sebaceous malignancies must be considered aggressive neoplasms with potential for regional and distant metastases. (biomedcentral.com)

β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)

The cytoplasm is basophilic with a perinuclear hof. (microscopic-haematology.com)

Anatomy18

Organisms4

Diseases155

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes22

Disciplines and Occupations2

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Nuclei8

Metastasis2

Malignant10

Epithelial10

Clear cytoplasm1

Tumors2

Carcinoma6

Eosinophilic2

S1002

Cells23

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Pancreatic Neoplasms1

Benign2

Polymerase Chain Re1

Immunohistochemistry1

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Nucleus5

Mucin3

Myeloproliferative1

Substances2

Granular1

Gene10

Transcription4

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Amino acids2

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Melanoma1

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Perinuclear1