• Chest radiograph of a child with idiopathic dilated cardiomyopathy. (medscape.com)
  • Idiopathic dilated cardiomyopathy (DCM) refers to congestive cardiac failure secondary to dilatation and systolic dysfunction (with or without diastolic dysfunction) of the ventricles (predominantly the left ventricle) in the absence of congenital, valvular, or coronary artery disease or any systemic disease known to cause myocardial dysfunction. (medscape.com)
  • Arola A, Tuominen J, Ruuskanen O, Jokinen E. Idiopathic dilated cardiomyopathy in children: prognostic indicators and outcome. (medscape.com)
  • Assuredly, idiopathic dilated cardiomyopathy (DCM), a primary non-ischemic cardiac muscle disease, is clearly recognized as the consequence of systolic dysfunction and dilatation of chamber size of the left or both of ventricles [1, 2]. (researchsquare.com)
  • Hypertensive heart disease, human Immunodeficiency virus associated cardiomyopathy, idiopathic dilated cardiomyopathy and diabetes were the aetiology of HFrEF in 65%, 23%, 13% and 10.4% of patients, respectively. (wits.ac.za)
  • Whilst most have a structurally normal heart it can also be associated with congenital heart disease, rare cardiac tumours or hypertrophic cardiomyopathy and hence echocardiography should be performed ( 7 ). (escardio.org)
  • Necropsy showed no dilated or hypertrophic cardiomyopathy. (nature.com)
  • Conclusions: Pulsatile iVAC2L MCS in patients with advanced coronary artery disease at high to prohibitive operative risk resulted in LV unloading and reduced myocardial oxygen consumption particularly in patients with ACS or significant MR with higher filling pressures at baseline. (kcl.ac.uk)
  • AIMS: To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). (imperial.ac.uk)
  • Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. (elifesciences.org)
  • The work will be of interest to investigators of mechanisms of substrate recruitment by protein kinases, and particularly to those who are trying to understand the mechanisms of familial dilated cardiomyopathy. (elifesciences.org)
  • A detailed family history for familial cardiomyopathy is revealing in as many as 25% of cases. (medscape.com)
  • The patient is a 62-year-old male with a history of ischemic cardiomyopathy, CAD s/p CABG, HFrEF s/p AICD, DM, HTN, and restrictive lung disease presenting with dyspnea, cough, and lower extremity swelling for several months. (emdocs.net)
  • The efficacy of mitral valve surgery in children with dilated cardiomyopathy and severe mitral regurgitation. (medscape.com)
  • Whereas mitral regurgitation can be primary (caused by primary disease, such as flail leaflets) or secondary (caused by a dilated annulus and left ventricular dysfunction), TR is almost always secondary (caused by the underlying conditions leading to right ventricular [RV] dilation). (medscape.com)
  • Complications include restrictive cardiomyopathy , progression to cardiogenic shock , ventricular thrombus, pulmonary or systemic embolus, and mitral or aortic valve regurgitation . (medscape.com)
  • Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM), there is little information about its frequency and distribution pattern according to underlying genetic substrate. (nih.gov)
  • RV dysfunction is an important predictor of morbidity and mortality in cardiac patients, especially those having dilated cardiomyopathy (DCM). (springeropen.com)
  • Background: Dilated cardiomyopathy (DCM) is an important cause of mortality and morbidity. (ssjournals.com)
  • As mortality from other pregnancy conditions, such as hemorrhage and hypertensive disorders, has decreased in developing countries, cardiomyopathy has accounted for an increasing proportion of maternal deaths. (cdc.gov)
  • A recent study reviewing preventable causes of maternal death from 1995-1999 found that cardiomyopathy was the most common cause of pregnancy-related death in North Carolina, representing 21% of all cases of maternal mortality. (cdc.gov)
  • Echo-Doppler parameters of RV and LV function including RV global longitudinal strain, basal & apical RV strain, LV ejection fraction and LV global longitudinal strain were evaluated in 42 DCM patients & 28 normal subjects, aiming to assess the value of apical versus basal RV strain in detection of RV dysfunction in patients with dilated cardiomyopathy. (springeropen.com)
  • Clozapine-induced cardiomyopathy should be taken into account when monitoring patients treated with this antipsychotic and regular electrocardiograms should be performed in order to detect possible alterations as soon as possible. (biomedcentral.com)
  • PATIENTS--32 patients with dilated cardiomyopathy and 24 healthy controls. (bmj.com)
  • Onset is usually insidious but may be acute in as many as 25% of patients with dilated cardiomyopathy (DCM), especially if exacerbated by a complicating lower respiratory infection. (medscape.com)
  • Conclusion For patients with AMI, early and low-dose pravastatin therapy (10 mg/daily) reduces recurrent major adverse cardiac events, mostly the requirement for revascularization. (go.jp)
  • Objectives: The objectives of the study were to evaluate the clinical presentation, cardiac magnetic resonance (CMR) features, and outcomes of patients with dilated cardiomyopathy (DCM). (aku.edu)
  • However for LBBB it may be an early manifestation of underlying ischaemic heart disease or cardiomyopathy so patients should also be invited for surveillance echocardiography. (escardio.org)
  • Conclusions The follow-up of glucose disorders needs to be maintained on a long-term basis in patients controlled for acromegaly. (medscape.com)
  • Clinical profile of congestive cardiomyopathy in children. (medscape.com)
  • This study tested the hypothesis that double overexpression of miR-19a & miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left-ventricular-ejection-fraction (LVEF) in dilated cardiomyopathy (DCM) (i.e., induced by doxorubicin) rat. (researchsquare.com)
  • Conclusion: LVSV, LVEF by CMR, and PE were significantly associated with all-cause MACE. (aku.edu)
  • Dilated cardiomyopathy (DCM) refers to dilation and systolic dysfunction of the ventricles (predominantly the left ventricle) with or without congestive cardiac failure. (medscape.com)
  • They are the most informative noninvasive tests for diagnosing the type of cardiomyopathy and the degree of dysfunction in the heart muscle. (medscape.com)
  • [ 6 ] Additionally, cardiovascular dysfunction may be linked to a specific cardiomyopathy with initial left ventricular hypertrophy, evolving to a dilated cardiomyopathy. (medscape.com)
  • This had a severe impact: The mice had hearts with walls that were thin and balloon-like - a cardiac pathology known as dilated cardiomyopathy. (eurekalert.org)
  • The concept of Cardiac Resynchronization Therapy (CRT) was first introduced twenty years ago, by proposing the implantation of a 4-chamber pacing system 1 in a patient with permanent pacing indications affected by severe dilated cardiomyopathy, in an attempt to improve cardiac output by constantly pacing the ventricles. (jafib.com)
  • The increasing trends in the reported prevalence of cardiomyopathy complicating pregnancy reported during the time period 1995-2006 are also concerning given that cardiomyopathy is an important contributor to other severe medical complications in pregnancy including cardiac arrest, acute myocardial infarction, pulmonary edema, and acute respiratory distress syndrome. (cdc.gov)
  • Conclusion: There was significant left atrial enlargement in this sample Indian population. (ssjournals.com)
  • 120ms) is commonly found in trained athletes but care is needed not to miss underlying pathology such as an atrial septal defect, brugada syndrome or arrhythmogenic right ventricular cardiomyopathy (see below) ( 1 ). (escardio.org)
  • Hypertensive heart disease (HHD) (42.9%) was the most common indication for echocardiography followed by heart failure (21.6%).HHD (58%) was the most common heart disease followed by dilated cardiomyopathy (7.4%) and valvular heart disease(6.1%).61(8.1%) subjects had normal echocardiogram. (ajol.info)
  • Hypertensive heart disease is the most common indication for echocardiography and also the predominant cause of heart disease in Onitsha,South East Nigeria followed by dilated cardiomyopathy and valvular heart disease. (ajol.info)
  • This paper describes results on the association between protein kinase A and peptides corresponding to wild-type PLN (residues 8-22) and peptides bearing mutations (R9C and A11E) which in the context of full-length PLN (52 residues) result in dilated cardiomyopathy. (elifesciences.org)
  • Mutations in the LMNA gene , encoding Lamin A /C (LMNA), are established causes of dilated cardiomyopathy (DCM). (bvsalud.org)
  • Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: a comparative study from the Pediatric Cardiomyopathy Registry. (medscape.com)
  • Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy, characterized by an enlarged heart with a decreased ejection fraction. (elifesciences.org)
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
  • Most important are hypertension, stroke, cardiomyopathies and coronary heart disease. (who.int)
  • Thus a re-challenge with clozapine of a patient who previously has experienced a clozapine-induced myocarditis or cardiomyopathy is strongly discouraged, as discussed in the review of Nielsen et al. (biomedcentral.com)
  • In conclusion, eosinophilic myocarditis is a rare disorder. (medscape.com)
  • Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches. (qxmd.com)
  • Background: Little is known about nationwide temporal trends in the clinical characteristics and treatment of dilated cardiomyopathy (DCM) in Japan. (elsevierpure.com)
  • Conclusions: Although the clinical characteristics of DCM changed, the implementation of optimal medical therapy for DCM increased from 2003 to 2013 in Japan. (elsevierpure.com)
  • These findings were confirmed in a cardiac MRI showing a dilated left ventricle (diameter 70.1 mm, see Fig. 1 ) and no signs of ischemia/post-ischemia or inflammation. (biomedcentral.com)
  • CONCLUSIONS--TTN missense variants are common and present a challenge for bioinformatic classification, especially when informative families are not available. (units.it)
  • The clinical symptoms of EDMD are manifested as skeletal muscle atrophy and weakness, joint contractures and dilated cardiomyopathy (DCM) with conduction disturbances. (longdom.org)
  • CONCLUSIONS: MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. (ucl.ac.uk)
  • So mostly people left it alone, which is fine, because it's most often treated by treating the things that dilate the RV. (medscape.com)
  • Conclusions and Clinical Relevance -Results suggested the genetic mutation associated with hyperuricosuria, first identified in Dalmatians, also appears to cause hyperuricosuria in Bulldogs and BRTs, indicating that similar management strategies for urate urolithiasis can be used in these breeds. (avma.org)
  • The most important cardiovascular diseases (CVDs) in the African Region are those related to atherosclerosis, cardiomyopathies and rheumatic heart disease. (who.int)
  • Data Conclusion This study could demonstrate the feasibility of PCASL to identify splenic switch-off during adenosine perfusion MRI, both by qualitative and quantitative assessments. (unav.edu)
  • BENTONVILLE, AR - In a newly published study , grain-free diets had no negative impact on canine cardiac function and did not lead to the development of dilated cardiomyopathy (DCM). (fourmuddypaws.com)
  • The results from this study suggest that increasing the inclusion of pulses up to 45% with the removal of grains and equal micronutrient supplementation does not impact cardiac function concurrent with dilated cardiomyopathy, body composition, or SAA status and is safe for healthy adult dogs to consume when fed for 20 wks. (fourmuddypaws.com)
  • Neutering was also associated with reduced risk of dilated cardiomyopathy and gastric dilatation volvulus in males. (escholarship.org)
  • Conclusion: Fully automated AI-derived analysis LV dilatation on routine unselected non-gated contrastenhanced CT thorax studies is feasible. (bath.ac.uk)
  • We have defined thresholds for the detection of LV dilatation on CT relative to CMR, which could be used to routinely screen for dilated cardiomyopathy at the time of CT. (bath.ac.uk)
  • For example, in the United States, the proportion of pregnancy-related deaths from cardiomyopathy increased in the time period 1979-1986 to 1991-1997 and up to 11.5% in the period 1998-2005, reaching almost 13% in 2005-2006. (cdc.gov)
  • The proportion of deaths attributable to cardiomyopathy in pregnancy may be even higher in geographic locations with a higher prevalence of this condition. (cdc.gov)
  • According to the New York Times, the FDA has reported that 560 dogs have been diagnosed with a rare heart condition called dilated cardiomyopathy. (fathead-movie.com)
  • Conclusions: The presented results indicate that assessment of circulating natriuretic peptides is of limited value in identifying cardiac involvement in EDMD. (longdom.org)
  • There has been a lot of buzz about the US Food and Drug Administration (FDA) statements alerting pet owners about a possible link between dilated cardiomyopathy (DCM), a type of heart disease, in dogs eating diets containing peas, lentils, potatoes and other legume seeds as main ingredients. (petcurean.com)