FludarabineDoxorubicinRituximabCalled relapsed or refractoryAcuteFollicular LymphomaIbrutinibMethotrexatePatientsAdultsCombinationClinicalTherapyTreatAgentGraft-versus-ChronicFludarabine phosphateNipentAcuteDoxorubicinPotent inhibitorCombinationHeavily pretreatedAdenosine deaminaseToxicityHairy cell leuChemotherapyDrugsTreatmentWorkSolid
Fludarabine7
- Fludarabine-containing regimens include FCR (fludarabine, cyclophosphamide, and rituximab) and FR (fludarabine and rituximab). (medscape.com)
- The current standard for upfront treatment of CLL is chemoimmunotherapy for younger fit patients, FCR (fludarabine, cyclophosphamide, and rituximab) being the prototype. (sagepub.com)
- Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)
- The program of six courses of fludarabine/cyclophosphamide was administered in 75% of patients and reduced in 19% of patients because of severe myelosuppression and/or sepsis, which was fatal in one patient. (pocketdrugguide.com)
- In another study, the efficacy of fludarabine/cyclophosphamide in a population of chronic lymphocytic leukemia patients was accurately determined by analyzing response rates according to the patients' treatment history. (pocketdrugguide.com)
- Patients relapsed after or were refractory to alkylating agents and failed to achieve a PR with their last fludarabine-based therapy. (pocketdrugguide.com)
- Pharmacokinetic parameters were independent from the other factors tested such as age, sex, chemotherapy regimen (fludarabine/cyclophosphamide versus bendamustine), IGHV mutational status, and FCGR3A 158VF status. (bmj.com)
Doxorubicin2
- One of the first studies of Fludara in patients with recurrent CLL showed this agent to be better than the combination of cyclophosphamide, doxorubicin and prednisone (CAP). (broomeoncology.com)
- So far, the standard first-line therapy still consists of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or a CHOP-like regimen. (biomedcentral.com)
Rituximab1
- The PCR (pentostatin, cyclophosphamide, and rituximab) regimen is given every 21 d with growth factor support and ID prophylaxis. (medscape.com)
Called relapsed or refractory1
- It is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. (bionity.com)
Acute2
- Additionally, pentostatin has been used to treat steroid-refractory acute and chronic graft-versus-host disease. (wikipedia.org)
- The patients were suffering with relapsed or refractory acute lymphoblastic leukaemia (ALL) (An additional 9 patients suffering with acute myelogenous leukaemia (AML) had similar pharmacokinetics but are not included in the figure below. (bionity.com)
Follicular Lymphoma2
- or adults with relapsed or refractory (r/r) large B-cell lymphoma after two or more lines of systemic therapy including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma. (wikimili.com)
- In May 2022, the indication in the US was updated to include the treatment of adults with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. (wikimili.com)
Ibrutinib1
- The novel oral kinase inhibitors ibrutinib and idelalisib are FDA-approved in the relapsed/refractory setting, and ibrutinib is approved upfront for those with del(17p). (sagepub.com)
Methotrexate1
- Patients with uveitis who are not responding well to steroid treatment and patients who have side effects from other medicines used to treat uveitis (such as cyclosporine, cyclophosphamide, methotrexate or azathioprine) or have refused treatment because of possible side effects of these medicines may be eligible for this study. (drugpatentwatch.com)
Patients3
- Pentostatin is also used in chronic lymphocytic leukemia (CLL) patients who have relapsed. (wikipedia.org)
- Patients in the first cohort did not receive post-transplant (PT)-cyclophosphamide (Cy) and 3 patients were transplanted. (nih.gov)
- both patients had been heavily pretreated and had been refractory to previous chemotherapy. (pocketdrugguide.com)
Adults1
- [19] In March 2019, NICE issued guidance approving Kymriah for treatment of relapsed or refractory diffuse large B-cell lymphoma in adults after 2 or more systemic therapies. (wikimili.com)
Combination1
- These drugs have produced long-term durable responses in the relapsed/refractory setting, and studies are underway using these as single agent upfront or in combination with both chemotherapy and monoclonal antibodies. (sagepub.com)
Clinical1
- Recently, we and others have demonstrated in vitro activity and clinical efficacy of the Bcl-2 inhibitor venetoclax as a single agent in relapsed/refractory T-PLL (r/r-TPLL). (haematologica.org)
Therapy1
- In April 2017, tisagenlecleucel received breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for the treatment of relapsed or refractory diffuse large B-cell lymphoma . (wikimili.com)
Treat1
- Pentostatin is used to treat hairy cell leukemia. (wikipedia.org)
Agent1
- Cyclophosphamide is an alkylating agent. (pocketdrugguide.com)
Graft-versus-2
- Additionally, pentostatin has been used to treat steroid-refractory acute and chronic graft-versus-host disease. (wikipedia.org)
- Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. (dana-farber.org)
Chronic5
- Pentostatin is also used in chronic lymphocytic leukemia (CLL) patients who have relapsed. (wikipedia.org)
- 11. Safety and activity of the anti-CD79B antibody-drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study. (nih.gov)
- 14. An Evidence-based Review of Anti-CD20 Antibody-containing Regimens for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma, or Follicular Lymphoma. (nih.gov)
- Pentostatin was used to treat 26 patients with advanced B-cell chronic lymphocytic leukemia resistant to conventional treatment. (nih.gov)
- In a clinical investigation in patients with refractory chronic lymphocytic leukemia using pentostatin at the recommended dose in combination with fludarabine phosphate, 4 of 6 patients entered in the study had severe or fatal pulmonary toxicity. (nih.gov)
Fludarabine phosphate2
- The use of pentostatin in combination with fludarabine phosphate is not recommended. (nih.gov)
- Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)
Nipent1
- Pentostatin (or deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug. (wikipedia.org)
Acute1
- Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias. (dana-farber.org)
Doxorubicin7
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C9666 ABDIC Regimen ABDIC A chemotherapy regimen consisting of bleomycin, dacarbazine, doxorubicin, lomustine and prednisone used for the treatment of relapsed or refractory Hodgkin lymphoma. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C161966 ACFTOR-BCG Regimen FAC-BCG A chemotherapy regimen consisting of tegafur, doxorubicin, cyclophosphamide, and Bacillus Calmette-Guerin (BCG) that may be used in the treatment of breast cancer. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C63427 AC-T Regimen AC-T A chemotherapy regimen consisting of cyclophosphamide and doxorubicin followed by paclitaxel, used as a neoadjuvant or adjuvant treatment for breast cancer. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C63446 ACVBP Regimen ACVBP A regimen consisting of doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone used to treat aggressive forms of non-Hodgkin lymphoma. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C161920 ADOC Regimen ADOC A chemotherapy regimen consisting of cisplatin, doxorubicin, vincristine, and cyclophosphamide for the treatment of thymic carcinoma. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C161924 ASHAP Alternating with M-BACOS Regimen ASHAP/M-BACOS A chemotherapy regimen consisting of doxorubicin, methylprednisolone, cytarabine, and cisplatin (ASHAP) alternating with methotrexate, leucovorin, doxorubicin, vincristine, bleomycin, cyclophosphamide, and methylprednisolone for the treatment of non-Hodgkin lymphoma. (nih.gov)
- RTX in combination with cyclophosphamide /doxorubicin /vincristine /prednisone (R-CHOP) remains the standard frontline regimen for diffuse large B-cell lymphoma. (biomedcentral.com)
Potent inhibitor1
- Comment: Pentostatin is a potent inhibitor of adenosine deaminase (pegademase). (medscape.com)
Combination1
- The combination of mitoxantrone and prednisone is approved as a second-line treatment for metastatic hormone-refractory prostate cancer . (mdwiki.org)
Heavily pretreated1
- However, pentostatin induced a 25% to 30% response rate in heavily pretreated CLL patients, including some who had received prior fludarabine, suggesting possible non-cross-resistance. (nih.gov)
Adenosine deaminase2
- Pentostatin is a potent transition state inhibitor of the enzyme adenosine deaminase (ADA). (nih.gov)
- In man, following a single-dose of 4 mg/m 2 of pentostatin infused over 5 minutes, the distribution half-life was 11 minutes, the mean terminal half-life was 5.7 hours, the mean plasma clearance was 68 mL/min/m 2 , and approximately 90% of the dose was excreted in the urine as unchanged pentostatin and/or metabolites as measured by adenosine deaminase inhibitory activity. (nih.gov)
Toxicity1
- palifermin increases toxicity of pentostatin by Other (see comment). (medscape.com)
Hairy cell leu3
- Pentostatin is used to treat hairy cell leukemia. (wikipedia.org)
- The following table provides efficacy results for 4 groups (columns) of patients with hairy cell leukemia: patients who initially received pentostatin, patients who initially received alpha-interferon (IFN), and 2 different groups of patients who received pentostatin after proving to be refractory to, or intolerant of IFN therapy. (nih.gov)
- The first 2 groups represent treatment results from the SWOG 8691 study, a large multicenter study comparing pentostatin and IFN in untreated (frontline) patients with confirmed hairy cell leukemia. (nih.gov)
Chemotherapy2
- Development of MAb-chemotherapy combinations for early and relapsed/refractory HCL. (nih.gov)
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C9511 AcFuCy Regimen ACFUCY A chemotherapy regimen consisting of dactinomycin, 5-fluorouracil, and cyclophosphamide for the treatment of ovarian cancer. (nih.gov)
Drugs1
- C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C10058 Altretamine/Cisplatin/Cyclophosphamide/Fluorouracil Regimen CHEX-UP A regimen consisting of altretamine, cisplatin, cyclophosphamide and fluorouracil that can be used for the treatment of ovarian cancer. (nih.gov)
Treatment1
- For the past ~25 years, cladribine alone (or less commonly pentostatin alone) has been the standard 1st and 2nd line treatment of HCL, but is usually non-curative. (nih.gov)
Work1
- Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
Solid1
- Pentostatin is a white to off-white solid, freely soluble in distilled water. (nih.gov)