CNTFRecombinant humanGlial cell-lNeuronalClinical trialGenetically modifiedRetinitis pigmentosaReceptorEscherichia ColiSurvivalProteinNeurogenesisGeneSubstancesLeukemiaAdultPatientsReductionPrimaryCognitiveVascularIntrinsicAnti-inflammatoryDifferentiationTranscription factorsTreatmentExtracellularRegulationSuggestsEarlyLeadsReleaseResults
CNTF21
- Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. (wikipedia.org)
- Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. (wikipedia.org)
- NT-501 is a product being developed by Neurotech that consists of encapsulated human cells genetically modified to secrete ciliary neurotrophic factor (CNTF). (wikipedia.org)
- Ciliary neurotrophic factor (CNTF) is important for neuronal and muscle development, and genetic variation in the CNTF gene has been associated with muscle strength. (umd.edu)
- Ciliary neurotrophic factor (CNTF) is produced by astrocytes and promotes neurogenesis and neuroprotection. (etsu.edu)
- Evidence Central , evidence.unboundmedicine.com/evidence/view/EBMG/455451/all/Ciliary_neurotrophic_factor__CNTF__for_amyotrophic_lateral_sclerosis_motor_neuron_disease. (unboundmedicine.com)
- Such designations should allow the company to accelerate clinical development of its continuous, long-term release formulation of the therapeutic protein Ciliary Neurotrophic Factor (CNTF), designed to be released into the vitreous body from a proprietary Encapsulated Cell Technology (ECT) device. (medgadget.com)
- NT-501 is designed to continually deliver a low, safe and therapeutic dose of CNTF, a well-established neurotrophic factor, into the back of the eye. (medgadget.com)
- The team has genetically modified human cells to produce a substance called 'ciliary neurotrophic factor' (CNTF). (fightforsight.org.uk)
- Dr. Kokoeva was intrigued by the observation that obese rodents and humans treated with the neuropeptide ciliary neurotrophic factor (CNTF) show a reduction in body weight that is sustained well beyond termination of treatment, a phenomenon not seen with any other weight lowering drug. (mcgill.ca)
- The IL-6 family of cytokines includes IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, and IL-11. (bl.uk)
- Our studies also show that these NPs have differential requirements for LIF and ciliary neurotrophic factor (CNTF) and for epidermal growth factor (EGF), fibroblast growth factor (FGF-2) and platelet-derived growth factor (PDGF) for their propagation in vitro. (karger.com)
- To create the different types of astrocytes used in the experiment, researchers isolated human glial precursor cells, first identified by Margot Mayer-Proschel, Ph.D. , associate professor of Genetics at the University of Rochester Medical Center, and exposed these precursor cells to two different signaling molecules used to instruct different astrocytic cell fate - BMP (bone morphogenetic protein) or CNTF (ciliary neurotrophic factor). (rochester.edu)
- IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. (cellsignal.com)
- Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
- Purpose: To assess the safety and efficacy of a ciliary neurotrophic factor (CNTF) intraocular implant on neuroprotection and neuroenhancement in glaucoma.Design: Open-label, prospective, phase I clinical trial.Participants: A total of 11 participants were diagnosed with primary open-angle glaucoma (POAG). (stanford.edu)
- We have compared the immunological, biochemical, and biological properties of three previously described cholinergic factors, cholinergic differentiation factor/Leukemia inhibitory factor (CDF/UF), ciliary neurotrophic factor (CNTF), and membrane-associatedneurotransmitter-inducing substance (MANS). (caltech.edu)
- CDF/U F differs from CNTF and MANS in that it does not have any ciliary neurotrophic activity. (caltech.edu)
- Thus, at least two distinct factors, CNTF and CDF/LlF, exist and have distinct but overlapping functions. (caltech.edu)
- We have investigated the possible role of CDF (cholinergic differentiation factor from skeletal muscle), CDF/LIF CNTF, and MANS in mediating the target directed noradrenergic to cholinergic switch that characterizes sweat gland innervation. (caltech.edu)
- The possible relationship between CNTF, LlF and sweat gland cholinergic differentiation factor(s) is discussed. (caltech.edu)
Recombinant human1
- Ciliary Neurotrophic Factor Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids and having a molecular mass of 25 kDa. (cellsystems.eu)
Glial cell-l1
- 2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
Neuronal1
- In the neonate, such injuries are even more harmful, since surgical treatment is limited and neuronal loss is particularly enhanced by neurotrophic factors deprivation. (hindawi.com)
Clinical trial1
- The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia. (emmes.com)
Genetically modified1
- ECT implants consist of cells that have been genetically modified to produce a desired therapeutic factor that are encapsulated in a section of semi-permeable hollow fiber membrane. (medgadget.com)
Retinitis pigmentosa1
- neurotrophic factors for the treatment of retinal degeneration in Retinitis Pigmentosa (RP), Geographic Atrophy (serious condition associated with the Dry form of Age-related Macular Degeneration), Glaucoma, Retinal Vein Occlusion and others. (medgadget.com)
Receptor1
- Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. (wikipedia.org)
Escherichia Coli1
- Optimized DNA sequence encoding Rat Ciliary Neurotrophic Factor mature chain was expressed in Escherichia Coli. (reprokine.com)
Survival2
- It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. (wikipedia.org)
- Pool-specific regulation of motor neuron survival by neurotrophic support. (nih.gov)
Protein4
- The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. (wikipedia.org)
- Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. (wikipedia.org)
- For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
- BACKGROUND: C1q/tumor necrosis factor-related protein 5 (CTRP5) has been reported to be a crucial regulator in cardiac ischemia/reperfusion (I/R) injury. (bvsalud.org)
Neurogenesis1
- Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
Gene2
- A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. (wikipedia.org)
- The transforming gene products of these viruses, such as the E1A oncoproteins of adenovirus 5, led to the identification of cellular factor p60, known as cyclin A. This research was the first demonstration of a physical link between cellular transformation and the cell cycle, thereby paving the way for the melding of these two areas of research. (newswise.com)
Substances1
- On the contrary, reconnection of transected stumps by using biocompatible sealants may significantly facilitate the process, as well as taking the advantage of employing the adhesive as scaffold to engraft stem cells, as well as neurotrophic substances, to the injury site. (hindawi.com)
Leukemia1
- We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
Adult2
- Adult ciliary neurotrophic factor receptors help maintain facial motor neuron choline acetyltransferase expression in vivo following nerve crush. (nih.gov)
- We also have demonstrated that cells proliferate on an ongoing basis in the adult hypothalamus, even in the absence of external cues such as growth factor administration. (mcgill.ca)
Patients1
- Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices. (nih.gov)
Reduction1
- Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. (pbrc.edu)
Primary1
- Phase I NT-501 Ciliary Neurotrophic Factor Implant Trial for Primary Open-Angle Glaucoma: Safety, Neuroprotection, and Neuroenhancement. (stanford.edu)
Cognitive1
- Since schizophrenia is considered a neurodevelopmental disorder, early intervention with neurotrophic factors may be more effective in ameliorating the cognitive deficits and psychopathological symptoms associated with this pathology. (benthamscience.com)
Vascular1
- anti-angiogenic factors for the treatment of vascular proliferation in Diabetic Retinopathy and the Wet form of AMD, and for the treatment of abnormal vascular permeability for various forms of Macular Edema. (medgadget.com)
Intrinsic2
- Studies show that replicative senescence or cellular senescence is induced by intrinsic or extrinsic environmental factors [ 11 ]. (hindawi.com)
- The shortening of telomeres constitutes an intrinsic factor, whereas DNA damage is considered an extrinsic factor. (hindawi.com)
Anti-inflammatory2
- A number of proteins have been discovered in the field of ophthalmology that possess powerful neurotrophic, anti-angiogenic and anti-inflammatory properties. (medgadget.com)
- Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6. (dadamo.com)
Differentiation2
- Expression of the differentiation activity in footpads occurs at a time period appropriate for a role for this factor(s) in vivo. (caltech.edu)
- Comparison with other differentiation molecules suggests that it is distinct from MANS, CDF and the heparin binding cholinergic factor. (caltech.edu)
Transcription factors1
- Finally, we show that LIF increases the expression of the core transcription factors: Klf4, Fbx15, Nanog, Sox2 and c-Myc. (karger.com)
Treatment1
- Current treatment is focussed on lowering eye pressure, which is a risk factor for the condition, with eye drops or surgery to improve drainage from the eye. (fightforsight.org.uk)
Extracellular1
- These MSC influences can range from relatively rare activities that require cell contact, such as mitochondrial transfer and cell fusion, to relatively common paracrine MSC actions through extracellular microvesicles or secreted factors. (biomedcentral.com)
Regulation2
- Studies suggest that this pathway also has a role in a part of the nervous system known as the sympathetic nervous system, specifically in the regulation of sweating in response to temperature changes and other factors. (medlineplus.gov)
- Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. (biomedcentral.com)
Suggests1
- Numerous evidence produced over the years suggests a deficit in a wide spectrum of neurotrophic factors in schizophrenia. (benthamscience.com)
Early1
- IL-6 is one of the important pro-inflammatory factors, especially in early phage of inflammation. (dadamo.com)
Leads1
- Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. (reprocell.com)
Release1
- By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. (stanford.edu)
Results1
- In this context, results from initial clinical trials with neurotrophic factors and their future potential to improve cognition and psychosocial functioning in schizophrenia are discussed. (benthamscience.com)