AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
GenotypeHLA AntigensAntigensAntigens, BacterialAntigens, NeoplasmAntigens, SurfaceAntigens, ViralHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHLA-DR AntigensAntigens, ProtozoanPolymorphism, GeneticMolecular Sequence DataAntigens, Polyomavirus TransformingAllelesH-2 AntigensAntigens, CDHLA-A AntigensAntigens, FungalHLA-B AntigensHLA-DQ AntigensAntigens, HelminthHLA-D AntigensAntibodies, MonoclonalHistocompatibility AntigensCarcinoembryonic AntigenGene FrequencyAmino Acid SequenceHLA-A2 AntigenReceptors, Antigen, T-CellAntigens, Viral, TumorGenetic Predisposition to DiseaseEpitopesPolymerase Chain ReactionT-LymphocytesBase SequencePolymorphism, Single NucleotideHistocompatibility TestingProliferating Cell Nuclear AntigenPhenotypeGenetic VariationEnzyme-Linked Immunosorbent AssayAntigens, CD8Receptors, Antigen, B-CellProstate-Specific AntigenO AntigensImmunoglobulin GHaplotypesCell LineLymphocyte ActivationHepatitis B Surface AntigensCross ReactionsHLA-C AntigensAntigens, CD15Mice, Inbred BALB CSequence Analysis, DNAAntigens, Tumor-Associated, CarbohydratePhylogenyHLA-DRB1 ChainsCase-Control StudiesAntigens, CD3Antibody SpecificityBlood Group AntigensT-Lymphocytes, CytotoxicB-LymphocytesMutationMice, Inbred C57BLHLA-DQ beta-ChainsAntigens, CD4HLA-DR3 AntigenFluorescent Antibody TechniqueAntibody FormationAntigens, CD45Antigen-Antibody ReactionsHLA-DR4 AntigenHLA-B7 AntigenAntigens, CD1Polymorphism, Restriction Fragment LengthCells, CulturedReceptors, AntigenHLA-B27 AntigenImmunizationImmune SeraAntibodies, BacterialFlow CytometryHepatitis B AntigensAntigens, DifferentiationRecombinant ProteinsInterferon-gammaAntigen-Presenting CellsCD8-Positive T-LymphocytesPeptidesHLA-A1 AntigenGenes, MHC Class IIHomozygoteCytotoxicity, ImmunologicCD4-Positive T-LymphocytesHepacivirusTime FactorsAutoantigens
Tissue AntigensAllogeneicTumorHistocompatibilityReceptorsPrevalenceGenesTransplantationReceptorDonorsImmuneRecognitionSpecificAssociationPotentialCellCellsPatientsProductsDRB1Systemic lupus erythemAllelesAllelePemphigusPeptideMacrophagesDonorMoleculesClinicalEpitopesDifferentialSensitizationLymphocytesAcutePatients
Tissue Antigens2
Allogeneic2
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Tumor5
  • In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
  • This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
  • These receptors allow NK cells to spare autologous normal cells and to kill cells in which MHC class I expression is down-regulated (eg, by tumor transformation or viral infection) or cells expressing non-self MHC class I alleles unable to engage these receptors (eg, allogenic transplantation settings). (ashpublications.org)
Histocompatibility4
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
  • Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Receptors3
  • Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
  • 1-3 Among receptors negatively regulating NK-cell function, a crucial role is played by those interacting with MHC class I molecules. (ashpublications.org)
  • In humans, HLA class I-specific receptors include killer Ig-like receptors (KIRs) specific for determinants shared by groups of HLA-A, -B, and -C allotypes 4 and CD94/NKG2A heterodimer specific for the nonclassic, class I molecule HLA-E 5 . (ashpublications.org)
Prevalence2
  • It is known that the prevalence of the HLA-DRB1*04:01 variant directly correlates with the latitude and longitude of the population. (wikipedia.org)
  • The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). (univr.it)
Genes1
  • HLA genes play a role in the predisposition of several diseases. (univr.it)
Transplantation1
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Receptor1
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Donors1
  • A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
Immune4
  • However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)
  • The main cause of sarcoidosis is immune irregularities in genetically predisposed individuals which manifests antigen(s) like microorganism or their products, due to an ex-aggregated immune response. (ijpsr.com)
  • The immune irregularities have been found to be the main cause of sarcoidosis in genetically predisposed individuals, elicited by the antigen(s) like microorganisms or their products, pollens, viruses, bacteria, and borrelia, due to an ex-aggregated immune response. (ijpsr.com)
  • There are many shreds of evidence that suggest that the extrinsic antigens, environmental conditions, and genetic factors play a crucial role in the development of sarcoidosis through an exaggerated immune response. (ijpsr.com)
Recognition2
  • After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
  • TCR transgenic T cells demonstrated HLA-A*02:01/ADRB3 295 mediated ES recognition and killing in ELISpot and xCELLigence assays. (oncotarget.com)
Specific1
  • It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)
Association2
  • Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. (univr.it)
  • We observed an association between some HLA class-I antigens and AICU. (univr.it)
Potential1
  • Amino-acid exchange scans clearly indicated the cross-reactive potential of HLA-A*02:01/ADRB3 295 - and HLA-A*02:01/CHM1 319 -TCR transgenic T cells. (oncotarget.com)
Cell1
  • We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
Cells1
  • We identified HLA-A*02:01/peptide-restricted T cells directed against ADRB3 295 . (oncotarget.com)
Patients5
  • HLA-DRB1*04:01 gene variant is found three times more often in asymptomatic carriers of SARS-CoV-2 than in patients with symptoms of COVID-19. (wikipedia.org)
  • Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. (univr.it)
  • Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. (univr.it)
  • No differences were found between patients and controls as regards to HLA-DRB1* genotype. (univr.it)
  • CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
Products1
  • HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. (wikipedia.org)
DRB112
  • HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. (wikipedia.org)
  • HLA-DRB1*04:01 gene variant is found three times more often in asymptomatic carriers of SARS-CoV-2 than in patients with symptoms of COVID-19. (wikipedia.org)
  • It is known that the prevalence of the HLA-DRB1*04:01 variant directly correlates with the latitude and longitude of the population. (wikipedia.org)
  • High susceptibility to pemphigus vulgaris due to HLA-DRB1*14:54 in the Slovak population. (cdc.gov)
  • Allelic variation in HLA-DRB1* loci in Syrian pemphigus vulgaris patients. (cdc.gov)
  • HLA DRB1* and DQB1* alleles are associated with disease severity in patients with pemphigus vulgaris. (cdc.gov)
  • Human leukocyte antigen class II (DRB1 and DQB1) alleles and haplotypes frequencies in patients with pemphigus vulgaris among the Serbian population. (cdc.gov)
  • 7. HLA-DRB1 and tumor necrosis factor gene polymorphisms in Japanese patients with multiple sclerosis. (nih.gov)
  • 11. Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. (nih.gov)
  • 12. [The role of HLA DRB1 genetic polymorphisms in non-Hodgkin's lymphomas]. (nih.gov)
  • 13. Independent contribution of HLA-DRB1 and TNF alpha promoter polymorphisms to the susceptibility to Crohn's disease. (nih.gov)
  • 18. Association of tumour necrosis factor-alpha, lymphotoxin-alpha and HLA-DRB1 gene polymorphisms with Löfgren's syndrome in Czech patients with sarcoidosis. (nih.gov)
Systemic lupus erythem1
  • 4. Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients. (nih.gov)
Alleles4
  • HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. (cdc.gov)
  • 9. TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients. (nih.gov)
  • 16. Major histocompatibility complex class I chain related (MIC) A gene, TNFa microsatellite alleles and TNFB alleles in juvenile idiopathic arthritis patients from Latvia. (nih.gov)
  • In this study, we describe a panel of artificial APCs (AAPCs) consisting of murine 3T3 cells transduced to express human B7.1, ICAM-1, and LFA-3 that each stably express one of a series of six common HLA class I alleles. (aai.org)
Allele1
  • T cells sensitized with either peptide-loaded or transduced AAPCs recognized epitopes presented by each HLA allele known to be immunogenic in humans. (aai.org)
Pemphigus6
  • Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus. (cdc.gov)
  • Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo. (cdc.gov)
  • Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. (cdc.gov)
  • Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients. (cdc.gov)
  • HLA-E*0101/0103X is Associated with Susceptibility to Pemphigus Vulgaris: A Case-control Study. (cdc.gov)
  • Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis. (cdc.gov)
Peptide3
  • AN - ADRENERGIC FIBERS is also available HN - 2012 BX - Noradrenergic Neurons FX - Adrenergic Fibers MH - Agatoxins UI - D060848 MN - D12.776.92.249 MN - D20.888.65.870.324 MN - D23.946.833.65.870.324 MS - A class of polyamine and peptide toxins which are isolated from the venom of spiders such as Agelenopsis aperta. (nih.gov)
  • 2. Peptide from cytosol associates with class I MHC and is recognized by Tc cells. (slideshare.net)
  • Peptide from vesicles associates with class II MHC and is recognized by Th cells. (slideshare.net)
Macrophages5
  • PMID- 3894221 TI - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. (nih.gov)
  • AB - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13 20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. (nih.gov)
  • Consistent with this finding, DP but not DR or DQ antigens were observed on vascular elements and macrophages in the villi of 16-week placenta. (nih.gov)
  • AB - The faster degradation of antigen by macrophages in Biozzi low (L) responder mice, compared to Biozzi high (H) responder mice, is thought to be responsible for their lower antibody response. (nih.gov)
  • Differential distribution of MHC molecules Tissue MHC class I MHC class T cells +++ +/- B cells +++ +++ Macrophages +++ ++ Other APC +++ +++ Thymus epithelium + +++ Neutrophils +++ - Hepatocytes + - Kidney + - Brain + - Erythrocytes - - The highest level of class I molecules are expressed on lymphocytes: 1 % of the total plasma membrane proteins or 5 x 105 molecules / cell. (slideshare.net)
Donor3
  • To better define the role of KIRs in HSCT, we studied KIR genotypes and HLA class I ligands in a homogeneous group of 45 thalassemia patients transplanted with bone marrow cells from an HLA-identical, unrelated donor. (nih.gov)
  • In non-rejector combinations, liver allografts possess remarkable properties of tolerance induction and antigen-specific immunosuppression, leading to a state of donor-specific unresponsiveness in which grafts of other organs are also accepted. (nih.gov)
  • Moreover, liver transplantation can terminate ongoing rejection reactions in other organs and convert an existing state of sensitization against donor antigens into one of unresponsiveness. (nih.gov)
Molecules3
  • These types of diseases occur when self molecules, often unknown antigens (auto-antigens), are seen by the immune system as non-self and are thereby attacked immunologically by the production of autoantibodies against them. (intechopen.com)
  • A few cell types (e.g., neurons and sperm cells at certain stages of differentiation) appear to lack class I MHC molecules altogether. (slideshare.net)
  • Thymic epithelial cells and some other cell types can be induced to function as APC and then express class II molecules under certain conditions. (slideshare.net)
Clinical1
  • 2. A study of the HLA-DR region in clinical subgroups of multiple sclerosis and its influence on prognosis. (nih.gov)
Epitopes3
  • The hepatitis C virus (HCV) mutates within human leucocyte antigen (HLA) class I restricted immunodominant epitopes of the non-structural (NS) 3/4A protease to escape cytotoxic T lymphocyte (CTL) recognition and promote viral persistence. (bmj.com)
  • CTL recognition of naturally occurring and artificially introduced escape mutations in HLA-A2-restricted NS3 epitopes were determined using CTLs from human blood and genetically immunised HLA-A2-transgenic mice. (bmj.com)
  • The major viral species had functional proteases with 1073-1081 epitopes that were generally recognised by cross reactive human and murine HLA-A2 restricted CTLs. (bmj.com)
Differential1
  • Fetal liver sections and cell suspensions showed differential expression of class II antigens. (nih.gov)
Sensitization1
  • This replenishable panel of AAPCs can be used for immediate sensitization and expansion of virus-specific T cells of desired HLA restriction for adoptive immunotherapy. (aai.org)
Lymphocytes1
Acute1
  • Venous blood was obtained from six patients (four HLA-A2+) with chronic HCV infection and from one HLA-A2+ patient with acute HCV infection. (bmj.com)
Patients1
  • Phase II study of high-sensitivity genotyping of KRAS, NRAS, BRAF and PIK3CA to ultra-select metastatic colorectal cancer patients for panitumumab plus FOLFIRI: the ULTRA trial. (idibell.cat)