AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
Neurotoxicity SyndromesSyndromeHandArmNeurotoxinsDown SyndromeMetabolic Syndrome XNeuronsNephrotic SyndromeSjogren's SyndromeNeuroprotective AgentsNervous System DiseasesMethamphetamineBrainTurner SyndromeHand InjuriesHand DisinfectionAmyloid beta-PeptidesAbnormalities, MultipleMyelodysplastic SyndromesManganese PoisoningCells, CulturedNerve DegenerationN-Methyl-3,4-methylenedioxyamphetamineCushing SyndromeDose-Response Relationship, DrugChlorpyrifosMethylmercury CompoundsMercury Poisoning, Nervous SystemAcute Coronary SyndromePolycystic Ovary SyndromeNervous SystemMicrogliaHand StrengthWilliams SyndromePeripheral Nervous System DiseasesHand Joints1-Methyl-4-phenylpyridiniumDopamineTime FactorsRats, Sprague-DawleyMPTP PoisoningN-MethylaspartateCell DeathDiGeorge SyndromeTreatment OutcomeHorner SyndromeCerebral CortexPrader-Willi SyndromeMutationLong QT Syndrome1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineGuillain-Barre SyndromeDisease Models, AnimalHemolytic-Uremic SyndromeCarpal Tunnel SyndromeCompartment SyndromesGlutamic AcidTourette SyndromeAntiphospholipid SyndromeHand DermatosesCorpus Striatum
North AmericaMyelodysplastic syndromePesticidesPeripheralOccurrenceMechanismDeficitsWeaknessToxinsNauseaMedianAcutePatientsSymptomsTremorsClinicalComplicationsWorkDisordersParkinson'sObesityRecognitionIntravenousPresentExcessiveHypertensionIncludeFoundMotorSecond most commonStrongCancerTreatmentPeopleStudyCasesDiseaseCentralWomenResultConcernsPainArticleStrength
North America2
  • However, since most mushroom species are rarely eaten, many toxins are poorly documented and syndromes not yet observed in North America may turn up as more and more people experiment with eating wild mushrooms. (namyco.org)
  • Acute inflammatory demyelinating polyradiculoneuropathy is the most frequent pattern of Guillain-Barré syndrome encountered in North America and Europe. (medlink.com)
Myelodysplastic syndrome2
  • Myelodysplastic syndrome (MDS) in children is rare, accounting for (bvsalud.org)
  • Aileron Therapeutics Inc. (NASDAQ: ALRN) (FRA: O15) is a clinical stage biopharmaceutical firm that is engaged in developing and commercializing a new class of therapeutics to help treat myelodysplastic syndrome, acute myeloid leukemia, cancer and other ailments. (qualitystocks.com)
Pesticides1
  • In addition to the median nerve compression that can occur due to manual work, exposure to biochemical hazards such as white spirits, varnishes, dye, paints, and pesticides during work cause neurotoxicity, which may make the median nerve more vulnerable to develop Carpal Tunnel Syndrome. (intecorept.com)
Peripheral1
  • Main toxicities were (sorafenib-GEMOX/sorafenib) neutropenia (23%/0), thrombocytopenia (33%/0), diarrhoea (18%/9), peripheral neuropathy (5%/0) and hand-foot syndrome (5%/18). (nature.com)
Occurrence2
  • Mood and personality changes are a common occurrence following physical or organic damage to the brain. (iloencyclopaedia.org)
  • There is certainly some concern that circulating IL-6 known amounts boost after administration of tocilizumab, contributing to an elevated occurrence of neurotoxicity [20,23]. (thetechnoant.info)
Mechanism7
  • Several theories have been proposed to explain the exact mechanism through which these agents cause neurotoxicity. (ajnr.org)
  • 2) Williams R, Cheng L, Mudge A, Harwood A. A common mechanism of action for three mood-stabilizing drugs. (madinamerica.com)
  • In this article, the authors propose that a common mechanism of action in which lithium, carbamazepine, and valproic acid "inhibit the collapse of sensory neuron growth cones and increase growth cone area. (madinamerica.com)
  • 3) Harwood A, Agam G. Search for a common mechanism of mood stabilizers. (madinamerica.com)
  • Authors review the search for a common mechanism of action among mood stabilizers, as a means of understanding their therapeutic effects and justification for being a unified class of drugs. (madinamerica.com)
  • While reviewing some possibilities, the authors conclude that no common mechanism has been established, nor theory of common action. (madinamerica.com)
  • At present, the mechanism of neurotoxicity caused by immunotherapy has not been completely elucidated. (hindawi.com)
Deficits1
  • According to this study , 41% of craniotomies result in neurological deficits such as the inability to speak or walk after surgery, palsy and weakness in the arms. (raggedclown.com)
Weakness5
  • A diagnosis of amyotrophic lateral sclerosis (ALS) was first made 2 years ago when Mr A noticed bilateral weakness in his arms and then atrophy. (psychiatrist.com)
  • Falls with injury, loss of ability to attend to hygiene and other activities of daily living, problems with speech, problems with swallowing, and weakness of the respiratory muscles causing respiratory failure and death are all common concerns as the disease progresses. (psychiatrist.com)
  • This painful condition - which involves the median nerve on the palm of your hand, causes symptoms such as tingling in the fingers, numbness, weakness, and pain in the forearm and wrist. (intecorept.com)
  • As is the case in Carpal Tunnel Syndrome, it causes functional disability and symptoms such as pain, numbness, tingling sensations, and weakness in the corresponding hand and arm. (intecorept.com)
  • 04 ). In most instances, weakness is noticed initially in the legs, but it can begin in the arms or the face. (medlink.com)
Toxins1
  • Microbial toxins, like the neurotoxins of Lyme disease, require a different and more targeted treatment approach than do the more common environmental toxins. (indexarticles.com)
Nausea1
  • Nausea and vomiting are quite common, but the principle effects are on the central nervous system: confusion, visual distortion, a feeling of greater strength, delusions and convulsions. (namyco.org)
Median3
  • The median nerve - "the eye of the hand" runs from the top of the arm (at the branchial plexus) down through your arm and forearm and into the palm side of your thumb, index finger, middle finger, ring finger, and nail bed. (intecorept.com)
  • Carpal Tunnel Syndrome can run in families who carry a strong tendency for median nerve entrapment due to abnormal anatomy of the carpal tunnel and the structures of the wrist and forearm. (intecorept.com)
  • The median age of the patients was 57 years (range: 41~74), and the most common sites of metastasis were liver, lung or lymph node. (e-crt.org)
Acute3
  • This study concerns the third of a series of three examinations of hand strength and vibration thresholds in a two year period after acute OP poisoning among 48 Nicaraguan men. (bmj.com)
  • In a multicenter, single-arm, open-label phase 2 study on patients with relapsed or refractory B-precursor acute lymphoblastic leukemia, the distribution of any grade neurologic ir-AEs frequency was 52% among patients receiving blinatumomab, and grade 3 or 4 neurologic ir-AEs occurred in 11% and 2% patients, respectively [ 19 ]. (hindawi.com)
  • Molecular mimicry and ganglioside antibodies play an important role in the pathogenesis of some variants of Guillain-Barré syndrome (eg, acute motor axonal neuropathy). (medlink.com)
Patients6
  • The frequency of cyclosporin A (CsA)-induced neurotoxicity is thought to be between 25% and 35% (1, 2) , and FK 506 neurotoxicity has been found in 32% of patients undergoing orthotopic liver transplantation (3) . (ajnr.org)
  • Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)
  • In the patients who did achieve ROSC in the calcium arm, 74% had hypercalcemia. (umaryland.edu)
  • The timely and accurate identification of neurotoxicity helps clinicians detect and treat these complications early, thereby enhancing treatment efficiency and improving the prognosis of patients. (hindawi.com)
  • Page 3 DEXAMETHASONE, CYTARABINE, AND CISPLATIN (DHAP) INTRAVENOUS CANCER TREATMENT EDUCATION Common Side Effects Common side effects that have been known to happen in patients receiving DHAP are listed in the left side of this table. (ivcanceredsheets.com)
  • After four or five years of increasing dosages their effect becomes sporadic and unpredictable (the "on-off syndrome") and patients become increasingly helpless and depressed. (digitalnaturopath.com)
Symptoms5
  • Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. (wikipedia.org)
  • Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly. (wikipedia.org)
  • A mild degree of overproduction of cortisol without obvious symptoms, however, is more common. (wikipedia.org)
  • There are multiple other causes and reasons why someone should get Carpal Tunnel Syndrome-mimicking symptoms. (intecorept.com)
  • symptoms (of mitochondrial damage) such as fatigue, muscle pain, shortness of breath, and abdominal pain can easily be mistaken for collagen vascular disease, chronic fatigue syndrome, fibromyalgia, or psychosomatic illness. (hormonesmatter.com)
Tremors1
Clinical1
  • Parkinsonism is a clinical syndrome characterized by tremor , bradykinesia (slowed movements), rigidity , and postural instability . (wikipedia.org)
Complications1
  • The cer is about 2%-5% and as high as 26% in most common complications include renal small-cell lung carcinoma [ 5 ]. (who.int)
Work1
Disorders2
  • Depression and anxiety disorders are also common. (wikipedia.org)
  • In addition, variants of Guillain-Barré syndrome and related disorders are briefly discussed. (medlink.com)
Parkinson's1
Obesity2
  • Many of the features of Cushing's are those seen in metabolic syndrome, including insulin resistance, hypertension, obesity, and elevated blood levels of triglycerides. (wikipedia.org)
  • A study recently found that obesity is directly related to Carpal Tunnel Syndrome because adipose tissue (fat cells) accumulated within the carpal tunnel and squeezed the surrounding structures. (intecorept.com)
Recognition2
  • Common mechanisms of recognition, engulfment, and degradation of the different types of cargo are assumed, but very little is known about the shared and specific molecules involved in the phagocytosis of each target by microglia. (frontiersin.org)
  • The condition is often designated as the Landry-Guillain-Barré-Strohl syndrome or Guillain-Barré syndrome (GBS) in recognition of the descriptions provided by these authors. (medlink.com)
Intravenous2
  • Intravenous injection of a therapeutic dose of propofol induces anesthesia, with minimal excitation, usually within 40 seconds from the start of injection (the time for one arm-brain circulation). (guidelinecentral.com)
  • Intravenous immunoglobulins or plasma exchange are proven effective therapy for Guillain-Barré syndrome. (medlink.com)
Present1
  • The four GCNs present only a small fraction of common interactions, related to canonical functions, like immune response or erythrocyte differentiation. (bvsalud.org)
Excessive1
  • Cushing's syndrome is caused by either excessive cortisol-like medication, such as prednisone, or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands. (wikipedia.org)
Hypertension1
  • Cortisol can also exhibit mineralocorticoid activity in high concentrations, worsening the hypertension and leading to hypokalemia (common in ectopic ACTH secretion) and hypernatremia (increased Na+ ions concentration in plasma). (wikipedia.org)
Include2
  • Other striking and distressing skin changes that may appear in Cushing's syndrome include facial acne, susceptibility to superficial fungus (dermatophyte and malassezia) infections, and the characteristic purplish, atrophic striae on the abdomen. (wikipedia.org)
  • 500 Other signs include increased urination (and accompanying increased thirst), persistent high blood pressure (due to cortisol's enhancement of epinephrine's vasoconstrictive effect) and insulin resistance (especially common with ACTH production outside the pituitary), leading to high blood sugar and insulin resistance which can lead to diabetes mellitus. (wikipedia.org)
Found1
Motor1
  • Guillain-Barré syndrome is now recognized to be a diverse disorder that can be divided into several patterns based on the predominant mode of fiber injury (demyelinating vs. axonal) and on nerve fibers involved (motor, sensory and motor, cranial). (medlink.com)
Second most common2
  • Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. (biomedcentral.com)
  • MM is the second most common hematologic malignancy and is difficult to cure. (biomedcentral.com)
Strong1
  • Nevertheless, there is a strong correlation between the neurotoxicity caused by prion proteins and the blockade of their normal proteolysis. (mdpi.com)
Cancer1
  • Worldwide, HCC is the fifth most common cancer in men and the seventh in women, and is responsible for more than 600,000 cancer deaths. (nature.com)
Treatment1
  • Thirty-five days after treatment the patient experienced emotional lability, which was assumed to be a depressive syndrome. (ajnr.org)
People1
Study1
Cases2
  • Vincristine-induced neurotoxicity is also well documented, but only a few cases of cortical blindness have been reported (4, 5) . (ajnr.org)
  • 60% of cases occurred in the left arm. (umaryland.edu)
Disease2
  • Untreated Cushing's syndrome can lead to heart disease and increased mortality. (wikipedia.org)
  • On many levels, it makes sense that fluoroquinolone toxicity syndrome is a disease of mitochondrial damage and ensuing oxidative stress. (hormonesmatter.com)
Central1
  • This may be into a short, flexible temporary catheter in your arm, or through a central venous catheter. (ivcanceredsheets.com)
Women1
Result2
  • 1 Moreover, OPs are a common vehicle for suicide attempts, 2 which generally result in more severe poisonings than accidental occupational poisonings. (bmj.com)
  • Is fluoroquinolone toxicity syndrome a result of mitochondrial damage? (hormonesmatter.com)
Concerns1
  • When you dismiss my concerns out of hand, you remind me of a certain old-fashioned kind of doctor. (raggedclown.com)
Pain1
Article1
  • For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. (mdpi.com)
Strength1