Probenecid with colchicine is a combination medication used to treat gout. (wikipedia.org)
Medication (e.g., small doses of NSAIDs, colchicine, allopurinol [Zyloprim®], probenecid) may prevent continued accumulation of uric acid in the joints and further attacks. (hampdenpodiatryassociates.com)
Probenecid is a uricosuric and renal tubular blocking agent and is used in combination with colchicine to treat chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout. (pharmacycode.com)
Febuxostat2
However, the major approach to long term prevention of gout and the complications of uric acid nephropathy is the use of uricosuric acids such as probenecid (1951: Benuryl) and benzbromarone (not available in the United States) and/or inhibitors of xanthine oxidase, such as the xanthine derivative allopurinol (1966: Aloprim) and the newer nonnucleoside xanthine oxidase inhibitors such as febuxostat (2009: Uloric, Adenuric). (nih.gov)
Update on medications for gout discusses the urate lowering agents allopurinol, febuxostat, probenecid and pegloticase, but not lesinurad). (nih.gov)
Gout2
Probenecid is used to treat chronic gout and gouty arthritis. (medlineplus.gov)
Probenecid may increase the frequency of gout attacks during the first 6 to 12 months that you take it, although it will eventually prevent them. (medlineplus.gov)