• A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. (umassmed.edu)
  • Objective -To evaluate the effect of oral administration of dexamethasone (DEX) at clinically relevant doses on metabolic activities of cytochrome P450 (CYP) isoenzymes in dogs and rats. (avma.org)
  • In adult mice the cytochrome P450 Cyp1a1 gene is not constitutively expressed but is highly inducible by foreign compounds acting through the aryl hydrocarbon (Ah) receptor. (ox.ac.uk)
  • Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex. (nel.edu)
  • Ječmen T, Ptáčková R, Kavan D, Cerná V, Hodek P, Stiborová M, Hudeček J, Sulc M. Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex. (nel.edu)
  • Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. (nel.edu)
  • Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activ. (nel.edu)
  • Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M. Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. (nel.edu)
  • Levels of biochemical markers (cytochrome P450 (CYP450), ethoxyresorufin-O-deethylase (EROD), glutathione S-transferase (GST), vitellogenin (VTG)) were measured in selected tissues (liver, plasma, brain, gill and kidney) samples of brown trout. (nel.edu)
  • The interindividual variability of cyclosporin A (CsA) pharmacokinetics might be explained by heterogeneity in the cytochrome P450 3A (CYP3A) subfamily. (transhumanist.ru)
  • The aim of the present study was to investigate the influence of the cytochrome P450 (CYP) 3A4/5 genotype in paediatric liver transplant recipients and donors, and the contribution of age and gender to tacrolimus disposition on the first day after transplantation. (transhumanist.ru)
  • After AFB 1 is absorbed in the intestine, it is converted into various metabolites by many cytochrome oxidase P450 family members (CYP 450 s, CYPs) in the liver. (hindawi.com)
  • Primary human hepatocytes in culture are commonly used to evaluate cytochrome P450 (P450) induction via an enzyme activity endpoint. (aspetjournals.org)
  • One not often talked about is how it interacts with the cytochrome P450 system in the liver. (web.app)
  • 8 Sep 2015 Cannabidiol is a safe, non-intoxicating, and non-addictive cannabis compound with significant therapeutic attributes, but CBD-drug interactions Aims: Cannabidiol (CBD), one of the major constituents in marijuana, has been to clarify cytochrome P450 (CYP) isoforms involved in the CBD oxidations. (web.app)
  • Via @Healthline, "Both CBD and grapefruit have an effect on cytochromes P450 (CYPs), a family of enzymes important to drug metabolism. (web.app)
  • The researcher who explained the CBD interaction with cytochrome P450 was Lester Bornheim to whom we owe discovering the potential of CBD in the treatment of refractory epilepsy. (web.app)
  • Similar to delta-9-THC, a majority of CBD is… CBD and other plant cannabinoids can potentially interact with many pharmaceuticals, decreasing their effectiveness by inhibiting the activity of cytochrome P450, a family of liver enzymes. (web.app)
  • The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. (web.app)
  • Warfarin is metabolized via the cytochrome P450 system by CYP 2C9, 1A2, and 3A4. (tag-challenge.com)
  • Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. (csnpharm.com)
  • Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. (csnpharm.com)
  • inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor. (csnpharm.com)
  • 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. (csnpharm.com)
  • Cytochromes P450 monooxygenases represent a large superfamily of heme enzymes, which require a dioxygen molecule and two electrons supplied by a NAD(P)H-dependent protein redox partner to form catalytically active high-valent ferryl-oxo intermediate. (schoolbag.info)
  • Cytochromes P450 represent a superfamily of heme enzymes with a common fold and mechanism that requires an atmospheric dioxygen molecule, two electrons from NAD(P)H, and one or two protons available from solvent water to form an active catalytic ferryl-oxo intermediate (1). (schoolbag.info)
  • All cytochromes P450 have one heme b (protoporphyrin IX) buried deeply in the protein globule, with molecular masses in the range 45-60 kDa. (schoolbag.info)
  • Most reactions performed by cytochromes P450 can be catalyzed effectively by Compound I, which is formally the same high-valent intermediate in all isozymes (5, 6). (schoolbag.info)
  • Thus, the broad range of metabolized substrates and the unprecedented variability of the chemical reactions catalyzed by cytochromes P450 can be attributed largely to the differences in substrate binding properties of different isozymes. (schoolbag.info)
  • With respect to their functional roles in living organisms, cytochromes P450 can be separated tentatively into the enzymes essential for biosynthetic pathways and the xenobiotic metabolizing enzymes (1). (schoolbag.info)
  • The former group includes cytochromes P450 involved into the biosynthesis of steroid hormones, antibiotics, and the transformation of vitamins and cofactors such as retinoids, carotenoids, eicosanoids, and fatty acid derivatives as well as those involved in endogenous intracellular and extracellular signaling. (schoolbag.info)
  • As a result, some cytochromes P450 from this group are critical for normal life cycle, and deficiencies can lead to serious diseases (7). (schoolbag.info)
  • In contrast, most cytochromes P450 that belong to the latter group can metabolize a variety of substrates of different sizes through multiple chemical mechanisms and even can form several different products from one substrate. (schoolbag.info)
  • Despite the unprecedented variability of chemical reactions catalyzed by cytochromes P450, all the important features of their mechanism can be attributed to the oxidative transformations driven by the main catalytic intermediate, which is a ferryl-oxo heme complex with the porphyrin pi-cation radical, or Compound I (3, 4, 8). (schoolbag.info)
  • Nonclassic reactions catalyzed by some cytochromes P450, which do not use oxygen, and thus deviate from the main P450 mechanism, include direct reductive processes driven by the heme iron (conversion of nitric oxide to nitrous oxide by CYP55, reductive dehalogenation, reduction of azo compounds and quinines, etc. (schoolbag.info)
  • Cytochrome P450 (abbreviated CYP , P450 , infrequently CYP450 ) is a very large and diverse superfamily of hemoproteins found in all domains of life. (wikidoc.org)
  • [1] Cytochromes P450 use a plethora of both exogenous and endogenous compounds as substrates in enzymatic reactions. (wikidoc.org)
  • The name cytochrome P450 is derived from the fact that these are colored ('chrome') cellular ('cyto') proteins, with a "pigment at 450 nm", so named for the characteristic Soret peak formed by absorbance of light at wavelengths near 450 nm when the heme iron is reduced (often with sodium dithionite ) and complexed to carbon monoxide . (wikidoc.org)
  • The active site of cytochrome P450 contains a heme iron center. (wikidoc.org)
  • Furthermore, of 13 human cytochrome P-450s (P-450s) examined, five (CYP1A1, CYP1A2, CYP2B6, CYP2E1, and CYP3A4) were active in the metabolic activation of coumarin, suggesting a potential risk of coumarin toxicity in humans. (aspetjournals.org)
  • Utilizing an activity guided fractionation scheme, acai berry extracts were assayed in CYP1A1 and CYP1A2 enzyme reactions to determine constituents responsible for enzyme inhibition. (uncg.edu)
  • Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (ox.ac.uk)
  • The two SNPs rs2470893 and rs2472297 (P-values=1.6 × 10(-11) and 2.7 × 10(-11)), which were also in strong linkage disequilibrium (r(2)=0.7) with each other, lie in the 23-kb long commonly shared 5' flanking region between CYP1A1 and CYP1A2 genes. (ox.ac.uk)
  • CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. (ox.ac.uk)
  • We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. (ox.ac.uk)
  • Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo- p -dioxin evaluated with a multicompartment geometric model of hepatic zonation. (cdc.gov)
  • Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. (web.app)
  • CYP1A1, CYP1A2, and CYP3A4 metabolize the (R)-enantiomer and CYP2C9 metabolizes the more potent (S)-enantiomer. (tag-challenge.com)
  • This process is largely carried out in the liver and is accomplished by a superfamily of heme-containing enzymes, termed the Cytochrome P450's. (uncg.edu)
  • COUMADIN is stereoselectively metabolized by hepatic microsomal enzymes (cytochrome P-450) to inactive hydroxylated metabolites (predominant route) and by reductases to reduced metabolites (warfarin alcohols). (tag-challenge.com)
  • This study investigated whether the association between low level benzene exposure and shortened gestation is modified by two susceptibility genes, CYP1A1 and GSTT1. (cdc.gov)
  • When both CYP1A1 and GSTT1 were considered, the greatest decrease was found among exposed mothers with the CYP1A1 AA-GSTT1 absent group (0.79 (SE, 0.25) week) and the CYP1A1 AA-GSTT1 present group (0.50 (SE, 0.22) week). (cdc.gov)
  • Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight. (johnshopkins.edu)
  • This study investigates the relationship between maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 with preterm delivery (PTD) as a whole and preterm subgroups. (johnshopkins.edu)
  • After adjusting covariates, regression analyses were performed to identify individual and joint associations of maternal smoking, two functional variants of CYP1A1 and GSTT1 with PTD. (johnshopkins.edu)
  • Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. (johnshopkins.edu)
  • A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (curehunter.com)
  • Cytochrome P-450 CYP1B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Cytochrome P-450 CYP1B1" by people in this website by year, and whether "Cytochrome P-450 CYP1B1" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Cytochrome P-450 CYP1B1" by people in Profiles. (umassmed.edu)
  • When reporter mice were bred onto a genetic background expressing a lower affinity form of the Ah receptor (DBA allele), transgene and murine Cyp1a1 protein expression were both attenuated in the adult mouse liver upon xenobiotic challenge. (ox.ac.uk)
  • A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (cdc.gov)
  • When stratified by the maternal CYP1A1 genotype, the estimated decrease was 0.54 (SE, 0.12) week for the AA group, which was significantly greater (p = 0.003) than that for the Aa/aa group, which showed no decrease in gestational age. (cdc.gov)
  • In general PAH carcinogenesis involves activation by the enzyme P-450 to diol epoxide metabolites with an epoxide ring in the bay or fjord region. (wikipedia.org)
  • This substance is transformed by CYP1A1 into the highly carcinogenic metabolites anti-diolepoxide (3) and syn-diolepoxide (4). (wikipedia.org)
  • Treatment of Ishikawa cells with 10 nM TCDD induced a 9.7-fold increase in CYP1A1-dependent ethoxyresorufin O-deethylase (EROD) activity and a 10.5-fold increase in chloramphenicol acetyltransferase (CAT) activity in cells transfected with pRNH11c containing an Ah-responsive human CYP1A1 gene promoter insert (-1142 to +2434). (tamu.edu)
  • Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 1 M). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties. (csnpharm.com)
  • This review highlights significant advances in our understanding of the AFB 1 metabolic activation, like cytochrome P450s (CYPs), and AFB 1 metabolic detoxification, like glutathione S-transferases (GSTs) in poultry. (hindawi.com)
  • TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. (utmb.edu)
  • The number of cells displaying endogenous CYP1A1 activity could be increased in the embryo upon xenobiotic challenge, but only within areas where the CYP1A1 promotor was already active. (ox.ac.uk)
  • CYP1A1, a typical XRE-regulated gene, mRNA was induced without the application of ligand to the culture medium. (biomedcentral.com)
  • This expression pattern was confirmed as reflecting the endogenous gene by measuring Cyp1a1 mRNA levels and protein expression by immunohistochemistry. (ox.ac.uk)
  • Addition of a natural ligand of AhR, FICZ, induces AhR translocation to the nucleus and transcription of the AhR target gene Cyp1a1, showing that the AhR pathway is functional in B cells. (figshare.com)
  • This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity. (curehunter.com)
  • Furthermore, no influence of KTZ on the pharmacokinetics of CYP1A1/2, CYP2C21, and CYP2D15 substrates are likely. (avma.org)
  • Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. (csnpharm.com)
  • We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. (utmb.edu)
  • These novel data suggest that the Cyp1a1 protein may play a role in murine development and that regulation of the Cyp1a1 gene during this period is either through the action of a high affinity Ah receptor ligand or by an alternative regulatory pathway. (ox.ac.uk)
  • Some of CBD oil's side effects can be dangerous if you do not understand the Cytochrome P-450 System. (web.app)
  • In contrast to the absence of constitutive Cyp1a1 and lacZ transgene expression in tissues of the adult mouse, a constitutive cell-specific and time-dependent pattern of CYP1A1 promoter activity was observed in the embryo. (ox.ac.uk)
  • In general PAH carcinogenesis involves activation by the enzyme P-450 to diol epoxide metabolites with an epoxide ring in the bay or fjord region. (wikipedia.org)
  • Owing to its broad substrate specificity of mainly xenobiotics and its preferential extrahepatic expression, cytochrome P450 1A1 (CYP1A1) is a principle member of the CYP detoxifying enzyme superfamily involving in carcinogenesis. (nih.gov)
  • This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity. (bvsalud.org)
  • The genotoxic impact of carcinogen exposure is heavily influenced by a complex array of metabolic pathways, which includes the cytochrome P 450 (CYP) enzyme system. (biomedcentral.com)
  • The results found and utilization of NADPH and arachidonic acid, cofactors of CYP- and cyclooxygenase (COX)-dependent enzyme systems, respectively, as well as inhibitors of CYP1A1/2 and 3A, demonstrate that the CYP1A and 3A enzymes play a major role in ellipticine activation in liver microsomes. (nel.edu)
  • Azelastine hydrochloride is oxidatively metabolized to its main, and biologically active, metabolite desmethylazelastine by the cytochrome P450 enzyme system. (drugbank.com)
  • A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. (jefferson.edu)
  • PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert toxic/carcinogenic effects. (cdc.gov)
  • In addition to its effects on steroid hydroxylase activities, I3C also elevated NADPH-cytochrome P450 reductase activity, a necessary component to the P450 monooxygenase system. (nih.gov)
  • A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (bvsalud.org)
  • In phase I, oxidation, hydrolysis, reduction, and cyclization reactions are catabolized mainly by the cytochrome P450 (CYP450) superfamily of monooxygenase enzymes. (biomedcentral.com)
  • Two polymorphisms of the CYP1A1 gene-A4889G and T6235C-are known to affect activation of estrone and estradiol and to deregulate concentration of highly active tamoxifen metabolites. (nih.gov)
  • We evaluated associations within clinicopathologic features, including overall 5-year survival, with CYP1A1 gene status. (nih.gov)
  • Methylation status of 93 CpG sites, densely scattered within approximately 1.5 kb 5' regulatory region of CYP1A1, and its association with gene transcription was analyzed in tissue cohorts dissected from 40 patients with gastric cancer. (nih.gov)
  • Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. (nih.gov)
  • Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review. (cdc.gov)
  • Cytochrome P450 1A1 (CYP1A1) Gene Polymorphisms and Susceptibility to Breast Cancer: a Meta-Analysis in the Chinese Population. (cdc.gov)
  • Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample. (ox.ac.uk)
  • The relationship of air pollutants with cytochrome P450 1A1 (CYP1A1) gene expression in the umblical. (ac.ir)
  • This study investigated whether the association between low level benzene exposure and shortened gestation is modified by two susceptibility genes, CYP1A1 and GSTT1. (cdc.gov)
  • Although our lab between 1975 and 1980 had published several lines of evidence in mouse and rabbit, showing that P1-450 and P-448 were enzymes derived from separate genes, it was not until we had the cDNA sequences in hand (1981-84) that most competitors were convinced that we had been correct all along. (sciencewatch.com)
  • Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. (cdc.gov)
  • The level of expression of genes encoding for nine major xenobiotic metabolising Cytochrome P450s (CYPs) and the P-glycoprotein (Pgp) was determined in three different regions of the small intestine of male and female Sprague Dawley rats and the expression was compared with that in the liver. (nih.gov)
  • Below are the most recent publications written about "Cytochrome P-450 CYP2D6" by people in Profiles. (musc.edu)
  • 21103,21108,21096} It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).{21107,21098} α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively). (bertin-bioreagent.com)
  • Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis. (cdc.gov)
  • Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk. (cdc.gov)
  • The induction of CYP1A1 was localized in nonciliated bronchiolar epithelial (Clara) cells, alveolar septa, and endothelial cells by immunofluorescence microscopy. (cdc.gov)
  • This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung. (cdc.gov)
  • This activity has been attributed in part to the induction of cytochrome P450 CYP1A subfamily members and the resulting increased metabolic inactivation of chemical carcinogens. (nih.gov)
  • Essential role for induction of cytochrome P-448. (wakehealth.edu)
  • A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (cdc.gov)
  • Effects of cytochrome P450 inhibitors on peroxidase activity. (nel.edu)
  • Martinkova M, Kubickova B, Stiborova M. Effects of cytochrome P450 inhibitors on peroxidase activity. (nel.edu)
  • A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. (umassmed.edu)
  • Of several enzymes metabolizing xenobiotics, cytochrome P450 (CYP) and peroxidase enzymes seem to be most important. (nel.edu)
  • The cytochrome superfamily consists of nearly 60 members in humans (Human Genome Project 2013), which may be expressed differently in individual cells when challenged by xenobiotics, leading to cellular heterogeneity that remains concealed in a bulk analysis. (biomedcentral.com)
  • Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes. (nel.edu)
  • Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes. (nel.edu)
  • Recently, we found that after cytochrome P450 (CYP)-mediated oxidation ellipticine forms covalent DNA adducts. (nel.edu)
  • Alteration of pulmonary xenobiotic pathways was determined by monitoring the protein levels and activities of P-450 isozymes (CYP1A1 and CYP2B1), glutathioneS-transferase (GST), and NADPH:quinone oxidoreductase (QR). (cdc.gov)
  • However, acute asphalt fume exposure significantly increased the activity and protein level of CYP1A1 whereas it markedly reduced the activity and protein level of CYP2B1 in the lung. (cdc.gov)
  • Using the reconstituted enzymatic system, we demonstrated that the detoxication ellipticine metabolites, 7-hydroxyellipticine and 9-hydroxyellipticine, are mainly generated by CYP1A1 and 1A2, while those responsible for DNA binding, 13-hydroxy-, 12-hydroxyellipticine and ellipticine N(2)-oxide, by CYP3A1 and 2C3. (nel.edu)
  • Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. (ox.ac.uk)
  • Cytochrome P-450 CYP2C8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This substance is transformed by CYP1A1 into the highly carcinogenic metabolites anti-diolepoxide (3) and syn-diolepoxide (4). (wikipedia.org)
  • OBJECTIVE: To test the hypothesis that hyperoxia induces greater lung injury and inflammation in Nrf2-/- mice compared to wild type (WT) that differs between sexes, and that this phenotype will be rescued by the administration of the cytochrome P450 (CYP) 1A inducer beta-naphthoflavone (BNF). (nih.gov)
  • Individual differences in cytochrome P-450 efficiency partly explain their variations in resistance to tamoxifen and estrogen metabolism. (nih.gov)
  • Cytochrome P450 (CYP) 1A enzymes are protective against hyperoxic lung injury and may contribute to sex-dependent pathology. (nih.gov)
  • 80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). (ox.ac.uk)
  • Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects. (cdc.gov)
  • Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies. (cdc.gov)
  • Cytochrome P 450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones. (biomedcentral.com)
  • This graph shows the total number of publications written about "Cytochrome P-450 CYP2C8" by people in this website by year, and whether "Cytochrome P-450 CYP2C8" was a major or minor topic of these publications. (umassmed.edu)