• Glucosamine sulfate may be efficacious in ways that glucosamine hydrochloride is not. (wikipedia.org)
  • Published in the Annals of Pharmacotherapy, the authors of this review concluded that "The available evidence suggests that glucosamine sulfate may be effective and safe in delaying the progression and improving the symptoms of knee OA. (wikipedia.org)
  • This finding was confirmed by a 2013 meta-analysis of 19 glucosamine trials which concluded that while neither form of glucosamine appeared significantly more effective than placebo at symptom improvement, glucosamine sulfate alone showed efficacy in improving physical function in knee OA as measured by the Lequesne Index in trials lasting more than 24 months. (wikipedia.org)
  • In 2006, the U.S. National Institutes of Health (NIH) funded a 24-week, 12.5 million-dollar multicenter clinical trial (the GAIT trial) to study the effect of chondroitin sulfate, glucosamine hydrochloride, chondroitin/glucosamine in combination, and celecoxib as a treatment for knee-pain in two groups of patients with osteoarthritis of the knee: Patients with mild pain (n=1229), and patients with moderate to severe pain (n=354). (wikipedia.org)
  • A study published in the journal Arthritis and Rheumatism in 2007 found that glucosamine sulfate was more effective than a placebo at treating knee OA symptoms. (doctorshealthpress.com)
  • For the study, 318 patients with moderately severe symptoms were given either 1,500 mg glucosamine sulfate, three grams acetaminophen, or a placebo daily for six months. (doctorshealthpress.com)
  • Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria ( Uncaria guianensis ) and 1500 mg of RNI 249 ( Lepidium meyenii ) administered orally, twice daily. (biomedcentral.com)
  • The glucosamine sulfate formulation is more popular and is approved as a prescription formulation in Europe. (biomedcentral.com)
  • They reported that Glucosamine sulfate helped reduce knee pain and improved joint space narrowing . (intelligentlabs.org)
  • Taking chondroitin sulfate together with glucosamine hydrochloride might reduce blood levels of glucosamine. (medlineplus.gov)
  • It's also not clear if this interaction occurs with other forms of glucosamine, such as glucosamine sulfate. (medlineplus.gov)
  • Glucosamine is a supplement that comes in several forms and is sometimes combined with ingredients such as shark cartilage or chondroitin sulfate. (healthfully.com)
  • The different forms of glucosamine supplements include glucosamine hydrochloride, glucosamine sulfate and N-acetyl-glucosamine 1 2 . (healthfully.com)
  • Research on glucosamine is generally focused on glucosamine sulfate, but there is some information available on glucosamine hydrochloride, also called glucosamine HCl 1 . (healthfully.com)
  • Glucosamine sulphate cannot be practically used as such for the preparation of medicinal products or dietary supplements because, for chemical reasons, it is a highly unstable compound. (orthoteers.com)
  • Asassessed by WOMAC scores, symptoms worsened slightly in patients on placebo compared with the improvement observed after treatment with glucosamine sulphate. (orthoteers.com)
  • ES for pain relief from IA hyaluronic acid, glucosamine sulphate, chondroitin sulphate and avocado soybean unsponifiables also diminished and there was greater heterogeneity of outcomes and more evidence of publication bias. (lu.se)
  • Data sources Searches were conducted of Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception to 11 September 2021. (bmj.com)
  • Methods: A systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and the Cochrane Library. (lu.se)
  • Medline, EMBASE, Google Scholar, Web of Science, and the Cochrane Central Register of Controlled Trials were initially searched in first quarter 2012 and last searched in March 2013. (orthobullets.com)
  • A 2008-2009 review of all known studies of glucosamine supplements for horses, for example, found that almost all studies had failed to meet usual standards and were fatally compromised by basic errors in their execution, including failure to test whether active ingredients were as stated, lack of adequate (or any) control groups or baseline measurements, very small sample sizes, and ignoring prior research or self-evident omissions. (wikipedia.org)
  • More recently, other reviews found little evidence that glucosamine and chondroitin supplements were any better than a placebo or at most only slightly better. (wikipedia.org)
  • Researchers at the University of Washington, in Seattle, evaluated whether 13 vitamin and mineral supplements and glucosamine, chondroitin, saw palmetto, Ginkgo biloba , garlic, fish-oil, and fiber supplements were associated with total mortality. (thecamreport.com)
  • We also manually searched review articles, manuscripts, and supplements from rheumatology and OA journals and sought unpublished data by contacting content experts, study authors, and manufacturers of glucosamine or chondroitin. (healthfully.org)
  • In general, the clinical trials of the mid-1990s that furnished positive results showing glucosamine efficacy were later deemed to be of poor quality due to shortcomings in their methods, including small size, short duration, poor analysis of drop-outs, and unclear procedures for blinding. (wikipedia.org)
  • A second 2005 review of glucosamine clinical trials reached a different conclusion. (wikipedia.org)
  • Objective To evaluate benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA. (healthfully.org)
  • Study Selection Studies were included if they were published or unpublished double-blind, randomized, placebo-controlled trials of 4 or more weeks' duration that tested glucosamine or chondroitin for knee or hip OA and reported extractable data on the effect of treatment on symptoms. (healthfully.org)
  • Methods Two reviewers independently extracted relevant data and assessed the risk of bias of trials using the Cochrane risk of bias tool. (bmj.com)
  • The authors of the study analyzed the moderate-to-severe pain group and found that in this group, the combination of glucosamine and chondroitin was more effective at providing pain relief than the positive control with 79% of the glucosamine group reporting at least a 20% reduction in pain compared to 70% for celecoxib and only 54% reporting a similar reduction in the placebo group. (wikipedia.org)
  • A Cochrane review on herbal back pain relief highlighted two studies that showed Devil's Claw as being more effective than placebo for relieving low back pain. (avogel.ie)
  • Researchers specifically said the results "suggest that clinicians should consider glucosamine as a supplement for patients with OA. (doctorshealthpress.com)
  • We'll also find out if the popular joint supplement Glucosamine can help with menopausal joint pain management. (intelligentlabs.org)
  • Although some preliminary studies have looked at the effects of glucosamine HCl in the human body, no decisive conclusions have been made about how it works in the human body when consumed as a supplement. (healthfully.com)
  • A systematic review in 2007 found that effect sizes from glucosamine supplementation were highest in industry-funded studies and lowest in independent studies, which may lead one to believe that bias is responsible for the heterogeneity of the clinical study findings regarding the efficacy of glucosamine. (wikipedia.org)
  • Meanwhile, a 2018 review of 18 recent studies concluded that glucosamine has favorable effects on knee OA pain. (doctorshealthpress.com)
  • May I kindly draw your attention to a Cochrane review where authors showed that glucosamine was generally safe to ingest but does not help with pain. (blogspot.com)
  • A 2015 Cochrane review on bracing found that wearing a brace, such as a valgus knee brace, neutral brace, or neoprene sleeve, may have little or no effect on pain reduction, knee function, or quality of life. (healthykneesclub.com)
  • A Cochrane review of all relevant studies, however, failed to confirm any benefits for asthma treatment. (dcscience.net)
  • Glucosamine + Chondroitin: For Bad Arthritis Pain Only? (healthfully.org)
  • Below is a meta-study done to evaluate glucosamine and chondrotin (very popular, alternative arthritis treatment). (healthfully.org)
  • Cochrane Database of Systematic Reviews. (blogspot.com)
  • Dr. Towheed is a Professor of Medicine (Rheumatology) and of Public Health Sciences at Queen's with expertise in systematic reviews and meta-analyses, including Cochrane reviews. (queensu.ca)
  • The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. (biomedcentral.com)
  • Using related criteria response rates to reparagen were favorable when compared to glucosamine. (biomedcentral.com)
  • Some of the evidence for the effectiveness of glucosamine is disputed. (wikipedia.org)
  • Although glucosamine is increasingly used by these patients, researchers at Oslo University Hospital Outpatient Clinic in Norway tell us little was known about the effectiveness of glucosamine for this condition until now. (thecamreport.com)
  • Glucosamine can be ingested orally since it is a derivative of chitin, present in the shells of crustaceans (e.g. (pileje.com)
  • Will Menopause Joint Pain Go Away With Glucosamine? (intelligentlabs.org)
  • What does Glucosamine have to do with menopause and joint pain? (intelligentlabs.org)
  • The present study aimed at investigating whether 18-week dietary integration with palmitoyl-glucosamine co-micronized with curcumin was able to maintain pain relief in dogs with OA-associated chronic pain receiving meloxicam (1.5 mg/ml oral suspension) on a tapering regimen (progressive 25% decrease of the original 0.1 mg/kg/day dose, on a biweekly basis) during the first 8 weeks of treatment. (bvsalud.org)
  • CONCLUSION: The findings appear to suggest that dietary integration with palmitoyl-glucosamine co-micronized with curcumin was able to maintain meloxicam-induced pain relief in dogs with severe OA chronic pain. (bvsalud.org)
  • Interestingly, in that subgroup, the combination of glucosamine and chondroitin appeared to be effective in relieving pain. (healthfully.org)
  • Despite the difficulty in determining the efficacy of glucosamine, it remains a viable treatment option. (wikipedia.org)
  • Bij patiënten met knie- en heupartrose is er meer onderzoek gedaan, waarbij systematische reviews laten zien dat er geen klinisch relevante verbetering van klachten door chondroïtine en/of glucosamine preparaten kon worden aangetoond (Gabay et al. (richtlijnendatabase.nl)
  • s study on overweight menopausal women showed that Glucosamine was more effective at knee OA prevention than diet/exercise therapy. (intelligentlabs.org)
  • Deze laatste gegevens hebben er zelfs toe geleid dat het gebruik van chondroïtinesulfaat en glucosamine beiden werden ontraden door de National Institute for Health and Care Excellence (NICE) richtlijnen in het Verenigd Koninkrijk voor de behandeling van knie- en heupartrose (National Clinical Guideline Centre, 2014). (richtlijnendatabase.nl)
  • 2002). Deze studie heeft echter een hoog risico op bias, en levert geen overtuigend bewijs voor een positief effect van chondroïtinesulfaat op structurele uitkomsten bij handartrose. (richtlijnendatabase.nl)