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  • autonomic
  • The last two decades have witnessed the recognition of a significant relationship between the autonomic nervous system and cardiovascular mortality, including sudden cardiac death. (ahajournals.org)
  • 1 2 3 4 Experimental evidence for an association between propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has spurred efforts for the development of quantitative markers of autonomic activity. (ahajournals.org)
  • Other types of structural brain injury, including scattered cerebral infarcts and specific regions of gray matter volume loss, can also occur following cardiac surgery and may contribute to the physiological and behavioral deficits in cardiovascular autonomic responses. (hindawi.com)
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • ventricular
  • The most significant toxicity is cardiovascular and includes sinus tachycardia, high-degree atrioventricular heart block, prolongation of the PR interval, sinoatrial block and arrest, ventricular fibrillation, torsade de pointes. (inchem.org)
  • Therefore, reduced electrical stability of cardiomyocytes may cause the heart to enter a life-threatening state of ventricular arrhythmia as response to the natural release of catecholamines from nerve endings on the heart muscle and from the adrenal glands into the circulation. (wikipedia.org)
  • These two gene variants did not affect KCNQ1-KCNE1 currents when co-expressed in CHO cells, but produced larger currents than wild-type KCNE5 when coexpressed with Kv4.3-KChIP2, giving a possible mechanism for Brugada syndrome, i.e., increased ventricular Ito density. (wikipedia.org)
  • systemic circulation
  • Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. (hindawi.com)
  • This paper provides an overview of the gut microflora and its significance, a focus on the mechanisms employed by bacteria to gain access to the systemic circulation, and how critical illness creates a hostile environment in the gut and alters the microflora favoring the growth of pathogens that promote bacterial translocation. (hindawi.com)
  • synergistically
  • In conclusion, obesity in combination with presence of a parental history of diabetes may be particularly hazardous in men as these two factors were observed to synergistically increase the risk of developing type 2 diabetes in men. (jove.com)
  • The PGI2-IP axis along with the production of nitric oxide, acting together additively and potentially synergistically, are powerful and physiological negative regulators of platelet function and thereby blood clotting in humans. (wikipedia.org)
  • platelet
  • cAMP goes on to inhibit any undue platelet activation (in order to promote circulation) and also counteracts any increase in cytosolic calcium levels that would result from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). (wikipedia.org)
  • No evidence of platelet dysfunction or an increase in surgical bleeding after administration of inhaled epoprostenol has been found. (wikipedia.org)
  • IP(-/-) mice) exhibit increased tendency to thrombosis in response to experimentally-induced Endothelium, a result which appears to reflect, at least in part, the loss of IP's anti-platelet activity. (wikipedia.org)
  • mechanisms
  • In this chapter, we will describe mechanisms of brain damage undergoing cardiac surgery and focus on the interaction between cardiovascular changes and damage to specific brain regions. (hindawi.com)
  • While the exact mechanisms by which vascular dysfunction develops in CKD are incompletely understood, increased oxidative stress and a subsequent reduction in nitric oxide (NO) bioavailability are important contributors. (jove.com)
  • The physiological mechanisms underlying precapillary resistance is no longer considered to be a result of precapillary sphincters outside of the mesentery organ. (wikipedia.org)
  • bodily
  • The second major physiological stress, the HPA axis regulates the release of cortisol, which influences many bodily functions such as metabolic, psychological and immunological functions. (wikipedia.org)
  • Neuroscience research suggests that an NDE is a subjective phenomenon resulting from "disturbed bodily multisensory integration" that occurs during life-threatening events. (wikipedia.org)
  • cytosolic calcium
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • The mutation would compromise the stability of the Ryr2's closed state and increase its sensitivity to stimuli like luminal and cytosolic calcium. (wikipedia.org)
  • aorta
  • It is made of three cusps that close during diastole, preventing the flow of blood back into the left ventricle, and three sinuses that open during systole, allowing the flow of oxygenated blood into the aorta and into circulation. (nuclearcardiologyseminars.com)
  • Function of the aorta is improved in both hypertensive and normotensive subjects after the administration of diltiazem. (ahajournals.org)
  • Aorta functions not only as a conduit delivering blood to the tissues but also as an important modulator of the entire cardiovascular system, buffering the intermittent pulsatile output from the heart to provide steady flow to capillary beds. (ahajournals.org)
  • Previous studies by us 18 and others 19 have shown that nifedipine administration increases the distensibility of the aorta. (ahajournals.org)
  • biological
  • M. T. Bedran-de-Castro, V. M. A. Farah, and E. M. Krieger, "Influence of general anesthetics on baroreflex control of circulation," Brazilian Journal of Medical and Biological Research , vol. 23, no. 11, pp. 1185-1193, 1990. (hindawi.com)
  • Physiological or biological stress is an organism's response to a stressor such as an environmental condition. (wikipedia.org)
  • and -λογία, -logia), environmental physiology or physiological ecology is a biological discipline that studies the adaptation of an organism's physiology to environmental conditions. (wikipedia.org)
  • This phenomenon indicates that alternative splicing of TNNT2 pre-mRNA is under the control of a genetically built- in systemic biological clock. (wikipedia.org)
  • blood
  • We now know that the health of the endothelium and the blood vessels directly affects overall cardiovascular health. (thehealthguardian.com)
  • Increased cortisol usually acts to increase blood glucose, blood pressure, and surpasses lysosomal, and immunological activity. (wikipedia.org)
  • This phenomenon occurs due to dilation of the blood vessels, probably as a result of withdrawal of sympathetic nervous system tone. (wikipedia.org)
  • There are two types of capillaries: true capillaries, which branch from arterioles and provide exchange between tissue and the capillary blood, and metarterioles, found only in the mesenteric circulation. (wikipedia.org)
  • Tissue heart valves, in contrast, do not require the use of anticoagulant drugs due to the improved blood flow dynamics resulting in less red cell damage and hence less clot formation. (wikipedia.org)
  • During systole, when blood volume increases in the finger, the control system increases cuff pressure, too, until the excess blood volume is squeezed out. (wikipedia.org)
  • Interpretation
  • Connection to the cultural beliefs held by the individual, which seem to dictate some of the phenomena experienced in the NDE and particularly the later interpretation thereof. (wikipedia.org)
  • humans
  • Recent studies in animal models and humans have shown that atrial fibrillation induced by rapid atrial pacing itself produces shortening of the atrial effective refractory period (AERP) and reverses the normal physiological rate adaptation of refractoriness. (ahajournals.org)
  • Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. (jove.com)
  • nitric oxide
  • Acetylcholine binds to muscarinic receptors on the endothelial cell surface, leading to an increase of intracellular calcium and increased nitric oxide (NO) production. (jove.com)
  • patients
  • BA length, diameter and volume, and cerebral lesions were analysed by MRI/TOF-MR angiography or CT/CT angiography in 20 LOPD patients and 40 controls matching in age, sex- and cardiovascular risk factors. (springer.com)
  • The information deduced from the DanTest QHRV Arterial Vascular Assessment is invaluable for detecting risk factors and facilitating the identification of patients who may be at risk for cardiovascular events. (unovita.com)
  • However, the risk of brain injury after surgery is also increased in these patients [ 1 ]. (hindawi.com)
  • The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients. (jove.com)
  • Patients with CKD demonstrate both impaired FMD BA , and increased aPWV. (jove.com)
  • changes
  • In conclusion, the impact of changes in GABAergic input is very difficult to predict in these settings, emphasizing the need for experiments performed in conscious animals when aiming at determining the cardiovascular effects of compounds acting on GABAergic neurons. (hindawi.com)
  • Physiological changes can include changes in sympathetic activation or HPA activity, and immunological function. (wikipedia.org)
  • A detailed analysis of the phenomenon of delayed anti-anginal action revealed that PgI2-pretreatment protected against consequences of ischaemia, such as early morphological changes, early and late postocclusion and reperfusion arrhythmias due to coronary artery occlusion or ouabain intoxication. (wikipedia.org)
  • effects
  • The picture is however blurred in the presence of anaesthesia where both the concentration and type of anaesthetics can result in different effects on the cardiovascular system. (hindawi.com)
  • In addition to CNS effects GABAergic neurons also have a significant impact on the cardiovascular system. (hindawi.com)
  • Beyond the well over 200 adverse health effects linked to wheat consumption that now exist in the peer-reviewed biomedical literature, we hope to point out in the following article how cardiovascular health is better served by eliminating this uniquely problematic grain from the diet. (greenmedinfo.com)
  • Observe the physiological effects of the Valsalva maneuver and of rapid postural change. (adinstruments.com)
  • These protect them from the damaging effects of ice formation and falling rates of enzyme catalysis at low temperatures, and from enzyme denaturation and increased photorespiration at high temperatures. (wikipedia.org)
  • studies
  • 2 The advent of transgenic technology will undoubtedly result in increasing numbers of studies using murine preparations and this will require investigators to become adept at using this, as yet, poorly characterised model. (southalabama.edu)
  • Unfortunately, although the literature contains an increasing number of studies which employ mouse hearts, the fundamental characteristics of the preparation (e.g. pressure-volume and calcium-function relationships) have yet to be completely characterised. (southalabama.edu)
  • Moreover, studies in experimental animals have shown that diltiazem improves aortic elastic properties. (ahajournals.org)
  • atherosclerosis
  • Therefore, when the glycocalyx is disturbed, and/or excessive glycocalyx shedding there is induced -- presumably by dietary lectins like wheat lectin -- the resulting increased arterial wall shear stress and inflammation contributes to atherosclerosis. (greenmedinfo.com)
  • activity
  • Andreone and Giacoma (1989) speculated that newt migration into the ponds increases after rainy days, since after rainfall, newt activity is not limited by humidity. (wikipedia.org)
  • Decreased PSNS activity or increased SNS activity will result in reduced HRV. (wikipedia.org)
  • Less is known about the physiological inputs of the low frequency (LF) activity (0.04 to 0.15 Hz). (wikipedia.org)
  • subsequent
  • Since PGI2 is primarily produced in a nucleated endothelial cell, the COX inhibition by NSAID can be overcome with time by increased COX gene activation and subsequent production of more COX enzymes to catalyze the formation of PGI2. (wikipedia.org)