RanitidineFamotidineReceptor antagonistAntihistaminesReceptorsCytochrome P450 enzymesSecretionGastric acidInhibitTerfenadineSelectiveProton pump inhibMedicinesUlcersAgonistsInteractionsDecreaseInhibitsInhibitorsMuscarinicItraconazoleTabletsOverdoseInhibitionMedicationsTheophyllineTherapyGavisconInjectionsRefluxBlockersToxicityClinicalMedicationCitationIncludeAffectsCardiovascularPregnancyWeakWidelyDrugSimilarSide effectsEffectsDrugs called
Ranitidine11
- The development of longer-acting H2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidine, decreased the use of cimetidine, and though it is still used, cimetidine is no longer among the more widely used of the H2 receptor antagonists. (wikipedia.org)
- Oral treatment of gastric ulcers by the histamine H-2 receptor antagonists Ranitidine, cimetidine and Omoperazol. (uaeequafed.ae)
- The H2 receptor antagonist chemical ranitidine was removed from the market in the United States and Europe in 2020. (medlineplus.gov)
- Ranitidine , or cimetidine, is a medication that is prescribed to treat heartburn and other stomach problems. (thesaurus.net)
- Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. (pharmacycode.com)
- Histamine H2 receptor antagonists (cimetidine, ranitidine, and famotidine) decrease acid production in the stomach. (gastrovadodara.com)
- Offering you a complete choice of products which include enteric coated rabeprazole sodium and domperidone sr capsules, pantoprazole tablet ip 40 mg, bisacodyl gastro-resistant tablets ip 5 mg, cimetidine tablets ip 400 mg, ranitidine tablets ip 150 mg and cimetidine tablet 200mg. (stravahealthcare.in)
- The ability of cimetidine and ranitidine to augment cholinergic function is suggested in a number of literature reports and will be systematically explored in this project. (grantome.com)
- Experiments will be conducted to evaluate the effects of cimetidine and ranitidine on vagal activity, on responses to electrical stimulation of parasympathetic nerves, and on the direct actions of acetylcholine and related cholinergic stimulants. (grantome.com)
- While limited data exists in humans on the safety of histamine-type II (H-2) receptor antagonists, ranitidine (Zantac®) is the only H-2 antagonist, which has been studied specifically during pregnancy. (health.am)
- A study on the safety of cimetidine (Tagamet®) and ranitidine (Zantac®) suggests that pregnant women taking these drugs from the first trimester through their entire pregnancy have delivered normal babies. (health.am)
Famotidine4
- Other medications in this class include cimetidine, famotidine, and nizatidine. (thesaurus.net)
- Histamine antagonists, which keep the stomach from releasing acid, including Axid (nizatidine), Pepcid (famotidine), Tagamet (cimetidine) and Zantac (ranitadine). (thepaleogut.com)
- Other acid-suppressing drugs include the histamine H2-receptor antagonists (e.g., cimetidine or Tagamet and famotidine or Pepcid). (dramyknaperek.com)
- Tagamet, generically known as cimetidine, and Pepcid, generically known as famotidine, belong to a class of drugs called histamine receptor antagonists. (hellomotherhood.com)
Receptor antagonist10
- Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. (wikipedia.org)
- Cimetidine (Tagamet): An over-the-counter histamine H2 receptor antagonist that also shows very weak activity as an AR antagonist. (wikipedia.org)
- H2 receptor antagonist overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
- Below are names of three H2 receptor antagonist chemicals. (medlineplus.gov)
- H2 receptor antagonist medicines are available over-the-counter and by prescription. (medlineplus.gov)
- An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. (pharmacycode.com)
- PHARMACOLOGICAL ACTION: Cimetidine is a histamine H2-receptor antagonist. (pharmaceutical-medicines.com)
- Maitidine is a drug in the class of histamine H2 receptor antagonist. (drugstocker.com)
- Maitidine is a selective dose-dependent reversible histamine H2- receptor antagonist. (drugstocker.com)
- Cimetidine, a histamine H2-receptor antagonist, has been shown in several studies to protect against ouabain-induced arrhythmias and lethality. (grantome.com)
Antihistamines2
- Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists. (pharmacycode.com)
- Question 2 - All antihistamines (histamine antagonists) act on histamine H 2 receptors throughout the body. (miracleskills.com)
Receptors3
- Cimetidine is a competitive inhibitor of histamine at the histamine H2 receptors of the parietal cells, and thus is known as a histamine antagonist. (fsu.edu)
- It also inhibits competitively the other actions of histamine mediated by H2 -receptors. (drugstocker.com)
- From these data, it should be possible to determine for the first time the influence of endogenous brain histamine on digitalis toxicity and the class of receptors involved. (grantome.com)
Cytochrome P450 enzymes2
- Due to its non-selective inhibition of cytochrome P450 enzymes, cimetidine has numerous drug interactions. (wikipedia.org)
- Relative to enzalutamide and apalutamide, shows greater efficacy as an AR antagonist, improved activity against mutated AR variants in prostate cancer, little or no inhibition or induction of cytochrome P450 enzymes, and little or no central nervous system distribution. (wikipedia.org)
Secretion3
- Cimetidine is a potent inhibitor of tubular creatinine secretion. (wikipedia.org)
- These drugs are used to treat gastric and duodenal ulcers by inhibition of gastric acid secretion stimulated by food, insulin, histamine, caffeine, and pentagastrin. (fsu.edu)
- This study investigated whether an antireflux agent would remain effective after the decrease in acid secretion produced by a typical clinical dosage regimen of cimetidine (400 mg q.d.s., 7 days). (strath.ac.uk)
Gastric acid1
- Cimetidine Tablets are histamine H2 receptor antagonists that are prescribed for treatment of excessive gastric acid production in stomach. (actizapharmaceutical.com)
Inhibit2
- Cimetidine is used to inhibit stomach acid production and is used in the treatment of heartburn and peptic ulcers. (wikipedia.org)
- These findings are consistent with the hypothesis that H2-antagonists act through a cholinergic mechanism to inhibit indirect, sympathetically mediated components of digitalis toxicity. (grantome.com)
Terfenadine1
- Newer histamine antagonists, such as terfenadine and cimetidine do not show similar sedative side effects. (miracleskills.com)
Selective3
- Cimetidine can also interact with a number of psychoactive medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors, causing increased blood levels of these drugs and the potential of subsequent toxicity. (wikipedia.org)
- They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). (wikipedia.org)
- The role of brain histamine in digitalis toxicity will be explored by making intra-cerebroventricular injections of selective histamine receptor agonists, antagonists, and drugs that alter brain histamine levels, and observing the resultant effects upon the arrhythmogenic and lethal doses of ouabain. (grantome.com)
Proton pump inhib1
- There are two types of drugs that cut down on the production of acid in the stomach: histamine antagonists (H2 antagonists or H2 blockers) and proton pump inhibitors (PPIs). (webmd.com)
Medicines2
- H2 receptor antagonists are medicines that help decrease stomach acid. (medlineplus.gov)
- Other medicines may also contain H2 receptor antagonists. (medlineplus.gov)
Ulcers2
- Cimetidine treats acid reflux, stomach ulcers, heartburn, and other digestion problems caused by too much stomach acid. (rxwiki.com)
- Before giving Maitidine to patients with gastric ulcers, the possibility of malignancy should be excluded since Cimetidine may mask symptoms and delay diagnosis. (drugstocker.com)
Agonists1
- Inactive as either antagonists or agonists on the H2-receptor were psilocin, bufotenine, mescaline, different classes of anticonvulsant drugs, barbiturates and narcotic agonists and antagonists, as well as lithium chloride, chlordiazepc, ice, THC and procaine. (erowid.org)
Interactions4
- Examples of specific interactions include the following: Cimetidine affects the metabolism of methadone, sometimes resulting in higher blood levels and a higher incidence of side effects, and may interact with the antimalarial medication hydroxychloroquine. (wikipedia.org)
- citation needed] Clinically significant drug interactions with the CYP1A2 substrate theophylline, the CYP2C9 substrate tolbutamide, the CYP2D6 substrate desipramine, and the CYP3A4 substrate triazolam have all been demonstrated with cimetidine, and interactions with other substrates of these enzymes are likely as well. (wikipedia.org)
- Which histamine-2 antagonist is associated with the most drug interactions? (rnpedia.com)
- Cimetidine was the first histamine-2 antagonist developed and is associated with the most toxic drug interactions of the group. (rnpedia.com)
Decrease1
- Cimetidine may decrease the effects of CYP2D6 substrates that are prodrugs, such as codeine, tramadol, and tamoxifen. (wikipedia.org)
Inhibits2
- Cimetidine inhibits ALA synthase activity and hence may have some therapeutic value in preventing and treating acute porphyria attacks. (wikipedia.org)
- Cimetidine inhibits the renal excretion of metformin and procainamide, resulting in increased circulating levels of these drugs. (wikipedia.org)
Inhibitors1
- Nonsteroidal androgen synthesis inhibitors like ketoconazole can also be described as "NSAAs", although the term is usually reserved to describe AR antagonists. (wikipedia.org)
Muscarinic1
- Drotaverine is Cholingergic muscarinic antagonist. (heylook.fi)
Itraconazole1
- Cimetidine reduces the absorption of ketoconazole and itraconazole (which require a low pH). (wikipedia.org)
Tablets1
- Cimetidine Tablets get metabolized in liver producing cimetidine sulfoxide, hydroxycimetidine, and guanyl urea cimetidine as metabolites. (actizapharmaceutical.com)
Overdose1
- Cimetidine appears to be very safe in overdose, producing no symptoms even with massive overdoses (e.g., 20 g). (wikipedia.org)
Inhibition1
- 3 Hl-antagonists (including cyproheptadine) blocked the H2 receptor (as shown by inhibition of dimaprit). (erowid.org)
Medications1
- Like several other medications (e.g. erythromycin), cimetidine interferes with the body's metabolization of sildenafil, causing its strength and duration to increase (therefore also its side effects to be more likely and prominent). (wikipedia.org)
Theophylline1
- Cimetidine will increase the effects of theophylline. (rnpedia.com)
Therapy2
- The results suggest that the mechanism of action of Liquid Gaviscon is not compromised by concurrent H2-antagonist therapy. (strath.ac.uk)
- Therefore, Cimetidine therapy cannot be recommended in children unless in the judgement of the physician, anticipated benefits outweigh the potential risk. (drugstocker.com)
Gaviscon3
- The area under the gastric and fundal emptying curves demonstrated that Liquid Gaviscon (sodium alginate compound) had a significantly greater gastric residence than the meal, both during the control period and after cimetidine pre-treatment, and that the majority of the Gaviscon was located in the fundus. (strath.ac.uk)
- The distribution of Gaviscon into the fundus was not affected by cimetidine pre-treatment. (strath.ac.uk)
- Cimetidine pre-treatment slightly, but not significantly, increased the time for half the meal and the Gaviscon to empty from the stomach. (strath.ac.uk)
Injections1
- Intravenous injections of cimetidine should be given slowly and intravenous infusion is recommended in patients with cardiovascular impairment. (drugstocker.com)
Reflux1
- It is now becoming common practice to co-administer H2 receptor antagonists and anti-reflux agents in the treatment of reflux oesophagitis. (strath.ac.uk)
Blockers2
- Histamine stimulates acid production, especially after meals, so H2 blockers are best taken 30 minutes before meals. (webmd.com)
- They are also known as histamine H2-receptor antagonists but are also known as H2 blockers. (articlemela.com)
Toxicity2
- Cimetidine has a theoretical but unproven benefit in paracetamol toxicity. (wikipedia.org)
- Recent experiments demonstrate that efferent cholinergic tone is essential in order for cimetidine to exert protection against digitalis toxicity. (grantome.com)
Clinical2
- Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous double-blind clinical trials found it to be no more effective than a placebo. (wikipedia.org)
- There is no evidence of clinical use in babies and Cimetidine should therefore not be given to infants under one year of age. (drugstocker.com)
Medication1
- Cimetidine is both an over-the-counter and a prescription medication. (rxwiki.com)
Citation2
- citation needed] Cimetidine was developed in 1971 and came into commercial use in 1977. (wikipedia.org)
- citation needed] Following administration of cimetidine, the elimination half-life and area-under-curve of zolmitriptan and its active metabolites were roughly doubled. (wikipedia.org)
Include1
- Common side effects of cimetidine include headaches, dizziness, and diarrhea. (rxwiki.com)
Affects1
- Do not drive or operate heavy machinery until you know how cimetidine affects you. (rxwiki.com)
Cardiovascular1
- Histamine is located near cardiovascular control centers in the CNS and exerts modulatory effects on cardiac function mediated through the sympathetic nerves. (grantome.com)
Pregnancy1
- It was therefore recommending that women who used cimetidine should stay away from it uses during pregnancy, because it is a teratogenic agent and could cause harm or impairment to their offspring's. (imsuinfo.com)
Weak1
- Cimetidine has a weak anti-androgenic effect and gynaecomastia and impotence have also occasionally occurred in men, receiving relatively high doses for conditions such as the Zollinger-Ellison syndrome. (drugstocker.com)
Widely1
- Question 3 - One of the compounds in question 2, Terfenidine, was a widely used anti-histamine until its withdrawal from the market in the 1990's, owing to its interaction with the hERG receptor. (miracleskills.com)
Drug2
- Cimetidine was approved in the United Kingdom in 1976, and was approved in the United States by the Food and Drug Administration for prescriptions in 1979. (wikipedia.org)
- Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109035/6/cimetidine. (unboundmedicine.com)
Similar1
- Similar to enzalutamide and apalutamide, but with increased efficacy as an AR antagonist, little or no central nervous system distribution, and no induction of seizures in animals. (wikipedia.org)
Side effects1
- Serious side effects have been reported with cimetidine. (rxwiki.com)
Effects2
- Because of its hormonal effects, cimetidine rarely may cause sexual dysfunction including loss of libido and erectile dysfunction and gynecomastia (0.1-0.2%) in males during long-term treatment. (wikipedia.org)
- The concern of this research was the Behovioural teratogenic effects of cimetidine on the offspring's of Albino Rats. (imsuinfo.com)
Drugs called1
- Cimetidine belongs to a group of drugs called Histamine H2 Receptor Antagonists. (rxwiki.com)