Clinical drug combinations. Medical search. Frequent questions

Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. (biomedcentral.com)
In addition, the regulatory requirements are more complex when the agents are used in combination, since the safety profile of each drug needs to be demonstrated before clinical trials, and this can be further delayed due to regulatory and IP issues, in particular if the two drugs are being developed by different companies [ 1 ]. (biomedcentral.com)
August 24, 2023 - Several new clinical trials in prostate cancer have opened in recent months. (nih.gov)
June 1, 2023 - ComboMATCH will comprise numerous phase 2 precision medicine cancer treatment trials that aim to identify promising drug combinations that can advance to larger clinical trials. (nih.gov)
In the past decade over 25% of EU clinical trial applications have originated from the UK, which ranks first or among the leading European nations for the number of early clinical trials each year. (kcl.ac.uk)
The safety and tolerability profile of LYNPARZA in this trial was in line with that observed in prior clinical trials, with no new safety signals. (merck.com)
They'll do this through studies called clinical trials. (webmd.com)
Clinical trials are now testing new PNH medicines and combinations. (webmd.com)
Learn more about our clinical trials and the highly specialized care teams that lead them. (cancer.gov)
Patients diagnosed with pancreatic cancer are encouraged to seek out clinical trials that will ultimately improve pancreatic cancer treatment. (medicinenet.com)
Future clinical AD trials on disease modifying drugs will require a shift to very early identification of individuals at risk of dementia. (lu.se)
Conclusion: The outcome of PROSPECT-AD may support AD drug development research as well as primary or tertiary prevention of dementia by providing a validated tool using a remote approach for identifying individuals at risk of dementia and monitoring individuals over time, either in a screening context or in clinical trials. (lu.se)

The initial data with our drug candidates, including MDM2-p53 inhibitor APG-115, novel Bcl-2/Bcl-xL dual inhibitor palcitoclax or APG-1252, and IAP inhibitor APG-1387, support further study with great potential in combination therapies," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. (pharmiweb.com)
Our results suggest that the combination of chidamide and bortezomib can significantly reduce the proliferation, invasion, and migration of MGC-803 and BGC-823 cells, providing a framework for the clinical evaluation of combined therapies for gastric cancers. (dovepress.com)
His areas of interest include the use of novel therapies and drug combinations for the treatment of lymphomas as well as novel methods of molecular monitoring of disease and response to treatment, such as circulating tumor DNA (ctDNA). (cancer.gov)
Molecularly-annotated cancer cell lines are further being used to explore the efficacy of novel drug therapies, both as single-agents and in combination with standard therapies. (edu.au)
Patients often use second-line therapies if and when they develop resistance to initially prescribed treatments or experience clinical failures. (biospace.com)
The study revealed the potential of applying AI and machine learning to discover effective combinations in therapies for cancer and other complex diseases. (eurekalert.org)

June 27, 2023 - The investigational drug vorasidenib substantially slowed the growth of tumors in people with low-grade gliomas that had mutations in the IDH1 or IDH2 genes. (nih.gov)
May 15, 2023 - NIH-funded clinical trial will determine safety, tolerability of experimental drug. (nih.gov)
January 11, 2023 - The initial treatment used for some younger women with an aggressive form of breast cancer may be about to change, based on results of a new clinical trial. (nih.gov)
1 These data were presented during an oral presentation ( Abstract #8002 ) at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place in Chicago, from 2-6 June. (itbusinessnet.com)
A poster of the amended clinical trial design was presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, held June 2-6 in Chicago, Illinois (see abstract ). (kron4.com)

We will accelerate our clinical development programs, hoping to offer more treatment options for cancer patients with unmet medical needs. (pharmiweb.com)
APG-115-US-002 is an open-label, multi-center, Phase Ib/II study in U.S. , which was designed to assess safety, toxicity, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of APG-115 in combination with pembrolizumab in patients with advanced solid tumors. (pharmiweb.com)
As of April 1, 2020, in the Phase Ib study, 19 patients were treated with APG-115 in 4 alternate-day (QOD) dose cohorts (50 mg, 100 mg, 150 mg, and 200 mg) in combination with pembrolizumab. (pharmiweb.com)
Seattle, WA, 13 February 2017 - Janssen Sciences Ireland UC (Janssen) announced positive results from the full data read out for two Phase III studies evaluating the safety and efficacy of switching virologically suppressed patients from a three- or four-drug antiretroviral regimen to the two-drug regimen of dolutegravir (ViiV Healthcare) and rilpivirine (Janssen). (jnj.com)
We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). (nih.gov)
Devimistat in combination with GC is well tolerated and has an acceptable safety profile in patients with untreated advanced BTC. (nih.gov)
5 , 6 One study 4 showed that adolescent psychiatric patients taking combination trazodone with strong CYP 2D6 inhibitors including fluoxetine and paroxetine were 6 times less likely to respond to treatment and 3 times more likely to experience self-harm. (psychiatrist.com)
CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)
1 Additionally, the daratumumab combination regimen resulted in an ORR of 82 percent vs. 62 percent (p=0.2028), with very good partial response (VGPR) or better achieved in 64 percent vs. 35 percent of patients, and CR or better achieved in 34 percent vs. 9 percent of patients. (jnj.com)
0.0001).1 Additionally, the daratumumab combination regimen resulted in an ORR of 85 percent vs. 64 percent (p=0.0001), with VGPR or better achieved in 64 percent vs. 26 percent of patients, and CR or better achieved in 28 percent vs. 8 percent of patients treated with DVd vs. Vd, respectively. (jnj.com)
1 Additionally, the daratumumab combination regimen resulted in an ORR of 85 percent vs. 67 percent (p=0.0435), with VGPR or better achieved in 64 percent vs. 31 percent of patients, and CR or better achieved in 38 percent vs. 6 percent of patients. (jnj.com)
Re-treated patients who fail to achieve undetectable HCV-RNA at Week 12 of therapy, or whose HCV-RNA remains detectable after 24 weeks of therapy, are highly unlikely to achieve SVR and discontinuation of therapy should be considered [see Clinical Studies (14.1) ]. (drugs.com)
The recommended dose of REBETOL when used in combination with PegIntron in pediatric patients ages 3-17 years is 15 mg/kg/day in two divided doses (see Table 2 ). (drugs.com)
This finding helps establish that such pre-existing mutations can lurk in a patient's tumor at 10 times the rarity than previously appreciated and still cause rapid drug resistance, raising the possibility that even more rare mutations exist in other patients, below the detection rate of current technology. (newswise.com)
On October 21, 2022, the FDA approved tremelimumab (Imjudo) in combination with durvalumab for adult patients with unresectable hepatocellular carcinoma. (aacrjournals.org)
The approval was based on the results from the HIMALAYA study, in which patients with unresectable hepatocellular carcinoma who were naïve to previous systemic treatment were randomly assigned to receive one of three study arms: tremelimumab in combination with durvalumab ( n = 393), durvalumab ( n = 389), or sorafenib ( n = 389). (aacrjournals.org)
Cemiplimab has been a major step forward for patients with advanced CSCC and we believe that this is a tumor where combination therapeutic effects are highly likely. (businesswire.com)
Objective To determine the effect of combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease. (bmj.com)
Conclusions Combinations of statins, aspirins, and β blockers improve survival in high risk patients with cardiovascular disease, although the addition of an angiotensin converting enzyme inhibitor conferred no additional benefit despite the analysis being adjusted for congestive cardiac failure. (bmj.com)
Updated clinical data from the Phase 1/2 study sponsored by GSK plc (LSE/NYSE: GSK) evaluating nirogacestat in combination with low-dose belamaf (belantamab mafodotin-blmf), GSK's antibody-drug conjugate targeting BCMA, in patients with RRMM will be presented in a poster presentation. (advfn.com)
Our goal is to improve the outcomes for patients with multiple myeloma and we believe that developing a robust clinical data set across BCMA modalities and treatment lines can help us demonstrate where within the multiple myeloma treatment landscape nirogacestat has the greatest opportunity to maximize clinical benefit. (advfn.com)
As of the December 9, 2022 data cut-off, patients received a median of 4 (range 1-20) cycles of the combination and a median of 3 (range 1-9) monotherapy cycles. (advfn.com)
CONCLUSION: Combinations of paracetamol and pregabalin, or paracetamol, pregabalin and dexamethasone did not reduce morphine consumption and pain score compared with paracetamol alone for patients undergoing abdominal hysterectomy. (druglib.com)
The Phase 3 PAOLA-1 trial evaluated LYNPARZA in combination with bevacizumab as first-line maintenance therapy in patients with advanced ovarian cancer, who were without evidence of disease after surgery or following response to platinum-based chemotherapy. (merck.com)
LYNPARZA plus bevacizumab also improved median progression-free survival (PFS) to nearly four years (46.8 months) versus 17.6 months with bevacizumab plus placebo, and 46.1% of patients who received LYNPARZA in combination with bevacizumab remain progression free versus 19.2% of patients who received bevacizumab alone. (merck.com)
1 The investigational combination immunotherapy regimen demonstrated an ORR of 86.6 percent (71/82) across all dose levels, and an ORR of 96.3 percent (26/27) among patients receiving the recommended Phase 2 regimen (RP2R). (itbusinessnet.com)
By combining teclistamab and talquetamab, two bispecific antibodies that have demonstrated high efficacy responses in targeting distinct antigens, we evaluated the potential of this unique combination regimen for patients who were resistant or refractory to multiple lines of therapy," said Yael Cohen, M.D., Head of Myeloma Unit, Hematology Institute Tel-Aviv Sourasky Medical Center, Israel, and principal study investigator. (itbusinessnet.com)
These first results from the RedirecTT-1 study demonstrate the potential impact of combining teclistamab and talquetamab to overcome resistance mechanisms and in patients with EMD, and we look forward to evaluating this combination regimen further. (itbusinessnet.com)
Additionally, based on the original protocol, if ≥3 of the planned 10 patients within the pilot phase experienced a partial response (PR) by RECIST criteria within 16 weeks, the combination would be considered promising and an expansion cohort of an additional 30 patients would be initiated for enrollment. (kron4.com)
However, experts raised some questions about whether the combination would also offer improved overall survival and whether the accompanying toxicity would be acceptable to patients. (medscape.com)
Patients who received the combination had an almost fourfold greater risk of grade 3 or higher adverse events related to treatment, said Wu, professor of oncology, Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangzhou, China. (medscape.com)
Overall, 45% of patients on monotherapy and 56% in the combination arm were still on treatment. (medscape.com)
0001). At 24 months, 57% of the patients in the combination arm were disease-free vs 41% in the monotherapy group. (medscape.com)
The PFS benefit appeared most pronounced among patients with CNS metastases at baseline - a median of 24.9 months in the combination arm vs 13.8 months with monotherapy (HR, 0.47). (medscape.com)
But patients without CNS metastases who received the combination therapy also showed improvements in PFS (HR, 0.75). (medscape.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

The duration of treatment should be individualized to the patient depending on baseline disease characteristics, response to therapy, and tolerability of the regimen [see Indications and Usage (1.1) , Adverse Reactions (6.1) , and Clinical Studies (14) ]. (drugs.com)
Notwithstanding the success of combination therapy, the use of a single drug that modulates several targets might be therapeutically advantageous over the use of drugs in combination. (biomedcentral.com)
Another current trend in therapy is drug repurposing or the re-discovery of a new therapeutic area for a drug used traditionally to treat a given pathology, either through the ability to modulate an additional target or by the involvement of the primary target in multiple pathologies. (biomedcentral.com)
Examples include the use of the anti-angina drug sildenafil to treat sexual disfunction or the infamous sedative thalidomide as therapy for multiple myeloma. (biomedcentral.com)
at the moment it's at the discretion of the clinician, the local clinician, to take them further for an individual therapy and in the future, once this concept is better established and all the infrastructure is working really on a daily basis, then we want to really run a clinical trial where we compare the principle of individualised therapy versus just giving a backbone chemotherapy as we do now. (ecancer.org)
CAMBRIDGE, Mass.--( BUSINESS WIRE )--Ankyra Therapeutics, a clinical stage biotechnology company developing a new form of local immunotherapy termed "anchored immunotherapy," today announced a clinical trial supply agreement with Regeneron to evaluate ANK-101 in combination with Regeneron's anti-PD-1 therapy, Libtayo ® (cemiplimab). (businesswire.com)
The only potential cure is a bone marrow transplant, a procedure in which radiation or drug therapy is used to destroy your existing marrow and replace it with marrow from a donor. (webmd.com)
The data suggest that inhibitors of the Fd/FNR redox system should be avoided as ART partner drugs in ART combination therapy for treating malaria. (biorxiv.org)
Artemisinin (ART)-based combination therapy is recommended by the World Health Organization for the first-line treatment of malaria in uncomplicated Plasmodium falciparum infections. (biorxiv.org)
The high overall response rates characterised in this study are encouraging and support the continued evaluation of this regimen as a combination therapy. (itbusinessnet.com)
Lasker Clinical Research Scholar in the Pediatric Oncology Branch , is researching CAR T-cell therapy for leukemias and lymphomas. (cancer.gov)
A clinical trial led by Sadhana Jackson, M.D. , Adjunct Investigator in the Pediatric Oncology Branch , is researching a drug therapy for diffuse midline gliomas, a type of aggressive brain tumor. (cancer.gov)
A clinical trial led by Kathryn A. Lurain, M.D., M.P.H. , Assistant Research Physician in the HIV and AIDS Malignancies Branch , is researching a combination drug therapy for HIV-associated B-cell non-Hodgkin lymphomas. (cancer.gov)
A clinical trial led by Mark Roschewski, M.D. , Senior Clinician in the Lymphoid Malignancies Branch , is researching a therapy for B-cell lymphoma of the central nervous system. (cancer.gov)
By analysing the relations between the protein modules targeted by drugs and the protein modules associated with cancer cell lines in the human protein-protein-interaction network (PPI), and the interrelations among the protein modules, this deep-learning-based algorithm can identify synergistic drug combinations that yield effective therapy with less toxicity. (eurekalert.org)
The guidelines contain recommendations for the clinical use of antiretroviral agents in the treatment of adults and adolescents (defined in Considerations for Antiretroviral Therapy in the HIV-Infected Adolescent) who are infected with the human immunodeficiency virus (HIV). (cdc.gov)

The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
Significant monotherapy anti-tumor activity has been seen in multiple murine tumor models and in a Phase I clinical trial of canine melanoma. (businesswire.com)
Further studies have shown that ANK-101 drives expression of local PD-L1 and pre-clinical combination studies with PD-1 blockade demonstrated improved therapeutic activity in PD-1-refractory tumor models. (businesswire.com)
Ankyra Therapeutics is a biotechnology company that has developed a highly differentiated technology platform that expands the therapeutic window of cytokine drugs by forming a stable depot in the tumor after local administration leading to prolonged immune activation and potent local and systemic immunity with reduced systemic toxicity. (businesswire.com)
The combination of AHCC with PLD demonstrated a 64.1% reduction in tumor growth compared to the untreated group (p value = 0.03) and a 31.2% improvement in tumor response with combination regimen compared to PLD alone. (researchgate.net)

If approved, this treatment could be the first two-drug regimen for HIV and could offer those living with HIV who are virally suppressed the option to switch to a regimen which does not include a nucleotide reverse transcriptase inhibitor (NRTI). (jnj.com)
These data represent the first assessment of daratumumab in combination with a next generation proteasome inhibitor (PI) and an immunomodulatory agent earlier in the treatment paradigm for multiple myeloma. (jnj.com)
She was enrolled in a clinical trial combining a MEK and a CDK4 inhibitor. (newswise.com)
Simply adding a PIK3CA inhibitor to the MEK/CDK4 combination would likely be too toxic, so the team analyzed 300 proteins to find targets that might be present in more than one of the three pathways. (newswise.com)
Treating mice with an S6 inhibitor re-sensitized them to treatment with the MEK/CDK4 combination, restoring the drugs' ability to shrink the PIK3CA mutation-bearing melanomas. (newswise.com)
Kwong said an optimized human version of the S6 inhibitor in mice has not yet been developed, but their findings point to a possible target for human drug development. (newswise.com)
Researchers are at work now to develop an inhibitor drug for it. (webmd.com)
Methods This non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. (bmj.com)
The Phase 2 clinical trial is designed to evaluate the company's CXCR4 inhibitor motixafortide in combination with PD-1 inhibitor cemiplimab and standard of care chemotherapies gemcitabine and nab-paclitaxel, versus gemcitabine and nab-paclitaxel alone, in first-line pancreatic cancer (PDAC). (kron4.com)
The combination of Lonafarnib, a farnesyl-transferase inhibitor (FTI) and PKC412 had additive and synergistic effects in both FLT3/ITD positive and negative cell lines. (lu.se)

1 These data will be featured as an oral presentation at the American Society of Clinical Oncology (ASCO) 2017 Annual Meeting on Sunday, June 4 at 11:45 a.m. (jnj.com)
Initial results from the pre-planned interim analysis were presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. (advfn.com)

Expert Opinion on Drug Delivery 13(5): 659-665, February 2016. (upenn.edu)

CONSORT flowchart diagram of the clinical trial for the herbal drug combination. (elifesciences.org)
The herbal drug combination identified for the clinical trial was among the top 20 choices in all the 10 rounds and is marked with red dots. (elifesciences.org)
In March, Montefiore was the first New York location to join the multicenter trial, which evaluated remdesivir, a broad-spectrum antiviral drug given intravenously. (covid19clinicaltrial.com)
Of the 1,063 clinical trial participants, 91 of them, nearly 10%, were from Montefiore and Einstein.Following up on remdesivir's promising results, the trial is now studying remdesivir in combination with baricitinib or placebo in a double-blind, randomized trial. (covid19clinicaltrial.com)
But recurrence was low among women who received low-dose temozolomide with T-DM1 in a phase I clinical trial. (nih.gov)
December 28, 2022 - A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma. (nih.gov)
The combination study will proceed following Ankyra's first-in-human phase I clinical trial, which is starting in the first quarter of 2024. (businesswire.com)
This trial will investigate the potential drug-drug interaction between dapivirine vaginal Ring-004 and vaginally administered miconazole nitrate, and will evaluate the safety of co-administration of the dapivirine vaginal ring and miconazole nitrate in healthy, HIV-negative women. (drugpatentwatch.com)
A quasi-experimental trial was designed to evaluate the effectiveness of this combination in lowering perceived stress and promoting happiness, sleep quality, meditation experience, and life satisfaction among institutionalized older adults in Taiwan. (jmir.org)
This is the first trial to explore the effectiveness of a combination of 3D virtual reality and hands-on aromatherapy in improving older adults' psychological health. (jmir.org)
In addition, new data from the Phase 1b clinical trial sponsored by Janssen Research & Development, LLC (Janssen) evaluating nirogacestat in combination with teclistamab, Janssen's bispecific antibody targeting BCMA and CD3, will be presented in an oral presentation. (advfn.com)
We are pleased that updated data from the GSK-sponsored trial continue to support our thesis that the combination with nirogacestat may further optimize the benefit-risk profile of belamaf monotherapy. (advfn.com)
This ongoing Phase 1/2 trial, which is sub-study 3 of GSK's DREAMM-5 platform trial (NCT04126200), aims to determine if low-dose belamaf in combination with nirogacestat results in similar efficacy with an improved ocular toxicity profile compared to belamaf alone at a higher dose. (advfn.com)
A randomized clinical trial. (druglib.com)
Can I Take Part in a Clinical Trial for PNH Treatment? (webmd.com)
A clinical trial led by Jonathan M. Hernandez, M.D. , Investigator in the Surgical Oncology Program , is researching chemotherapy for liver-only cholangiocarcinoma. (cancer.gov)
A clinical trial led by Christopher Kanakry, M.D. , Lasker Clinical Research Scholar in the Center for Immuno-Oncology , is researching blood stem cell transplants for blood cancers such as leukemias or lymphomas. (cancer.gov)
Results from a clinical trial conducted by CCR researchers show that people with low-grade lymphomatoid granulomatosis who are treated with interferon-alpha, a type of immunotherapy, can live for decades after diagnosis. (cancer.gov)
It turned out that its effectiveness is recently verified in a clinical trial study. (eurekalert.org)
Sponsored by Columbia University , the single-arm pilot phase of the Phase 2 trial focused on the safety of the drug combination. (kron4.com)
however, Jänne noted that the combination has not been tested in a randomized trial. (medscape.com)

These results were presented on Sept. 9 at the European Society for Medical Oncology (ESMO) 2022 Congress, and the SOLO-1 results were published in the Journal of Clinical Oncology . (merck.com)

As I said, the genomes are simpler so it will be much easier to interpret the results of giving a targeted drug, even a monotherapy, and probably the mechanisms of resistance because it's just less noisy and less, what we call, passenger mutations. (ecancer.org)
The safety profile of the combination was consistent with that observed with each drug as a monotherapy. (itbusinessnet.com)
This report provides information on the therapeutic development based on the Influenza A Infections dealing with all the pipeline drugs, comparative analysis at various stages covering Filed, Phase III, Phase II, Phase I, IND filed, Preclinical, Discovery and unknown stages, therapeutics assessment by monotherapy and combination products and molecule type drug information. (prnewswire.com)
And, notably, because the overall survival data in the interim analysis are immature, it's unclear whether the combination will offer an overall survival benefit over osimertinib monotherapy, Wu said. (medscape.com)
At the data cutoff, the median follow-up was 16.5 months in the osimertinib monotherapy arm and 19.5 months in the combination arm. (medscape.com)

The score statistics of 10 rounds of random herbal drug combinations (1000 random combination from each round) for the treatment of plasma cell mastitis. (elifesciences.org)
An expert shares her take on emerging strategies for combination treatment for NAFLD and NASH with GLP-1 receptor agonists plus SGLT2 inhibitors. (clinicaloptions.com)
The answer often revolves around the point combinations used for treatment. (elotus.org)
Daratumumab appeared to improve poor outcomes associated with high risk cytogenetics, and these data support its consistent clinical benefit in combination with two of the most widely used treatment classes. (jnj.com)
Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. (biomedcentral.com)
CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel (Plavix), drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam. (wikipedia.org)
ANK-101 is being evaluated for the treatment of advanced solid tumors alone and in combination with anti-PD-1 agents. (businesswire.com)
Another way researchers are trying to make PNH treatment better is by looking at new medicines and combinations of medicines. (webmd.com)
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment Resistant Depression: A Decade of Clinical Follow-up The Journal of Clinical Psychiatry October 2021. (upenn.edu)
A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Other drug combinations may be used to treat cancer that has recurred (come back) or hasn't responded to treatment. (cancer.org)
PITTSBURGH, April 20 /PRNewswire-FirstCall/ -- Mylan Inc. today announced that Matrix Laboratories Limited, its India-based subsidiary in which it holds a 71.2% controlling interest, has been selected by the Clinton HIV/AIDS Initiative (CHAI) under its UNITAID-funded projects as the primary supplier of five antiretroviral (ARV) drugs used in second-line HIV/AIDS treatment regimens. (biospace.com)
UNITAID is an international drug purchase facility, established to provide long-term, sustainable and predictable funding to increase access and reduce prices of quality drugs and diagnostics for the treatment of HIV/AIDS, malaria and tuberculosis in developing countries. (biospace.com)
In recent years, AI and data science have become increasingly important in cancer treatment and drug discovery because of the capability to process large-scale complex biological and clinical data. (eurekalert.org)
Schistosoma haematobium or S. mansoni and large-scale control efforts include providing regular treatment to at-risk groups and supporting drug delivery through schools. (who.int)
In 1996, the Department of Health and Human Services and the Henry J. Kaiser Family Foundation convened the Panel on Clinical Practices for the Treatment of HIV to develop guidelines for the clinical management of HIV-infected persons. (cdc.gov)
These guidelines were developed by the Panel on Clinical Practices for Treatment of HIV Infection, convened by the Department of Health and Human Services (DHHS) and the Henry J. Kaiser Family Foundation. (cdc.gov)
It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
Whether to treat very early and treat as many people infected as possible to limit infection, or how best to use these drugs for prevention, as well as treatment, for individual health and the public health is probably the dominant question we face today. (cdc.gov)
Treatment of severe generalized dystonia may require a combination of oral anticholinergic drugs, muscle relaxants, and benzodiazepines. (msdmanuals.com)

These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. (biomedcentral.com)
The team, led by Lawrence Kwong , Ph.D., assistant professor of Translational Molecular Pathology , set out to find resistance mechanisms that arise against a combination of MEK and CDK4 inhibitors to treat melanoma that has a mutation in the NRAS gene. (newswise.com)
NRAS mutations occur in 15-20 percent of melanomas, and the MEK/CDK4 combination is often effective initially against these tumors, but resistance arises. (newswise.com)
One of the main questions in cancer drug resistance is how often it comes from a pre-existing or a completely new mutation" said Gabriele Romano, Ph.D., a postdoctoral fellow in Translational Molecular Pathology and the study's first author. (newswise.com)
nonetheless, mutations of Fd gene ( fd ) may modulate ART resistance and Fd would be an important target for antimalarial drugs. (biorxiv.org)
But resistance to EGFR TKIs remains a problem, which has led experts to explore combination strategies that might overcome resistance and improve clinical outcomes. (medscape.com)
Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)

Using a traditional approach this study provides pre-clinical data to support the benefits previously observed and reported in the clinical setting and supports future endeavors to integrate AHCC into standard of care to be given with chemotherapy. (researchgate.net)
It is a novel AI framework that can make synergistic chemotherapy drug combination predictions. (eurekalert.org)
Recent data indicate that combining first-generation EGFR TKIs with chemotherapy may have an additive effect and further improve outcomes with the drugs. (medscape.com)

The SWORD Phase III results represent an important step forward in our efforts to deliver a two-drug regimen that may help simplify dosing regimens and reduce pill burden for people living with HIV," says Lawrence M. Blatt, Global R&D Head, Infectious Diseases & Vaccines, Janssen. (jnj.com)
As would be expected when switching from a stable regimen to a new regimen (in most cases containing two new drugs), more adverse events were reported and led to withdrawal from the study in the DTG+RPV arm (DTG+RPV: 21, CAR: 3). (jnj.com)
Yi-Long Wu, MD, PhD, who was not involved in the research, said that although the combination regimen does appear to offer a benefit, it may come at a steep cost. (medscape.com)

1 Although its efficacy data as a hypnotic are mixed, trazodone is second only to nonbenzodiazepine drugs and is used by up to 1% of Americans each month. (psychiatrist.com)
Among the advantages of multitarget drugs vs drug combinations are the more predictable pharmacokinetic (PK) and pharmacodynamic (PD) relationship of the components of a single medicine, the possibility that one motif might improve the bioavailability of the second entity, the greater efficacy against advanced-stage diseases, the lower toxicities, the simultaneous presence of the chemical entities in multiple tissues, and the improved patient compliance [ 2 ]. (biomedcentral.com)
Clinical Efficacy of repetitive Transcranial magnetic Stimulation in Depression Clinical Guide to the Administration of Transcranial Magnetic Stimulation. (upenn.edu)

Matrix's second-line products selected for the 2009 UNITAID-CHAI projects include heat-stable Lopinavir/Ritonavir, Tenofovir and two fixed-dose combinations that use Tenofovir. (biospace.com)
The seven ARVs for which Matrix was selected under the UNITAID Pediatric Project include several first-line fixed-dose combinations. (biospace.com)
Fixed-dose combinations are multiple ARV drugs combined into a single pill. (biospace.com)
Abacavir drug exposures in African children under 14 kg using paediatric solid fixed dose combinations according to World Health Organization weight bands. (bvsalud.org)

Histone deacetylase inhibitors (HDACi) have been considered as a potential anticancer drug nowadays. (dovepress.com)

This helps increase the automated testing accuracy of thousands to millions of samples in the drug development phase. (t-systems.com)
In phase Ib, devimistat was infused over 2 hours in combination with GC on days 1 and 8 every 21 days with a primary objective to determine the recommended phase II dose (RP2D). (nih.gov)
We even have more limitations to get access to drugs, of course, because usually you have to have completed an adult phase I study before you can start a paediatric phase I and usually there is not a lot of interest with the pharma companies to do that at all because this will never be a big market. (ecancer.org)

Dr. Melani is a Staff Clinician and a clinical researcher specializing in lymphoma. (cancer.gov)

All of Matrix's ARV facilities in India meet World Health Organization (WHO) and U.S. Food and Drug Administration (FDA) quality standards, and the company has strong partnerships with all major funding agencies involved in the procurement of ARVs. (biospace.com)

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). (nih.gov)
REBECCA WILLIAMS focuses her practice on FDA regulatory matters and advises life sciences and health care clients on a broad range of regulatory and compliance issues under the Food, Drug and Cosmetics Act and related laws. (fdli.org)
The Working Group of the Association for Molecular Pathology Clinical Practice Committee recommended these three variant alleles to be included in the minimal clinical pharmacogenomic testing panel, called tier 1. (wikipedia.org)
The information on this page should be considered as examples of background information for the current influenza season for clinical practice regarding the use of influenza antiviral medications. (cdc.gov)

These proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (wikipedia.org)

This case describes a dose-related type of adverse drug reaction. (psychiatrist.com)
The recommended dose of REBETOL when used in combination with PegIntron is 800 mg to 1,400 mg based on patient body weight in two divided doses (see Table 1 ). (drugs.com)
The recommended dose of REBETOL when used in combination with INTRON A depends on the patient's body weight (see Table 3 ). (drugs.com)
Pediatrics The recommended dose of REBETOL when used in combination with INTRON A is 15 mg/kg per day orally in two divided doses (see Table 2 ). (drugs.com)
Compared with low-dose chidamide or bortezomib alone, the low-dose drug combination significantly inhibited the proliferation, migration, and invasion of MGC-803 and BGC-823 cells and induced apoptosis of the cells. (dovepress.com)
The pharmacokinetics of abacavir (ABC) in African children living with HIV (CLHIV) weighing dose combinations (FDC) according to WHO weight bands dosing are limited. (bvsalud.org)

4 Oncology Center of Excellence, U.S. Food and Drug Administration, Silver Spring, Maryland. (aacrjournals.org)

Uncritical acceptance of medical innovations or lack of evidence can result in the endorsement of ineffective or potentially dangerous treatments, subsequently leading to the withdrawal of drugs (for example, rofecoxib) or limitations on use. (bmj.com)
What About New PNH Treatments or Combinations? (webmd.com)
New treatments or combination treatments also might cost more. (webmd.com)

It is the reader's job to evaluate the accuracy of any information and results from interactive programs found on the Clinical Education Alliance Site. (clinicaloptions.com)
We are excited to expand our clinical collaborations to evaluate the combination of ANK-101 with cemiplimab in cutaneous squamous cell carcinoma (CSCC)," said Dr. Joe Elassal, Chief Medical Officer at Ankyra. (businesswire.com)
The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
The following two HHEs were conducted by NIOSH at the request of law enforcement agencies to evaluate incidents involving drugs where officers experienced health effects. (cdc.gov)

To achieve the best therapeutic effect, multiple types of drugs are commonly prescribed by doctors to treat complex diseases like cancers and HIV/AIDS. (eurekalert.org)

Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. (druglib.com)
We investigated the analgesic effect of pregabalin and dexamethasone in combination with paracetamol after abdominal hysterectomy. (druglib.com)
Paracetamol (acetaminophen) and combinations. (medlineplus.gov)

This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. (wikipedia.org)
Exposure was current use of different combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors before death in cases, or the equivalent date in controls. (bmj.com)
1 - 5 Although combinations of drugs (as proposed in the Polypill) 6 have been received with enthusiasm, we found no direct evidence evaluating the effects of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in combination. (bmj.com)

Efforts are underway to use chemoinformatics to help understand drug effects from a signal transduction network perspective [ 3 ], to confidently predict new molecular targets for known drugs, and to explain polypharmacology. (biomedcentral.com)
Molecular signatures of canine osteosarcoma prognosis could also predict clinical outcomes for human osteosarcomas. (cancer.gov)
So, we used AI to analyse the proteins that are targeted by drugs and the cancer cells, as well as the interrelations among the proteins, to help predict synergistic cancer drug combinations accurately,' said Dr Zhang. (eurekalert.org)

4 The following case report describes a probable drug-drug interaction between trazodone and fluoxetine resulting in exacerbation of symptoms, which rapidly resolved after discontinuation of trazodone. (psychiatrist.com)
Given the timing and patterns of these symptoms, an adverse drug-drug reaction was suspected between trazodone and fluoxetine. (psychiatrist.com)
7 The present case illustrates the need for high clinical suspicion, as these drug-drug reaction symptoms can mimic index psychiatric symptoms. (psychiatrist.com)
Four police officers (Officers 2-5) developed symptoms while responding to a 911 call about an unconscious person with a possible drug overdose in a hotel room. (cdc.gov)

Primary candidate marker from speech will be a combination of most significant features in comparison to biomarkers as reference measure. (lu.se)

He emphasised that the predictions are made by examining not only the directly targeted proteins by drugs and the cancer cells, but also the relations between the proteins, thus yielding a superior performance in identifying the best synergistic anti-cancer drug combination of low toxicity. (eurekalert.org)
They found that GraphSynergy's prediction performance is better in identifying synergistic drug combinations of low toxicity. (eurekalert.org)

This represents an important milestone in the continued development of APG-1387," said Drew W. Rasco, MD, Associate Director of Clinical Research at the START Center for Cancer Care in San Antonio. (pharmiweb.com)
Through the showcase at ASCO, Ascentage Pharma is demonstrating its capabilities of global clinical development in apoptosis. (pharmiweb.com)
The pandemic has taught us the need for faster drug development, speed now is at the forefront of biotechnology research. (t-systems.com)
To hasten progress, countries in Asia-Pacific (APAC) are ramping up their investments into AI drug development for their biotech ecosystems. (t-systems.com)
The CPMR is the first UK research centre to focus on the translation of scientific discoveries into technologies and approaches that expedite drug development. (kcl.ac.uk)
Developing strategic initiatives to support your drug development activities. (prnewswire.com)
Such insight helps healthcare professionals to understand the predictions and provide guidance in future drug development. (eurekalert.org)

It was so clinically impressive in its relentless progression, the awful opportunistic infections that we seem to be unable to really treat successfully, the clinical picture of people wasting away, the association with tuberculosis. (cdc.gov)
In 1996, a fundamental change occurred when it was realized that combinations of antiretroviral drugs could control the progression of the disease, and it was [an] absolute game changer. (cdc.gov)

Diagnosis is clinical. (msdmanuals.com)

In conclusion, the combination of PKC412 together with chemotherapeutic drugs is more effective in FLT3/ITD positive AML cells. (lu.se)

The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. (dovepress.com)
Pharmacogenomics is a study that analyzes how an individual's genetic makeup affects the response to drugs of this individual. (wikipedia.org)
The purpose of this study is to determine whether repeated use of 0.25% miconazole nitrate ointment in newborns and infants with a yeast infection in the diaper area causes the yeast to become resistant to the drug. (drugpatentwatch.com)
This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. (lu.se)
Further clinical study is required to investigate clinical implications and safety of the proposed alternative ABC doses. (bvsalud.org)

Then, the relatively insensitive gastric cancer cell lines (MGC-803 and BGC-823) were treated with low concentrations of chidamide alone, bortezomib alone, or chidamide and bortezomib combination to detect the effects on cell proliferation, apoptosis, migration, and invasion. (dovepress.com)

The Middle-East is also increasing their investment in AI-driven drug discovery with the region's largest AI-powered biotechnology research centre by Insilico Medicine. (t-systems.com)

We also look forward to more clinical studies and molecular biological evidence of APG-115. (pharmiweb.com)
Clinicians may consider alternative combinations of medications given the results from prior studies 4 and this report. (psychiatrist.com)

To benefit from those effects, it is required that the multitarget drug exhibit balanced in vitro and in vivo activities to match potency for the corresponding targets, as well as optimized PK and safety profiles. (biomedcentral.com)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)

Synergy, Additivity, or Independent Drug Action? (aacr.org)

Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. (cdc.gov)

As a globally focused biotech company, Ascentage Pharma showcased the research advances of its drug candidates at ASCO for the third consecutive year and attracted global attention. (pharmiweb.com)
This allows for establishing better workflows and faster clinical research for quicker drug breakthroughs. (t-systems.com)
1 Office of Oncologic Diseases, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. (aacrjournals.org)
Timil H. Patel, Office of Oncologic Diseases, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. (aacrjournals.org)
A research team led by a scholar from City University of Hong Kong (CityU) has recently developed a novel artificial intelligence (AI) framework that can make synergistic anti-cancer drug combination predictions on both the therapeutic and toxic effects. (eurekalert.org)

At the time of its licensure, use of MMRV vaccine was preferred for both the first and second doses over separate injections of equivalent component vaccines (MMR vaccine and varicella vaccine), which was consistent with ACIP's 2006 general recommendations on use of combination vaccines (CDC. (cdc.gov)
Officer 1 found materials consistent with illicit drugs, including the contents of an unlabeled rubber container. (cdc.gov)

Clinical experience with intravenous zanamivir under an emergency investigational new drug program in the United States. (cdc.gov)

Upon entry, they saw drug paraphernalia and powders scattered in plain view. (cdc.gov)

there are minimal clinical data to guide these decisions. (cdc.gov)

Expert Opinion on Drug Safety 13(8): 1133-41, 2014. (upenn.edu)

Dr Pfister talks to e cancertv at WIN 2014 about novel drug targets and potential combinations in treating childhood brain tumours. (ecancer.org)

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. (cdc.gov)

Other evaluations of incidents involving first responders with unintentional occupational exposures to drugs, with similar implications for prevention, are available on the NIOSH website . (cdc.gov)

Although polypharmacology might be associated with compound promiscuity, it should be considered a different category since the so-called promiscuous drugs are instead a class of compound that show a wide spectrum of biological activities and adverse reactions [ 1 ]. (biomedcentral.com)

ASCO2020) Ascentage Pharma Presents Latest Clinical Data. (pharmiweb.com)

Anatomy5

Organisms7

Diseases19

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology1

Phenomena and Processes26

Disciplines and Occupations5

Technology, Industry, Agriculture3

Information Science5

Health Care11

Geographicals1

Trials12

Therapies6

20235

Patients40

Therapy16

Tumor5

Inhibitor10

American Society2

20161

Trial21

20221

Monotherapy5

Treatment20

Resistance7

Chemotherapy3

Regimen3

Efficacy3

Fixed-dose combinations4

Anticancer drug1

Phase3

Clinician1

World Health Organ1

Practice4

Lipids1

Dose6

Oncology1

Treatments3

Evaluate4

Cancers1

Paracetamol3

Inhibitors3

Predict3

Symptoms4

Biomarkers1

Toxicity2

Development7

Progression2

Diagnosis1

Conclusion1

Study5

Bortezomib1

Biotechnology1

Studies2

Vitro2

Synergy1

Infection1

Research5

Consistent2

Intravenous1

Paraphernalia1

Minimal clinical1

Safety1

Novel drug1

Publication1

Exposures1

Adverse Reactions1

Data1