Clinical corneal edema. Medical search. Frequent questions

Patients of Northern European descent do have an increased incidence of Fuchs corneal dystrophy. (medscape.com)
This dystrophy does predispose to the development of corneal edema (see Pathophysiology, Causes, Histologic Findings). (medscape.com)
Fuchs corneal dystrophy, a known predisposing factor in the development of postoperative corneal edema, occurs approximately 3 times more frequently in women than in men. (medscape.com)
Purpose: The aim of this study was to evaluate how Scheimpflug-derived parameters of eyes with Fuchs endothelial corneal dystrophy (FECD) are influenced by Descemet membrane endothelial keratoplasty (DMEK) depending on FECD severity and the presence of subclinical edema. (hu.nl)
The STORM study looked at patients with corneal edema, swelling of the cornea, which Eveleth said is a "significant problem" for patients, especially for those with damage caused by conditions such as Fuchs dystrophy, which causes vision to worsen over the years and can lead to blindness without transplant surgery. (sdbj.com)
Protection of the corneal endothelium in patients with Fuchs dystrophy undergoing surgery represents a significant unmet medical need," said Mark Packer, M.D., chief medical officer of Trefoil Therapeutics. (sdbj.com)
Trefoil is conducting clinical trials for TTHX1114 as an intracameral injection into the eye for patients susceptible to corneal edema due to endothelial damage, including Fuchs Endothelial Corneal Dystrophy (FECD) and other corneal endothelial dystrophies (CED) and patients with other risk factors undergoing ocular surgeries. (pharmiweb.com)
Dysfunction of BTR1 leads to diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy (FECD). (bvsalud.org)
Congenital corneal stromal dystrophy is a very rare autosomal dominant dystrophy that is caused by a mutation in the DCN gene that encodes decorin (a proteoglycan of the extracellular matrix). (bvsalud.org)
We herein report 4 cases of congenital stromal corneal dystrophy in 2 families, highlighting the previously undescribed histopathologic features, the possible differential diagnosis of this entity and the key role played by decorin staining in its diagnosis. (bvsalud.org)
Epithelial basement membrane corneal dystrophy is a rare entity, characterized by recurrent corneal erosions secondary to a disorder in the attachment of the corneal epithelium to the basement membrane. (bvsalud.org)
Reis-Bucklers corneal dystrophy (CDRB) is an autosomal dominant disorder of the superficial corneal stroma that manifests as recurrent corneal erosions in early childhood. (nih.gov)
Microscopically, CDRB may be differentiated from other forms of corneal dystrophy by confluent opacities in the Bowman layer and subepithelium, which are the product of extracellular bodies that stain red with Masson trichrome stain and appear as crystalloid rod-shaped bodies on transmission electron microscopy (summary by Tanhehco et al. (nih.gov)
Less frequent clinical characteristics include nail dystrophy, dental anomalies, cutaneous syndactyly of the digits, and renal malformations. (nih.gov)
Sanjay V. Patel, M.D., is a corneal specialist and corneal transplant surgeon who has research interests in Fuchs' endothelial corneal dystrophy, corneal transplantation outcomes and trials, corneal imaging, and regenerative methods of treating corneal disease. (mayo.edu)
Fuchs' dystrophy clinical studies. (mayo.edu)
Dr. Patel's research in Fuchs' endothelial corneal dystrophy spans discovering and understanding the mechanisms of the disease to the clinical assessment of patients needing corneal transplantation. (mayo.edu)
In this "Clinical Minute," we'll be discussing a retrospective chart review in which investigators studied the refractive outcomes of phacoemulsification in eyes with Fuchs endothelial corneal dystrophy. (eyehealthacademy.org)
A retrospective chart review evaluated the refractive outcomes of phacoemulsification in eyes with Fuchs endothelial corneal dystrophy. (eyehealthacademy.org)
Kendall Donaldson, MD, sits down with Neda Shamie, MD, to discuss a retrospective chart review in which investigators evaluated the refractive outcomes of phacoemulsification in eyes with Fuchs endothelial corneal dystrophy. (eyehealthacademy.org)

Patients in this category suffer either from opacity of the ocular media (e.g., corneal edema, hyphema/hypopyon, cataract, etc.) or from retinal disease (e.g. (vin.com)
The most common adverse reactions were reported in 1-6% of patients and included increased intraocular pressure, conjunctival hyperemia and/or hemorrhage, corneal edema, ocular pain, headache, tearing and vision blurred. (rxlist.com)
In addition to treating more severe diseases like Fuchs, the STORM study also showed that TTHX1114 can also treat many types of corneal endothelial damage, such as complications that arise from ocular surgery, of which there are roughly 4.5 to 5 million performed in the U.S. each year. (sdbj.com)
Trefoil is also developing the compound as an eye drop to reduce the duration and impact of ocular herpes virus related ulcers and other corneal ulcers. (sdbj.com)
For practical clinical purposes in small animals, glaucoma is often defined as an IOP elevation beyond what is compatible with the health of ocular tissues. (vin.com)
Dr. Polse's research included corneal physiology, ocular disease processes, and contact lenses. (berkeley.edu)
Therefore, lens material selection, lens fitting and customization and ocular health monitoring are crucial to prevent or manage edema. (reviewofcontactlenses.com)
You're listening to Eye on Ocular Health on ReachMD, and this episode is part of our "Clinical Minute" series. (eyehealthacademy.org)
Aramis Biosciences is a clinical-stage immuno-ophthalmology biopharmaceutical company committed to the development of disease-modifying therapy for ocular surface disease. (ois.net)
Critically important Graves disease occurs in 25% of patients, however sub clinical involvement with extreme ocular muscle enlargement is seen radiographically it up to 70% of patients. (standardofcare.com)
Knowledge of the clinical profile of patients who underwent penetrating keratoplasty enabled identification of the main ocular diagnoses that result in this type of transplant as a therapeutic indication. (bvsalud.org)
Ocular Monkeypox This report describes five patients who developed ocular monkeypox, highlighting its varying clinical manifestations and the importance of prompt evaluation and treatment to prevent complications. (medscape.com)

However, the most important influence on corneal deturgescence is the presence of an active metabolic pump in the endothelium. (medscape.com)
Another factor is the presence of intact immuno-regulatory systems of the anterior chamber to which the corneal endothelium is exposed. (aao.org)
Loss of the immunoregulatory systems of the anterior chamber can influence corneal allograft immunity, and the expression of FasL on corneal endothelium has been observed to be essential for allograft protection in animal models. (aao.org)
Corneal swelling when wearing these lenses may be caused by multiple factors, such as hypoxic stress, increased intraocular pressure (IOP), compromised functional condition of the endothelium and lens suction. (reviewofcontactlenses.com)
Influence of Preoperative Corneal Endothelial Status on Postoperative Corneal Endothelium Density after Cataract Surgery. (jkos.org)
To analyze the influence of preoperative corneal endothelial status on postoperative corneal endothelium density after cataract surgery. (jkos.org)
Diseases surgical technique developed since the start of the involving the corneal endothelium can be controlled twentieth century for the realization of corneal with endothelial or penetrating keratoplasties, and transplantation (CT). (bvsalud.org)
CT is the most common type those diseases that involve both the endothelium and of tissue transplantation made around the world, the corneal stroma generally require PK when there is substitution of all corneal layers (the (REINHART, 2011). (bvsalud.org)

Keratoconus surpassed PBK in 1990 as the leading indication for corneal transplantation in some studies in the United States. (medscape.com)
TTHX1114 provides hope that patients at risk of corneal decompensation may maintain good vision and avoid the risks of corneal transplantation. (sdbj.com)
Corneal allograft rejection Penetrating keratoplasty, or the transplantation of corneal allografts, has an extremely high success rate (>90%) even in the absence of systemic immunomodulation. (aao.org)
Once activated, however, antibody-dependent DH and CTL-related mechanisms can target transplantation antigens in all corneal layers. (aao.org)
Corneal transplantation. (mayo.edu)
Clinical studies, including multicenter trials, are in progress to assess the outcomes of different techniques of corneal transplantation. (mayo.edu)

[ 1 ] As corneal edema progresses and worsens, first stromal and then intercellular epithelial edema develops. (medscape.com)
Figure 3-1 Endothelial graft rejection with stromal and epithelial edema on the trailing aspect of the migrating Khodadoust line (inset) . (aao.org)
The study comprised 35 eyes out of which 28 eyes had clear cornea , 4 eyes had descemet membrane folds, 3 eyes with focal stromal oedema and 1 eye with diffuse corneal oedema at post-op day 1. (ascrs.org)
Studies assessing corneal stromal and corneal endothelial regeneration to treat corneal stromal and endothelial diseases are planned. (mayo.edu)
The cornea had mild stromal edema, and the anterior chamber was normal depth with +1 flare and +2 pigmented cells within it. (medscape.com)

Pseudophakic bullous keratopathy (PBK) and aphakic bullous keratopathy (ABK) refer to the development of irreversible corneal edema as a complication of cataract surgery. (medscape.com)
Acuvail (ketorolac tromethamine) Ophthalmic Solution is a nonsteroidal anti-inflammatory drug ( NSAID ) used to treat pain inflammation after cataract surgery or corneal refractive surgery, and also to relieve eye itching caused by seasonal allergies. (rxlist.com)
Incidence of cystoid macular edema after cataract surgery in patients with and without uveitis using optical coherence tomography. (medscape.com)
Latanoprost-Dependent Cystoid Macular Edema Following Uncomplicated Cataract Surgery in Pseudoexfoliative Eyes. (medscape.com)
Law SK, Kim E, Yu F, Caprioli J. Clinical cystoid macular edema after cataract surgery in glaucoma patients. (medscape.com)

Corneal endothelial status and central corneal thickness were measured before surgery and 1 day, 1 month, 3 months and 6 months after surgery. (jkos.org)
Clinical parameters, including corneal endothelial cell losses, visual acuity, intraocular pressure, spherical equivalent refraction and central corneal thickness were measured to compare the intergroup indices. (jkos.org)

Osmotic forces and the electrolyte balance within the corneal stroma also tend to draw water into the cornea. (medscape.com)
Histopathologic examination of the corneal button showed spherical cysts in mid stroma and inflammatory infiltrates ( Figure , panel D). At the last follow-up (3 months after surgery), the corneal graft was clear with no evidence of infection. (cdc.gov)
After a DMD, the overlying corneal stroma and epithelium swell, and visual acuity can be permanently affected. (eyewiki.org)
Postoperative risk factors include abnormalities in DM and corneal stroma interface, pre-existing endothelial disorders and corneal ectatic disorders. (eyewiki.org)

In the U.S. alone, there are about 50,000 corneal transplants performed each year for Fuchs and other corneal conditions. (sdbj.com)

It has to be evaluated if the effect on corneal edema changes with longer wearing periods, larger samples or other influences. (bsz-bw.de)
For the injectable TTHX1114 product, the next phase is to "show in a clinical trial the drug has an effect on corneal edema that is due to multiple causes," Eveleth said, adding that those additional trials could take several years to complete and file with FDA and that TTHX1114 could be a marketable product by the end of 2028. (sdbj.com)

Corneal transparency is, in a large part, dependent on the ability of the cornea to remain in a dehydrated state. (medscape.com)
Evaporation from the corneal tear film results in slightly hypertonic tears that tend to draw fluid out of the cornea. (medscape.com)
The cornea can become hazy if there is edema due to the abrasion. (medscape.com)
They showed that oxygen deficiency was the main cause of corneal edema, which if prolonged, could result in physiological changes in the cornea, compromising visual acuity and lens comfort. (berkeley.edu)
The diagnosis of DMD is mostly clinical, based on history and slit lamp examination, especially if the cornea is clear. (eyewiki.org)

Compared with the control group, postoperative best-corrected visual acuity for the "no edema" group did not differ (0.03 ± 0.12 vs. −0.02 ± 0.08 logarithm of the minimum angle of resolution, P = 0.150) but was worse for the subclinical edema group (0.06 ± 0.08 vs. −0.02 ± 0.08 logarithm of the minimum angle of resolution, P = 0.001). (hu.nl)

Conclusion: Our clinical results do not correlate with current theoretical calculations, which predict a greater amount of corneal swelling with increasing tear layer thickness. (bsz-bw.de)
After correcting for small variations in the initial central fluid reservoir thickness, the central corneal edema was similar between the reverse piggyback (2.32±1.15%) and the standard scleral lens conditions (2.02±0.76%) in 10 young healthy participants with normal corneas. (constantcontact.com)
Theoretical models have shown that a scleral lens made of materials with a Dk higher than 100, a thickness less than 260μm and a vault less than 150μm prevents corneal swelling related to hypoxia. (reviewofcontactlenses.com)
There were increases in corneal thickness at 1 day and 1 month after surgery that were significantly higher in the low-endothelial cell density group than the 2,000-2,500 cells/mm² cell density group (p (jkos.org)

Use caution in patients with limited corneal endothelial cell reserve. (nih.gov)

The company added that adverse events, including elevated intraocular pressure and corneal edema, were transient. (drugdeliverybusiness.com)

Experimental investigations have been conducted on mechanisms underlying the visual and systemic effects of tertiary amine exposure, included mydriasis and cylcoplegia due to effects on the innervation of the sphincter muscle of the iris, edema and rupture of the corneal epithelium, blockade of parasympathetic and sympathetic ganglia, and histamine release. (cdc.gov)
Foreign body sensation can be present due to irregular corneal epithelium. (eyewiki.org)

Surgical trauma, inflammation, and corneal dystrophies can accelerate this normal aging loss. (medscape.com)

Urgent consultation is needed for suspected corneal ulcerations (microbial keratitis). (medscape.com)
Corneal keratitis and staining. (medscape.com)
See also Corneal Abrasion and Corneal Ulceration and Ulcerative Keratitis in Emergency Medicine . (medscape.com)
these findings were identical to the clinical picture of Acanthamoeba keratitis. (cdc.gov)

Flavopiridol treatment notably reduced corneal opacity and the clinical scores of infected corneas. (researchsquare.com)

In addition to developing TTHX1114 as an injection to treat various conditions that lead to corneal edema. (sdbj.com)
In this case, spontaneous resolution is unlikely and if not treated in time, can lead to corneal decompensation and opacification. (eyewiki.org)

The goal of the corneal regeneration studies is to bring the treatment of corneal disease to many more patients, including those with corneal blindness in the developing world. (mayo.edu)
The Company's first candidate is for the treatment of corneal edema secondary to corneal endothelial disease, and is the first off-the-shelf, clinically validated cell therapy for corneal care, having received regulatory approval in Japan. (ois.net)

Results: In this study, there was found to be no significant difference in corneal edematous response during lens wear between the two test groups. (bsz-bw.de)
Results indicated no statistically significant difference in corneal edema between each of the scleral lenses with Dk from 100 to 180. (reviewofcontactlenses.com)

Preoperative and 6 months postoperative Scheimpflug imaging was used to analyze pachymetry, presence of tomographic features (loss of isopachs/displacement of the thinnest point/focal posterior depression), and corneal backscatter. (hu.nl)

Diffuse corneal edema is usually seen in TASS. (dovepress.com)
The hallmark sign of DMD is localized or diffuse corneal edema over the DMD that, with time, can become persistent. (eyewiki.org)

The clinical diagnosis is often based on spillover inflammation (i.e., cells and protein flare) observed with a slit lamp in the aqueous or vitreous humors. (aafp.org)
The topical formulation of TTHX1114 is designed to accelerate corneal ulcer wound healing by stimulating epithelial cell growth, potentially reducing common complications associated with corneal ulcers, such as pain, inflammation, and loss of vision due to corneal scarring. (pharmiweb.com)
Ashvattha Therapeutics is advancing a new class of clinical-stage nanomedicine therapeutics that transverse tissue barriers to selectively target activated cells only in regions of inflammation. (ois.net)
Approximately 3-5% of patients have severe disease with pain, inflammation, corneal ulceration or compressive optic neuropathy. (standardofcare.com)

Retinal examination can reveal diabetic retinopathy associated with the diabetic retinal edema. (medscape.com)
Advances in Fourier-domain optical coherence tomography (Fd-OCT) permit visualization of three-dimensional morphology of in-vivo retinal structures in a way that promises to revolutionize clinical and experimental imaging of the retina. (spie.org)

SAN DIEGO--(BUSINESS WIRE)-- Trefoil Therapeutics , a clinical-stage biotechnology company focused on restoring sight to people with corneal diseases, today announced multiple presentations providing evidence for clinical and preclinical efficacy of the company's investigational medicine TTHX1114 for improving visual outcomes and protection against corneal endothelial damage at the Annual Association for Research in Vision and Ophthalmology (ARVO) Meeting in New Orleans, April 23-27, 2023. (pharmiweb.com)
David Eveleth will be a panelist in a symposium titled "Emerging Therapeutics to Maintain Corneal Health" on April 25, 2023, from 8:45-10:30 am in the La Nouvelle C room. (pharmiweb.com)

Rarely, corneal neovascularization regresses completely without treatment, and corneal transparency is restored. (msdmanuals.com)
Patient-related risk factors include age over 65 years, previous history of chemical injury, corneal neovascularization, dense cataracts, and lack of adequate anaesthesia. (eyewiki.org)

Table 1 lists the main systemic disorders associated with uveitis, typical clinical findings, and suggested diagnostic studies. (aafp.org)

The full title of her thesis is 'estimating keratoconus progression using biometric and biomechanical parameters to adjust treatment protocols for corneal crosslinking (CXL). (constantcontact.com)
Biomicroscopy revealed profuse corneal edema and keratoconus and fluorescein staining was negative. (embrapa.br)

Surgery was performed in two steps: 1) superficial keratectomy and 360º conjunctival flap, and 2) superficial keratectomy to restore corneal transparency. (embrapa.br)

There are currently no treatments that directly address corneal ulcers related to herpes infection. (sdbj.com)
In addition to herpes, corneal ulcers can arise from a variety of other diseases or from injury. (sdbj.com)

Trefoil Therapeutics CEO David Eveleth, Ph.D. is excited about the results of the Phase 2 study of its lead drug candidate, an engineered form of Fibroblast Growth Factor (FGF1) that stimulates corneal cell proliferation and migration and protects cells from stress and injury - all important attributes of one's vision. (sdbj.com)
His topic will be: The Role of Fibroblast Growth Factor derivatives in corneal endothelial regeneration which will be presented from 9:13-9:27 am. (pharmiweb.com)

FECD severity was based on the modified Krachmer scale and the absence/presence of subclinical edema. (hu.nl)
Although most analyzed parameters correlated with FECD severity, corneal tomography might be best suited for objective grading of disease severity to aid in surgical decision-making. (hu.nl)

Skin involvement tends to be more severe with CN, and may include irritation, bulla formation, and subcutaneous edema. (medscape.com)
Severe effects (eg, pulmonary edema, chemical pneumonitis) usually occur only with prolonged exposure in an enclosed space. (medscape.com)
For example, given a similar route of exposure, clinical effects may vary from mild to severe, depending on the concentration of tear gas to which a person has been exposed. (cdc.gov)
Although most DMDs are small and self-sealing with no corresponding visual complaints, some can present with severe corneal edema and vision loss if the detachment is extensive. (eyewiki.org)
In cases where severe corneal edema is present, other diagnostic tests can aid the diagnosis. (eyewiki.org)
During the 2022 global monkeypox (mpox) outbreak, some patients have experienced severe clinical manifestations. (cdc.gov)
Until data from controlled studies are available, these interim clinical considerations facilitate strategic decision-making about the use of MCMs to manage specific severe manifestations of mpox. (cdc.gov)
A CDC clinical team began providing consultations § to U.S. clinicians caring for patients with mpox, developing guidance and other online clinical resources for health care providers, and issuing health alerts ¶ when emerging clinical concerns (e.g., severe infections in patients with advanced HIV infection) were detected. (cdc.gov)
There are diagnostic and clinical management strategies that may help address severe manifestations of monkeypox. (cdc.gov)
In prior monkeypox outbreaks in Nigeria, co-infection with HIV was associated with worse clinical outcomes, including severe manifestations of monkeypox, hospitalization, and death. (cdc.gov)

San Diego-based Trefoil Therapeutics is a clinical-stage biotechnology company focused on leveraging its engineered FGF1 protein technology platform to develop first-in-class pharmacologic treatments for serious corneal endothelial diseases and epithelial disorders. (pharmiweb.com)

The severity of corneal diseases was evaluated by slit-lamp microscopy. (researchsquare.com)
The initial use for this device is Laser Scleral Microporation® (LSM), an innovative, clinical stage, minimally invasive rejuvenation therapy for the treatment of presbyopia, and potentially other eye diseases including glaucoma. (ois.net)
Allgenesis, established in 2014, is a clinical-stage, biopharmaceutical company that focuses on the development of novel therapies for the treatment of unmet medical needs in diseases of the front and back of the eye. (ois.net)
Artificial Intelligence and Corneal Diseases Find out more about the emerging applications of artificial intelligence in the field of ophthalmology, specifically in relation to corneal conditions. (medscape.com)

Customised approaches, based on an objective progression risk assessment, are likely to optimise the clinical outcomes and provide some insight into the unanswered question: who, when and how to crosslink? (constantcontact.com)
Improving visual outcomes by preserving outer retina morphology in eyes with resolved pseudophakic cystoid macular edema. (medscape.com)
Corneal imaging techniques are being evaluated as novel methods for assessing disease severity, detecting subclinical edema and predicting surgical outcomes. (mayo.edu)

With the development of new surgical techniques, instrumentation and pharmacological advances, corneal transplant procedures can undergo changes directly in the clinical profile of patients with the indication for penetrating keratoplasty technique. (bvsalud.org)

The safety and efficacy of most of the glaucoma medications approved by the US Food and Drug Administration (FDA) have not been studied specifically in children in controlled clinical trials, although most clinicians are guided by extensive clinical experience. (aao.org)
Glaucoma can be classified into three major clinical groups: 1) congenital, 2) primary, and 3) secondary. (vin.com)
The clinical signs associated with glaucoma depend on the stage of disease, level and duration of IOP elevation, and the type of glaucoma. (vin.com)
In general, the clinical signs of glaucoma can be divided into acute and chronic signs with some overlap. (vin.com)
Preexisting clinical conditions for penetrating keratoplasty were found, such as changes in vascularization, glaucoma, previous surgery, aphakic and pseudophakic eyes and keratoplasties combined with other types of surgeries. (bvsalud.org)

The clinical research discussed in this press release is preliminary and the outcome of such studies may not be predictive of the outcome of later clinical trials. (pharmiweb.com)
What this means is that we strive for innovative simplicity and the use of components that have a history of medical safety, so that our nanomedicines can be tested in clinical trials and developed into useful products. (hopkinsmedicine.org)
Our faculty have developed several FDA approved products or are currently in mid-to-late stage clinical trials. (hopkinsmedicine.org)
Recent publications in the first under joint and pheroid technology in clinical trials. (myjuicecup.com)
Learn about clinical trials that address specific scientific questions about human health and disease. (mayo.edu)

The most common clinical features of Graves' ophthalomopathy are upper eyelid retraction, edema, erythema of the periorbital tissues and conjunctiva and propptosis. (standardofcare.com)

Anterior segment examination of the right eye revealed a subconjunctival hemorrhage involving the inferior temporal conjunctiva, with an adjacent corneal epithelial abrasion measuring approximately 1 mm in diameter. (medscape.com)

Retina: AG-73305 is a novel, first-in-class, bi-specific Fc-fusion protein (anti-VEGF+anti-Integrin) designed for the treatment of diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD). (ois.net)
Brolucizumab for the Treatment of Diabetic Macular Edema What have we learned about the efficacy and safety of brolucizumab as a treatment option for diabetic macular edema? (medscape.com)

Lesions on a significant proportion of the total body surface area, which may be associated with edema and secondary bacterial or fungal infections among other complications. (cdc.gov)

An estimated 500,000 patients annually suffer corneal complications of herpes virus reactivation in the U.S. Globally, 10 % of all blindness - 4 million people - is attributable to herpes infections. (sdbj.com)

I-site newsletter is a global educational newsletter FOR HEALTH CARE PROVIDERS launched in 2009, that monthly provides independent updates from the international literature on specialty rigid contact lenses such as corneal, orthokeratology and scleral lenses and related topics. (constantcontact.com)
I n certain cases, fitting scleral lenses is challenging, as they can induce edema and compromise corneal health. (reviewofcontactlenses.com)

Affected individuals develop corneal opacities that result in significant visual impairment. (nih.gov)

Measurements were collected using both the Pentacam® HR Corneal Tomographer, as well as the Visante Anterior Segment Optical Coherence Tomographer (OCT). The apical clearance was measured using the Visante OCT at two intervals during the test day: immediately after application of the lens and immediately prior to the removal of the lens. (bsz-bw.de)
However, if there is significant corneal edema, imaging tools such as anterior segment optical coherence tomography (AS-OCT) are fundamental for the diagnosis. (eyewiki.org)
DMD is usually seen as a translucent membrane in the anterior chamber, at the site of corneal incision or DM perforation. (eyewiki.org)

Of eyes without preoperative clinical edema (n = 75), 18.7% showed 0 or 1 tomographic feature (no edema group) and 82.4% had 2 or 3 features (subclinical edema group). (hu.nl)

The organism showed cytotoxicity after in vitro inoculation of a rabbit corneal epithelial cell line. (cdc.gov)

The aim of this study by a group from Queensland University of Technology in Brisbane (Australia) was to compare the magnitude of corneal edema that this could potentialy induce to that produced by standard scleral lens wear. (constantcontact.com)
The authors concluded that following 90 minutes of lens wear, the highly oxygen-permeable reverse piggyback system did not induce a clinically or statistically greater magnitude of central corneal edema compared to standard scleral lens wear in young adults with healthy corneas, and this approach may potentially be suitable to address poor front-surface scleral lens wettability or to correct residual refractive error during diagnostic scleral lens fitting. (constantcontact.com)

Pseudophakic cystoid macular edema. (medscape.com)
Pharmacologic therapy of pseudophakic cystoid macular edema: 2010 update. (medscape.com)

The main goal of this paper is to clinically verify the effect of varying tear layer depths on induced corneal edema during lens wear. (bsz-bw.de)
More serious and even permanent eye injuries (eg, corneal abrasions, foreign bodies) can be caused by tear gas particles, other foreign particles, or the blast injury itself. (medscape.com)
Note: The actual clinical manifestations of tear gas exposure may be more variable than the syndrome described above. (cdc.gov)
No significant effects were noted on corneal sensitivity, tear secretion, or pupil size. (theodora.com)

Although the exact frequency of emergency department visits for corneal abrasions is unknown, a 1985 survey showed that around 3% of all cases to US general practitioners were corneal abrasions. (medscape.com)
Patients with corneal abrasions are managed on an outpatient basis. (medscape.com)
Tetanus prophylaxis, eye patching, and antimicrobial therapy for patients with corneal abrasions who present to the emergency department (ED) are reviewed below. (medscape.com)

Other clinical signs include buphtalmia, mydriasis, corneal edema, episcleral congestion and a subluxated lens. (slu.se)

Anatomy5

Organisms1

Diseases18

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes2

Dystrophy20

Ocular12

Endothelium8

Transplantation6

Stromal5

Cataract surgery5

Central corneal thickness2

Stroma4

Fuchs1

Effect on corneal edema2

Cornea5

Visual acuity1

Thickness4

Limited corneal endothelial cell1

Intraocular1

Epithelium2

Dystrophies1

Keratitis4

Reduced corneal opacity1

Lead to corneal2

Treatment of corneal2

Difference in corneal2

Pachymetry1

Diffuse2

Inflammation4

Retinal2

20232

Neovascularization2

Uveitis1

Keratoconus2

Transparency1

Ulcers2

Fibroblast Growth2

FECD2

Severe10

Endothelial diseases1

Diseases4

Outcomes3

Transplant1

Glaucoma5

Trials5

Periorbital1

Hemorrhage1

Diabetic2

Secondary1

Complications1

Scleral lenses2

Opacities1

Anterior3

Subclinical1

Epithelial cell1

Induce2

Pseudophakic2

Tear4

Abrasions3

Mydriasis1