Cytokines pre b cell receptors. Medical search. Frequent questions

Previous work in our laboratory has suggested that Toll-like receptors (TLRs) are involved in endometrial epithelial recognition of pathogens and that ligation of endometrial TLRs results in the production of cytokines and chemokines important for both immune and reproductive functions of the endometrium. (duke.edu)
RESULTS: Stimulation of TLR3-expressing cells with the synthetic TLR3 ligand, Poly I:C, resulted in the production of cytokines and chemokines important for endometrial function and regulation. (duke.edu)
Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)
One of the major clinical manifestations of CFTR mutations is neutrophil dominated inflammation 2 , 3 , implying that defective CFTR affects the immune function of airway epithelial cells, in particular the production of nuclear factor (NF)-κB-dependent chemokines. (ersjournals.com)
Increasing evidence suggests that respiratory epithelial cells with dysfunctional CFTR have exaggerated activation of NF-κB/inhibitor of NF-κB complex associated with upregulated expression of chemokines 4 , 5 . (ersjournals.com)
The effects of corticosteroids are predominantly mediated by the inhibition of NF-κB deoxyribonucleic acid (DNA)-binding activity, which controls genes encoding inflammatory cytokines, chemokines and adhesion molecules in respiratory epithelial cells 10 - 13 . (ersjournals.com)

It is an accessory chain essential for the active interleukin 10 receptor complex. (creativebiomart.net)

Mechanistic analyses revealed that Res activated the oxidant/antioxidant-activated receptor Nrf2 to induce cytoprotective genes. (cdc.gov)
The 2E8 cells had rearranged and expressed κ light-chain genes but displayed them on the surface along with surrogate light chains and μ heavy chains. (elsevierpure.com)
This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. (creativebiomart.net)
The secondary objectives of the study are to describe the expression of pro-inflammatory genes in Peripheral Blood Mononuclear Cells (PBMCs) of sporadic ALS patients, to assess the ability of tocilizumab to reduce the expression of pro-inflammatory genes in PBMCs and pro-inflammatory cytokines in the cerebrospinal fluid (CSF) of patients with sporadic ALS and to assess the CSF penetration of tocilizumab. (neals.org)

Humanigen believes that GM-CSF neutralization with lenzilumab also has the potential to reduce the hyper-inflammatory cascade known as cytokine release syndrome common to chimeric antigen receptor T-cell (CAR-T) therapy and acute Graft versus Host Disease (aGvHD). (businesswire.com)
The work to be presented shows that T cells carrying a NY-ESO-1-specific T cell receptor (TCR) combined with a chimeric PD1-41BB switch receptor, have significantly increased TCR-T cell proliferation, functionality and anti-tumor activity, compared to T cells expressing the TCR alone. (yahoo.com)
Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). (nih.gov)
It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). (nih.gov)
Two children with relapsed and refractory pre-B-cell ALL received infusions of T cells transduced with anti-CD19 antibody and a T-cell signaling molecule (CTL019 chimeric antigen receptor T cells), at a dose of 1.4×10(6) to 1.2×10(7) CTL019 cells per kilogram of body weight. (nih.gov)
In addition, the chimeric antigen receptor T cells were observed in the cerebrospinal fluid (CSF), where they persisted at high levels for at least 6 months. (nih.gov)
cytokine blockade with etanercept and tocilizumab was effective in reversing the syndrome and did not prevent expansion of chimeric antigen receptor T cells or reduce antileukemic efficacy. (nih.gov)
Chimeric antigen receptor-modified T cells are capable of killing even aggressive, treatment-refractory acute leukemia cells in vivo. (nih.gov)
CAR (chimeric antigen receptor) T-cell therapy is the latest wave in hematology and has been validated in various forms of leukemia and lymphoma . (medscape.com)

So far, there is no sufficient evidence that in vivo, EpoR signaling can induce erythroid progenitors to undergo cell division, or whether Epo levels can modulate the cell cycle. (wikipedia.org)
However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
Our studies revealed that nSP induced high ROS and pro-inflammatory cytokine production, and these cellular responses may induce excess osteoclast differentiation. (springer.com)
They conclude that IRE1 has a dual role in the UPR, as it can splice XBP1 mRNA for survival or degrade pre-miR-301a to induce apoptosis.The authors use HoloMonitor, a label-free and non-invasive live cell imaging technique, to measure the cell viability and morphology of human bronchial epithelial cells under different conditions of ER stress and miRNA modulation. (phiab.com)
Depending on the cellular context, TNF can induce diverse effects such as necrosis, apoptosis, differentiation, angiogenesis, cell migration and immune cell activation. (eurekaselect.com)
cells and potentially induce severe adverse Rabbit Polyclonal to OR2A5/2A14 effects. (campaignfornonviolentschools.org)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)

IL-7 Human Recombinant produced in HEK cells is a glycosylated monomer, having a molecular weight range of 19-30kDa due to glycosylation. (prospecbio.com)
The precursor protein (pre-IL-33) was cleaved by caspase-1 into a mature 18-kDa protein (IL-33) in in vitro experiments using a recombinant protein [ 2 ]. (hindawi.com)
THP-1 cells were cultured in vitro and treated with recombinant human IL-8 and CXCR2 surface expression was analyzed. (bvsalud.org)

It is known that EpoR can activate mitogenic signaling pathways and can lead to cell proliferation in erythroleukemic cell lines in vitro, various non-erythroid cells, and cancer cells. (wikipedia.org)
We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. (creativebiomart.net)
Bruton's tyrosine kinase (BTK) is a part of the cytokine signalling pathways involved in malignancies and autoimmune disorders. (cytokinesignalling.com)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
Tumor-induced glaucoma may be produced by obstruction of outflow pathways by pigment cells (pigment dispersion syndrome), melanin-laden macrophages (melanomalytic glaucoma), or tumor cells. (medscape.com)

At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis. (wikipedia.org)
Primary role of EpoR is to promote proliferation of erythroid progenitor cells and rescue erythroid progenitors from cell death. (wikipedia.org)
Induction of proliferation by the EpoR is likely cell type-dependent. (wikipedia.org)
The activity was determined by the dose dependent stimulation of the proliferation of murine 2E8 cells and is typically 0.3ng/ml corresponding to a specific activity of 3,333,334units/mg. (prospecbio.com)
Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
Indeed, tumours promote a constant influx of myelomonocytic cells that play as key orchestrators of cancer-related inflammation, supporting proliferation and survival of malignant cells, subversion of adaptive immune response, angiogenesis, stroma remodeling and metastasis formation. (eurekaselect.com)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)

Subsequent differentiation stages (proerythroblast to orthochromatic erythroblast) involve a decrease in cell size and eventual expulsion of the nucleus, and are likely dependent upon EpoR signaling only for their survival. (wikipedia.org)
Together, these data suggest that EpoR in erythroid differentiation may function primarily as a survival factor, while its effect on the cell cycle (for example, rate of division and corresponding changes in the levels of cyclins and Cdk inhibitors) in vivo awaits further work. (wikipedia.org)
Collectively, the results suggested that nanosilica exerts no effect on RANKL-induced osteoclast differentiation of RAW264.7 cells, although a detailed mechanistic examination of the nSP70-mediated cytotoxic effect is needed. (springer.com)
Five stromal-cell-dependent lymphocyte clones are described that correspond to late pre-B or early B-cell stages of differentiation. (elsevierpure.com)
They are useful for determining the molecular requirements for pre-B replication, for studying the stromal cells that supply those factors, and for delineating the final sequence of differentiation events as newly formed lymphocytes prepare to exit the bone marrow. (elsevierpure.com)
Ly-6 antigens were inducible on 2E8 and 1A9 cells, but the lymphocytes were otherwise arrested in differentiation. (elsevierpure.com)
The normal replication and differentiation of pre-B cells is probably regulated by complex interactions with multiple cytokines and matrix components of the marrow microenvironment. (elsevierpure.com)
They also can inspire angiogenesis by direct differentiation, cell-to-cell interaction, or paracrine effects. (biomedcentral.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
They can be distinguished by antigen-specific surface receptors and other cell surface molecules called clusters of differentiation (CDs), whose presence or absence define some subsets. (msdmanuals.com)

Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)
Our results revealed that nSP exerted higher cytotoxicity in macrophage cells compared with submicron-sized silica particles. (springer.com)

In CAR-T, lenzilumab successfully achieved the pre-specified primary endpoint at the recommended dose in a Phase 1b study with Yescarta® in which the overall response rate was 100% and no patient experienced severe cytokine release syndrome or severe neurotoxicity. (businesswire.com)
Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
Mutations in IL-7Rα observed in patients with severe combined immunodeficiency (SCID) also underlies the importance of IL-7 signaling in T-cell development in humans. (biolegend.com)
Administration of IL-33 to mice induces production of Th2 cytokines and severe pathological changes in mucosal organs [ 2 ]. (hindawi.com)
Toll-like diseases and causes severe and long-lasting health problems in the case of chronifi- receptor. (cdc.gov)
It is the prototype of the primary immunodeficiency diseases and is caused by numerous molecular defects that lead to severe compromise in the number and function of T cells, B cells, and occasionally natural killer (NK) cells. (medscape.com)
We determined VEGF and endostatin levels in the sera of 20 healthy, non-pregnant women and 64 pregnant women: 20 healthy, 20 with mild pre-eclampsia and 24 with severe pre-eclampsia. (who.int)
However, serum levels were significantly higher with mild or severe pre-eclampsia compared with normal pregnancies and significantly higher with severe rather than with mild pre-eclampsia. (who.int)
VEGF and endostatin could be used to differentiate between pre-eclamptic and normal pregnancies and to discriminate mild pre-eclampsia from severe pre-eclampsia. (who.int)
It is thought that vascular insuf- pre-eclampsia, and 24 patients with severe ficiencies during placentation contribute pre-eclampsia). (who.int)

MDG1015 contains our high-avidity, NY-ESO-1 TCR combined with our proprietary PD1-41BB co-stimulatory switch receptor that blocks the PD1/PD-L1 inhibitory axis while simultaneously activating the T cell through the well described -41BB pathway further enhancing the activity and persistence of the TCR-T in the hostile tumor microenvironment (TME). (yahoo.com)
It is safe to assume that the phenotype and functions of non-tumor cells such as endothelial cells, fibroblasts or macrophages residing in the microenvironment of primary tumors differ from those of similar non-tumor cells residing in metastatic microenvironments. (eurekaselect.com)
This short review summarizes state of the art with respect to interactions between the brain microenvironment with brain-metastasizing tumor cells. (eurekaselect.com)
An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
The tumor microenvironment of malignant gliomas is usually immunosuppressive,22 and this has been shown after CAR T?cell infusion.10 Immune checkpoint receptors (e.g. (campaignfornonviolentschools.org)
Here, we investigate the function of MM-derived MIF in the MM microenvironment by examining its effects on bone marrow stromal cells (BMSC). (biomedcentral.com)
To investigate the effects of MIF secretion by MM on its microenvironment, we used cytokine arrays to establish if cytokine changes occur when MM cells are cultured with primary BMSC. (biomedcentral.com)

4 Elevation of CRP in obesity results from infiltration of the expanded adipose tissue by macrophages that release inflammatory signals and cytokines such as interleukin-6, the main stimulus for CRP production. (nature.com)
Absence of ILC2s leads to utero-placental abnormalities, including poor vascular remodelling, increased Il1b and decreased Il4, Il5 , and Il13 gene expression, and reduced alternative activation of dendritic cells (DCs) and macrophages. (elifesciences.org)
Furthermore, it is possible that nSP circulating in the blood can reach the alveolar bone, which is presented in the submucosal layer, as well as various cells such as macrophages and osteoblasts. (springer.com)
Innate immune memory allows macrophages to adequately respond to pathogens to which they have been pre-exposed. (bvsalud.org)
Tissue infiltration by activated innate immune cells, including monocytes, macrophages, and neutrophils, if untreated, leads to rapidly progressive organ injury, that can involve many organ systems. (nature.com)
FP induces apoptosis of eosinophils 18 and also reduces the production of several cytokines such as IL-1β, IL-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) by alveolar macrophages 19 and lymphocytes 20 , 21 . (ersjournals.com)
Monocytes migrate into tissues, where over about 8 hours, they develop into macrophages under the influence of macrophage colony-stimulating factor (M-CSF), secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Macrophages are activated by cytokines (eg, IFN-gamma, interleukin (IL)-4, IL-13) and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)
Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)

Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. (prospecbio.com)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
IL-33 can promote survival, adhesion, and cytokine production in human mast cells [ 11 ], but the mechanism behind its involvement in inflammatory conditions remains unclear. (hindawi.com)
However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
Epithelioid cells are associated with more aggressive behavior and carry a poorer prognosis for the patient's survival. (medscape.com)
SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)

Pure T-cell deficiencies are caused by defects in either a CD3 subunit (such as CD3 δ, CD3 ζ, CD3 ε ) or in CD45 tyrosine phosphatase, key proteins involved in pre-TCR and/or TCR signaling at the positive selection stage. (medscape.com)
Both heart cells and lung cells are covered with surface proteins known as angiotensin-converting enzyme 2 (ACE2) - these molecules serve as "doorways" for the virus to enter cells. (sott.net)
When tissues in the body are damaged - either by an invading virus such as SARS-CoV-2 or by other means, the body's natural healing response involves releasing inflammatory molecules, such as small proteins called cytokines , into the bloodstream. (sott.net)
It's really hard to tease out whether having more ACE2 is helpful or harmful, as these proteins are how the virus enters the cells, but also known to protect the cells against injury , Michos said. (sott.net)

B and T cells, type 2 dendritic cells, and natural killer (NK) cells share a common ancestor: the common lymphoid progenitor (CLP). (medscape.com)
Secondary B-cell lymphopoiesis is an antigen-dependent process that occurs in the germinal centers of peripheral lymphoid organs with specific antibody production. (medscape.com)
Group 2 innate lymphoid cells (ILC2s) adapt to tissue physiology and contribute to immunity, inflammatory pathology and metabolism. (elifesciences.org)
This important study describes the protective role of group 2 innate lymphoid cells (ILC2s) in tissue physiology and contributes to immunity, inflammatory pathology, and metabolism in maintaining homeostasis during pregnancy. (elifesciences.org)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)

These may include a steroid, a histamine-1 (H1) receptor antagonist (such as diphenhydramine/Benadryl), and an antipyretic (such as acetaminophen/Tylenol). (oncolink.org)
For hormonal studies, cells were pre-treated with ethanol vehicle, 10(-8) M E2, and/or 10(-7) M P. For antagonist assays, cells were treated with the ER antagonist, ICI 182, 780, or the PR antagonist, RU486, for two hours prior to treatment with hormones. (duke.edu)
Following hormone or hormone/antagonist pre-treatment, cells were stimulated with vehicle, the synthetic TLR3 ligand, polyinosinic-polycytidylic acid (Poly I:C), a negative dsDNA control, or a positive control. (duke.edu)
The effects of E2 were not observed on cells which did not express ERalpha or in cells pre-treated with the ER antagonist, ICI 182, 780. (duke.edu)
Study 2: Ob-CT and Ob-Pre mice were treated with GLP-2 antagonist or saline. (bmj.com)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)

CFU-e progenitors enter the cell cycle at the time of GATA-1 induction and PU.1 suppression in a developmental manner rather than due to EpoR signaling. (wikipedia.org)
The study demonstrated that Res prevents PQ-induced ROS production, inflammation, and fibrogenic reactions in cultured cells by activating Nrf2 signaling. (cdc.gov)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)

Induction of innate immunity was investigated via specific cytokine markers. (gsk.com)
Our study revealed the following findings: (1) While pre-stimulation with the Toll-like receptor 4 ligand LPS inhibits the induction of IRG-1, TNF-α and IL-6 expression, pre-stimulation with TLR 1/2 ligands only affects cytokine production but not IRG-1 expression upon subsequent TLR4 engagement. (bvsalud.org)
Pre-treatment of BMSC with the MIF inhibitor ISO-1 significantly reduced the MIF induction of IL-6/IL-8 by BMSC (Fig. 1h ). (biomedcentral.com)

In a protective feedback mechanism, these cytokines suppress IL-1β-producing DCs, in line with a protective role of uILC2s against endotoxin-induced abortion. (elifesciences.org)
However, treatment with E2 did suppress cytokine and chemokine production resulting from TLR3 stimulation with Poly I:C, suggesting that E2 modulates TLR3 function. (duke.edu)
Pre-clinical evidence suggests that MDSC suppress anti-tumor immune responses. (iospress.com)

10,000 parasites/µL) was associated mononuclear cells exposed to malaria antigens in vitro with increased risk for perinatal MTCT (ARR 2.0), com- pared to low-density malaria. (cdc.gov)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) must be processed into peptides and complexed with surface class II MHC molecules on professional APCs (which specialize in presenting antigens to T cells) to be recognized by CD4 helper T (Th) cells. (msdmanuals.com)

Lenzilumab is a proprietary Humaneered® first-in-class monoclonal antibody that has been proven to neutralize GM-CSF, a cytokine of critical importance in the hyperinflammatory cascade, sometimes referred to as cytokine release syndrome, or cytokine storm, associated with COVID-19 and other indications. (businesswire.com)
The cytokine-release syndrome and B-cell aplasia developed in both patients. (nih.gov)
Toxicity, including cytokine release syndrome, does remain an issue but is quite manageable in most patients. (medscape.com)

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. (wikipedia.org)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
The protein encoded by this gene belongs to the cytokine receptor family. (creativebiomart.net)
Checkpoint inhibitors also can be directly delivered by the adoptively transferred CAR T?cells via gene modification, which aims to reduce the adverse effects that can be caused by systemic delivery of checkpoint inhibitors.32, 34 Chitinase-IN-1 This is an additional strategy we will utilize to further liberate the function of IL-13R2 CAR T?cells in immunotherapy of malignant gliomas. (campaignfornonviolentschools.org)
Cystic fibrosis (CF) is a lethal inherited disorder caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) in airway epithelial cells 1 . (ersjournals.com)

To what extent different pattern recognition receptors, cytokines and resolution signals influence innate immune memory needs further elucidation. (bvsalud.org)
Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)

Trophoblast cells (fetal) and endothelial cells (maternal) express sFlt1. (frontiersin.org)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)

Tumor Necrosis Factor (TNF) is a pleiotropic cytokine with a central role in immune homeostasis, inflammation and host defence. (eurekaselect.com)
Inhaled fluticasone propionate (FP) is widely used to reduce pulmonary inflammation in chronic obstructive pulmonary disease, but the potential effects of FP on airway epithelial cells from patients with cystic fibrosis (CF) are unknown. (ersjournals.com)

These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
The generation of IL-7-deficient and IL-7Rα-deficient mice and monoclonal antibody blocking experiments confirmed the requirement of IL-7 for B-cell development in mice. (biolegend.com)
Age-related loss of bone marrow pre-B- and immature B-lymphocytes in the autoimmune-prone flaky skin mutant mice. (southernbiotech.com)
4. Gillan V, Lawrence RA, Devaney E. B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. (southernbiotech.com)
Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice. (southernbiotech.com)
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice. (southernbiotech.com)
8. Løvås T, Bruusgaard JC, Øynebråten I, Gundersen K, Bogen B. DNA vaccines: MHC II-targeted vaccine protein produced by transfected muscle fibres induces a local inflammatory cell infiltrate in mice. (southernbiotech.com)
In mice, MDSC can be identified by species-specific cell surface markers (CD11b + Gr-1 + ) and may be further classified as monocytic (M-MDSC, Ly-6C hi ) or granulocytic (G-MDSC, Ly-6G + ) based on additional cell surface markers [ 6 ]. (iospress.com)
ob/ob mice (Ob-CT) were treated with either prebiotic (Ob-Pre) or non-prebiotic carbohydrates as control (Ob-Cell). (bmj.com)
Prebiotic-treated mice exhibited a lower plasma lipopolysaccharide (LPS) and cytokines, and a decreased hepatic expression of inflammatory and oxidative stress markers. (bmj.com)
1 × 10 6 MM.1S-luc cells (ShE control n = 10, and ShMIF n = 7) were injected via the tail vein of 6-8-week-old NSG mice. (biomedcentral.com)

Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e. (wikipedia.org)
Interestingly, the expression of two IκB kinases (IKK)-α/β, the degradation of cytosolic IκB-β inhibitor and the NF-κB deoxyribonucleic acid binding activity were markedly reduced after FP treatment in both CF and non-CF bronchial epithelial cells. (ersjournals.com)
It was shown by the authors that fluticasone propionate exerts an anti-inflammatory effect by blocking a signal transduction leading to a reduced level of IκB-α/β kinases in bronchial epithelial cells. (ersjournals.com)

Despite often comprising only a small proportion of tissue resident immune cells, ILCs are present in most tissues and have been shown to orchestrate inflammatory responses to viruses, intracellular bacteria and parasites. (elifesciences.org)

METHODS: Endometrial epithelial cell lines were cultured and examined for the presence of TLR3 and hormone receptors by endpoint RT-PCR. (duke.edu)
Suppression of Poly I:C-induced cytokine and chemokine production by cells treated with 10(-8) M E2, but not cells treated with 10(-7) M P, was observed in endometrial epithelial cell lines expressing TLR3 and estrogen receptor alpha (ERalpha). (duke.edu)

Figure 1 Illustration demonstrating a hypothetical summary of the potential effect of aryl-hydrocarbon receptor activation on multipotent mesenchymal stromal cell function. (wjgnet.com)
MSC: Multipotent mesenchymal stromal cell. (wjgnet.com)
IL-7 was initially described as a stromal derived factor which is capable of inducing the growth of pre-B cells in vitro . (biolegend.com)
The efficiency of lymphocyte growth at limiting dilution varied substantially on different stromal-cell clones and may reflect functional heterogeneity of stromal cells. (elsevierpure.com)
Most lymphocyte clones were similar to uncloned lymphocytes from Whitlock-Witte cultures in that they responded only transiently to interleukin-7 (IL-7) and then died, unless maintained on a stromal-cell clone. (elsevierpure.com)
Tumors derived from this clone were infiltrated by stromal cells and lymphocytes taken from the tumors' retained characteristics of the original clone. (elsevierpure.com)
Cloned lymphocyte lines that are dependent on stromal cells should continue to be important tools for molecular definition of those interactions. (elsevierpure.com)
Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. (biomedcentral.com)
Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. (biomedcentral.com)

Additionally, EpoR has been implicated in suppressing expression of death receptors Fas, Trail and TNFa that negatively affect erythropoiesis. (wikipedia.org)
PQ at 10 uM induced transformation of normal human lung fibroblast WI-38 cells into myofibroblasts, as shown by the de nova synthesis of a-smooth muscle actin, and heightened production of inflammatory cytokines TNFa and IL-6 and growth factor TGFb1. (cdc.gov)

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. (gsk.com)
Adaptive immune responses were assessed based on receptor binding domain specific antibodies and neutralizing antibodies as well as memory B and T cells. (gsk.com)
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells. (southernbiotech.com)
Monoclonal antibodies are created in a lab to attach to targets found on specific types of cancer cells. (oncolink.org)
These antibodies can work in different ways, including stimulating (revving up) the immune system to kill the cell, blocking cell growth or other functions needed for cell growth. (oncolink.org)
In contrast, negative psychological states and limited social interactions have been linked to lower white blood cell activity, reduced numbers of antibodies and increased stress hormone response [ 2 , 4 - 5 ]. (ecancer.org)
For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
B cells' primary function is to develop into plasma cells, which manufacture and secrete antibodies. (msdmanuals.com)

Lupus erythematosus is a heterogeneous connective-tissue disease associated with polyclonal B-cell activation and is believed to result from the interplay of genetic, environmental, and hormonal factors. (medscape.com)

In vitro studies showed that IL-7 induces oocyte maturation and inhibits apoptosis in granulosa cells. (biolegend.com)

In both patients, CTL019 T cells expanded to a level that was more than 1000 times as high as the initial engraftment level, and the cells were identified in bone marrow. (nih.gov)
The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
Eosinophils are required for the maintenance of plasma cells in the bone marrow. (southernbiotech.com)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. (southernbiotech.com)
After that, Kaplan firstly proposes the term "mesenchymal stem cells," which are cells isolated from fully developed bone marrow (BM) that can usually differentiate into several types of mesenchymal origin cells [ 4 ]. (biomedcentral.com)

Recently, an in vitro study on the expression of ΔF508 CFTR (CFTR which contains a deletion of phenylalanine at position 508) in the ovary cells of Chinese hamsters, which do not express CFTR, revealed a seven-fold increase in the activation of NF-κB compared to the wild-type CFTR or the G551D mutant. (ersjournals.com)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

Stereoselectivity and the potential endocrine disrupting activity of di-(2-ethylhexyl)phthalate (DEHP) against human progesterone receptor: a computational perspective. (endometriosi.it)
Binding of DEHP to progesterone receptor (PR) represents a potential mechanism of interference in the reproductive functions. (endometriosi.it)
In this study, the effects of 17beta-estradiol (E2) and progesterone (P) on TLR3 expression and function in endometrial cell lines were investigated. (duke.edu)

The Hu08BBz exhibited a 75% reduction in orthotopic tumor growth using low-dose CAR T?cell infusion. (campaignfornonviolentschools.org)

Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
However, the presence of B cells in these individuals suggests important differences between the role of IL-7 in murine and human lymphocyte development. (biolegend.com)
Bruton's tyrosine kinase, a downstream target of PI3K signalling, has been shown to be crucial in the B lymphocyte and myeloid cell contribution to murine models of arthritis. (cytokinesignalling.com)

Medigene AG (Medigene, FSE: MDG1, Prime Standard), an early stage immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, will present a poster at the American Association for Cancer Research Virtual Annual Meeting (AACR) 2023 being held on April 14-19, 2023. (yahoo.com)
Several glycoproteins have recently been demonstrated to be associated with surface immunoglobulin (Ig) on mature B-lineage cells and plasma-cell tumors. (elsevierpure.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-κB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-κB-dependent interleukin (IL)-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) along with the activation of NF-κB in non-CF and CF human bronchial gland epithelial cells. (ersjournals.com)

In this study, we found that Res at pharmacological doses effectively attenuated PQ-induced cell toxicity and fibrogenic response in human lung cells. (cdc.gov)
PQ dose-dependently caused toxicity in normal human bronchial epithelium BEAS-2B cells including increased cell death, oxidative stress, and loss of mitochondrial inner membrane potential. (cdc.gov)
Nrf2 was required for normal defense against PQ toxicity and fibrogenic reactions as loss of Nrf2 significantly increased PQ toxicity, myofibroblast transformation, and cytokine expression. (cdc.gov)

It is therefore to be expected that the patho-biologic consequences of interactions between tumor cells and the microenvironments of the primary tumor or of the metastatic lesions will also be different. (eurekaselect.com)

In addition, some evidence on macrocytosis in hypoxic stress (when Epo can increase 1000-fold) suggests that mitosis is actually skipped in later erythroid stages, when EpoR expression is low/absent, in order to provide emergency reserve of red blood cells as soon as possible. (wikipedia.org)
EpoR expression can extend as far back as the hematopoietic stem cell compartment. (wikipedia.org)
Inhibition of paraquat-induced oxidative stress, proinflammatory cytokine expression, and fibroblast-tomyofibroblast transformation by resveratrol via the Nrf2 pathway. (cdc.gov)
Thus, expression of authentic light chain need not coincide with termination of surrogate light-chain utilization in newly formed B cells. (elsevierpure.com)
2) Prior TNF-α stimulation does not affect LPS tolerance but rather increases LPS-mediated cytokine expression. (bvsalud.org)
BACKGROUND: CXC-chemokine receptor 2 (CXCR2) expression was found to be down-regulated on circulating monocytes of cancer patients. (bvsalud.org)
They also identify a novel target of miR-301a-3p, a pro-apoptotic UPR factor called GADD45A, and demonstrate that blocking miR-301a-3p binding to GADD45A mRNA increases GADD45A expression and promotes cell death. (phiab.com)
The present authors and previous studies, have previously demonstrated that epithelial expression of interleukin (IL)-8 is excessively elevated in the bronchial epithelial cells of human CF adults 6 . (ersjournals.com)
Out of 29 liver tissue sections examined, 14 had a low level of expression of insulin receptor type 1 by immunohistochemical studies. (who.int)

5. Roger Pertwee (University of Aberdeen) reviewed current knowledge of the two cannabinoid receptors CB1 (found in the brain and some peripheral organs) and CB2 (peripheral only). (druglibrary.net)
Cytokine storms damage organs throughout the body, including the heart and liver , she added. (sott.net)

One unusual lymphocyte clone (2E8) was propagated for more than 1 year in IL-7 alone and was selectively responsive to that cytokine. (elsevierpure.com)
Other naturally occurring fatty acid derivatives also interact with cannabis receptors, and one of these, 2 arachidonylglycerol, may act selectively at CB2 receptors. (druglibrary.net)

NK cells, a component of innate immunity, are variably affected. (medscape.com)

The cytokines cause an inflammatory response in the body. (oncolink.org)

EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. (wikipedia.org)

CLP differentiates into 2 intermediate progenitors, termed early B cells and T/NK/DC trilineage cells. (medscape.com)

Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)

This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. (prospecbio.com)
More than 300 CDs have been identified many of which are absent from lymphocytes but present on other cells of the immune system. (msdmanuals.com)

Given that cell types are significantly distinct, which represents an important factor in stimulation, and that PEMFs can have different effects in terms of frequency and intensity, time of exposure, and waveform, it can be tough to know how to use a device safely and effectively. (equivont.com)
Elevated levels significantly increased risk more than severity of pre-eclampsia. (who.int)

Invading trophoblast cells will encounter maternal complement system (C) in the decidua and in the intervillous space. (frontiersin.org)

a major loss or dysfunction in T cells can cause secondary B-cell deficiency, resulting in a clinical disorder that manifests as a combined B- and T-cell deficiency. (medscape.com)
The strong immune response and protection in pre-clinical testing of this second-generation mRNA backbone are very encouraging and represent an important milestone for its further development. (gsk.com)
Evobrutinib is an oral BTK inhibitor that has demonstrated efficacy in pre-clinical and autoimmune disease models. (cytokinesignalling.com)
provide a review of all the current BTK inhibitors in preclinical and clinical trials for B-cell malignancies and autoimmune disorders, including rheumatoid arthritis. (cytokinesignalling.com)
Associations of MDSC in clinical bladder cancer cohorts are outlined in addition to evaluation of the suggested roles of MDSC in pre-clinical bladder cancer models. (iospress.com)
Based on these results, we are designing a pre-clinical trial to evaluate the security of canine IL-13R2 CAR T?cells in doggie with spontaneous IL-13R2-positive glioma, which will help to Chitinase-IN-1 inform a human clinical trial design for glioblastoma using humanized scFv-based IL-13R2 targeting CAR T?cells. (campaignfornonviolentschools.org)
Therefore, to improve the performance of this promising strategy in the clinical treatment of GBMs, it is necessary to generate a fully humanized, highly specific, scFv-based IL-13R2 CAR T?cell and demonstrate its function both and in clinically relevant pre-clinical models of GBM. (campaignfornonviolentschools.org)
Although clinical trials are often based on numerous pre-clinical animal studies, most of these studies have been performed on rodent small animal models. (campaignfornonviolentschools.org)

The immune cells that participate in this process are stimulated by a substance called interleukin-6 (IL-6) whose effect is blocked by tocilizumab and thus, may slow the death of motor neurons and slow the disease. (neals.org)

Although there is no particular quantitative assay to provide MSCs identification in mixed cells population [ 8 ], the International Society for Cellular Therapy (ISCT) has provided minimum principles to determine MSCs. (biomedcentral.com)

CRP binds to phosphocholine and related molecules on microorganisms and on membranes of apoptotic and necrotic cells. (nature.com)
The emergence of tumor cells that no longer express the target indicates a need to target other molecules in addition to CD19 in some patients with ALL. (nih.gov)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

We then measured the cytokine concentration to determine the inflammatory profile of each of our models. (scirp.org)
Our data suggest that non-painful-inflammatory stimuli inhibit the reward system, independent of cytokine concentration. (scirp.org)
It was demonstrated that a relevant concentration of FP (10 −8 M) inhibited constitutive and P. aeruginosa LPS-induced IL-6 and IL-8 production of non-CF and CF bronchial epithelial cells. (ersjournals.com)
La concentration sérique pour ces facteurs chez les femmes non encein- tes était similaire à celle des femmes enceintes en bonne santé. (who.int)
Toutefois, la concentration sérique était significativement plus élevée en présence d'une prééclampsie bénigne ou grave par rapport aux grossesses normales et significativement plus élevée pour les prééclampsies graves par rapport aux prééclampsies bénignes. (who.int)

Medigene AG (FSE: MDG1) is a leading immuno-oncology company dedicated to developing T-cell therapies to effectively eliminate cancer. (yahoo.com)
Its end-to-end technology platform, built on multiple proprietary and exclusive product enhancement and product development technologies, allows Medigene to create best-in-class differentiated, T Cell Receptor engineered T cell (TCR-T) therapies for multiple solid tumor indications that are optimized for both safety and efficacy. (yahoo.com)
View and download slide summaries of the latest original articles focusing on cytokine signalling therapies within rheumatoid arthritis. (cytokinesignalling.com)

Anatomy38

Organisms10

Diseases9

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes64

Information Science3

Chemokines6

Interleukin-10 recep1

Genes4

Chimeric9

Induce7

Antigen receptors1

Recombinant3

Pathways5

Proliferation11

Differentiation10

Cytotoxicity2

Severe10

Microenvironment7

Macrophages9

Survival6

Proteins4

Lymphoid5

Abstract1

Antagonist6

Signaling5

Induction3

Suppress3

Antigens4

Release syndrome3

Gene5

Signals2

Endothelial cells3

Inflammation2

Mice11

Kinases3

Intracellular1

Epithelial cell lines2

Stromal9

TNFa2

Antibodies8

Polyclonal1

Apoptosis1

Bone6

Vitro2

Progesterone3

Tumor Growth1

Murine3

Tumors3

Lipopolysaccharide1

Toxicity3

Interactions1

Expression9

Organs2

Selectively2

Innate immunity1

Inflammatory response1

Protein1

Progenitors1

Immune responses1

Lymphocytes2

Significantly2

Complement1

Clinical8

Tocilizumab1

Assay1

Molecules5

Concentration5

Therapies3