Ciliary neurotrophic factor receptor alpha subunit. Medical search. Frequent questions

The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. (novusbio.com)
Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. (novusbio.com)
Our studies also show that these NPs have differential requirements for LIF and ciliary neurotrophic factor (CNTF) and for epidermal growth factor (EGF), fibroblast growth factor (FGF-2) and platelet-derived growth factor (PDGF) for their propagation in vitro. (karger.com)
Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene . (wikidoc.org)
[6] Like CNTF it is a neurotrophic factor , and may stimulate nerve cells to survive. (wikidoc.org)
NT-501 is a product being developed by Neurotech that consists of encapsulated human cells genetically modified to secrete ciliary neurotrophic factor (CNTF). (wikidoc.org)
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27. (antibodies-online.cn)
Viral mediated expression of a growth-promoting factor, ciliary neurotrophic factor (CNTF), in retinal ganglion cells (RGCs) promotes axon regeneration without altering the lesion size or the degree of lesion-filling GFAP+ cells. (bvsalud.org)
Lastly, we performed RNA-sequencing on the injured optic nerve and reveal that CNTF overexpression in RGCs results in significant changes in the expression of distinct genes, including those that encode chemokines, growth factor receptors, and immune cell modulators. (bvsalud.org)

The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. (wikipedia.org)
It binds preferentially to ephA receptors ( EPH FAMILY RECEPTORS ) with the exception of the EPHA1 RECEPTOR . (nih.gov)
It binds to the common neurotrophin receptor p75 NTR and the TrkB receptor tyrosine kinase that are expressed by subsets of developing neurons, including the sensory neurons of the nodose ganglion ( Reichardt, 2006 ). (silverchair.com)
TGF-α is related to EGF and binds to the EGF receptor, whereas TGF-β is structurally distinct from TGF-α. (antibodies-online.cn)
The S1 subunit contains a receptor binding domain or RBD that binds with the specific receptors, while the S2 subunit helps membrane fusion. (openaccesspub.org)

CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. (novusbio.com)
The main chain fold conforms to the four alpha-helix bundle topology previously observed for several members of the hematopoietic cytokine family. (ox.ac.uk)
Interleukin 11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1 alpha -stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive murine plasmacytoma cell line T1165. (rndsystems.com)
It has been recognized to be a member of the alpha-helical cytokine family. (thermofisher.com)
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. (thermofisher.com)
They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. (antibodies-online.cn)

Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues. (thermofisher.com)
The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. (thermofisher.com)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes . (wikidoc.org)
Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. (wikidoc.org)
In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)
GxxxA design at the correct position in TM1 of 1 imparts a new function to the 1 subunit that's perhaps not seen in the wild type protein. (plasignaling.com)
The SARS-CoV-2 spike protein is a significant type 1 trans-membrane protein with two subunits, S1 and S2. (openaccesspub.org)
The crucial step of receptor binding depends on the closed and open conformations of the S-Protein ectodomain trimer 10 , 11 . (openaccesspub.org)
NICD1, which not is a skeletal focus, can be controlled by docking to the hormone-bound addition 1-alpha( HIF1A) which serves in the protein when amine homodimers are progressive. (evakoch.com)

IL-11 exerts its biological activities through binding to a specific high-affinity receptor having an apparent molecular mass of 150 kDa. (rndsystems.com)
Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250kDa each. (embl.de)
Thus, an understanding of the biology of the ciliary epithelium, at the cellular and molecular levels, is essential in our knowledge of how intraocular pressure is regulated in normal and disease processes. (yale.edu)

Finally, we have studied the role of nanoarchitecture of ephrin ligands in Eph receptor activation. (5dok.org)

The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6. (thermofisher.com)

The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. (novusbio.com)
This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage. (wikipedia.org)
This involves exploring the signal transduction mechanisms that are activated when signalling molecules such as neuregulin-1 (ARIA, beta-heregulin 1), or agrin active ErbB or MuSK receptors in the membrane of muscle respectively. (edu.au)

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. (thermofisher.com)

In summary, the present data suggest that deficits of BDNF levels and signaling through ERK1/2 and alpha-CaMKII might contribute to cognitive and neuroplastic defects associated with prenatal exposure to cannabinoids. (researchgate.net)
We show that although NF-κB signalling is required for BDNF-promoted neurite growth from both foetal and postnatal mouse sensory neurons, there is a developmental switch between these stages in the NF-κB activation mechanism and the phosphorylation status of the p65 NF-κB subunit required for neurite growth. (silverchair.com)
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted signalling proteins that plays a crucial role in regulating both neuronal survival and the growth of neural processes in the developing nervous system ( Bibel and Barde,2001 ). (silverchair.com)

A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored, cell-surface heparan sulfate proteoglycans that may play a role in CELL GROWTH PROCESSES and CELL DIFFERENTIATION by modulating ligand-receptor interactions. (bvsalud.org)
A model for receptor binding based on the structure of the GH ligand-receptor complex requires additional, novel features to account for these data. (ox.ac.uk)

This receptor and its cognate ligand support the survival of neurons. (wikipedia.org)
It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks . (wikidoc.org)
Herein, we investigate how inflammatory mediators, including microglia, interleukin 1 beta (IL1β), and signaling through interleukin 1 receptor type 1 (IL-1R1), influence the survival of retinal neurons in response to excitotoxic damage. (biomedcentral.com)

The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. (ox.ac.uk)
The structure of murine leukemia inhibitory factor (LIF) has been determined by X-ray crystallography at 2.0 A resolution. (ox.ac.uk)
We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)

This receptor is most closely related to the interleukin-6 receptor. (wikipedia.org)
Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor . (wikidoc.org)

Sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved surface character. (ox.ac.uk)

Analysis of an in-house oblique enzyme-linked immunosorbent assay of feline panleukopenia VP2 subunit antigen compared to hemagglutination inhibition assay to watch tiger antibody ranges by Bayesian strategy Background: Feline panleukopenia virus (FPV) is an etiologic pathogen of feline panleukopenia that infects all members of Felidae together with tigers (Panthera tigris). (elisareagents.com)

We applied a differential network method (Regulatory Impact Factors) whose aim is to use patterns of differential co-expression to detect regulatory molecules transcriptionally rewired between the groups. (1library.net)

Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding. (thermofisher.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human Epidermal Growth Factor Receptor (EGFR) in samples from serum, plasma, tissue homogenates or other biological fluids. (bestpractice-life.pl)
Description: Quantitative sandwich ELISA kit for measuring Human epidermal growth factor receptor, EGFR in samples from serum, plasma, tissue homogenates. (bestpractice-life.pl)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epidermal Growth Factor Receptor (EGFR) in serum, plasma, tissue homogenates and other biological fluids. (bestpractice-life.pl)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Epidermal Growth Factor Receptor (EGFR) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (bestpractice-life.pl)

However, before we can gain a proper understanding of their role in mice that are missing these ion channel subunits, we need to know their developmental expression profile in the developing mouse. (edu.au)

Because the progesterone receptor can localise to avian mitochondria, our data continue to point to muscle mitochondrial metabolism as an important component of the phenotypic expression of variation in broiler FE. (1library.net)

Description: A sandwich ELISA kit for detection of Tumor Necrosis Factor Alpha from Pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)

This matches the SF1 [GeneSymbol=SF1] transcription factor binding site V$SF1_Q6 (v7.4 TRANSFAC). (gsea-msigdb.org)
The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
caused by systemic administration of kainic acid, it has been shown that convulsive activity correlates with indicators of oxidative stress, apoptosis and expression of the AP-1 transcription factor in the rat hippocampus. (ihna.ru)

An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. (umassmed.edu)
It will also have links through our USA collaborators to understanding the role of such growth factors in the proliferation tumor cells within the brain (U87 a nasty brain tumor). (edu.au)
In particular, this project is aimed at looking at the signalling pathways that are activated when these growth factors activate their receptors, which are on these stem and tumor cells. (edu.au)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Tumor Necrosis Factor Alpha (TNFa) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (agctsequencing.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Pig Tumor Necrosis Factor Alpha (TNFa) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)

The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)

So far, the soluble IL-6 receptor is unique in acting as an agonist together with its ligand. (thermofisher.com)
It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)

Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)

The expression levels of LPL (lipoprotein lipase), HSL (Hormone-sensitive lipase), FAS (fatty acid synthase), and PPARα/PPARγ (peroxisome proliferator-activated receptor alpha/gamma) were significantly changed in the sheep preadipocytes during differentiation for 7 days. (academic-accelerator.com)
ATP synthase F1 subunit beta [So. (gsea-msigdb.org)
ATP synthase F1 subunit gamma [S. (gsea-msigdb.org)

This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)

05) expression of peroxisome proliferator-activated receptor α (PPARα) and expressions for Ppara and hormone sensitive lipase (HSL) in the liver of IUGR-C rats than the IUGR rats. (academic-accelerator.com)
Furthermore, a robust reduction of total and phospho-alpha-CaMKII was found in the hippocampus of rats prenatally exposed to WIN 55,212-2. (researchgate.net)

However, a subsequent study challenged the significance with this residue in B subunit induced modulation ofCaV1. (plasignaling.com)

download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)

The ciliary epithelium, a bilayer of secretory neuroepithelial cells, is the site of synthesis of aqueous humor (inflow system), and it regulates its secretion by the coordinated action of a complex transport system that involves ion channels and active transporters. (yale.edu)
The ciliary epithelium, a bilayer of secretory neuroepithelial cells, is the site of synthesis of aqueous humor (inflow system), and regulates its secretion by the coordinated action of a complex transport system involving ion channels and active ion secretion, from the stromal to the aqueous-humor surface, followed by osmotic water movement. (yale.edu)
mediator complex subunit 26 [Sou. (gsea-msigdb.org)

Pluripotent neurotrophic factor that plays a role in neuronal differentiation and survival. (plurisomes.com)

Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. (2medicalcare.com)

Preliminary evidence in rodent models of peripheral neuropathy suggest that DCA-induced neurotoxicity may be mitigated by naturally occurring antioxidants and by a specific class of muscarinic receptor antagonists. (srcinhibitors.com)

Finally, we show that LIF increases the expression of the core transcription factors: Klf4, Fbx15, Nanog, Sox2 and c-Myc. (karger.com)

In addition to temporal changes in growth factor presentation, mechanical stiffness of tissues is also dynamically altered over time. (5dok.org)

IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). (rndsystems.com)

Of these, LIF shows closest structural homology to granulocyte colony-stimulating factor and growth hormone (GH). (ox.ac.uk)

Studies show that replicative senescence or cellular senescence is induced by intrinsic or extrinsic environmental factors [ 11 ]. (hindawi.com)
The shortening of telomeres constitutes an intrinsic factor, whereas DNA damage is considered an extrinsic factor. (hindawi.com)

Using the interaction of recombinant hCD40 ligand with HEK-Blue sensor cells expressing the CD40 receptor as example, we show that such an assay can be developed based on BCIP/NBT (5-bromo-4-chloro-3-indolyl phosphate/nitroblue tetrazolium chloride) as substrate. (envite.org)

Analysis of the biological function and receptor specificity of a series of human-mouse LIF chimeras implicate two regions of receptor interaction that are located in the fourth helix and the preceding loop. (ox.ac.uk)

Upon an electrochemical switch, growth factor presentation was reversed, which initiated cellular differentiation along the neuronal lineages. (5dok.org)

Below is a small sample of the many proteins, growth factors, transcription factors it contains. (plurisomes.com)
The roles of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), as well as insulin. (edu.au)

CNTF9

Binds5

Cytokine6

Protein11

Molecular3

Ligands1

Gp1301

Membrane3

Encodes1

BDNF3

Ligand-receptor2

Neurons3

Leukemia Inhibi3

Interleukin2

Oncostatin1

Antigen1

Molecules1

Extracellular1

Epidermal4

Mice1

Mitochondrial1

ELISA Kit1

Transcription factor3

Tumor5

Glycoprotein1

Agonist2

Modulators1

Synthase3

Glutamate1

Rats2

Modulation1

Enzymes1

Complex3

Survival1

Nerve growth1

Antioxidants1

Expression1

Tissues1

Inhibitory1

Hormone1

Intrinsic2

Assay1

Biological1

Cellular1

Growth2