• Inflammation
  • WALTHAM, Mass.--(BUSINESS WIRE)--Aug 23, 2018--Kala Pharmaceuticals, Inc. (NASDAQ:KALA), a biopharmaceutical company focused on the development and commercialization of therapeutics using its proprietary mucus-penetrating particle (MPP) technology, today announced that the U.S. Food and Drug Administration (FDA) has approved INVELTYS TM (loteprednol etabonate ophthalmic suspension) 1% for the treatment of post-operative inflammation and pain following ocular surgery. (apnews.com)
  • Today's approval of INVELTYS is welcome news for the eye care community as it provides a clear advancement in the treatment for inflammation and pain following ocular surgery. (apnews.com)
  • The goals of treatment are to reduce pain, decrease inflammation, and improve a person's overall functioning. (wikipedia.org)
  • feline
  • The purpose of this study was to investigate the safety and therapeutic effects of allogeneic feline adipose-derived mesenchymal stromal cells (fAd-MSCs) implanted subconjunctival around the ocular surface lesion in five cats with FEK refractory to current available treatments. (springer.com)
  • acute
  • The clinical hallmark of HSV encephalitis has been the acute onset of fever and focal neurologic (especially temporal-lobe) symptoms. (doctorslounge.com)
  • infectious
  • Ozurdex ® is indicated for the treatment of non-infectious uveitis affecting the posterior segment of the eye. (drugs.com)
  • Infectious keratitis can progress rapidly, and generally requires urgent antibacterial, antifungal, or antiviral therapy to eliminate the pathogen. (wikipedia.org)
  • trials
  • The approval of INVELTYS offers patients and their eye care professionals the first and only BID ocular corticosteroid therapy that has been shown in clinical trials to be clinically effective while maintaining a proven safety profile, which may improve compliance and prove less burdensome for patients. (apnews.com)
  • On behalf of the Kala team, I want to thank the many patients and clinicians who participated in our clinical trials. (apnews.com)
  • The NDA will include data from three clinical trials studying approximately 2,000 patients, including one Phase 2 trial and two Phase 3 efficacy and safety trials (STRIDE 1 and STRIDE 2). (apnews.com)
  • Miltefosine is primarily used for the treatment of visceral and New World cutaneous leishmaniasis, and is undergoing clinical trials for this use in several countries. (wikipedia.org)
  • viral
  • Clinical differentiation of HSV encephalitis from other viral encephalitides, focal infections, or noninfectious processes is difficult. (doctorslounge.com)
  • Quantification of FHV or FCV copy number on quantitative PCR assays can help interpretation of results, as high viral loads in clinical specimens suggest active viral replication and involvement in the disease process, whereas lower loads may be more consistent with asymptomatic carrier status. (vin.com)
  • contact lens
  • Risk factors for developing acanthmoeba keratitis include contact lens wear, use of homemade saline, exposure to contaminated water, and corneal trauma.Over 80% of cases are related to contact lens use. (harvard.edu)
  • sterile
  • If the contralateral eye requires treatment, a new applicator must be used, and the sterile field, syringe, gloves, drapes, and eyelid speculum should be changed before Ozurdex ® is administered to the other eye. (drugs.com)
  • Migration
  • Dendritic cells (DCs) are present in the central avascular area of inflamed corneas, but the mechanisms of their migration to this location are poorly understood. (jove.com)
  • antiviral
  • Treatment was initiated with topical prednisolone acetate 1.0% QID, while maintaining antiviral and prophylactic antibiotic coverage. (eyerounds.org)
  • There are no specific antiviral drugs in common use at this time for FVR, although one study has shown that ganciclovir, PMEDAP, and cidofovir hold promise for treatment. (wikipedia.org)
  • specific clinical
  • GRADE is a systematic approach to grading the strength of the total body of evidence that is available to support recommendations on a specific clinical management issue. (aao.org)
  • clinically
  • Clinical practice guidelines should be clinically relevant and specific enough to provide useful information to practitioners. (aao.org)
  • visceral
  • Several medical agents have some efficacy against visceral or cutaneous leishmaniasis, however, a 2005 survey concluded that miltefosine is the only effective oral treatment for both forms of leishmaniasis. (wikipedia.org)
  • efficacy
  • Treatment efficacy was evaluated in basal conditions and after 3, 6, 10 and 14 days on the basis of the following criteria: keratic injection, Tyndall phenomenon, vitreous changes, endothelial precipitates and pain severity, all according to 4-point scales. (biomedsearch.com)
  • initiation
  • Dendritic cells (DCs) are the key players involved in initiation of adaptive immune response by activating antigen-specific T cells. (jove.com)
  • disease
  • We recently reported that these peptides are highly recognized by CD8 + T cells from "naturally" protected HSV-1-seropositive healthy ASYMP individuals (who have never had clinical herpes disease). (arvojournals.org)
  • Kala has initiated a third Phase 3 clinical trial, STRIDE 3 (STRIDE - Short Term Relief In Dry Eye), evaluating KPI-121 0.25% for the temporary relief of the signs and symptoms of dry eye disease. (apnews.com)
  • Biological DMARDs may be used when disease does not respond to other treatments. (wikipedia.org)
  • mild
  • During the first ten days of treatment, all subjective symptoms resolved with the exception of mild blurring of vision. (eyerounds.org)