Colorectal cancer cell transformation neoplastic. Medical search. Frequent questions

IRS-1 dominant-negative mutant functions as tumor suppressor, whereas ectopic IRS-1 stimulates oncogenic transformation. (wikipedia.org)
Thus, we will test the biological function of the CD44 cell adhesion molecule and continue to develop tumor markers that complement standard clinicopathologic staging in colorectal carcinoma. (grantome.com)
Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
Though tumor microenvironments (TMEs) are quite well understood in some cancers, each microenvironment differs from the other in internal perturbations and metabolic skew thereby impeding the development of appropriate diagnostics, drugs, vaccines, and therapies. (bvsalud.org)
Cancer associated bioenergetics modulations regulate TME, angiogenesis, immune evasion, generation of resistant niches and tumor progression, and a thorough understanding is crucial to the development of metabolic therapies. (bvsalud.org)
In tumor tissues, lncRNAs are markedly deregulated and pervasively involved in development and progression of cancers [ 6 - 8 ]. (jcancer.org)
It has been hypothesized that inactivation of the RASSF1A tumor suppressor facilitates K-RAS-mediated transformation by uncoupling it from apoptotic pathways such as the Hippo pathway. (cancerindex.org)
p21 and other tumor suppressor genes' inactivation are therefore most likely involved in the first steps of the cancer model, with later stages possibly involving protooncogene activation and inflammation. (medscape.com)
PGM1 inhibits hepatocellular carcinoma cell (HCC) proliferation and growth by utilizing sufficient extracellular glucose to convert glycogen, while deletion of the PGM1 gene inhibits glycogen synthesis and leads to glycolysis of additional glucose, thus promoting tumor cell proliferation and growth [ 15 ]. (biomedcentral.com)
5 6 However, for individuals with cancer, circulating tumor-derived DNA (ctDNA) can be shed into the bloodstream, providing an opportunity for early cancer detection through liquid biopsy approaches. (bmj.com)
At least 50% of the Western population will develop a colorectal tumor by age 70 years. (medscape.com)
Abstract Objective: Accumulating evidence for differential expression of microRNA-224 (miR-224) in various types of human cancer suggests that it may be play a crucial role in tumor biology. (kipdf.com)
Overall, mitochondrial dysfunction caused by mtDNA mutations, malfunctioned TCA cycle enzymes, electron respiratory chain leakage and subsequent oxidative stress, and/or aberrant oncogenic and tumor suppressor signaling is known to alter cellular metabolic pathways, disrupt redox balance, and cause resistance to apoptosis and therapies that significantly contribute to the development of multiple types of human cancers. (encyclopedia.pub)
but, molecular events involved in malignant transformation are under investigation, and early molecular alterations have been identified such as the alteration of a tumor suppressor gene, the mutation of the ARID1A and loss of its encoded BAF250a [5]. (irispublishers.com)
Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)
In 48 cases of squamous cell carcinoma of the larynx the thymidine labeling index was a more important predictor of survival (p=0.015) than prognostic DNA values and tumor stage. (cancerprev.org)
Teratoma is a congenital germ cell tumor, composed of a wide diversity of tissue, containing all three germ cell layers. (ispub.com)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)

Writer Overview Mutations gasoline microbial cancers and progression. (bioerc-iend.org)
IRS-1, as a signalling adapter protein, is able to integrate different signalling cascades, which indicates its possible role in cancer progression. (wikipedia.org)
Furthermore, recent findings showed the intriguing effects of microbiota in cancer susceptibility, neoplastic progression, co-infections with carcinogenic agents, and response to therapy. (biomedcentral.com)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
In head and neck cancer, the histologic progression of severity from hyperplasia, dysplasia, and carcinoma in situ to invasion provides a framework to understand the genetic progression of cancer. (medscape.com)
The expression of p53 is directly linked to a blockage of cell cycle progression at G0/G1 phase and upregulates Bax, cytochrome studies have shown the ability of the bioactive compounds of flavokawain B and alpinetin to target UCK2 enzyme specifically, inducing cell cycle arrest and subsequently leading to cancer cell death, possibly through interfering the MDM2-p53 signalling pathway. (nanoker-society.org)
Background: The putative functions of the cellular prion protein (PrP c ) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. (iiarjournals.org)
With respect to cancer development and progression, elevations and mutations of PrP c expression have been shown to increase the risk for malignancy and metastasis in breast and colorectal cancer. (iiarjournals.org)
Since both natural supplements and direct regulation of PrP c expression contribute to inhibition of cancer progression and growth, we hypothesized that knockdown of PrP c could lead to an enhanced synergic effect on the inhibition of cancer growth by fucoidan. (iiarjournals.org)
Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Kipps TJ (2010) B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. (springer.com)
This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
Conclusion: Our data indicated that miR-224 upregulation was associated with aggressive progression and poor prognosis in cervical cancer. (kipdf.com)
Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
The triangle composed of nutrition, inflammation and immunity, and cancer illustrates how qualitative and quantitative imbalances in food intake predispose organisms, in a manner dependent on or independent of the immune system, to a time-dependent deterioration in function that culminates in the development and progression of cancer. (nature.com)
The trefoil factor (TFF) family comprises three thermo-stable and protease-resistant proteins (TFF1, TFF2 and TFF3) and plays an essential role in gastrointestinal mucosa protection and regeneration, and TFFs have recently been found to be involved in the development and progression of various types of cancer. (spandidos-publications.com)
Recent studies suggest that TFFs are involved in the development and progression of various types of cancer, including breast, lung, prostate, stomach and colon cancer ( 6 - 15 ). (spandidos-publications.com)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
In this context, we assess the reliability of the neurotensinergic system to cancer progression as well as the regulation and mechanism of the system in order to determine its potential in colorectal cancer diagnosis, surveillance and screening. (springer.com)

Research of Low-frequency Microsatellite Instability has been linked to Microsatellite Instability, High-frequency Microsatellite Instability, Malignant Neoplasms, Neoplasms, Colorectal Cancer. (novusbio.com)
When clinical-pathological characteristics are compared between primary CE and synchronous epithelial ovarian cancer (EOC) [10], the incidence of endometriosis is higher in patients with EC than in EOC (100% vs. 35%), other malignant neoplasms such as colorectal cancer which is one of the most frequent intraabdominal cancers in women that could exist in association with endometriosis. (irispublishers.com)

Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
Background Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. (ehu.es)
Furthermore, silencing PrP c expression with si-PRNP amplified the fucoidan-induced changes in cell proliferation, apoptosis, and migration. (iiarjournals.org)
PGM1 knockdown stimulated both cell proliferation and colony formation, and inhibited cell cycle arrest and apoptosis, while overexpression of PGM1 produced the opposite effects in CRC cells both in vivo and in vitro. (biomedcentral.com)
This study aimed to consider the oxidative damage induced by cadmium (Cd) and apoptosis and the role of N-acetylcysteine (NAC) in preserving hepatic cells against Cd toxicity. (springer.com)
Hepatic cells apoptosis was measured using TUNEL assay method. (springer.com)
Cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. (springer.com)
Ray P, Guha D, Chakraborty J, Banerjee S, Adhikary A, Chakraborty S, Sa G (2016) Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. (springer.com)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
The migration was investigated by the transwell, and the apoptosis and cell cycle were assayed by the flow cytometry. (biomedcentral.com)
decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)

Probable driver mutations were present in around 1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorectal epithelium. (cam.ac.uk)
Our group has demonstrated that the disaccharidase sucrase-isomaltase (S-I), the galactose-binding lectin galactin 3, and the MUC1 mucin DF3 are upregulated at different times during the neoplastic transformation of bowel epithelium. (grantome.com)
Although the exact mechanism of carcinogenesis is unclear, it has been suggested that the changes seen in the lamina propria are brought about through landscaper defects, where changes in this tissue layer lead to an environment predisposing to neoplastic transformation of the overlying epithelium. (mhmedical.com)
It is the result of a multistep process that involves the transformation of normal cervical epithelium to preneoplastic cervical intraepithelial neoplasia that is subsequently transformed to invasive cervical cancer [2]. (kipdf.com)
In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)

Abstract Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of malignancy. (nanoker-society.org)
Due to the selective expression of UCK2 in malignancy cells, a selective inhibition of this important enzyme necessitates the discovery of its potential inhibitors for malignancy chemotherapy. (nanoker-society.org)
The present study was carried out to demonstrate the potentials of natural phytochemicals from your rhizome of to inhibit UCK2 useful for colorectal malignancy. (nanoker-society.org)
Introduction Cervical cancer is the third most common malignancy among women worldwide, with an estimated global incidence of over 500,000 new cases and tremendously high death cases of 260,000 annually [1]. (kipdf.com)
This is a review of the knowledge about endometriosis and its potential risk of malignancy, particularly with colorectal cancer. (irispublishers.com)

Several risk factors and pathologies, including ageing, smoking, obesity and diabetes have been associated with poor prognosis in colorectal cancer patients. (frontiersin.org)

The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head and neck squamous cell carcinomas (HNSCCs) and oral mucocele lesions has not been established. (biomedcentral.com)
Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to be on the rise. (academicjournals.org)
The underlying premise of early detection and interception efforts is that finding cancers at early stages, or even high-risk premalignant lesions, allows for curative or earlier treatment leading to reduced mortality and morbidity. (bmj.com)
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. (mcmaster.ca)
Inflammatory bowel disease (IBD) is of special concern as long-standing chronic intestinal inflammation may increase the risk for colitis-associated colorectal cancer (CAC) development due to cellular transformation to neoplastic lesions. (ecu.edu)
However, in cancer cells and pre-neoplastic lesions, FASN expression has been frequently found to be upregulated. (biomedcentral.com)

Tolnaftate In Tolnaftate multi-cellular microorganisms mutator phenotypes accelerate tumorigenesis by producing mutations that get over the hereditary and environmental obstacles to unrestrained proliferation [3 4 In tumors that aren't Tolnaftate originally mutator-driven chemotherapeutic treatment provides selection pressure for sub-clonal mutator cell lineages to emerge which easier evolve drug-resistance. (bioerc-iend.org)
Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)

In breast cancer, lncRNAs are abnormally expressed and demonstrate differential expression in subtypes of tumors [ 9 , 10 ]. (jcancer.org)
2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)
Intravenously injected radiolabeled anti-carcinoembryonic antigen monoclonal antibody into patients with colorectal cancer accumulated specifically in primary tumors, liver metastases, disseminated tumors and metastatic lymph nodes. (cancerprev.org)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)

In this review, colorectal cancer (CRC) is examined as a classical example of multistep carcinogenesis. (ox.ac.uk)
The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, the endogenous ligands for guanylyl cyclase C (GCC, GUCY2C), the intestinal receptor for diarrheagenic bacterial enterotoxins. (jefferson.edu)
Furthermore, impaired DNA repair capacity was suggested to associate with enhanced susceptibility to cancer and deficiency in DNA repair enzyme, human 8-oxoguanine DNA N-glycosylase 1(hOGG1), a key enzyme responsible for 8-oxo-dGua repair, may also be involved in carcinogenesis [ 11 ]. (hindawi.com)
Colorectal cancer (CRC) is one of the most common cancers all over the world, and dysbiosis in the gut microbiota may play a role in colorectal carcinogenesis. (biomedcentral.com)
Fatty acid synthase (FASN) is frequently activated and overexpressed in human cancers, and plays a crucial role in the carcinogenesis of various cancers. (biomedcentral.com)

For example, in the hereditary cancer syndromes familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, mutations have been discovered in the APC gene and DNA mismatch repair genes. (medscape.com)
These include polyps, sporadic colorectal carcinoma (CRC) and familial colon cancer (familial adenomatous polyposis [FAP]), and hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)

Our hypothesis is that molecules involved in differentiation, tissue invasion, or cell adhesion within primary colon or rectal carCinomas are associated with the development of visceral metastases. (grantome.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
Data obtained in metabolic epidemiological and laboratory animal model studies are sufficiently convincing in showing the enhancement of colon cancer by certain types of fat and protection against it by certain dietary fibers. (aacrjournals.org)
As I reflect on my research activities in colon cancer prevention since 1971, I recognize the contributions of several colleagues and collaborators at the American Health Foundation and worldwide who have had a major impact on my scientific achievements. (aacrjournals.org)
More than 510,000 individuals died of colon cancer in 1996 (1) . (aacrjournals.org)
2013. Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. . (oregonstate.edu)
2013. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. . (oregonstate.edu)
A reasonable model is based on colon cancer development. (medscape.com)
Some modeling analyses suggest 5 separate events are required in colon cancer. (medscape.com)
These phenomena have proven that the bioactive compounds could be useful for future therapeutic use in colon cancer. (nanoker-society.org)
Materials and Methods: PrP c expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. (iiarjournals.org)
Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. (iiarjournals.org)
Conclusion: Combination of fucoidan with silencing of PrP c has a synergic effect on the inhibition of HT29 colon cancer cell growth. (iiarjournals.org)
In in vitro studies, the addition of NT to human colon cancer cell lines resulted in significantly increased cancer cell growth and the growth of xenografted human colon cancer cells in mice [ 9 ]. (springer.com)

The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. (cam.ac.uk)
The primary goal of Project 8 is to improve the estimation of prognosis of human colorectal carcinoma through the use of biologically defined markers. (grantome.com)
Thus, we will study the intratumoral expression of molecules whose potential as markers has been demonstrated in pilot studies in Projects I - V. We will assess whether these markers improve the prognostication of colorectal carcinoma when included in a multivariate analysis with standard stage and grade information. (grantome.com)
Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). (hindawi.com)
Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer (NMSC) worldwide, in particular, in fair-skinned population and its incidence has been rising over the past several years [ 1 - 3 ]. (hindawi.com)
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. (biomedcentral.com)
[ 1 ] Identifying candidate precursors or enabling genes may pave the way for cancer screening, as with the ret proto-oncogene and medullary thyroid carcinoma . (medscape.com)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
We aimed to study whole genomic lncRNA expression patterns in colorectal adenoma-carcinoma transition and to analyze the underlying functional interactions of aberrantly expressed lncRNAs. (biomedcentral.com)
The defined lncRNA sets may have a regulatory role in the colorectal adenoma-carcinoma transition. (biomedcentral.com)
risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease. (oaepublish.com)
Cancer is an impending bottleneck in the advanced scientific workflow to achieve diagnostic, prognostic, and therapeutic success. (bvsalud.org)
The inherent ability of each cancer to evolve through various genetic and epigenetic transformations and metabolic reprogramming underlies therapeutic limitations. (bvsalud.org)
Furthermore, we provide evidence for the therapeutic application of PrP c silencing with other anticancer drugs for cancer. (iiarjournals.org)
It also contributes significantly to cancer-related deaths, despite continuous progress in developing diagnostic and therapeutic methods ( 15 ). (iiarjournals.org)
Therefore, there remains a need to identify reliable biomarkers and cancer-related molecular mechanisms that can assist with making decisions regarding a patient's prognosis and developing suitable therapeutic strategies. (biomedcentral.com)
Plants are natural reservoirs of novel compounds and provide a promising therapeutic approach for treatment of cancer. (researchsquare.com)
Therefore, it is important to understand the complete knowledge of the molecular biology, genetics, causes and cellular origin of cervical cancers which are of value in the development of improved therapeutic strategies and in the identification of prognostic markers. (kipdf.com)
A better understanding of the roles of mitochondrial dysfunction in cancer is essential for the future design of effective therapeutic strategies against diverse types of cancers. (encyclopedia.pub)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)

In error-prone cell divisions mutations occurred on the same chromosome more frequently than expected Tolnaftate by chance often in DNA with comparable predicted replication timing consistent with a spatiotemporal dimension to the hypermutator state. (bioerc-iend.org)
One of the most abundant way to obtain potential mutations in dividing cells are polymerase mistakes that are corrected with the synergistic actions of polymerase proofreading and mismatch fix (MMR) [2]. (bioerc-iend.org)
Yeast cells with mutant alleles for Pol ε proofreading deficiency (enzymatic amplification of the genome [30 31 Because DNA polymerases are used to amplify the DNA foundation misincorporation events can lead to the rating of thousands of false mutations. (bioerc-iend.org)
The multihit model postulates that several unique genetic mutations combine to cause cancer. (medscape.com)
In colorectal cancer, multiple mutations are present. (medscape.com)
Although the exact process has not been elucidated, the sum of these mutations is believed to lead to cancer development in this model. (medscape.com)
Both are linked to transformation due to deregulated kinase/phosphatase signaling or STAT5 gain-of-function (GOF) mutations. (nature.com)
We review cell-free DNA (cfDNA)-based approaches using mutations, methylation, or fragmentomes for early cancer detection. (bmj.com)
Recent technological advancements in the characterization of ctDNA, 5 7-9 including those to inform therapy selection through detection of EGFR gene mutations or other actionable changes in panels of genes 10-12 have demonstrated the feasibility and clinical utility of blood-based tests to guide the clinical management of patients with cancer, typically at late stages. (bmj.com)

2016. Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer. . (oregonstate.edu)
Overexpression of this enzyme have been implicated in several cancers and it is therefore considered a hallmark of cancer. (nanoker-society.org)
Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
In this study, the authors used DNA microarray to compare and identify genes induced by HER2 in mammary epithelial cell line with ectopic HER2 overexpression and breast cancer cell lines derived from patients with different level of HER2 expression. (biomedcentral.com)

In Uganda, literature has shown that, cervical cancer incidence and death rates was 45.6 and 25 per 100,000 women respectively. (academicjournals.org)
Human papillomavirus testing for primary screening of cervical cancer precursors. (mcmaster.ca)
The previous microarray detection also shown that miR-224 was one of miRNAs with significant upregulation in cervical cancer tissues relative to adjacent normal tissues. (kipdf.com)
However, little is known about the function of miR-224 in human cervical cancer. (kipdf.com)
The aim of this study was to investigate the clinical significance of miR-224 expression in cervical cancer. (kipdf.com)
Methods: MiR-224 expression in 126 pairs of fresh human cervical cancer and adjacent normal tissues was measured by real-time quantitative RT-PCR assay. (kipdf.com)
Results: miR-224 expression was significantly upregulated in cervical cancer tissues when compared with corresponding adjacent normal tissues (P (kipdf.com)
It was also significantly higher in the cancerous tissues of patients with advanced FIGO stage cervical cancer than those with early FIGO stage (P = 0.02). (kipdf.com)
Finally, there were sufficient evidence to confirm its value in the status of vascular invasion (P = 0.01) and human papillomavirus (HPV) infection (P = 0.02) in cervical cancer. (kipdf.com)
More importantly, Kaplan-Meier analysis showed that cervical cancer patients with high miR-224 expression tend to have shorter overall survival. (kipdf.com)
MiR-224 was identified for the first time as an independent marker for predicting the clinical outcome of cervical cancer patients. (kipdf.com)
Early detection and diagnosis have become accurate and inexpensive through routine papanicolaou tests, and the recent advent of human papillomavirus (HPV) vaccine may have a significant impact on prevention of cervical cancer which is strongly associated with infection and subsequent transformation of cervical cells by specific HPV subtypes [3]. (kipdf.com)
Although radiotherapy, chemotherapy and surgery have been recently used as standard treatment modalities for patients with cervical cancer, with consequent disease remission, clinical outcomes vary significantly between patients and can be difficult to predict. (kipdf.com)
the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)
Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)

Levels in breast cancer and adjacent non-cancerous breast tissue were analysed against pathological and clinical parameters (TNM staging, survival over a 10-year follow-up period). (cancerindex.org)
Paradigmatic is the role of HPV infection in oropharyngeal cancers and the clinical relevance of such association. (biomedcentral.com)
Our approach to the primary prevention of large bowel cancer is to translate the findings from clinical epidemiological and laboratory studies into sound advice for patients and for the public at large to reduce fat intake and increase fiber intake, specifically cereals and grains. (aacrjournals.org)
The early detection of cancer is intended to identify a malignant transformation in asymptomatic individuals at average risk or elevated risk of developing cancer, that is measurable by a screening test, but not advanced enough to cause clinical symptoms or to be detected during usual clinical care. (bmj.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
However, the clinical significance of TFFs in colorectal cancer (CRC) patients remains unclear. (spandidos-publications.com)
Clinical colorectal cancer 2017 11 17 (1): 50-57.e8. (cdc.gov)

IRS-1 protein is known to be involved in various types of cancer, including colorectal, lung, prostate and breast cancer. (wikipedia.org)
Case-control studies have previously reported that increased urinary 8-oxo-7,8-dihydroguanine (8-oxo-Gua) and 8-oxo-dGuo levels were detected in patients with metastatic head and neck cancer, breast cancer, and lung cancer [ 9 , 10 ]. (hindawi.com)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
With respect to cancer therapy, fucoidan appears to be highly efficient in treating certain types of cancer, including breast, prostate and lung, as well as leukemia ( 10 - 12 ). (iiarjournals.org)
For example, the National Lung Screening Trial has shown that early detection and interception of lung cancer through surgical resection reduces overall mortality in this high-risk population. (bmj.com)
2 Currently only five cancer types-breast, cervical, colorectal, lung, and prostate-have widely accepted screening tests and only four have national screening recommendations in the USA ( online supplemental table S1 ). (bmj.com)

Predictors for detecting colorectal neoplasia were identified. (springer.com)
Plasma NTS has the potential to be a non-invasive biomarker for colorectal neoplasia. (springer.com)
Both of the above rely on colonoscopy, which remains the gold standard for the detection of colorectal neoplasia. (springer.com)

Cancer Epidemiol Biomarkers Prev (2000) 9 (3): 239-247. (aacrjournals.org)
Cancer Epidemiol Biomarkers Prev 2008;17:3062- to pancreatic cancer. (who.int)

Cells with an elevated price of mutation are thought to possess a "mutator phenotype" and adjust quicker than non-mutator cells. (bioerc-iend.org)
IRS-1 is required for maintenance of neoplasmic phenotype in adenomatous polyposis coli (APC) - mutated cells, it is also needed for transformation in ectopically expressing oncogenic β-catenin cells. (wikipedia.org)
2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)
In this study, our aims were to explore the role of FASN in regulating the "HER2-PI3K/Akt axis" activity and malignant phenotype of colorectal cancer. (biomedcentral.com)
A downregulation of FASN effectively inhibits the activity of "HER2-PI3K/Akt axis" and alters the malignant phenotype in colorectal cancer cells. (biomedcentral.com)

In breast cancer tissues, UASR1 was upregulated. (jcancer.org)
Gene expression was compared between cancer and adjoining non-cancerous tissues. (biomedcentral.com)
But, the accepted hypothesis is the implantation of endometrial tissue in the peritoneal cavity due to retrograde menstruation, or when endometrial tissues and cells adhere to the surfaces of the peritoneum, annexes and other pelvic organs [1-4]. (irispublishers.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)

CDK2AP1 expression in disease-free patients at 10 years was more than threefold that of patients who died of breast cancer. (cancerindex.org)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Hamartomatous polyps may also be found in patients with Cowden disease, Cronkhite, Bannayan-Riley-Ruvalcaba syndrome, and basal cell nevus syndrome. (medscape.com)
Patients with JP are at approximately 50 percent risk for the developing GI cancers, the majority of which are colorectal cancers, but they are also at risk for upper GI cancers. (mhmedical.com)
GPR65 is mainly expressed in immune cells and is functionally critical for intestinal homeostasis, as identified by Genome-Wide Association Study (GWAS), for being a genetic risk factor in patients with IBD. (ecu.edu)
Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Most patients with cancer die from metastases rather than the primary cancer. (msdmanuals.com)
Breast cancer cases of female patients under 35 years of age in Togo: A series of 158 cases. (cdc.gov)
Survival Outcomes in Patients With RAS Wild Type Metastatic Colorectal Cancer Classified According to Köhne Prognostic Category and BRAF Mutation Status. (cdc.gov)

We and others have found that CD44 isoforms are upregulated during neoplastic transformation and participate in the adhesion of colorectal carcinomas to hepatic endothelial cells and basement membrane proteins. (grantome.com)
Furthermore, fucoidan can also play a crucial role in inhibiting induced cancer signaling molecules, such as vascular endothelial growth factor (VEGF) ( 13 , 14 ). (iiarjournals.org)
The cfDNA molecules present within the circulation were described as early as 1948, with the majority of cfDNA being derived from dying white blood cells (WBCs), vascular endothelial cells, and hepatocytes. (bmj.com)
GPR4, on the other hand, is mainly expressed in endothelial cells and confers a proinflammatory role that our group had previously uncovered the mechanism for. (ecu.edu)
In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Calcium channel blockers verapamil, nifedipine, diltiazem and isradipine arrested basic fibroblast growth factor induced human umbilical arterial endothelial cell proliferation. (cancerprev.org)
As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)

The landscape of somatic mutation in normal colorectal epithelial cells. (cam.ac.uk)
Moreover, a positive correlation between induction of BRAF V600E and MGL binding to epithelial cells of the gastrointestinal tract was found in vivo using an inducible BRAF V600E mouse model. (oncotarget.com)

Excessive reactive oxygen species (ROS) generated by UVR have been shown to contribute to malignant transformation of keratinocytes into cancerous cells including BCC probably through oxidative DNA damage, defects in DNA repair, and interference with cellular signaling [ 6 , 7 ]. (hindawi.com)
This collection aims to gather and share novel information focusing on epidemiology, molecular biology, cellular biology, genetics, and epigenetics as well as translational research of infectious agents causing cancer. (biomedcentral.com)
Usually, a cell has hundreds or thousands of mitochondria, which can occupy up to 25% of the cellular cytoplasm. (encyclopedia.pub)
These two pools of proteins are required to maintain mitochondria as a cellular power hub and a signaling nexus that are essential for normal cell function. (encyclopedia.pub)
Of note, the reprogramming of cellular metabolism and the aberrant redox status have been heralded as major emerging hallmarks of neoplastic transformation. (encyclopedia.pub)
This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)

Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
All known oncogenic pathogens can promote cell survival and transformation because of their common abilities to cause chronic insults, genetic and epigenetic alterations, deregulated metabolic pathways, and immune escape. (biomedcentral.com)
The global burden of pathogen-related cancers is expected to grow with the identification of novel oncogenic microorganisms or uncommon tropism of known agents in the body sites. (biomedcentral.com)
We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
The expression of a mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity. (nature.com)
Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)
Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)

Cells from cancers show aberrant behaviour such as unrestrained growth, invasion into adjacent tissue and metastasis. (ox.ac.uk)

The pathologic features of juvenile polyps are dilated, cystic glands, infiltration of the lamina propria by inflammatory cells, and an overabundance of stroma. (mhmedical.com)
This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. (springer.com)
Plasma NTS had an optimal sensitivity of 60.4% and specificity of 71.6% for the diagnosis of colorectal polyps and cancers. (springer.com)

In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
And the influence of FASN on proliferation and migration of colorectal cancer cells was also explored. (biomedcentral.com)

Colorectal cancer is the third-leading cause of cancer related mortality in the United States. (mdpi.com)
This report details the preventive strategies aimed at reducing the incidence and mortality of large bowel cancer by nutritional manipulation and chemopreventive agents. (aacrjournals.org)
This lecture summarizes our approaches to the reduction of the incidence and mortality of colorectal cancer by nutritional manipulation and chemopreventive agents. (aacrjournals.org)
Low socioeconomic status is yet another independent risk factor for premature mortality, including death from cancer 3 . (nature.com)
Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality worldwide, accounting for over 600,000 deaths annually ( 1 ). (spandidos-publications.com)
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. (frontiersin.org)
Colorectal cancer (CRC) is a worldwide health problem that ranks third in incidence and fourth in mortality with an estimated 1.2 million cases and 0.6 million deaths annually. (springer.com)

In vitro studies using CRC cell lines showed an association between MGL ligand expression and the presence of BRAF V600E . (oncotarget.com)

we propose a system of FCGR3A regulation in human NK cells in which CpG dinucleotide sequences and concurrent DNA methylation confer developmental and cell type-specific transcriptional regulation, whereas miR-218 provides an additional layer of posttranscriptional regulation during the maturation process. (cusabio.com)

However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal tissue-is comparatively limited, as for most cancer types. (cam.ac.uk)
Normalised CDK2AP1 expression was 38-fold higher in adjacent non-cancerous breast tissue than in breast cancer. (cancerindex.org)
This study aims to explore its mechanism by defining changes in gene expression between neoplastic and normal tissue samples before and after treatment. (karger.com)
Although endometriosis is considered a benign condition, it shares some characteristics of cancer proliferation, such as invasion, tissue damage, neoangiogenesis and spread to distant organs [3]. (irispublishers.com)
We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)

3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
The primary function of mitochondria is to support the TCA cycle and aerobic respiration by oxidative phosphorylation, generating ATP through the mitochondrial respiratory chain to fulfill the energy needs for cell survival. (encyclopedia.pub)
Earlier detection of colorectal cancer (CRC) results in improved survival. (springer.com)
It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)

more importantly,it has enabled us to approach cancer prevention. (aacrjournals.org)
Developing natural products and dietary supplements has proven to be a promising strategy for the cancer therapy and prevention. (iiarjournals.org)
The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. (mdanderson.org)

Genetic pathways in colorectal and other cancers. (ox.ac.uk)
These phytochemicals frequently act by means of regulating molecular pathways which are embroiled in development and dissemination of cancer. (researchsquare.com)
There are numerous pathways that are associated with the cancer development in body. (researchsquare.com)

The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
Many theories have been proposed to explain this condition: retrograde menstruation theory, metaplastic, transformation, the migration of cells through the lymphatic system or via hematogenous spread, Iatrogenic during CS. (blogspot.com)
The migration was also impaired in FASN-silenced cells. (biomedcentral.com)

The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
First there is an overview which shows that cancers develop by a process of somatic evolution. (ox.ac.uk)
The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. (lookformedical.com)
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)

18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)

Rapid advancements in the area of early cancer detection have brought us closer to achieving the goals of finding cancer early enough to treat or cure it, while avoiding harms of overdiagnosis. (bmj.com)
We evaluate progress in the development of early cancer detection tests in the context of the current principles for cancer screening. (bmj.com)
1 The actualization of early cancer detection and interception, however, is not simple. (bmj.com)
In addition, for those cancers with demonstrated benefits of early detection, there remains substantial room for improving the accessibility of screening approaches worldwide and the benefit-to-risk ratios. (bmj.com)
To this end, the concept of blood-based, cell-free DNA (cfDNA)-based early cancer detection testing holds promise to close the cancer screening gap in underserved populations. (bmj.com)
Therefore, identification of molecular markers of CRC that might enhance the objective classification or the early detection of the disease remains highly relevant, as CRC is one of the most curable cancers if detected early [ 2 ]. (biomedcentral.com)
Strategies for earlier detection include screening and earlier recognition of cancer in symptomatic individuals. (springer.com)
However, some cancers have or acquire the ability to avoid detection and/or destruction by the immune system, allowing them to proliferate. (msdmanuals.com)

Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)

The LS extract was tested in the MKN-45 human gastric cancer cell line to demonstrate its effective antioxidant potential and cytotoxicity. (bvsalud.org)
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that function as regulatory factors in many human diseases, including cancer. (jcancer.org)
For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)
To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer over a long-term follow-up period. (cancerindex.org)
Infectious agents cause approximately 20% of all human cancer cases worldwide, with higher rates in low-income countries. (biomedcentral.com)
Six human viruses, including high-risk alpha human papillomaviruses (HPV), hepatitis B (HBV) and C (HCV) viruses, human T-cell lymphotropic virus 1 (HTLV-1), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (HHV-8), have been classified as class 1 carcinogens by the International Agency for Research on Cancer. (biomedcentral.com)
Large bowel cancer is one of the most common human malignancies in Western countries including North America. (aacrjournals.org)
Large bowel cancer is one of the most common and persistent human malignancies in the Western world, including the United States. (aacrjournals.org)
This technologic and biologic revolution continued through the 1960s to today, and the explosion in technology has fueled the current expansion of knowledge into the working of the human cell. (medscape.com)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
However, the more precise role of TFFs in human cancer remains unclear. (spandidos-publications.com)
Membrane-associated and cytoplasmic human chorionic gonadotropin (hCG), its subunits and its fragments were present in human cancer cells of neuroblastomas, medulloblastomas, retinoblastomas, and malignant gliomas of nude mice. (cancerprev.org)
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)

Phosphoglucomutase 1 (PGM1) is known for its involvement in cancer pathogenesis. (biomedcentral.com)

In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
These phytochemicals have been tried against cancer viability at both in vitro and in vivo levels. (researchsquare.com)

Significance of Mitochondrial-Dysfunction in Cancer" Encyclopedia , https://encyclopedia.pub/entry/1619 (accessed December 08, 2023). (encyclopedia.pub)

All these features of cancer cell behaviour can be explained in terms of genetic changes and the functional impact of these changes. (ox.ac.uk)

Although these results support the potential development of fucoidan as an anticancer drug, there is little information on the anticancer effect of fucoidan on colorectal cancer (CRC). (iiarjournals.org)
A key target in this respect is natural killer (NK) cells in order to generate an anticancer-immune response. (academicjournals.org)
It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. (mdpi.com)

She obtained her postdoctoral training in the Department of Cancer Biology at The University of Texas MD Anderson Cancer Center, joined the Department of Genetics in 2002, where she established the Molecular Cytogenetics Facility as an Institutional specialty resource. (mdanderson.org)

There is growing optimism for the view that realization of preventive concepts in large bowel cancer will also serve as a model for preventing malignancies such as cancer of the prostate and breast. (aacrjournals.org)

Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. (cam.ac.uk)
Launch A network of DNA metabolic actions keeps genomic integrity during each cell department [1] making certain eukaryotic mutation prices remain significantly less than one mutation per billion base-pairs synthesized. (bioerc-iend.org)

This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
However, its biological role in colorectal cancer (CRC) has remained unknown. (biomedcentral.com)
Long non-coding RNAs (lncRNAs) play a fundamental role in colorectal cancer (CRC) development, however, lncRNA expression profiles in CRC and its precancerous stages remain to be explored. (biomedcentral.com)

Anatomy18

Organisms6

Diseases31

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes65

Disciplines and Occupations2

Information Science6

Health Care21

Geographicals1

Tumor22

Progression18

Neoplasms2

Apoptosis13

Epithelium5

Malignancy5

Prognosis in Colorectal Cancer1

Lesions6

Tumorigenesis4

Tumors8

Carcinogenesis5

Hereditary nonpol2

Differentiation5

Colon cancer13

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Therapeutic10

Mutations9

Overexpression4

Cervical Cancer15

Clinical7

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Biomarkers2

Phenotype5

Tissues6

Patients10

Endothelial7

Epithelial Cells2

Cellular7

Oncogenic7

Metastasis1

Polyps3

Proliferation and migration2

Mortality7

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20231

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20021

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