CyclophosphamideDoxorubicinEtoposideCisplatinBleomycinPrednisoneRegimenMethotrexateRituximabVinblastineDexamethasoneIrinotecanSulfateTherapeuticPatients with newly diagnosedAdjuvantInductionTherapyEfficacyDrugsSurvivalCommonlyMildApoptosisVeinProtocolsCyclesReductionTreatmentCancerDoseLymphomaDaysDocetaxelReceivePrimaryActiveMinutes
Cyclophosphamide18
- Brief window therapy (12 wks) was immediately followed-up by vincristine, dactinomycin, and cyclophosphamide (VAC), chemotherapy, surgery, and irradiation, with continuation of either VM or IE in patients with initial response. (elsevierpure.com)
- I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. (clinicaltrials.gov)
- To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the EFS of patients with standard-risk relapsed favorable histology Wilms tumor (SRrFHWT) as compared to historical controls. (clinicaltrials.gov)
- I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the overall survival (OS) of patients with newly diagnosed stage 4 DAWT as compared to historical controls. (clinicaltrials.gov)
- Subsequently, a combination of cyclophosphamide (CTX), vincristine (VCR), and methotrexate (MTX) was shown to be active, but a survival advantage compared to CTX alone could not be demonstrated because effective CNS prophylactic therapy, in the form of intrathecal therapy, was not given. (hindawi.com)
- A combination of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard treatment regimen for DLBCL. (news-medical.net)
- Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first-line cyclophosphamide, vincristine, and prednisone (CVP) chemotherapy. (drugs.com)
- Previously untreated diffuse large B-cell, CD20-positive NHL in combination with (cyclophosphamide, doxorubicin, vincristine, and prednisone) (CHOP) or other anthracycline-based chemotherapy regimens. (drugs.com)
- Previously untreated and previously treated CD20-positive CLL in combination with fludarabine and cyclophosphamide (FC). (drugs.com)
- Much of the information regarding efficacy of treatment for canine lymphoma has come from studies using combinations of cyclophosphamide, vincristine, and prednisone. (vin.com)
- Design and Methods Oral cyclophosphamide, thalidomide, and dexamethasone was compared with infusional cyclophosphamide, vincristine, doxorubicin, and dexamethasone in patients with newly diagnosed multiple myeloma. (haematologica.org)
- Cyclophosphamide-thalidomide-dexamethasone was non-inferior to cyclophosphamide-vincristine-doxorubicin-dexamethasone for progression-free and overall survival, and there was a trend toward a late survival benefit with cyclophosphamide-thalidomide-dexamethasone in responders. (haematologica.org)
- A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. (haematologica.org)
- Compared with cyclophosphamide-vincristine-doxorubicin-dexamethasone, cyclophosphamide-thalidomide-dexamethasone was associated with more constipation and somnolence, but a lower incidence of cytopenias. (haematologica.org)
- Conclusions The cyclophosphamide-thalidomide-dexamethasone regimen showed improved response rates and was not inferior in terms of survival outcomes to the standard infusional regimen of cyclophosphamide-vincristine-doxorubicin-dexamethasone. (haematologica.org)
- 14 , 15 It has previously been shown that the addition of cyclophosphamide to VAMP (vincristine, doxorubicin, and methylprednisone), a regimen very similar to VAD, increases response rates. (haematologica.org)
- 2 , 16 Having developed an oral induction regimen comprising cyclophosphamide, thalidomide, and dexamethasone (CTD), 17 , 18 we compared its efficacy and safety to that of cyclophosphamide plus VAD (CVAD) in a large randomized trial setting whereby, apart from the difference in the mode of administration, thalidomide was in effect an alternative to vincristine plus doxorubicin. (haematologica.org)
- Patients on treatment with rituximab (R) either alone or in combination with chemotherapy, including an alkylating agent (e.g. bendamustine [R-B] or cyclophosphamide, hydroxydoxorubicin, vincristine, prednisone [R-CHOP]) for relapsed indolent non-Hodgkin's lymphoma (iNHL). (who.int)
Doxorubicin7
- If you are having vincristine in combination with another chemotherapy drug called doxorubicin , the infusion may be given over a few days using a pump that you take home. (macmillan.org.uk)
- This combination contains the chemotherapy drugs vincristine sulfate (Oncovin), procarbazine hydrochloride, and doxorubicin hydrochloride (Adriamycin) and the steroid hormone prednisone. (cancer.gov)
- If both drugs are applied simultaneously, doxorubicin inhibits apoptosis induction of vincristine. (uni-muenchen.de)
- While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)
- Combination vincristine, doxorubicin, and dexamethasone (VAD) is considered a standard infusional induction therapy for younger MM patients prior to HDT and ASCT. (haematologica.org)
- Various treatment protocols have been used, but those based on a combination of cisplatin and doxorubicin appear to have the best overall success rates. (medscape.com)
- A Japan Clinical Oncology Group studied 23 patients who received cisplatin/vincristine/doxorubicin/etoposide before resection and/or radiotherapy. (medscape.com)
Etoposide5
- Purpose This study was designed to estimate the partial and complete response rates (CR and PR) of two novel drug pairs (vincristine and melphalan vs. ifosfamide and etoposide) and to improve overall survival of previously untreated patients with metastatic rhabdomyosarcoma. (elsevierpure.com)
- Patients and Methods One hundred twenty-eight patients were randomly assigned to phase II window therapy consisting of vincristine and melphalan (VM-containing regimen) or ifosfamide and etoposide (IE-containing regimen). (elsevierpure.com)
- He was started on a combination of cisplatin and etoposide in a neoadjuvant fashion. (ispub.com)
- Vincristine and vinblastine are most commonly used, and new drugs such as etoposide, teniposide, and vinorelbine are being used in human medicine but have not yet received widespread use in veterinary oncology. (vin.com)
- A three-arm, open-label, randomized, non-inferiority trial found that paclitaxel plus ART was superior to both oral etoposide plus ART and bleomycin and vincristine plus ART, supporting its use for advanced AIDS-associated Kaposi sarcoma in resource-limited settings. (medscape.com)
Cisplatin2
- Commonly used drugs include cisplatin, vincristine, and methotrexate. (wikipedia.org)
- Patients with Stage i non-PFH, non-SCu hepatoblastoma or with Stage ii non-SCu hepatoblastoma will be classified as low-risk (stratum 2) and will be treated on Regimen T with 2 adjuvant cycles of cisplatin, 5-flouorouracil, and vincristine (C5V), a reduction from the standard 4 cycles of chemotherapy given on previous CoG trials. (childrens.com)
Bleomycin2
- Objective: To evaluate the theurapeutic response and acute toxicity of neoadjuvant chemotherapy between the combination of Platinum and Ifosfamide, and the combination of Platinum, Vincristine and Bleomycin in Cervical Carcinoma Stage IB2 and then continued with radical hysterectomy and pelvic lymphadenectomy. (ui.ac.id)
- Method: Thirteen samples received neoadjuvant chemotherapy of Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy of Platinum, Vincristine and Bleomycin, after receiving the neoadjuvant chemotherapy, clinically complete response samples underwent radical hysterectomy and pelvic lymphadenectomy (PI VS PVB = 3 VS 1). (ui.ac.id)
Prednisone2
- Doctors may start with a combination of docetaxel and prednisone, which is a steroid-based treatment. (medicalnewstoday.com)
- As the disease progresses, Chlorambucil is prescribed every three weeks, or CVP combination chemotherapy (Cyclophophamide, Vincristine, and Prednisone). (ecureme.com)
Regimen3
- all patients with any Stage iV hepatoblastoma as well as patients with any stage of hepatoblastoma and initial aFP [Less Than] 100 ng/mL will be classified as high-risk (stratum 4) and will be treated with the novel combination of vincristine, irinotecan, and temsirolimus in Regimen H in order to estimate the response rate of this new combination of agents. (childrens.com)
- This regimen includes 2 cycles of [Quote]up-front[Quote] vincristine, irinotecan, and temsirolimus in the initial 6 weeks of therapy. (childrens.com)
- In this study, however, scientists tested a different drug cocktail that substituted a targeted therapy, polatuzumab, for vincristine in the RCHOP regimen. (rochester.edu)
Methotrexate3
- Early studies with induction including 6-mercatopurine (6-MP) alone or in combination with steroids, methyl-glyoxal guanyl hydrazine and/or methotrexate led to poor results. (nature.com)
- Rheumatoid Arthritis (RA) in combination with methotrexate in adult patients with moderately-to severely-active RA who have inadequate response to one or more TNF antagonist therapies ( 1.3 ). (drugs.com)
- The dose for RA in combination with methotrexate is two-1,000 mg intravenous infusions separated by 2 weeks (one course) every 24 weeks or based on clinical evaluation, but not sooner than every 16 weeks. (drugs.com)
Rituximab2
- Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
- Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to a rituximab product in combination with chemotherapy, as single-agent maintenance therapy. (drugs.com)
Vinblastine1
- Vinblastine is more myelosuppressive than is vincristine in general. (vin.com)
Dexamethasone2
- This study involves treatment with a new combination of standard drugs: VELCADE, Doxil, and Dexamethasone. (drugpatentwatch.com)
- The goals of this study are to determine if this new combination therapy with VELCADE, Doxil and Dexamethasone is an effective treatment, and also to determine the side effects that occur when this combination treatment is given. (drugpatentwatch.com)
Irinotecan1
- Patients who respond to vincristine/irinotecan/temsirolimus (ViT) will continue to receive this combination. (childrens.com)
Sulfate1
- Each mL contains vincristine sulfate 1 mg. (medbroadcast.com)
Therapeutic2
- Agents such as tyrosine kinase, MAPK, PI3K, or hypoxia inducible factor inhibitors, alone or in combination, may represent novel therapeutic strategies that could be evaluated in prospective clinical trials. (thieme-connect.com)
- Transcriptional profiling and the development of personalized cancer medicine will help to pave the way for more specific therapeutic approaches and combinations. (thieme-connect.com)
Patients with newly diagnosed1
- This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). (clinicaltrials.gov)
Adjuvant1
- They had been receiving the drug as monotherapy or as part of combination therapy in the context of adjuvant or neoadjuvant treatment for breast cancer . (medscape.com)
Induction2
- The induction dose for adult patients with active GPA and MPA in combination with glucocorticoids is 375 mg/m 2 once weekly for 4 weeks. (drugs.com)
- The follow up dose for adult patients with GPA and MPA who have achieved disease control with induction treatment, in combination with glucocorticoids is two 500 mg intravenous infusions separated by two weeks, followed by a 500 mg intravenous infusion every 6 months thereafter based on clinical evaluation ( 2.6 ). (drugs.com)
Therapy7
- The purpose of this study is to assess a new combination of chemotherapy drugs as the first treatment for children newly diagnosed with neuroblastoma that has a high risk of returning after therapy. (mskcc.org)
- With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ∼ 80%, even higher among low-risk patients. (nature.com)
- 2011). A single drug is not very effective in cancer therapy therefore malignant diseases are usually treated with a combination of cytostatic agents. (uni-muenchen.de)
- There are varying dose recommendations for Kyprolis for multiple myeloma, depending on line of therapy and combination with other agents. (aetna.com)
- There are varying dose recommendations for Kyprolis for Waldenstrom's macroglobulinemia, depending on line of therapy and combination with other agents. (aetna.com)
- The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. (medbroadcast.com)
- Current trials employ 3-6 cycles of initial combination chemotherapy after biopsy, followed by local therapy, and another 6-10 cycles of chemotherapy, usually given at 2- to 3-week intervals. (medscape.com)
Efficacy4
- During a simulated vincristine shortage, a strategy that allocated by both greater efficacy per volume and worse alternatives improved survival compared to either alone, younger age, or the default of first-come, first-served. (confex.com)
- Since June 2021, Bristol-Myers Squibb has been conducting a Phase II clinical trial study in collaboration with Nektar Therapeutics to assess the safety, tolerability, and drug levels of Bempegaldesleukin (BEMPEG) in combination with nivolumab, and is also estimating its preliminary efficacy in children, adolescents, and young adults with recurrent or treatment-resistant cancer. (reportsanddata.com)
- The proposed combination of all three drugs may improve efficacy and response. (drugpatentwatch.com)
- We employed combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in T-PLL patients. (haematologica.org)
Drugs6
- Vincristine can be given in combination with other cancer drugs. (macmillan.org.uk)
- Combinations usually work better than single drugs because different drugs kill cancer cells in different ways. (cancer.gov)
- Each of the drugs in this combination is approved by the Food and Drug Administration (FDA) to treat cancer or conditions related to cancer. (cancer.gov)
- This combination may also be used with other drugs or treatments or to treat other types of cancer. (cancer.gov)
- Additionally, we studied the impact of p53 activation on the rate of apoptosis induced by combinations of cytostatic drugs (Ehrhardt, Schrembs, Moritz, Wachter et al. (uni-muenchen.de)
- The combination of all three drugs is experimental (not FDA approved). (drugpatentwatch.com)
Survival2
- To e valuate the impact of these allocation strategies on patient survival during a chemotherapy shortage, we developed a simulation model through the use-case of vincristine, a widely prescribed blood cancer chemotherapeutic recently in shortage. (confex.com)
- Based on the length of the recent vincristine shortage, mean survival rates for a 9-month scenario were modeled according to individual and combination allocation strategies across varying supply levels. (confex.com)
Commonly1
- Vincristine (VCR) is a commonly used chemotherapeutic agent for many lymphoid malignancies, including aggressive NHL. (biomedcentral.com)
Mild1
- Toxicities associated with vincristine are mild, but perivascular reaction can be a problem. (vin.com)
Apoptosis3
- To further explore the effects of BCL11A siRNA on the enhanced cytotoxicity of a chemotherapeutic drug, we investigated the effects of BCL11A siRNA combined with vincristine (VCR) on SUDHL6 cell proliferation and apoptosis. (biomedcentral.com)
- The combination of BCL11A siRNA and VCR increases apoptosis in SUDHL6 cells. (biomedcentral.com)
- Therefore, it follows that vincristine was unable to activate downstream apoptosis signaling. (uni-muenchen.de)
Vein1
- Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. (medbroadcast.com)
Protocols1
- most active protocols are based on five- to six-drug combinations of these agents. (medscape.com)
Cycles1
- The dose for CLL is 375 mg/m 2 in the first cycle and 500 mg/m 2 in Cycles 2-6, in combination with FC, administered every 28 days ( 2.3 ). (drugs.com)
Reduction1
- Preliminary results from a study using a combination of VELCADE with Doxil showed high response rates (disease reduction). (drugpatentwatch.com)
Treatment4
- Vincristine is usually given once a week, but your nurse or doctor will discuss your treatment plan with you. (macmillan.org.uk)
- Our study implies that BCL11A siRNA in combination with VCR may be a useful approach for improving effective treatment for B cell lymphoma. (biomedcentral.com)
- The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
- Several published clinical trials provide evidence that Doxil is an active agent in multiple myeloma and it is used in treatment combinations for multiple myeloma in general practice. (drugpatentwatch.com)
Cancer7
- Vincristine is a chemotherapy drug used to treat many types of cancer. (macmillan.org.uk)
- Medications are often used in combination to destroy urethral cancer that has metastasized. (wikipedia.org)
- They may try cabazitaxel if the first combination does not treat the cancer. (medicalnewstoday.com)
- Cycling cells are required for vincristine to kill cancer cells efficiently. (uni-muenchen.de)
- Vincristine belongs to the group of cancer-fighting medications known as antineoplastics . (medbroadcast.com)
- Vincristine is used alone or in combination with other antineoplastic medications to treat many different types of cancer , including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the cervix, colorectal cancer, and Wilms' tumor. (medbroadcast.com)
- As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. (medbroadcast.com)
Dose1
- I. Determine the maximum tolerated dose of bryostatin 1 when administered with vincristine in patients with recurrent or refractory HIV-related B-cell lymphoma. (knowcancer.com)
Lymphoma1
- In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
Days1
- Patients receive bryostatin 1 IV continuously on days 1 and 15 and vincristine IV over 5 minutes on days 2 and 16. (knowcancer.com)
Docetaxel1
- The incidence of febrile neutropenia/neutropenia with sepsis may also be higher in patients treated with trastuzumab in combination with docetaxel than in those treated with docetaxel alone. (medscape.com)
Receive1
- If you miss an appointment to receive vincristine, contact your doctor as soon as possible to reschedule your appointment. (medbroadcast.com)
Primary1
- Venetoclax was used in pairwise combinations ( Figure 1A ) in primary T-PLL samples with a mean post-thawing viability of 93% and mean purity of 94% ( Table 1 ). (haematologica.org)
Active1
- We probed putative mechanisms and demonstrated clinical feasibility and activity of a putative combination by treating two patients with active, r/r-T-PLL. (haematologica.org)
Minutes1
- Your nurse will give you vincristine as a drip (infusion) over 5 to 10 minutes. (macmillan.org.uk)