• In 1977, Schwartz, along with Harold Gainer, Ph.D, found that the glucose consumption in the rat suprachiasmatic nucleus is a function of time of day and environmental lighting conditions. (wikipedia.org)
  • Glucose consumption was studied via a technique using 14C-deoxyglucose (DG). (wikipedia.org)
  • DG is transported into the brain via the same mechanism which transports glucose, where it is then phosphorylated by hexokinase into 14C-deoxyglucose-6-phosphate(DG-6-P). The accumulation of DG-6-P reflects the rate of glucose consumption, and can be quantitatively measured using an autoradiograph. (wikipedia.org)
  • In Schwartz's and Gainer's study of suprachiasmatic nucleus glucose consumption, the suprachiasmatic nucleus was found to have higher glucose consumption during the daytime than during the night. (wikipedia.org)
  • and glucose consumption in the absence and presence of Matrigel™ using spectrophotometric methods. (biomedcentral.com)
  • Target genes activated by hypoxia inducible factor (HIF) decrease the dependence of the cell on oxygen, whereas Ras, Myc, and Akt can also upregulate glucose consumption and glycolysis. (pharmaceuticalintelligence.com)
  • Thioredoxin‑interacting protein (TXNIP) competes with c‑Myc to reduce glucose consumption in tumor cells to restrain cell proliferation. (spandidos-publications.com)
  • Sucralose is a hydrolyzed product of 6-chloro-6-deoxyglucose that enters the brain through the blood by inhibiting the process of d-glucose transportation across the epithelium [15]. (somebodyhealme.com)
  • TNF α and IFN γ treatment led to rapid consumption of glucose and metabolic skewing toward glycolysis in MSCs, which was required for the therapeutic efficacy of MSCs on IBD. (biomedcentral.com)
  • Malignancies of diverse origins deviate from healthy tissues in their high consumption of glucose. (oncotarget.com)
  • Since cancer cells prefer glycolytic metabolism as their energy source, high consumption of sugar can lead to faster growth and spread of cancer. (ktfnews.com)
  • Feng X, Wang P, Liu Q, Zhang T, Mai B and Wang X: Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration. (spandidos-publications.com)
  • Arai T, Mori K, Nakao S, Watanabe K, Kito K, Aoki M, Mori H, Morikawa S, Inubushi T (1991) In vivo oxygen-17 nuclear magnetic resonance for the estimation of cerebral blood flow and oxygen consumption. (springer.com)
  • The causes of tumour hypoxia are multifactorial and include factors related to oxygen delivery, such as anaemia, abnormal tumour vasculature and blood flow, and the rate of oxygen consumption in tumours. (biomedcentral.com)
  • Schwartz demonstrated that the suprachiasmatic nucleus is rhythmic in vivo using a 2-deoxyglucose radioactive marker for functional brain imaging. (wikipedia.org)
  • Evolution: The brain is enormously costly to the rest of the body, in terms of oxygen and nutrient consumption. (stackexchange.com)
  • The metabolism and growth rate of cancer cells are much faster than normal cells, and their consumption of sugar is also faster than we can imagine. (ktfnews.com)
  • Altered functional activity alters metabolic activity and the uptake of [#+C\deoxyglucose in the tissues. (nih.gov)
  • Effects of localized increases in functional ac- tivity on uptake of ['C]deoxyglucose into neural tissues. (nih.gov)
  • in discrete areas of the putamen and globus pallidus ipsilateral to the locus of penicillin application in (D). In autoradiographs of other brain sections from the animal with seizures (not shown), areas of increased uptake of ['C]}deoxyglucose are seen in the motor cortex adjacent to the site of penicillin ap- plication and in parts of the caudate nucleus and thalamus. (nih.gov)
  • Glucose uptake was monitored with fluorescently tagged glucose 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2-deoxyglucose (2-NBDG). (bvsalud.org)
  • 15. Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy. (nih.gov)
  • Tumor microenvironment components such as tumor-associated fibroblasts, macrophages, and immune cells can also undergo glycolytic reprogramming, mainly manifested as enhanced glycolysis, increased glucose uptake and consumption, enhanced lipid and protein synthesis, and increased amino acid uptake and catabolism such as glutamine, etc. (alfaoncology.com)
  • DEX treatment significantly increased endogenous glucose production and decreased whole body glucose disposal, as well as 2 deoxyglucose 2 DG uptake by normal daytime blood sugar skeletal muscle during euglycemic hyperinsulinemic clamps. (esaunggul.ac.id)
  • At 120min, a bolus of 14C-2-deoxyglucose is given to assess tissue-specific glucose uptake. (mmpc.org)
  • Schwartz demonstrated that the suprachiasmatic nucleus is rhythmic in vivo using a 2-deoxyglucose radioactive marker for functional brain imaging. (wikipedia.org)
  • In each group, nine mice were submitted to dynamic micro-PET imaging to estimate brain and skeletal muscle glucose consumption (C- and SM-MRGlu*) by Patlak approach, while six mice were sacrificed for ex vivo determination of the lumped constant, defined as the ratio between CMRGlu* and glucose consumption measured by glucose removal from the incubation medium ( n = 3) or biochemical analyses ( n = 3), respectively. (springeropen.com)
  • Arai T, Mori K, Nakao S, Watanabe K, Kito K, Aoki M, Mori H, Morikawa S, Inubushi T (1991) In vivo oxygen-17 nuclear magnetic resonance for the estimation of cerebral blood flow and oxygen consumption. (springer.com)
  • Even without the quantitation, the autoradiographs pro- vide a pictorial representation of the relative rates of glucose consumption in the various cerebral structures-the darker the area the higher the rate of glucose consumption (1). (nih.gov)
  • It had been shown that in the brain two molecules of glucose are normally converted into glucose-6-phosphate for every molecule of 2-deoxyglucose converted to 2-DG-6-phosphate. (nih.gov)
  • This stands for F 18 deoxyglucose and consists of a radioactive fluorine-marked dextrose molecule, which accumulates in pathological cells as cancer cells exhibit increased dextrose consumption. (imaging.at)
  • Colocalization between the endoplasmic reticulum (ER) and the fluorescent FDG analog 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose (2-NBDG) was performed in fresh skeletal muscle sections. (unige.it)
  • During his four years there his primary research projects were studies of peripheral circulation, and, with Benton King and Richard Wechsler, the effects of epinephrine and norephinephrine and epinephrine on cerebral blood flow (CBF) and cerebral 02 consumption (MCR02). (nih.gov)
  • Unlike other calorie restriction mimetics, such as 2-deoxyglucose, GlcN extends life span of ageing C57BL/6 mice, which show an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expression of several murine amino-acid transporters, as well as increased amino-acid catabolism. (anti-agingfirewalls.com)
  • Metabolic processes linked to neuronal activity - such as blood flow, glucose utilization and oxygen consumption - provide the signals detected with most functional brain-imaging techniques. (edu.sa)
  • The method is based on the up- take of 'C in the various cerebral tissues following an intravenous tracer pulse of [!4C]deoxyglucose. (nih.gov)
  • Oxygen consumption rate (OCR) was conducted by mito stress test kit. (bvsalud.org)
  • The expected respiratory damage was confirmed by a deceleration in ATP synthesis and oxygen consumption rate. (unige.it)
  • Reprinted from 7 March 1975,volume 187,pages 850-853 SCIENCE Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with ['*C ]Deoxyglucose Abstract. (nih.gov)
  • This report demonstrates that the [14C]deoxyglucose autoradiographic technique is a useful, indeed powerful method for mapping functional neural pathways. (nih.gov)
  • More specifically, we demonstrate that atovaquone treatment of MCF7 breast cancer cells inhibits oxygen-consumption and metabolically induces aerobic glycolysis (the Warburg effect), as well as oxidative stress. (oncotarget.com)
  • Such studies permit the study of sensitivity or resilience to acute stressors in at-risk or currently dependent individuals, of how alcohol can differentially reduce stress reactivity in different groups of participants, or how and whether a stressor induces alcohol craving or consumption. (nih.gov)
  • In the late 1950s, other researchers had discovered a glucose analog, 2-deoxyglucose (2-DG), which behaves just like glucose in the first step of the ten-step metabolic pathway of glycolysis. (nih.gov)
  • If suffi- cient time is allowed after the pulse for the free ['4C]deoxyglucose to have been cleared from the tissue, then the 14C concentration of the tissue repre- sents the [!4C]deoxyglucose-6-phosphate content which. (nih.gov)
  • In Schwartz's and Gainer's study of suprachiasmatic nucleus glucose consumption, the suprachiasmatic nucleus was found to have higher glucose consumption during the daytime than during the night. (wikipedia.org)
  • DG is transported into the brain via the same mechanism which transports glucose, where it is then phosphorylated by hexokinase into 14C-deoxyglucose-6-phosphate(DG-6-P). The accumulation of DG-6-P reflects the rate of glucose consumption, and can be quantitatively measured using an autoradiograph. (wikipedia.org)
  • A method has been developed for quantitative estimation of the rates of glucose consumption in the various structural components of the brain (1). (nih.gov)
  • 13. Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors. (nih.gov)
  • STS markedly decreases brain glucose consumption without altering measured FDG SUV in mouse experimental models. (springeropen.com)
  • Local glucose consumption is thus selectively modulated by neuronal activation while being relatively independent of hormonal whole body-derived signals. (springeropen.com)
  • We therefore tested whether these neuroprotective effects could relate to changes of glucose transport and consumption. (medscape.com)
  • We then observed that immortalization and H-Ras V12 -transformation of bronchial epithelial cells caused a stepwise increase in oxygen consumption, a global measure of electron transport chain activity. (biomedcentral.com)
  • Glucose consumption was studied via a technique using 14C-deoxyglucose (DG). (wikipedia.org)
  • However, it has no effect on oxygen consumption in normal human fibroblasts and, in this cellular context, behaves as an anti-inflammatory, consistent with the fact that it is well-tolerated in patients treated for infections. (oncotarget.com)
  • 1-!4C]Deoxyglucose (specific activity, 53 mc/mmole) was administered as a pulse via the femoral venous catheter. (nih.gov)
  • The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. (springeropen.com)
  • In 1977, Schwartz, along with Harold Gainer, Ph.D, found that the glucose consumption in the rat suprachiasmatic nucleus is a function of time of day and environmental lighting conditions. (wikipedia.org)
  • Understanding the biologic systems that underlie the relationship between stress and alcohol consumption may lead to better prevention efforts and more effective treatments for alcoholism. (nih.gov)