• Subsequent transcriptomic analysis identified genes differentially regulated by MeJA+NaCl treatment and NaCl alone. (frontiersin.org)
  • The transcriptionally regulated genes have different roles under stress response. (intechopen.com)
  • Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
  • Various genes regulating cellular and subcellular metal distribution have been identified and characterized. (frontiersin.org)
  • Genes involved in Fe acquisition in plants are induced under Fe-deficient conditions, and various genes putatively acting as Fe sensors have been discussed ( Kobayashi and Nishizawa, 2014 ). (frontiersin.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • These individuals are thought to have mutations in genes that have not yet been linked to the condition. (medlineplus.gov)
  • Other genes known to be associated with primary familial brain calcification also have roles in cell signaling and phosphate homeostasis. (medlineplus.gov)
  • These techniques have been especially useful in identifying genes that are directly regulated in response to changes in metal-ion status. (biomedcentral.com)
  • For example, our group has examined the genes regulated by the Zap1p transcription factor in S. cerevisiae using DNA microarrays and promoter motif analysis [ 1 ] (Figure 1 ). (biomedcentral.com)
  • Aft1p regulates genes involved in iron metabolism, and Mac1p regulates genes involved in copper homeostasis. (biomedcentral.com)
  • Like Zap1p, these factors activate the expression of target genes in metal-limiting conditions, to facilitate uptake and distribution of the metal ion. (biomedcentral.com)
  • Two of these environment, pathogens must be able to regulate the neces- methods, signature-tagged mutagenesis and in vivo sary genes in coordination as they move from the environ- expression technology, do not directly measure gene ment to the host and from one host niche to another. (cdc.gov)
  • The project will identify key genes, pathways, and biological processes that are differentially regulated in response to hypoxia. (lu.se)
  • Iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) are essential micronutrient mineral elements for living organisms, as they regulate essential cellular processes, such as chlorophyll synthesis and photosynthesis (Fe, Cu, and Mn), respiration (Fe and Cu), and transcription (Zn). (frontiersin.org)
  • Homeostasis is the property of an open system, especially living organisms, to regulate its internal environment to maintain a stable, constant condition, by means of multiple dynamic equilibrium adjustments, controlled by interrelated regulation mechanisms. (dadamo.com)
  • The image below illustrates phosphate homeostasis. (medscape.com)
  • Renal excretion of excess dietary phosphate intake ensures maintenance of phosphate homeostasis, maintaining serum phosphate at a level of approximately 3-4 mg/dL in the serum. (medscape.com)
  • in the brain where it plays a major role in regulating phosphate levels (phosphate homeostasis) by transporting phosphate across cell membranes. (medlineplus.gov)
  • Razzaque MS. FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player. (medscape.com)
  • While NPP1 is a key factor for cementum formation, NPP2 and NPP3 may be involved in regulation of PDL homeostasis. (umich.edu)
  • Plants show stress-specific regulation of transcription that affects their transcriptome under stress conditions. (intechopen.com)
  • Moreover, modulation of the proteins involved in cellular metal homeostasis may help in the regulation of metabolism, adaptability to a diverse range of environmental conditions, and biofortification. (frontiersin.org)
  • The results of this project will also provide an extensive knowledge about tRNA regulation during stress conditions. (europa.eu)
  • We determined that tRNA abundance changes during stress conditions are mainly regulated by tRNA degradation and we identified RNY1, a stress-related ribonuclease, as a key player in the specific regulation of tRNAs during stress conditions. (europa.eu)
  • These results provide a new insight into the mechanism of PIG3's functioning in DNA damage signaling and the regulation network of cellular DNA-PKcs expression homeostasis. (ijbs.com)
  • This regulation becomes important in the transplantation setting where HSCs undergo proliferation followed by a gradual transition to quiescence and homeostasis. (lu.se)
  • Shaikh A, Berndt T, Kumar R. Regulation of phospahte homeostasis by the phosphatonins and other novel mediators. (medscape.com)
  • We traditionally recognize vitamin D as the key vitamin for regulation of bone metabolism and homeostasis, but I want you to think out of the box here. (medscape.com)
  • CD97 in colonic enterocytes strengthens E-cadherin-based adherens junctions to maintain lateral cell-cell contacts and regulates the localization and degradation of β-catenin through glycogen synthase kinase-3β (GSK-3β) and Akt signaling. (wikipedia.org)
  • Under normal conditions, Keap1 promotes ubiquitination and eventual degradation of Nrf2. (springer.com)
  • Dr. Figueiredo seeks to understand how ribosome biogenesis and ribosome degradation is regulated in myofibers, the muscle cells and how those cellular processes impact on ribosome homeostasis/turnover, muscle protein synthesis and muscle size. (oakland.edu)
  • Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading. (oakland.edu)
  • In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications. (researchgate.net)
  • The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity. (diabetesjournals.org)
  • Tune H Pers receives the Leif C. Groop Award for Outstanding Diabetes Research in 2024 for research that has increased the understanding of how specific brain areas and cell populations regulate glycemic control, energy homeostasis, and genetic predisposition to obesity. (lu.se)
  • This year's recipient Tune H Pers investigates, among other things, the role of the brain for the development of obesity, a condition that increases the risk of type 2 diabetes. (lu.se)
  • Homeostasis refers to the body's ability to regulate its environment and maintain internal balance. (chriskresser.com)
  • A well-balanced ECS encourages favorable conditions in the body system, impacting the body's ability to manage metabolic stress 1 and may support overall health and well-being. (standardprocess.com)
  • Notably, CD97 antibody-mediated granulocytopenia only happens under the condition of pro-inflammation via an Fc receptor-associated mechanism. (wikipedia.org)
  • However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. (mdpi.com)
  • They also "inhibit inflammation, mobilize fats, and regulate the release of insulin," notes Petersen. (mindbodygreen.com)
  • All diseases involve a disturbance of homeostasis, and nearly all diseases involve some degree of pain and inflammation. (chriskresser.com)
  • In fact, research over the last several decades suggests that many serious conditions like heart disease previously thought to have other causes are in fact primarily caused by chronic inflammation. (chriskresser.com)
  • If we understand that most diseases are characterized by pain, inflammation and disturbance of homeostasis, we begin to understand why acupuncture can be effective for so many conditions. (chriskresser.com)
  • The systemic imbalance may occur under circumstances such as stress, and fatigue, which may trigger inflammatory responses in the body 3 and inflammation may cause unwanted health conditions. (standardprocess.com)
  • Our work aims to investigate whether the processes that regulate the tRNA availability in the cell are specific and how they can affect protein translation and directly impact cell fitness. (europa.eu)
  • Alternatively, changes in PDGFRB signaling could disrupt processes that regulate levels of phosphate and calcium in brain cells, leading to the formation of calcium deposits. (medlineplus.gov)
  • Potassium also regulates aldosterone by causing membrane depolarization and activation of signaling pathways that lead to aldosterone synthesis. (aacc.org)
  • Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
  • Deregulation in the synthesis of these hormones results in a number of clinical conditions. (aacc.org)
  • Unlike most adrenal hormones regulated heavily through the hypothalamic-pituitary-adrenal axis, secretion of aldosterone depends minimally on the action of corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH). (aacc.org)
  • Regulates the internal enviro-nment of the body, including temper-ature, salt concen-tra-tion, hormones, and more. (cheatography.com)
  • The pancreas is an organ and a gland that secretes two hormones, insulin and glucagon, for regulating glucose in the bloodstream. (kidneyurology.org)
  • These hormones help maintain homeostasis, a condition where everything remains stable within the body. (kidneyurology.org)
  • Iodine is needed to make hormones that regulate many body functions after they are released into the blood. (cdc.gov)
  • Generally with the recognition of divergence from the homeostatic condition positive feedbacks are called into play, whereas once the homeostatic condition is approached, negative feedback is used for "fine tuning" responses. (dadamo.com)
  • This creates a situation of "metastability", in which homeostatic conditions are maintained within fixed limits, but once these limits are exceeded, the system can shift wildly to a wholly new (and possibly less desirable) situation of homeostasis. (dadamo.com)
  • Although mouse HSCs have been well studied under homeostatic conditions, the mechanisms regulating HSC activation under stress remain unclear. (lu.se)
  • Silencing of the transcription factor hCAS/CSE1L, which regulated PIG3 expression, led to decreased PIG3 transcription and concurrently decreased apoptosis ( 3 ). (ijbs.com)
  • It also regulates neuronal APOPTOSIS. (bvsalud.org)
  • another ER chaperone), and becomes available to regulate inositol trisphosphate (IP3) receptor-mediated Ca 2+ release to maintain mitochondrial Ca 2+ homeostasis. (molvis.org)
  • The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and control bone metabolism. (mdpi.com)
  • This work aimed to uncover new regulatory mechanisms in the cell that may have broad impact in the understanding of how protein synthesis is regulated. (europa.eu)
  • His work currently focuses on mechanisms regulating repair of lung injury. (hopkinsmedicine.org)
  • Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and plasma membrane that are regulated by upstream regulators ( 15 ) . (researchsquare.com)
  • The results suggested a new regulatory mechanism via which butanoate and AMPK activation contributed to intestinal integrity and homeostasis by affecting metabolism, intestinal barrier function and transporter expression. (rsc.org)
  • The storage and distribution of these minerals in various cellular organelles is strictly regulated to ensure optimal metabolic rates. (frontiersin.org)
  • The ECS regulates nearly every metabolic process in the body system. (standardprocess.com)
  • This research aimed to map NPP1,2, and 3 expression in the developing periodontium in wild-type (WT) mice, as well as in PP i -deficient progressive ankylosis protein ( Ank ) and Enpp1 KO mice, to explore their roles in periodontal homeostasis. (umich.edu)
  • Enpp1-3 gene expression was assayed by real-time PCR in human periodontal ligament (PDL) cells and murine cementoblasts (OCCM-30) under osteogenic conditions. (umich.edu)
  • In PDL cells, Enpp2 and Enpp3 were significantly increased at later stages of mineralization (about 4-fold), while Enpp1 expression was unaltered by osteogenic conditions. (umich.edu)
  • In the context of these simulations, initial conditions are certain expression levels of some species that one might want to investigate. (american.edu)
  • With genome or EST sequences in hand, microarrays or macroarrays can be constructed to analyze gene-expression profiles at the genome-wide level over a range of conditions. (biomedcentral.com)
  • BACKGROUND: We previously reported that endothelins (ETs) regulate tyrosine hydroxylase (TH) activity and expression in the olfactory bulb (OB) of normotensive and hypertensive animals. (bvsalud.org)
  • PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. (koreamed.org)
  • We tone, local homeostasis, and the fibro- excluded any patient with cardiovascular inflammatory-proliferative process. (who.int)
  • Homeostasis is defined as "any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival. (entrepreneur.com)
  • To avoid iron toxicity, yet to deliver adequate amounts of iron for biological processes, life on Earth has evolved to have sophisticated machinery that regulates iron at both the systemic and the cellular levels. (american.edu)
  • The term is most often used in the sense of biological homeostasis. (dadamo.com)
  • The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
  • These results provide evidence that the involvement of mitophagy is crucial during OB differentiation, and KLF2 critically regulates it. (nih.gov)
  • This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • miR-720 regulated insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Under prolonged cellular stresses, the σR1 translocates to the extended ER network, whereby it interacts with and regulates the function of a variety of ion channels, receptors, or kinases. (molvis.org)
  • We know that vitamin D receptors regulate an active metabolite of vitamin D highly expressed in both the small and large bowel. (medscape.com)
  • Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)
  • These vital enzymes are necessary for normal cellular metabolism and homeostasis, too. (mindbodygreen.com)
  • Type IIc sodium-dependent phosphate transporter regulates calcium metabolism. (medscape.com)
  • 2/ 4 · give an account of the different components of the blood, their functions, production and renewal, and how hematopoiesis is regulated hormonally · explain the structure, function and control of different interacting body functions involved in the maintenance of the homeostasis of the body (circulation, respiration, digestion, metabolism and excretion). (lu.se)
  • Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC). (stanford.edu)
  • With that said, it's unsurprising that sirtuins are implicated in the development of many chronic conditions-from cardiovascular diseases (like hypertension) and neurodegenerative diseases (like Alzheimer's). (mindbodygreen.com)
  • Regulated cell death (RCD) plays an essential role in cell homeostasis, tissue remodeling, and diseases. (invivogen.com)
  • Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
  • As a result of aging, older organisms become increasingly vulnerable to a variety of age-related diseases and conditions, culminating in death. (agemed.org)
  • Se-Jin Lee, M.D., Ph.D., an internationally renowned geneticist focused on discovering causes and cures for muscle degenerative diseases like muscular dystrophy and muscle wasting conditions resulting from diseases such as cancer and sepsis, will join UConn Health and The Jackson Laboratory (JAX) as a joint faculty appointment. (jax.org)
  • His work has shown that lack of myostatin leads to dramatic increases in skeletal muscle mass in the body and that problems with myostatin levels contribute to disease progression for muscle degenerative and wasting conditions such as muscular dystrophy (a genetic disease causing muscle weakening or loss), sarcopenia (muscle loss due to the aging process) and cachexia (unexplained weight loss or wasting syndrome) resulting from diseases like cancer and sepsis. (jax.org)
  • Although vitamin D can enhance the absorption, especially under conditions of dietary phosphate depletion, intestinal phosphate absorption does not require the presence of active vitamin D. Specifically, high serum phosphate and high dietary phosphate intake do not significantly impair intestinal uptake. (medscape.com)
  • WRN critically regulates autophagy in various cellular stresses, including starvation, endoplasmic reticulum (ER) stress conditions to rescue the cell, and basal situations to restore proper cellular function. (nih.gov)
  • Since no experimental work has been done to systematically characterize the amounts of individual tRNAs at different conditions, the techniques developed during this project will provide other researchers with the tools needed to investigate the influence of tRNA abundance in multiple cellular processes. (europa.eu)
  • These organs are responsible for regulating blood sugar levels so other organs in the body can get adequate fuel in the form of glucose to function optimally. (kidneyurology.org)
  • It also helps to control cravings which aid in regulating body weight. (kidneyurology.org)
  • Homeostasis means regulating that the body so that it maintains a constant state with respect to its internal physical and chemical conditions. (noldus.com)
  • These conditions invariably end up causing the patient to lose their independence, memory, and sense of health - this is a less obvious form of aging, but one that can be warned off by regularly supplementing the body with CBD. (geniusbeauty.com)
  • Complex systems, such as a human body, must have homeostasis to maintain stability and to survive. (dadamo.com)
  • The brainstem is an area of the brain that connects the brain hemispheres to the spinal cord and is home to a part of the vagus nerve that is known to regulate the energy balance in the body. (lu.se)
  • In other words, each sirtuin specializes in regulating unique (and crucial) cellular functions. (mindbodygreen.com)
  • The dience-phalon, composed of the thalamus and hypoth-alamus, regulates sensory inform-ation relay and internal bodily functions, mainta-ining homeos-tasis. (cheatography.com)
  • The metenc-ephalon comprises the pons (regulates autonomic functions and connects brain regions) and the cerebellum (coord-inates voluntary muscle movements and posture, with cognitive functi-ons). (cheatography.com)
  • Regulates various autonomic functions such as breathing and sleep. (cheatography.com)
  • In addition, Lee's laboratory research focuses on the role that signaling molecules play in regulating human development and adult tissue homeostasis. (jax.org)
  • Aldosterone regulates reabsorption of sodium and water at the kidneys by promoting the synthesis of sodium and potassium channels on cells of the distal convoluted tubule (DTC). (aacc.org)
  • L'objectif de la présente étude était d'estimer l'apport en sel chez des résidents de la région est d'Arabie saoudite en mesurant leur excrétion urinaire de sodium en 24 heures. (who.int)
  • L'excrétion de sodium moyenne totale en 24 heures pour le groupe était de 140 mEq (E.T. 49) (153 mEq [E.T. 52] pour les hommes et 118 mEq [E.T. 37] pour les femmes). (who.int)
  • Ces valeurs sont supérieures à celles recommandées pour l'apport en sodium quotidien et représentent un risque de survenue d'hypertension et de maladies cardio- vasculaires dans la population saoudienne. (who.int)
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
  • Furthermore, it is unclear if bacterial size modulation is simply a byproduct of the complex cellular response to changing environmental conditions, or if it serves as an adaptive mechanism employed by the cell to improve fitness in time-varying environments. (nature.com)
  • The project aims to investigate the transcriptional differences between intestinal organoids cultured under normoxic (21% O 2 ) and hypoxic (1-5% O 2 ) conditions, with a particular focus on the involvement of the transcription factor HIF-2α. (lu.se)
  • Its function is the elimination of unwanted cells during physiological conditions such as embryonal development (in these conditions RCD is known as "programmed" cell death) or pathological conditions such as infection. (invivogen.com)
  • The objective of this study was to investigate the effects of dietary intervention on intestinal microbiota-mediated change in short chain fatty acid (SCFA) profile and intestinal homeostasis. (rsc.org)
  • Primary familial brain calcification is a condition characterized by abnormal deposits of calcium (calcification) in blood vessels within the brain. (medlineplus.gov)
  • however, because brain imaging tests are needed to see the calcium deposits, this condition is believed to be underdiagnosed. (medlineplus.gov)
  • Our results show that individual tRNAs change during stress conditions in yeast in a time dependent manner. (europa.eu)
  • Homeostasis is the property of a system that regulates its internal environment and tends to maintain a stable, constant condition of properties like temperature or pH. (absoluteastronomy.com)
  • Finally, the interaction between CD97 and its ligand CD55 regulates T-cell activation and increases proliferation and cytokine production. (wikipedia.org)
  • When the renin-angiotensin system is suppressed, ACTH has a more prominent role in regulating aldosterone. (aacc.org)
  • Angiotensin II (AngII), as the major effector of the renin-angiotensin-aldosterone system (RAAS), plays an important role in regulating blood pressure and arterial remodeling [ 5 ]. (hindawi.com)
  • The endocannabinoid system (ECS) is gaining attention in the public eye for its role in contributing to an individual's overall health and well-being by supporting the body's physiological homeostasis. (standardprocess.com)
  • A blend of exotic herbal ingredients, BeLiv Ultimate Blood Sugar Formula, is a proprietary therapeutic preparation which helps people with diabetes and other related conditions regulate and manage their blood glucose levels naturally. (kidneyurology.org)
  • The course focuses on integrative human physiology, which means how the internal organ systems interact to maintain homeostasis. (lu.se)
  • Bacteria dynamically regulate cell size and growth to thrive in changing environments. (nature.com)
  • In such environments, cell size and growth are regulated by trade-offs between prioritization of biomass accumulation or division, resulting in decoupling of single-cell growth rate from population growth rate. (nature.com)
  • As a result, it remains unclear how cells sense changes in the environment and dynamically regulate division and growth in response. (nature.com)
  • The Gaia hypothesis is a class of scientific models of the geo-biosphere in which life as a whole fosters and maintains suitable conditions for itself by helping to create a favorable environment on Earth for its continuity. (newworldencyclopedia.org)
  • However, bacteria do not exist naturally in such conditions, but instead thrive in rapidly changing environments. (nature.com)
  • Future research programs can be focused on the development of transgenic plants with enhanced stress tolerance in field conditions based upon the outcome of genomic approaches and knowing the mystery of nucleotides sequences hidden in cells. (intechopen.com)
  • Initially, lead is distributed to the blood plasma and soft tissues, but under steady state conditions 99% of the lead in blood is found in the erythrocyte, where much of it is bound to hemoglobin. (cdc.gov)
  • the tendency of a living system to maintain its internal stability as a result of the coordinated responses of its parts to any stimulus that would tend to disturb its normal conditions. (learn-biology.com)
  • The first thing to note is that not all organisms regulate internal conditions to the same degree. (learn-biology.com)
  • q]A [hangman] works to maintain an internal condition in a constant range, despite environmental changes. (learn-biology.com)