Germ-Line MutationLi-Fraumeni SyndromeMutation, MissenseMutationChromosomesDNA Mutational AnalysisPedigreeChromosome MappingHeterozygoteGenes, p53Polymerase Chain ReactionMolecular Sequence DataBase SequenceGenetic Predisposition to DiseasePoint MutationMicrosatellite RepeatsX ChromosomeGenotypeChromosome BandingChromosome AberrationsBreast NeoplasmsSex ChromosomesChromosomes, Human, Pair 1Cell LineGerm CellsChromosomes, HumanChromosomes, BacterialChromosome SegregationChromosome DeletionChromosomes, Human, Pair 11Chromosomes, Human, Pair 17Chromosomes, Human, Pair 7Chromosomes, Human, Pair 6Chromosomes, Human, Pair 9Chromosomes, Human, Pair 21Chromosomes, PlantFrameshift MutationChromosomes, FungalChromosomes, Human, 6-12 and XChromosomes, Human, Pair 2Chromosomes, Human, Pair 16Chromosomes, MammalianNeoplasms, Germ Cell and EmbryonalChromosomes, Human, Pair 22Chromosomes, Human, Pair 13Chromosome PairingGenetic LinkageChromosomes, Human, Pair 10KaryotypingChromosomes, Human, Pair 19Chromosomes, Human, XAllelesChromosomes, Human, YChromosomes, Human, Pair 8Chromosomes, Human, Pair 4Amino Acid SequenceChromosome DisordersChromosomes, Human, Pair 12PhenotypeChromosomes, Artificial, BacterialIn Situ Hybridization, FluorescenceChromosome PaintingCell Line, TumorChromosomes, Human, 1-3Chromosomes, Human, Pair 5Chromosomes, Human, Pair 15MeiosisChromosomes, Human, Pair 14SpermatogenesisChromosomes, Human, Pair 18Genetic MarkersChromosomes, Human, Pair 20ExonsChromosomes, Human, 16-18Chromosomes, Artificial, YeastCrosses, GeneticRecombination, GeneticSequence Analysis, DNATestisCloning, MolecularChromosomes, Human, 13-15Chromosome BreakageDNADrosophila melanogasterChromosomes, Human, 21-22 and YChromosome InversionDNA-Binding ProteinsHomozygoteRing ChromosomesX Chromosome InactivationDNA PrimersRNA, MessengerMitosisSpermatozoaChromosome PositioningModels, GeneticGonadsChromosomes, Human, 4-5Caenorhabditis elegansMutation Rate