Contractility myocytes smooth muscle. Medical search. Frequent questions

Thyroid hormone (TH) signaling is a relevant component of the adaptive response of the myocardium to stress, and plays a critical role in regulating both heart rate and contractility of myocytes: hyperthyroidism is correlated with atrial arrhythmias, hypertension, and heart failure, and increases the risk of heart failure and mortality in cardiopathic patients [ 1 ] . (encyclopedia.pub)

adrenergic receptor antagonists have also shown helpful in management of acute dissecting aortic aneurysm due to -blocker-mediated reduction in myocardial contractility and reduced rate of force development . (pharmacology2000.com)

Myocytes, myometrium, and uterine contractions. (ac.ir)
Thus, decreasing/increasing the diameter of uterine myocytes correlates with their well known influence on myometrium constriction/relaxation. (kiev.ua)

Promoting synthesis of the α isoforms of the myosin heavy chain (faster contractility), and reducing β isoform (slow contractility), enhancing systolic function. (encyclopedia.pub)

We expressed chimeric channels composed of different components of the Kv7.4 and Kv7.5 α -subunits in vascular smooth muscle cells to determine which components are essential for enhancement or inhibition of channel activity. (aspetjournals.org)
It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. (pharmfair.com)
In cultured vascular smooth muscle cells, the type I cGK mRNA concentration was reduced to 10% of the basal level by 4 x 10 -10 mol/L platelet-derived growth factor. (elsevierpure.com)

At the most basic level we can separate muscle tissue into smooth and striated, where the striations originate from a repeating pattern of regularly arranged proteins, whereas "smoothness" is conferred by an irregular arrangement without a repeating pattern. (derangedphysiology.com)
T3 binds thyroid hormones receptors (TRs) on the cellular membrane, promoting transcription processes involved in the synthesis of proteins responsible for cardiac contractility. (encyclopedia.pub)

Coordinated contractions of cardiac muscle cells during systole propel blood out of the atria and ventricles to the blood vessels of the systemic and pulmonary circulatory systems . (wikidoc.org)

These findings demonstrated that although lower concentrations of hydroalcoholic extract potentiated the spontaneous periodic contraction of rat uterine smooth muscle, but at higher concentrations it had inhibitory effect on rat uterus contraction. (ac.ir)

Of the freely available peer-reviewed resources appropriate for revision of this topic, none beat Sweeney & Hammers (2018) , as this review covers all possible examinable topics and has sections comparing skeletal muscle to smooth and cardiac muscle. (derangedphysiology.com)
The thyroid gland primarily secretes T4, which is then de-iodinated in its active form, T3, in the liver, kidney, and skeletal muscle. (encyclopedia.pub)
Unlike skeletal muscle , which contracts in response to nerve stimulation, and like single unit smooth muscle, cardiac muscle is myogenic , meaning that it is self-excitable stimulating contraction without a requisite electrical impulse coming from the central nervous system. (wikidoc.org)
In contrast to skeletal muscle , cardiac muscle cannot contract in the absence of extracellular calcium ions as well as extracellular potassium ions. (wikidoc.org)
and skeletal muscle which is activated by calcium stored in the sarcoplasmic reticulum (SR). (wikidoc.org)

It is shown, that separate dilutions of human serum and animal (as a source of ESBAR) and analogs of ESBAR ways to enhance the effectiveness of activation of beta-adrenoceptors (AR) of smooth muscle (uterus, coronary and renal arteries, trachea, stomach), myocardium, erythrocytes and platelets (respectively influenced of histidine and tryptophan). (cardiologymedjournal.com)

"It was expected answers would describe in detail the role of troponin, tropomyosin and calmodulin in mediating muscle contraction" , the examiners rejoined. (derangedphysiology.com)
By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. (pharmfair.com)
Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. (pharmfair.com)
If synchronization of cardiac muscle contraction is disrupted for some reason (for example, in a heart attack ), uncoordinated contraction known as fibrillation can result. (wikidoc.org)
[11] MYPT-1 is involved in a pathway for smooth muscle contraction. (cloudfront.net)

2] Systolic dysfunction is characterized by diminished ventricular contractility that results in an impaired ability to increase the stroke volume to meet systemic demands. (medscape.com)
The loss of myocytes leads to cardiac dilation and an increased afterload and wall tension, which results in further systolic dysfunction. (medscape.com)

In contrast to the chemical synapses used by neurons , electrical synapses , in the case of cardiac muscle, are created by ions flowing from cell to cell, known as an action potential . (wikidoc.org)

Dedicated muscle tissue in multicellular organisms tends to exhibit a comforting structural homology, to effect that one could recognise striated muscle in a jellyfish and feel a warm kind of brotherly Verbundenheit, but it evolved probably at least four separate times in separate clades rather than arising from some early eumetazoan ancestor. (derangedphysiology.com)
This transmission of impulses makes cardiac muscle tissue similar to nerve tissue, although cardiac muscle cells are notably connected to each other by intercalated discs . (wikidoc.org)

Trying to guess the examiners' minds from the way this syllabus item is positioned (in the "musculoskeletal" section), we can infer that the detailed anatomy and physiology of cardiac muscle is probably intended for the cardiovascular section , and what they wanted from us here is more of a comparison of the ultrastructural elements that distinguish the three muscle types. (derangedphysiology.com)
Cardiac muscle is a type of involuntary striated muscle found in the walls of the myocardium . (wikidoc.org)
Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle . (wikidoc.org)
if two cardiac muscle cells are in contact, whichever one contracts first will stimulate the other to contract, and so on. (wikidoc.org)
Since cardiac muscle is myogenic, the pacemaker serves only to modulate and coordinate contractions. (wikidoc.org)
The cardiac muscle cells would still fire in the absence of a functioning SA node pacemaker, albeit in a chaotic and ineffective manner. (wikidoc.org)

Cultured airway smooth muscle cells subjected to cyclic deformational strain have increased cell content of myosin light chain kinase (MLCK) and myosin and increased formation of actin filaments. (elsevierpure.com)

By using photon correlation spectroscopy the effect of contractile activity modulators of smooth muscle to the size (diameter) of rats uterine muscle cells was investigated. (kiev.ua)
Smooth muscle cells express Kv7.4 and Kv7.5 voltage-dependent potassium channels, which have each been implicated as regulators of smooth muscle contractility, though they display different sensitivities to signaling via cAMP/protein kinase A (PKA) and protein kinase C (PKC). (aspetjournals.org)
Smooth muscle cells commonly express two functional Kv7 α -subunits, Kv7.4 and Kv7.5, which have different sensitivities to inhibitory and stimulatory signaling ( Byron and Brueggemann, 2018 ). (aspetjournals.org)
In addition, PCLS can also be used to study calcium signaling and contractility of airway and smooth muscle cells. (precisionary.com)
To determine how these changes may increase cell contractility, we measured isometric force production with changes in cytosolic calcium in individual permeabilized cells. (elsevierpure.com)
Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. (pharmfair.com)
Сontractile properties of smooth muscle cells of the horn, cervix and broad ligament of the pig uterus. (cardiologymedjournal.com)
Chakraborti S, Roy S, Chowdhury A, Mandal A, Chakraborti T. Role of PKCα-p38 MAPK-Giα axis in peroxynitrite-mediated inhibition of β-adrenergic response in pulmonary artery smooth muscle cells. (cardiologymedjournal.com)
To investigate whether human adipose-derived stem cells (hADSCs) seeded on multilayered poly (l-lactide-co-ɛ-caprolactone) (PLCL) sheets improve bladder function in a rat model of detrusor smooth muscle-removed bladder. (korea.ac.kr)
Histological, immunohistochemical and immunoblot analyses revealed the uniform distribution of hADSCs in between PLCL sheets as well as differentiation of hADSCs into smooth muscle cells (SMC) which is illustrated by the expression of SMC markers. (korea.ac.kr)
The type I cGMP-dependent protein kinase (cGK) is one of the major pathways for the cGMP cascade and has been demonstrated to inhibit platelet aggregation, relax smooth muscle cells, and control cardiocyte contractility. (elsevierpure.com)
The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)

Regulation of smooth muscle calcium sensitivity: KCl as calcium-sensitizing stimulus. (ac.ir)
SIGNIFICANCE STATEMENT Kv7.4 and Kv7.5 channels are known signal transduction intermediates and drug targets for regulation of smooth muscle tone. (aspetjournals.org)

For what concerns non-genomic activities, T3 can induce changes in the myocyte membrane, involving changes in sodium, potassium, and calcium ion channels. (encyclopedia.pub)

This compensation allows increased contractility and brings stroke volume closer to baseline despite the increases in pressure and afterload. (medscape.com)

A second proposed mechanism for the drug's vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. (pharmfair.com)
Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels. (pharmfair.com)

From this constantly expanding appreciation for the role of calcium outside the muscle, we predict that calcium-induced-calcium-release ryanodine receptors could also be involved in determining cell fate. (biomedcentral.com)

Male rats were randomly divided into 4 groups: Normal, injury (detrusor smooth muscle-removed bladder), PLCL (detrusor smooth muscle-removed bladder implanted with PLCL sheets), and PLCL + ADSC (detrusor smooth muscle-removed bladder implanted with PLCL sheets seeded with hADSCs). (korea.ac.kr)
Further, the physiological study of PLCL + ADSC group showed significant improvement in compliance and contractility suggesting the functional improvement of the bladder. (korea.ac.kr)
hADSCs seeded on the multilayered PLCL sheets has the potential to differentiate into SMC, thus facilitating the recovery of compliance and contractility of the injured bladder. (korea.ac.kr)

This certainly seems to be the spirit of Question 11 from the second paper of 2015, which asked for a comparison of the anatomy and physiology of skeletal and smooth muscle. (derangedphysiology.com)
These findings may improve our understanding of the roles of these channels in smooth muscle physiology and disease, particularly in conditions where Kv7.4 and Kv7.5 are differentially expressed. (aspetjournals.org)

Smooth muscle cell calcium activation mechanisms. (ac.ir)
Therefore, development of PCLS allowed for the study and modeling of lung mechanics, smooth muscle activity, and ciliated cell function. (precisionary.com)
[17] ROCK1 activation by RhoA also promotes stabilization of F-actin , phosphorylation of regulatory myosin light chain (MLC) and an increase in contractility, which plays a crucial role in tumor cell migration and metastasis. (cloudfront.net)

The ouabain, that reduces contractile activity of smooth muscle, leads to increase this parameter up 23% from control. (kiev.ua)

Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. (affbiotech.com)
Care of the endocrine function may contribute to improving cardiac contractility, immune function, as well as infection control, and rehabilitation during and after a LVAD placement. (encyclopedia.pub)

In: Control of Uterine Contractility / Eds. (kiev.ua)

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. (pharmfair.com)

The diameter of myocytes, assessed by photon correlation spectroscopy, was amounted 7-10 microm which is Consistent with the results obtained by using laser confocal microscopy. (kiev.ua)

Anatomy68

Organisms17

Diseases11

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes51

Disciplines and Occupations2

Information Science3

Health Care1

Heart rate and contractility1

Myocardial1

Myometrium2

Myosin heavy1

Vascular smooth muscl3

Proteins2

Blood Vessels1

Uterine smooth1

Skeletal muscle5

Coronary1

Contraction5

Systolic2

Neurons1

Tissue2

Cardiac muscle6

Airway smooth1

Cells12

Regulation2

Potassium1

Afterload1

Mechanism2

Receptors1

Bladder3

Physiology2

Cell3

Contractile activity1

Function2

Control1

Channels1

Results1