Clinical tumor. Medical search. Frequent questions

To learn more about available sarcoma clinical trials, contact us at [email protected] or 513-636-2799. (cincinnatichildrens.org)
The incidence rate for any grade ICIs-related neurologic ir-AEs in patients included in clinical trials has been reported to be approximately 3.8% to 12% [ 20 ]. (hindawi.com)
Notably, in the JCAR015 Phase 2 Clinical Trial (ROCKET) conducted by Juno Therapeutics, five patients died because of severe cerebral edema, causing the cessation of clinical trials by the FDA [ 22 ]. (hindawi.com)
They've taken the concept from the lab into clinical trials, which is quite impressive. (foresight.org)
The systematic way in which these researchers addressed multiple variables and issues gives us some indication of what will be required to move nanoparticles and other nanotherapeutics from laboratory studies into clinical trials. (foresight.org)
When considering treatment for a primary or metastatic brain tumor, some people consider clinical trials. (abta.org)
Clinical trials can be a treatment consideration for all genders, ages and stages of the disease, from diagnosis to recurrence. (abta.org)
The ABTA Featured Clinical Studies Program aims to provide patients and caregivers a way to easily understand and navigate to available clinical trials and other types of patient studies (i.e. registries, surveys) to increase patient consideration and participation. (abta.org)
The database includes an extensive list of privately and publicly-funded clinical trials throughout the U.S. and the world. (abta.org)
The Brain Tumor Network (BTN) is a navigation resource for adult patients and caregivers in the USA seeking information about brain tumor treatment options including clinical trials. (abta.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. (clinicalconnection.com)
Learn more about clinical research and participating in a study at About Clinical Trials . (clinicalconnection.com)
ClinicalConnection.com is a resource that provides information on clinical trials and other research opportunities worldwide. (clinicalconnection.com)
We combine this information with the vast collection of brain tumor care data in our BTTR database to know which trials are best for you. (uclahealth.org)
Our phase 1 CAR T-cell clinical trials against CNS tumors are called BrainChild. (seattlechildrens.org)
Learn more about this and other clinical trials at Seattle Children's. (seattlechildrens.org)
What is the goal of the CAR T-cell CNS clinical trials? (seattlechildrens.org)
The BrainChild studies are phase 1 clinical trials. (seattlechildrens.org)
Who can join the CAR T-cell CNS clinical trials? (seattlechildrens.org)
Are there CAR T-cell clinical trials for other childhood cancers? (seattlechildrens.org)
The PLAT trials are phase 1 and 2 clinical trials testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory acute leukemia or lymphoma. (seattlechildrens.org)
Clinical trials regarding the therapy alone as well as in combination with the other agents are also leading to a substantial rise in the therapy acceptance. (researchandmarkets.com)
As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)
Ongoing clinical trials currently test the efficacy of T-VEC in solid tumors as well as cutaneous lymphomas. (usz.ch)
In addition to the oral presentation, three Iovance poster presentations at AACR will highlight the design of clinical trials in progress in solid tumors and chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). (biospace.com)
If successful, Cluster-Wells technology could be validated in large prospective clinical trials as a new tool to non-invasively monitor for minimal active disease and to better guide therapy for pediatric brain tumors, the most common cause of death due to disease in children. (curechildhoodcancer.org)
Chicago, IL (June 4, 2011) -- Data presented at the 47th American Society of Clinical Oncology (ASCO) annual meeting demonstrate the potential of circulating tumor cells (CTC) as a biomarker for metastatic prostate cancer clinical trials. (jnj.com)
We look forward to further investigating the potential predictive benefit of CTCs in metastatic prostate cancer clinical trials as there are limited ways of assessing therapeutic benefit in this disease, especially when it has metastasized to the bone. (jnj.com)
He notes that lab monitoring preparation is vital for clinical trials like this, and that the pandemic delayed their work. (childrenscancer.org)
Your gift to Children's Cancer Research Fund allows researchers to translate their great ideas into groundbreaking clinical trials. (childrenscancer.org)
Ivy Brain Tumor Center at the Barrow Neurological Institute in Phoenix, AZ is a non-profit translational research program that employs a bold, early-phase clinical trials strategy to identify new treatments for aggressive brain tumors, including glioblastoma. (azbio.org)
The Ivy Center's Phase 0 clinical trials program is the largest of its kind in the world and enables personalized care in a fraction of the time and cost associated with traditional drug development. (azbio.org)
Unlike conventional clinical trials focusing on single drugs, its accelerated trials program tests therapeutic combinations matched to individual patients. (azbio.org)

In this study, continuous infusion of epirubicin into the bladder and instillation of a single dose epirubicin will be evaluated in terms of side effects, tumor recurrence and progression rates. (centerwatch.com)
Statistical analysis was performed on the operation time, the incidence of obturator nerve reflex, the peri-operative bleeding, the parameters of indwelling ureteral catheter or double-J stent, the incidence of postoperative hydronephrosis, the clinical stage of tumor, and the recurrence rate. (urotoday.com)
There was no case of upper urinary tract hydronephrosis or tumor recurrence. (urotoday.com)
Whether in the early diagnosis of tumor, in the monitoring of metastasis and recurrence or in the evaluation of efficacy and prognosis, tumor markers were very important clinical reference indicators[ 4 , 5 ]. (ijpsonline.com)
Many studies showed that the carcinoem-bryonic antigen (CEA) and human cytokeratin fragment antigen 21-1 (CYFRA21-1) has a high value in predicting tumor recurrence and judging the prognosis of patients[ 2 , 3 ]. (ijpsonline.com)
In cases of malignant tumors, local recurrence up to 5 years was found in 36 (64.3%) cases. (medscimonit.com)
In the other 20 (35.7%) cases of malignant tumors, the patients remained under close follow-up in the outpatient clinic, without signs of local recurrence (follow-up 1-17 years). (medscimonit.com)
Moreover, the combination of IGFBP7high and estrogen receptor-positive tumors was associated with low recurrence risk only in tamoxifen-treated patients (Pinteraction= 0.029). (lu.se)

In cancer research, advancing a comprehensive understanding of the unique characteristics of individual tumor types and their microenvironment is of considerable importance for clinical translation. (nature.com)
Here we describe a multimodule integrated pipeline for the processing of freshly resected human brain tumor tissue and matched blood that enables analysis of the tumor microenvironment, with a particular focus on the tumor immune microenvironment (TIME). (nature.com)
This protocol will enable researchers to use this pipeline to address further research questions regarding the tumor microenvironment. (nature.com)
Tumor purity-related coexpression factors in the tumor microenvironment have essential clinical, genomic, and biological significance in lung cancer. (hindawi.com)
Tumor microenvironment possesses complexity because of a mixture of growth-promoting and inhibiting growth factors, nutrients, chemokines, and other noncancer types, which interact with each other and associate with tumor growth, disease progression, drug resistance, and especially, infiltrating T lymphocytes and tumor growth [ 2 ]. (hindawi.com)
We explored the coexpression factors most related to tumor purity and related biological functions and demonstrated the most relevant biological functions and mechanism of action affecting tumor purity in the lung cancer tumor microenvironment. (hindawi.com)
Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
The tumor microenvironment (TME) has a substantial impact on disease progression as well as response to therapy. (usz.ch)
The researchers within the TuPro consortium hypothesized that integrating a more comprehensive suite of omics tests could lead to a more complete understanding of patients' tumors, including providing insights into the tumor microenvironment, heterogeneity , and ex vivo responses to certain drugs. (darkdaily.com)
We review the relationship between TMB and the tumor immune microenvironment. (aacrjournals.org)
To address the limitations of the TMB, novel biomarkers are needed that account for the immunogenic quality of tumor mutations and capture the complexity of the tumor immune microenvironment. (aacrjournals.org)

New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
Clinical data of 97 patients initially diagnosed with lung lesions in our hospital from January 2018 to December 2019 were collected and divided into the lung cancer group and benign lesion group. (ijpsonline.com)
There were 52 patients diagnosed with stage I or II lung cancer by computed tomography and clinical diagnosis in the lung cancer group and 45 patients with benign lesions in the benign lesion group. (ijpsonline.com)
There were 56 (46%) patients with malignant tumors, 42 (34%) with benign tumors, 19 (16%) with inflammatory tumors, and 5 patients (4%) had other tumors. (medscimonit.com)
Most childhood ocular tumors are benign but there are also life threatening tumors. (banglajol.info)
In this second part of the series, we explain how to distinguish a select group of primary malignant bone tumors requiring further imaging and clinical workup from benign, tumor-like conditions. (appliedradiology.com)
The most frequent bone tumors, osteochondromas represent 20-50% of benign tumors and 10-15% of all bone tumors. (appliedradiology.com)
Some are benign tumors, which aren't cancer. (medlineplus.gov)
Adenomatoid tumors are rare and benign mesothelial tumors, which arise from the lining of organs. (wikipedia.org)
These benign tumors can grow up to 5.0 centimeters (most of them range around to 2.0 cm). (wikipedia.org)
L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, has been shown to be expressed in adenomatoid tumors (and negative in other benign mesothelial tissues and mesothelioma). (wikipedia.org)

In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
NCI-CONNECT (Comprehensive Oncology Network Evaluating Rare CNS Tumors) aims to advance the understanding of rare adult central nervous system (CNS) cancers. (abta.org)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
EPRI indirectly detects the low oxygen levels characteristic of growing tumors that occur in a wide range of cancers. (cancer.gov)
Iovance Biotherapeutics aims to improve patient care by making T cell-based immunotherapies broadly accessible for the treatment of patients with solid tumors and blood cancers. (biospace.com)
Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
In their published paper , the Swiss researchers say these three cancers were selected for the study "based on the potential clinical benefit and availability of sufficient tumor material for simultaneous analysis across all technologies. (darkdaily.com)
SonALAsense is a clinical-stage company developing sonodynamic therapy (SDT) as a first-in-class, noninvasive drug-device combination for the treatment of recurrent glioblastoma multiforme, diffuse intrinsic pontine gliomas, and other deadly cancers. (azbio.org)
This mini-review focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response and toxicity. (aspetjournals.org)

Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)

This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (metastatic), including central nervous system tumors. (braintumor.org)
However, investigating human brain tumor tissue is challenging due to the often-limited availability of surgical specimens. (nature.com)
Fig. 3: Variation in immune cell abundance and cell viability across different brain (tumor) tissue types. (nature.com)
Fig. 5: Immune cell yield and activation in brain (tumor) tissues differs across tissue dissociation methods. (nature.com)
Fig. 6: Cross-method validation of brain TIME and different isolation methods provide distinct advantages for the extraction of immune cells from brain tumor tissue. (nature.com)
Fig. 8: Representative data from human brain tumor tissue. (nature.com)
A dults diagnosed with brain cancer can help to advance research from the comfort of their homes by sharing copies medical records and/or providing a portion of their stored tumor tissue and/or a blood sample. (abta.org)
The structure of tumor tissue is complex. (hindawi.com)
Our dedicated neuropathologists perform the most complete molecular analysis of tumor tissue available. (uclahealth.org)
In the BrainChild-03 trial, a patient's own T cells are reprogrammed to recognize and target the protein B7-H3, which is expressed on many pediatric CNS tumors but not healthy brain tissue. (seattlechildrens.org)
TIL cells are extracted from a patient's own tumor tissue, expanded through a proprietary process, and infused back into the patient. (biospace.com)
Upon infusion, TIL reach tumor tissue, where they attack cancer cells. (biospace.com)
We investigated the ability of docetaxel to enhance in vivo tumor radioresponse and influence radiation injury to normal tissue. (aacrjournals.org)
The plasmakinetic needle electrode was used to treat the tumor with en bloc resection, and all the excised tissue was sent for pathological examination. (urotoday.com)
SONALA-001 targets only the glioblastoma tumor cells through selective uptake and conversion to a metabolite which is then activated by focused ultrasound, the SDT process, to kill just the tumor itself, not the surrounding tissue - a truly remarkable finding. (azbio.org)
Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)
Soft tissue tumors (STT) constitute a heterogeneous group of approximately 100 distinct neoplasms, including more than 50 malignant subtypes, so-called sarcomas. (lu.se)
We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)
When used as a diagnosis tool, the excision biopsy can collect a tissue sample from the tumor. (wikipedia.org)
Tumor-specific IGFBP7 protein levels were evaluated with immunohistochemistry using tissue microarrays in tumors from 878 patients. (lu.se)

Thus, the term "carcinoid" was replaced by the term "gastroenteropancreatic neuroendocrine tumors, GEP-NETs"[ 2 ]. (wjgnet.com)
Albany, USA) DelveInsight's ' Neuroendocrine Tumors Pipeline Insight 2023 ' report provides comprehensive global coverage of pipeline Neuroendocrine Tumors therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Neuroendocrine Tumors pipeline domain. (medgadget.com)
For Neuroendocrine Tumors emerging drugs, the Neuroendocrine Tumors pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. (medgadget.com)
DelveInsight's Neuroendocrine Tumors Pipeline analysis depicts a robust space with 55+ active players working to develop 60+ pipeline therapies for Neuroendocrine Tumors treatment. (medgadget.com)
In March 2023 , RayzeBio, Inc., a targeted radiopharmaceutical company developing an innovative pipeline against validated solid tumor targets, announced the completion of enrollment in the Phase 1b portion of the ACTION-1 Phase 1b/3 trial of RYZ101 in patients with SSTR+ gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who have progressed on Lutetium-177 labeled somatostatin analog therapy. (medgadget.com)
In March 2023 , NUCLIDIUM announced that the Neuroendocrine Tumors Research Foundation ("NETRF") has selected the company and its collaboration partner the University Hospital Basel (Universitätsspital Basel, "USB") as recipients of its Investigator Award. (medgadget.com)
The grant will support the initiation and execution of Phase 1 clinical trial with TraceNETTM, a novel copper-based radio diagnostic for detecting neuroendocrine tumors (NET). (medgadget.com)

An emerging technology being developed for multiple applications in cancer focuses on the analysis of circulating tumor cells (CTCs). (curechildhoodcancer.org)

This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
Amgen (Nasdaq: AMGN) today announced the publication of results from a pivotal Phase 3 study of 1,776 advanced cancer patients with different types of solid tumors (not including breast and prostate cancer) or multiple myeloma, which compared XGEVA (TM) (denosumab) to Zometa(R) (zoledronic acid) in preventing skeletal-related events (SREs). (amgen.com)

Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
Read more about how T-cell immunotherapy for CNS tumors works . (seattlechildrens.org)
Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
Along the same lines, TLS density may have predictive potential for the clinical response to immunotherapy. (usz.ch)
Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better? (aacrjournals.org)

Most childhood brain tumors are diagnosed and removed in surgery. (medlineplus.gov)

Fig. 4: Examples of IF staining across different brain (tumor) tissues. (nature.com)
These nontumor cells dilute the tumor purity in lung cancer tissues. (hindawi.com)
We measured tumor purity in 486 lung carcinoma tissues from TCGA-LUAD FPKM by using the "estimate" R package. (hindawi.com)
We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)
In 1998, CCR researchers used EPRI to create the first map of oxygen content in tissues and tumors of mice. (cancer.gov)
In addition, mitotic arrest and apoptosis in tumors and normal tissues were assessed after docetaxel administration to determine whether these cellular effects underly its radio-modifying action. (aacrjournals.org)
Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
The clinical use of mIBG as a radiopharmaceutical in cancer diagnosis and treatment can be further improved by taking a holistic approach considering mIBG transporters in both cancer and normal tissues. (aspetjournals.org)
Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
Although adenomatoid tumors are not known to infiltrate surrounding tissues, it is possible that there are multiple adenomatoid tumors in the same area. (wikipedia.org)

Ren MY, Li J, Wu YX, Li RM, Zhang C, Liu LM, Wang JJ, Gao Y. Clinical characteristics and prognosis of orbital solitary fibrous tumor in patients from a Chinese tertiary eye hospital. (wjgnet.com)
To explore the application value of tumor markers carcinoembryonic antigen and cytokeratin 19 fragment in the progression and prognosis of middle-advanced non-small cell lung cancer. (ijpsonline.com)
Serum carcinoembryonic antigen and cytokeratin 19 were abnormally highly expressed in non-Small cell lung cancer patients, which are useful for clinical diagnosing, treatment planning, efficacy monitoring, and prognosis evaluation. (ijpsonline.com)
The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. (lu.se)
Fortunately, patients with these HPV-associated tumors have a much better response to treatment and improved prognosis compared with individuals with traditional, non-HPV oropharyngeal SCCs. (medscape.com)
This study aimed to investigate whether IGFBP7 levels and messenger ribonucleic acid (mRNA) expression are associated with the patient and tumor characteristics and prognosis in breast cancer. (lu.se)

Such cells are derived from the primary tumor and can be found in the blood or other body fluids though in low numbers. (curechildhoodcancer.org)
If a Wilms tumor is suspected or if the primary tumor is histologically confirmed, it should be staged by using CT or MRI. (medscape.com)
Biopsy via endoscopic examination of the primary site with the patient under anesthesia remains the definitive procedure to establish the diagnosis and accurately assess the primary tumor. (medscape.com)

Tumors with inadequate oxygen supply, called hypoxic tumors, are more resistant to radiation and chemotherapy and have an increased risk of metastasis than tumors with normal oxygen levels. (cancer.gov)
Primary management of chondrosarcoma typically consists of surgical intervention, as the tumor is relatively resistant to radiation and chemotherapy. (appliedradiology.com)

The treatment regimen associated with the TIL therapy comprises of collection of lymphocytes that have the ability to engage themselves in the tumor cells destruction. (researchandmarkets.com)

Signs and symptoms of carcinoid tumors vary greatly and depend on the location and size of the tumor and on the presence of metastases. (medscape.com)
Diagnostic difficulties may arise in patients who have flushing without a large tumor or metastases and in those without symptoms. (medscape.com)
The availability of octreotide-receptor scintigraphy allows for the detection of the tumor and metastases. (medscape.com)
An early and frequent (94%) symptom of carcinoid tumors, especially those of midgut with metastases, is cutaneous flushing, which typically affects the head and neck. (medscape.com)
Positron emission tomography (PET) scanning with CT imaging is used in the evaluation of unknown primary tumors, synchronous primary tumors, and distant metastases. (medscape.com)

part 2 will enroll patients requiring a biopsy in order to assess BXQ-350 concentrations in the biopsied tumor. (braintumor.org)
Now known by the name UroNav, the device enables three-dimensional, real-time visualization of prostate tumors during biopsy. (cancer.gov)
The therapy is completely dependent on the tumor biopsy extracted from the patients rather than circulating T cells in the blood. (researchandmarkets.com)
The tumor location, histopathological diagnosis, and postoperative complications give us important information for the diagnosis of tumor prior to biopsy or tumor resection and for the determination of the treatment strategy and possible complications after surgery. (medscimonit.com)
If removal of the tumor is necessary then an excision biopsy is usually done on the patient. (wikipedia.org)

This paper mainly reviews the clinical features, pathogenesis, and therapeutic strategies of neurologic ir-AEs. (hindawi.com)
Targeted therapeutic nanoparticles that accumulate in tumors while bypassing healthy cells have shown promising results in an ongoing clinical trial, according to a new paper. (foresight.org)
Although studies have revealed the mechanisms involved in cancer malignant characteristics and identified reasonable therapeutic targets [ 4 ], current clinical prediction and treatment outcome of lung cancer are not satisfactory [ 5 ]. (hindawi.com)
Thus, docetaxel given within 2 days before irradiation acted as a potent enhancer of tumor radioresponse and increased the therapeutic gain of irradiation. (aacrjournals.org)
Sonodynamic therapy has tremendous potential to become a new nonsurgical therapeutic modality to treat brain tumors," said Nader Sanai, MD. "We found that MR-guided focused ultrasound combined with SONALA-001 demonstrated rapid and selective cell death in the patients' tumors, an encouraging discovery of this new noninvasive treatment option. (azbio.org)

SSE: 688235), and SpringWorks Therapeutics, Inc. (NASDAQ: SWTX), today announced that they will present updated clinical data from the Phase 1b trial of BeiGene's RAF dimer inhibitor, lifirafenib, in combination with SpringWorks' MEK inhibitor, mirdametinib, in patients with advanced or refractory solid tumors with RAS mutations, RAF mutations and other MAPK pathway aberrations. (businesswire.com)
The lifirafenib plus mirdametinib combination represents a novel targeted approach to treat solid tumors driven by RAS/RAF mutations, and other MAPK pathway aberrations. (businesswire.com)
This ongoing Phase 1b trial ( NCT03905148 ) is an open-label, dose escalation and expansion study to investigate the safety, pharmacokinetics (PK) and antitumor activities of mirdametinib in combination with lifirafenib, BeiGene's RAF dimer inhibitor, in patients with advanced or refractory solid tumors harboring RAS mutations, RAF mutations, and other MAPK pathway aberrations. (businesswire.com)
The combination showed antitumor activity in patients with various KRAS, NRAS, and BRAF mutations across several solid tumor types, including low-grade serous ovarian cancer (LGSOC), non-small cell lung cancer (NSCLC), and endometrial cancer. (businesswire.com)
The FDA has approved the PD-1 inhibitor, pembrolizumab, as a therapy for all solid tumors with TMB equal to or greater than 10 mutations/megabase as measured by the FoundationOne CDx assay. (aacrjournals.org)
The FDA has approved the programmed cell death protein-1 (PD-1) inhibitor, pembrolizumab, in solid tumors with a tumor mutational burden (TMB) ≥ 10 mutations/megabase based on the FoundationOne CDx assay. (aacrjournals.org)
In addition, RLY-4008 demonstrated strong activity against known clinical on-target resistance mutations in cellular and in vivo preclinical models. (ozarksfirst.com)
The identification of specific mutations is of immediate clinical importance by providing improved diagnostic precision and opportunities for prognostic evaluation. (lu.se)
Adenomatoid tumors of the female and male genital tract are characterized by somatic missense mutations in the TRAF7 gene, which leads to aberrant NF-kB pathway activation. (wikipedia.org)
Unlike some malignant mesotheliomas, adenomatoid tumors do not harbor CDKN2A deleterious mutations. (wikipedia.org)
By "initiate," we mean the ability of a substance to cause mutations in DNA that can lead to tumors. (cdc.gov)
By "promote," we mean the ability of a substance to cause cells that have already sustained such DNA mutations to then become tumors. (cdc.gov)

Your Name ) thought you would like to see this page from the Journal of Clinical Pathology web site. (bmj.com)
Careful multidisciplinary assessment of base of tongue tumors is paramount for appropriate treatment, which is based on staging, pathology, tumor location, functional outcomes, and patient preference. (medscape.com)
The decision to use surgical excision and other treatment modalities for malignant base of tongue tumors is primarily based on pathology, initial staging, tumor location, medical comorbidities, smoking history, and patient preference. (medscape.com)

These coexpression factors (SASH3 and CD53) can be used to classify tumor purity phenotypes and to predict clinical outcomes. (hindawi.com)
A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Experts at the UCLA Brain Tumor Center are using science and technology to improve outcomes and quality of life for brain tumor patients. (uclahealth.org)
In the past few years, the market has observed an increasing number of bio-pharmaceutical companies, leading to the rise in the competition for developing more targets that could generate more progressive outcomes at pre-clinical level and clinical level. (researchandmarkets.com)
Multidisciplinary tumor boards at Academic Medical Centers (AMC) maximize cancer outcomes. (jnccn.org)
Clinical outcomes of patients with pancreatic tumors discussed in Tumor Board. (bvsalud.org)
Despite the complex anatomy associated with base of tongue tumors, as well as concerns regarding posttreatment functional deficits, significant changes in management options for such neoplasms have vastly improved outcomes in recent years. (medscape.com)

The Ivy Brain Tumor Center dosed its first patient in March 2021 and is currently evaluating SDT using Insightec's magnetic resonance-guided focused ultrasound (MRgFUS) technology in combination with SonALAsense's proprietary intravenous formulation of 5-aminolevulinic acid (SONALA-001) to investigate the feasibility, safety, and biological effects of the treatment. (azbio.org)
The expansion cohorts were initiated in December 2021 and now consist of seven different cohorts based on FGFR2 alteration and tumor type. (ozarksfirst.com)

In the study, which appears April 4 in the journal Science Translational Medicine [ abstract ], the researchers demonstrate the particles' ability to target a receptor found on cancer cells and accumulate at tumor sites. (foresight.org)

Mice receiving both the initiator chemical plus exposure to MWCNT were significantly more likely to develop tumors (90% incidence) and have more tumors (an average of 3.3 tumors/mouse lung) than mice receiving the initiator chemical alone (50% of mice developing tumors with an average of 1.4 tumors/lung). (cdc.gov)

A clinical trial is a research study to determine if a new treatment or medical device is safe and effective or if a new treatment or device offers any benefit or advantage over treatments that are currently available. (abta.org)
These treatments include medications and other substances based on the unique molecular makeup of the tumor. (uclahealth.org)
In 2008, the team demonstrated that EPRI, when used in conjunction with MRI, provided detailed, three-dimensional information about the exact location of treatment-resistant tumors in living organisms in real time, thus creating a roadmap to help target treatments to these tumors. (cancer.gov)
Tumor growth delay was the end point of the treatments. (aacrjournals.org)
Second, in 2.5% (115/4600), NAVYA recommended treatments plan for clinical scenarios not covered by NCCN such as 2nd line therapy for metastatic biliary tract tumors, 3rd line treatments for patients with good ECOG, lack of clarity in diagnosis or conflicting diagnostic reports. (jnccn.org)
It's a database of treatments for brain tumors. (bvsalud.org)

A huge 30 × 22 × 4 cm 3 recurrent Dabska tumor of the flank was described in a 23-year-old woman and was successfully excised. (medscape.com)
The purpose of this study is to assess the side effects and best dose of a genetically engineered measles virus for treating patients who have a cancerous peripheral nerve sheath tumor that cannot be removed by surgery (unresectable) or that has come back after a period of improvement (recurrent). (mayo.edu)
ENLIGHTen-01 is a phase 1 clinical trial testing CAR T cells administered with UB-TT170, a small molecule fluorescein tag that targets folate receptors to mark tumors for clearance by CAR T cells, that is open to teens and young adults with recurrent or refractory osteosarcoma. (seattlechildrens.org)
Recurrent odontogenic keratocyst tumor: conservative or radical surgical treatment? (bvsalud.org)

This phase II trial studies the side effects and how well nirogacestat works in treating patients with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. (cincinnatichildrens.org)
The particles were also shown to be safe and effective: Many of the patients' tumors shrank as a result of the treatment, even when they received lower doses than those usually administered. (foresight.org)
If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
We continue to develop new brain tumor treatment technologies, such as the Novalis Tx® Stereotactic Radiosurgery System. (uclahealth.org)
Precisely locating and killing tumors in the body without harming surrounding cells is a major challenge in cancer treatment. (cancer.gov)
A major challenge in cancer treatment is to precisely locate and monitor tumors in the body so that the tumors can be killed without harm to surrounding cells. (cancer.gov)
Another imaging tool developed by CCR researchers helps in the identification of treatment-resistant tumors. (cancer.gov)
The spurt of knowledge available for the TILs has completely changed the concept of using simple cells infiltrating from the tumors as a novel and efficient treatment regimen. (researchandmarkets.com)
Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. (wjgnet.com)
Brain tumour treatment and care during the pandemic The Coronavirus pandemic has caused disruption to lots of different aspects of our daily lives. (brainstrust.org.uk)
Rapid advances for the capture and analysis of CTCs including the Cluster-Wells technology recently developed at Georgia Institute of Technology, provides a new way to monitor tumor growth or response to treatment. (curechildhoodcancer.org)
Results of the study titled, " Evaluation of circulating tumor cell (CTC) enumeration as an efficacy response biomarker of overall survival (OS) in metastatic castration resistant prostate cancer (mCRPC) " indicated that pre-treatment, CTCs and lactate dehydrogenase (LDH), both alone and in combination, were prognostic biomarkers, while baseline prostate-specific antigen (PSA) was not. (jnj.com)
A new brain tumor treatment developed by researchers Christopher Moertel, MD and Michael Olin, PhD received Investigational New Drug (IND) approval from the FDA this summer. (childrenscancer.org)
The treatment, called a checkpoint inhibitor, has promise to help a child's body effectively combat brain tumors when given a vaccine. (childrenscancer.org)
Dr. Olin discovered that brain tumors sometimes shield themselves with a protein called CD200, preventing a child's immune system and treatment from attacking it. (childrenscancer.org)
This will help guide how much of the treatment to give children in their clinical trial. (childrenscancer.org)
The TuPro Project's findings are available to doctors who analyze them at interdisciplinary tumor board meetings and generate treatment options, creating a "fast diagnostic loop" with an estimated four-week turnaround time from surgery to tumor board. (darkdaily.com)
In this paper a variety of intraocular, orbital and surface tumors are reviewed with their key sign of diagnosis and current treatment modalities. (banglajol.info)
On June 16, 2020, the FDA approved the programmed cell death protein-1 (PD-1) inhibitor, pembrolizumab (KEYTRUDA, Merck & Co., Inc.), for the treatment of tumor mutational burden-high (TMB-H) solid tumors. (aacrjournals.org)
Precise detection and diagnosis of specific tumor types and disease stages is essential for designing the appropriate and effective regimens for treatment. (aspetjournals.org)
Treatment-related toxicity is frequently a dose-limiting factor and represents a major challenge in clinical management of cancer. (aspetjournals.org)
Leapfrogging existing guidelines based CDSS, NAVYA online tumor board makes actionable expert treatment plans possible at a large scale. (jnccn.org)

Immediate single instillation of epirubicin has been shown to act by destroying circulating tumour cells after TURB(Transurethral Resection of a Bladder Tumor), and by an ablative effect on residual tumour cells at the resection site and on small overlooked tumours.European Association of Urology Guidelines on Bladder Cancer advocates single immediate postoperative intravesical chemotherapy. (centerwatch.com)
Clinical application of the needle electrode in transurethral plasmakinetic resection of bladder tumor around ureteral orifice: A report of 16 cases]. (urotoday.com)
To explore the clinical application value of using needle electrode in transurethral plasmakinetic resection of bladder tumor around ureteral orifice. (urotoday.com)
Retrospective analysis was performed on the clinical data of 16 cases who had bladder tumors around ureteral orifice and underwent transurethral resection using plasmakinetic needle electrode in Department of Urology, Peking University International Hospital from June 2015 to December 2019. (urotoday.com)
Ureteral catheters were indwelled prior to the operation of tumor resection in seven cases. (urotoday.com)
The transurethral plasmakinetic resection of bladder tumor using needle electrode can realize en bloc tumor resection without obturator nerve reflex and reduce the risk of ureteral orifice injury. (urotoday.com)

Pediatric patients mostly depend on their parent or caregiver for seeking medical attention thus many ocular tumor present with unnecessary delay. (banglajol.info)

Previous attempts to develop targeted nanoparticles have not successfully translated into human clinical studies because of the inherent difficulty of designing and scaling up a particle capable of targeting tumors, evading the immune system and releasing drugs in a controlled way. (foresight.org)
Tumor purity plays an essential role in the immune response to lung cancer. (hindawi.com)
We found that these factors were significantly negatively correlated with tumor purity and positively correlated with the immune score in the immunophenotyping analysis. (hindawi.com)
With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
Immune checkpoint inhibition results in significant and durable clinical responses in a proportion of cancer patients but is ineffective in others. (usz.ch)
Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
His goal was to "turn off" this shielding CD200 protein, allowing a previously developed vaccine and the child's immune system a chance to eradicate the brain tumor. (childrenscancer.org)

The options also depend on the type of tumor and where it is. (medlineplus.gov)
Because of this, researchers had a difficult time concluding that type of tumor has a mesothelial origin. (wikipedia.org)

Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
It is estimated that the novel clinical assets in the TIL therapy will shorten the market cycles for other viable cancer therapies by rapidly following the quick launch strategy for the products under TIL therapy. (researchandmarkets.com)
In another advancement toward accurate precision medicine , Swiss researchers from the University Hospitals of Zurich and Basel , ETH Zurich , the University of Zurich , and pharmaceutical company Roche have developed a multi- omic tumor profiling technology for cancer patients they hope will isolate biomarkers that allow doctors to tailor drug therapies to individual patients' medical needs. (darkdaily.com)
Once approved for clinical use, not only would these biomarkers become targets for specific cancer therapies, they also would require development of new diagnostic tests that anatomic pathologists could use to determine whether a biomarker was present in a patient. (darkdaily.com)
This research could lead to new precision medicine biomarkers for clinical laboratory cancer diagnostics and therapies. (darkdaily.com)
Relay Therapeutics is a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies with the goal of bringing life-changing therapies to patients. (ozarksfirst.com)

This phase I clinical trial measures the amount and effect of lidocaine injected into patients with glioblastoma while they are undergoing surgical removal of their brain tumors. (braintumor.org)
18F-FMAU PET/CT in addition to MRI may make the finding and diagnosing of brain tumors easier. (braintumor.org)
Quail, D. F. & Joyce, J. A. The microenvironmental landscape of brain tumors. (nature.com)
You can search with generic terms (brain tumor, brain cancer) or by specific tumor type. (abta.org)
Put your trust in our internationally recognized brain tumor experts. (uclahealth.org)
UCLA is one of the top five brain tumor research programs in the country. (uclahealth.org)
We have the best and brightest researchers exploring every aspect of brain tumor care. (uclahealth.org)
UCLA is proud to be one of few programs in the country examining the quality of brain tumor care. (uclahealth.org)
We evaluate all of our brain tumor patients to determine if they could benefit from a clinical trial. (uclahealth.org)
CNS tumors are brain and spinal cord tumors, such as atypical teratoid/rhabdoid tumor (ATRT), diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG). (seattlechildrens.org)
Is CAR T-cell therapy safe to give to children and young adults with relapsed or refractory CNS tumors (tumors of the brain or spinal cord)? (seattlechildrens.org)
Have I got a brain tumour? (brainstrust.org.uk)
Our vision is for everyone with a brain tumour to feel less afraid, less alone and more in control. (brainstrust.org.uk)
The Brain Tumour Data Dashboard lets you explore up -to-date, population level data about the brain tumours diagnosed in England between 2013 and 2015. (brainstrust.org.uk)
The bottom of the tree contains all the patients with brain tumours, and then each branch divides the data by a certain characteristics, like age, or location of tumour. (brainstrust.org.uk)
But the data is divided in an order, starting with location of the tumour (endocrine or brain), then by age, region, and gender. (brainstrust.org.uk)
With funding from CURE Childhood Cancer, Dr. Toby MacDonald at Emory University will utilize the Cluster-Wells technology to clinically evaluate CTCs in cell clusters derived from the bloodstream of children with brain tumors. (curechildhoodcancer.org)
In this study, they hope to identify which types of brain tumors generate CTCs and whether they can be used diagnostically to monitor the impact of therapy. (curechildhoodcancer.org)
Connor (above) is a brain tumor survivor. (childrenscancer.org)
This means the drug has been given the "okay" to be used for human patients and is a step closer to being ready for children with fatal brain tumors. (childrenscancer.org)
Their effort to build on it at the University of Minnesota may make all the difference to those suffering from brain tumors. (childrenscancer.org)
Initial results of this study were presented today at the European Society for Medical Oncology Congress during a mini oral session on CNS tumors by Nader Sanai, MD, director of the Ivy Brain Tumor Center and director of neurosurgical oncology at Barrow Neurological Institute. (azbio.org)
Additional clinical trial information can be found at NCT04559685 or the Ivy Brain Tumor Center's website . (azbio.org)
Follow the Ivy Brain Tumor Center on Facebook , Instagram , Twitter and LinkedIn . (azbio.org)
Brain tumors are abnormal growths inside the skull. (medlineplus.gov)
Childhood brain and spinal cord tumors can cause headaches and other symptoms. (medlineplus.gov)
Doctors use physical and neurological exams, lab tests, and imaging to diagnose brain tumors. (medlineplus.gov)
High-grade brain tumors, consistently located in the frontal lobes and olfactory tracts, were detected in 10 raccoons during March 2010-May 2012 in California and Oregon, suggesting an emerging, infectious origin. (cdc.gov)
Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
JCV, for example, induces brain tumors when intracerebrally inoculated in experimental animals ( 7 - 11 ). (cdc.gov)
In northern California and southern Oregon, we diagnosed 10 cases of olfactory tract/frontal lobe brain tumors in free-ranging raccoons during March 2010-May 2012. (cdc.gov)

In this study, the local and systemic side effects, tumor recurrens and progression rates of single or continuous epirubicin instillation during the early postoperative period were investigated in low and intermediate risk non-muscle-invasive bladder cancer. (centerwatch.com)
It is a safe and effective surgical method for treating bladder tumors around the ureteral orifice. (urotoday.com)
The influence of toxic working environment on the urothelial bladder tumors characteristics, the experience of "Sf. (medandlife.org)

The Phase I clinical trial was performed by researchers at BIND Biosciences, a company cofounded by Langer and Omid Farokhzad in 2007. (foresight.org)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
STRIvE-01 is a phase 1 trial testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory solid tumors that express the protein EGFR or B7H3. (seattlechildrens.org)
In winning the IND status, Adherex can now proceed with a Phase I clinical trial. (wraltechwire.com)
This approval was based on an exploratory analysis of the KEYNOTE-158 study, which was a single-arm, phase II multi-cohort study of pembrolizumab for select, previously treated advanced solid tumors. (aacrjournals.org)
RLY-4008 (lirafugratinib) is currently being evaluated in a global Phase 1/2 clinical trial (ReFocus) in patients with FGFR2-altered CCA and multiple other solid tumors including a single arm, potentially registration-enabling cohort for FGFRi-naïve FGFR2-fusion CCA. (ozarksfirst.com)

In cancer patients, TLS correlate with improved survival in a growing list of tumor types, suggesting that TLS contribute to anti-tumor immunity. (usz.ch)
Adherex, a biopharmaceutical firm based in RTP, took a major step in its product development Tuesday, announcing the FDA had approved an investigational new drug application for an anti-tumor product. (wraltechwire.com)

The aim of this study was to investigate the distribution of different types of primary orbital tumors, histopathological diagnosis, and postoperative complications. (medscimonit.com)
We analyzed 122 patients (68 women and 54 men) with orbital tumors, hospitalized in the ENT Department of the Medical University of Silesia in Katowice during 1990-2013. (medscimonit.com)
We characterized the occurrence and pathological profiles of orbital tumors. (medscimonit.com)

These data support the advancement of this combination into the dose-expansion portion of the study, which will focus on a biomarker selected patient population with a tumor agnostic approach. (businesswire.com)
High tumor mutational burden (TMB-H) has shown promise as a biomarker in lung cancer, but the broad applicability of TMB-H as a biomarker of response across all solid tumors is unclear. (aacrjournals.org)
Here, we elucidate the caveats of using TMB as a biomarker with a universal threshold across all solid tumors. (aacrjournals.org)
A growing body of research supports stromal tumour-infiltrating lymphocyte (TIL) density in breast cancer to be a robust prognostic and predicive biomarker. (lu.se)

Though most of these tumor present at tertiary eye hospital, the overall knowledge about these tumors can help ophthalmologists in diagnosis and proper referral. (banglajol.info)

In order to see adenomatoid tumors multiple imaging modalities are used. (wikipedia.org)

The ABTA Featured Clinical Studies Program allows medical centers and companies to pay to have their clinical study featured on the ABTA website. (abta.org)
In this study, we constructed a tumor purity coexpression network based on weighted gene coexpression network analysis (WGCNA) [ 8 ]. (hindawi.com)
These posters are intended to educate physicians about study design and will not include clinical data. (biospace.com)
The study is designed to evaluate the safety and drug metabolism of the agent as well as to look at the drug's activity on the tumor and its vasculature. (wraltechwire.com)
The researchers published their study in the journal Cancer Cell , titled, " The Tumor Profiler Study: Integrated, Multi-omic, Functional Tumor Profiling for Clinical Decision Support . (darkdaily.com)
The Tumor Profiler Study is an observational clinical study combining a prospective diagnostic approach to assess the relevance of in-depth tumor profiling to support clinical decision-making ("fast diagnostic loop") with an exploratory approach to improve the biological understanding of disease ("exploratory science loop")," the TuPro website states. (darkdaily.com)
The study, which appeared today in the Journal of Clinical Oncology , found that XGEVA was non-inferior to Zometa in delaying or preventing SREs. (amgen.com)
In a study of ultrasound and laboratory findings in Wilms tumor survivors with a solitary kidney, signs of kidney damage were seen in 22 of 53 patients (41.5%) on ultrasonography. (medscape.com)
Thus, although PyV-induced oncogenesis in laboratory animals has been a prolific model for the study of the cell cycle and cell transformation, natural infections rarely result in tumor formation, so the steps in cell transformation after natural infection are being revealed more slowly. (cdc.gov)
While adenomatoid tumors are present in both the various body areas of males and females, one study discovered that these tumors were more likely to occur in Caucasian males. (wikipedia.org)
The aim of this study is to assess whether the TB conduct decision was performed in patients with pancreatic tumors , their life status 90 days after the TB decision , and to analyze the reasons why the conduct was not performed. (bvsalud.org)
we conducted a retrospective study with patients with pancreas tumors , evaluated between 2017 and 2019. (bvsalud.org)
This study documents for the first time the clinical and epidemiological characteristics of lung cancer cases in Qatar from 1998 to 2005. (who.int)
The aim of the present study was to document the clinical and epidemiological characteristics of lung cancer cases in Qatar. (who.int)
The new NIOSH study is the first to show that MWCNT is a cancer promoter in a laboratory experiment, and reports the growth of lung tumors in laboratory mice following inhalation exposure to MWCNT rather than injection, instillation, or aspiration. (cdc.gov)
A study of 305 tumors by comparative genomic hybridization. (lu.se)
A study of the association between malignant tumors of the urogenital tract and progressive kidney failure (endemic nephropathy) was conducted. (cdc.gov)

Docetaxel enhances tumor radioresponse in vivo. (aacrjournals.org)
Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)

MRI diffusion studies have been shown to help differentiate Wilms tumor from neuroblastoma, with the apparent diffusion coefficient (ADC) being substantially higher for Wilms tumor. (medscape.com)
Dynamic contrast enhanced MRI can differentiate tumors from disorders in the testicular region. (wikipedia.org)

Almost every type of cancer has the potential to spread to the bone, putting patients at risk for devastating bone complications, like fracture or compression of the spinal cord," said David H. Henry , M.D., clinical professor of medicine, Pennsylvania Hospital, Philadelphia, PA. (amgen.com)

Knee radiographs are ubiquitous studies interpreted by many radiologists in daily clinical practice, since X-ray is the most appropriate imaging modality for initial evaluation of nearly all knee signs and symptoms. (appliedradiology.com)

Compared with the clinical monitoring techniques of Computed tomography (CT), Positron emission tomography computed tomography (PET-CT), and specific biomarkers, the detection of serum tumor markers was more simple, rapid and less invasive and has important clinical application value[ 6 - 9 ]. (ijpsonline.com)
Studies reliant on molecular detection of tumor-associated virus in isolation, however extensive, are inconclusive because association between PyVs and naturally occurring neoplasms varies and because PyV infections are highly prevalent, yet tumor formation is rare ( 3 , 4 , 12 - 14 ). (cdc.gov)

However, the continuous knowledge which was added by studying these tumors for nearly a century strengthen the notion that the above term was inaccurate or inadequate to describe several parameters of this heterogeneous group of gastrointestinal tumors (including the appendiceal one). (wjgnet.com)

mIBG enters cancer cells through the norepinephrine transporter (NET) where the radioactive decay of 131 I causes DNA damage, cell death, and tumor necrosis. (aspetjournals.org)

We highlight the risks of extrapolating evidence from a limited number of tumor histologies to all solid tumors, and we propose avenues for future research. (aacrjournals.org)
However, concerns exist whether TMB thresholds for predicting response to PD-1 blockade are equivalent across the spectrum of solid tumors, and there are scenarios where high TMB does not predict response. (aacrjournals.org)
RLY-4008 is currently being evaluated in a clinical trial in patients with advanced or metastatic FGFR2-altered solid tumors with a single arm, potentially registration-enabling cohort for FGFRi-naïve FGFR2-fusion CCA. (ozarksfirst.com)
Wilms tumor , or nephroblastoma, is the most common solid renal mass and abdominal malignancy of childhood, with a prevalence of 1 case per 10,000 population. (medscape.com)
These tumors appear to be small, solid, and circumscribed with a color that usually ranges from white to tan. (wikipedia.org)

At present, the biological processes related to the purity of lung cancer tumors remains unclear. (hindawi.com)
It is currently unclear which parameters determine whether a patient will respond to T-VEC and also the precise mechanisms underlying the clinical response is largely unknown. (usz.ch)

Postoperative pathological analysis showed that all the tumors were urothelial carcinoma, including 9 cases of low grade and 7 cases of high grade. (urotoday.com)

The initial clinical results of tumor regression even at low doses of the drug validates our preclinical findings that actively targeted nanoparticles preferentially accumulate in tumors," says Robert Langer, the David H. Koch Institute Professor in MIT's Department of Chemical Engineering and a senior author of the paper. (foresight.org)
Findings range from no tumor-related findings to full symptoms of carcinoid syndrome. (medscape.com)
In the absence of positive imaging findings and biochemical markers, consider differential diagnoses such as an adverse reaction to medications, other malignant disorders (eg, chronic myelogenous leukemia), mastocytosis, and other tumors. (medscape.com)
It is concluded that all the clinical, radiographic and histopathological findings must be taken into account when diagnosing this tumor, bearing in mind the high rate of relapse. (bvsalud.org)

In the Swiss "Tumor Profiler" (TuPro) project, the research team is examining the cellular composition and biology of tumors of 240 patients with melanoma , ovarian cancer , and acute myeloid leukemia . (darkdaily.com)

Approximately 80% of appendicial tumors are incidentally discovered during surgery for other indications, but some cause or coexist with acute appendicitis . (medscape.com)

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has provided some of the most in-depth analyses of the phenotypes of human tumors ever constructed. (nih.gov)

Anatomy14

Organisms10

Diseases98

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care9

Trials34

Recurrence8

Microenvironment11

Benign11

Cancers9

Malignant Peripheral Nerve Sheath Tumors1

Tissue20

Neuroendocrine tumors7

Circulating tumor cells1

Types of solid tumors2

Immunotherapy6

Childhood Brain Tumors1

Tissues10

Prognosis7

Primary tumor3

Resistant to radiation and chemotherapy2

Lymphocytes1

Metastases5

Biopsy5

Therapeutic5

Mutations12

Pathology3

Outcomes7

20212

Abstract1

Develop tumors1

Treatments6

Recurrent4

Treatment22

Resection6

Ocular Tumor1

Immune7

Type of tumor2

Therapies7

Brain31

Bladder3

Phase6

Anti-tumor2

Orbital3

BIOMARKER4

Tertiary eye hospital1

Modalities1

Study17

Vivo4

Differentiate2

Spinal1

Radiologists1

Detection2

Heterogeneous group1

Necrosis1

Solid5

Unclear2

Urothelial1

Findings4

Melanoma1

Acute1

Phenotypes1