Cholesterol association of apolipoprotein apolipoprotein e2. Medical search. Frequent questions

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
Several major APOE isoforms can be distinguished: E2, E3, and E4. (dovepress.com)
Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)
The results presented demonstrate that the association between ApoE gene and CVD may be modulated by the presence of MetS, with an increased CV burden observed among E4 allele carriers with the syndrome. (biomedcentral.com)
The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
Background Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. (muni.cz)
We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. (muni.cz)
Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world. (medscape.com)
E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (PubMed:25122793, PubMed:29695434, PubMed:24838241). (proteopedia.org)
The interaction between E2 and host apolipoprotein E/APOE allows the proper assembly, maturation and infectivity of the viral particles (PubMed:25122793, PubMed:29695434). (proteopedia.org)
Independent associations of TOMM40 and APOE variants with body mass index. (sdu.dk)
Apolipoprotein E (APOE) is a lipoprotein found primarily in chylomicrons and intermediate-density lipoprotein (IDL). (docsopinion.com)
APOE transports lipoproteins, fat-soluble vitamins, and cholesterol. (docsopinion.com)
Notably, the gene APOE identified by the 2017-based analysis has been implicated to have an association with ASD in a recent study (2018) with DNA methylation analysis. (silverchair.com)
Apolipoprotein E (ApoE) is expressed as Molecular Biology of Neurodegenerative Diseases. (web.app)
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. (web.app)
Apolipoprotein E spielt im Katabolismus von Chylomikronen, IDL und VLDL-Remnants wie auch von ApoE-reichem HDL eine wichtige Rolle. (web.app)
Apolipoprotein E (APOE) plays an important role in cholesterol transport and genetic variants in APOE have been linked to the risk of Alzheimer's disease. (web.app)
2020-08-16 · The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (web.app)
APOE / Apolipoprotein E Protein LS-G39871 is a Recombinant Human APOE / Apolipoprotein E produced in Human Cells Lys19-His317 with 6His, C-terminus tag(s). (web.app)
The purpose of the present study was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low density lipoprotein (LDL) receptor (LDLr-/-) and apoE (apoE-/-) knockout mice. (eurekamag.com)
ApoE-/- LCAT-/- mice fed the atherogenic diet, compared with apoE-/- mice, had higher concentrations of plasma FC, EC, apoB lipoprotein cholesterol, and phospholipid, and significantly more aortic FC (149 +/- 62 versus 109 +/- 33 mg/g) and EC (101 +/- 23 versus 69 +/- 20 mg/g) than did the apoE-/- mice. (eurekamag.com)
We conclude that LCAT deficiency in LDLr-/- and apoE-/- mice fed an atherogenic diet resulted in increased aortic cholesterol deposition, likely due to a reduction in plasma HDL, an increased saturation of cholesteryl esters in apoB lipoproteins and, in the apoE-/- background, an increased plasma concentration of apoB lipoproteins. (eurekamag.com)
Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE e2/e3/e4) genes were studied in relation to LDL particle size distribution in 377 healthy, middle-aged men. (ox.ac.uk)
This test determines a person's genetic risk for heart disease associated with the commonly studied gene called apoE, which is involved in the metabolism of cholesterol and triglycerides (fats in the blood). (news-medical.net)
ApoE is a protein that affects how efficiently cholesterol is cleared from cells and taken to the liver for excretion from the body. (news-medical.net)
Six possible apoE genotypes exist: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4. (news-medical.net)
For participants with the APOE E3/E3 genotype, LDL-cholesterol ( P = 0.02) increased in the NGI group (n = 7), and TAG ( P = 0.03) and TAG:HDL-cholesterol ( P = 0.04) increased in the HGI group (n = 10), following consumption of whole grain wheat sourdough compared to white bread. (biomedcentral.com)
however, it significantly increased LDL-cholesterol, TAG and TAG:HDL-cholesterol in participants with the APOE E3/E3 genotype. (biomedcentral.com)

Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. (medscape.com)
The distribution of apolipoprotein E gene polymorphism in Chinese civil aircrews, and a possible risk factor to their overweight and dyslipidemia is cumulative flight time. (cdc.gov)
The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. (web.app)

In fact, epidemiological studies suggested that E4 allele carriers were particularly predisposed to develop higher cholesterol levels and higher coronary artery disease (CAD) mortality, meanwhile others studies concluded E3 and E4 alellles presences were associated with higher risk in men. (biomedcentral.com)
Yet, APOE4 allele revealed an association with retinopathy. (muni.cz)
1997) No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. (web.app)
1-3 Although individuals carrying the ε4 allele have higher and those carrying the Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. (web.app)
The strongest genetic risk factor is the presence of the epsilon4 allele of the apolipoprotein E gene, which encodes a protein that has a crucial role in cholesterol metabolism. (lidsen.com)

Apolipoprotein B (apoB ) is a major component of atherogenic lipoprotein particles such as LDL, VLDL and Lp(a). (docsopinion.com)
Several studies suggest that apoB is a better predictor of heart disease risk than LDL cholesterol ( 4 ). (docsopinion.com)
Furthermore, it has been shown that apoB may be elevated despite normal or low concentrations of LDL cholesterol ( 5 ). (docsopinion.com)
2012). Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. (gianlucatognon.com)
After 16 weeks of atherogenic diet (0.1% cholesterol, 10% calories from palm oil) consumption, LDLr-/- LCAT-/- double knockout mice, compared with LDLr-/- mice, had similar plasma concentrations of free (FC), esterified (EC), and apoB lipoprotein cholesterol, increased plasma concentrations of phospholipid and triglyceride, decreased HDL cholesterol, and 2-fold more aortic FC (142 +/- 28 versus 61 +/- 20 mg/g protein) and EC (102 +/- 27 versus 61+/- 27 mg/g). (eurekamag.com)

Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
The major alleles are called e2, e3, and e4. (docsopinion.com)
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham Off spring Study. (web.app)

Usefulness of childhood non-high density lipoprotein cholesterol levels versus other lipoprotein measures in predicting adult subclinical atherosclerosis: the Bogalusa Heart Study. (jamanetwork.com)
Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. (uchicago.edu)
Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis. (uchicago.edu)
4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. (uchicago.edu)

Finding genes and variants for lipid levels after genome-wide association analysis. (medscape.com)
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. (medscape.com)
Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children. (cdc.gov)
Genome-wide association study identifies variants screening. (who.int)

Mahley RW, Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal metabolism. (medscape.com)
The aim of this study was to investigate alterations in cholesterol metabolism during the perimenopausal transition that could increase the long-term risk of neurodegenerative disease in women, particularly Alzheimer's disease. (gremjournal.com)
Brain and serum cholesterol metabolism during chronological and endocrine aging were evaluated in rat models recapitulating the main characteristics of human perimenopause. (gremjournal.com)
Analysis of brain proteins involved in cholesterol metabolism showed export and clearance defects during endocrine aging and a decline in mobilization during post-menopausal chronological aging. (gremjournal.com)
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (web.app)
Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets. (uchicago.edu)

Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients. (cdc.gov)
Apolipoprotein C-III (apo C-III) is found on the surface of triglyceride-rich lipoproteins ( 6 ). (docsopinion.com)
Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream. (web.app)
Apolipoprotein E is the recognition site for receptors involved in the clearance of remnants of very low density lipoproteins and chylomicrons (summary by Blum, 2016). (web.app)
Human plasma lipoproteins regulate apolipoprotein E secretion from a post-Golgi compartment. (uchicago.edu)

Goel and colleagues [ 8 ] documented that in Indians the risk factors for CAD occur at much lower levels of total cholesterol and low-density lipoprotein cholesterol than other populations. (hindawi.com)
Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women. (jamanetwork.com)
In hypothyroid patients, despite the reduced activity of HMG-CoA reductase, there is often an increase in the serum total cholesterol concentration, mainly due to raised levels of serum LDL cholesterol and intermediate density lipoprotein (IDL) cholesterol 4,12 . (hormones.gr)
Whole grains have the potential to reduce CVD risk through improvements in circulating lipids including decreased total-cholesterol, LDL-cholesterol and triacylglycerols (TAG), and increased HDL-cholesterol [ 11 ]. (biomedcentral.com)
In that trial, rats who were fed KO showed weight loss and a drop in LDL "bad" cholesterol, total cholesterol and triglyceride levels. (healthyfellow.com)
A starting KO dosage of 500 mg daily significantly reduced blood sugar levels, LDL, total cholesterol and triglycerides, and raised the beneficial HDL cholesterol in the participants. (healthyfellow.com)

lecithin cholesterol acyltransferase. (hormones.gr)
There was no clinicopathological data suggesting lipoprotein glomerulopathy or lecithin cholesterol acyltransferase deficiency, both of which are well-known causes of glomerular lipidosis. (biomedcentral.com)

The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). (muni.cz)

Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. (medscape.com)
Metabolic syndrome is characterized by a large waistline, high blood pressure, glucose intolerance, low HDL cholesterol , and elevated triglycerides . (docsopinion.com)
It has been proposed that carbohydrate restriction may improve this lipid pattern as it raises HDL cholesterol and lowers triglycerides. (docsopinion.com)

Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. (cdc.gov)
BACKGROUND: Genome-wide association studies of Alzheimer's disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. (cornell.edu)
The association between lipid disorders and heart disease is well known. (docsopinion.com)
Medical checkups usually involve measurements of cholesterol and other lipid parameters, and most doctors advise their patients on how to improve their lipid pattern. (docsopinion.com)
The ApoE4 isoform is associated with lipid disorders, high blood cholesterol, and increased risk of coronary heart disease and stroke ( 8 ). (docsopinion.com)
Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. (uchicago.edu)

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. (sdu.dk)
Shaded area represents current guideline-recommended thresholds for elevated non-high-density lipoprotein cholesterol in adolescence (≥144.79 mg/dL) and adulthood (≥189.58 mg/dL). (jamanetwork.com)
Are you targeting non-high-density lipoprotein cholesterol? (jamanetwork.com)
Usefulness of non-high-density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men in 22-year follow-up. (jamanetwork.com)
In general, overt and subclinical hypothyroidism is associated with hypercholesterolemia mainly due to elevation of low density lipoprotein (LDL) cholesterol levels, whereas high density lipoprotein (HDL) cholesterol concentration is usually normal or even elevated 3-5 . (hormones.gr)
Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. (uchicago.edu)

Apolipoprotein E Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases. (web.app)

Those harbouring mutations in the above genes can be treated to lower the cholesterol levels, prevent early CVD, and avoid death. (hindawi.com)
In rodent brain, chronological aging, particularly before perimenopause, was associated with an up-regulation of genes involved in cholesterol synthesis, efflux, and export. (gremjournal.com)
Cholesterol 25-hydroxylase (CH25H), the enzyme responsible for 25-HC production, has also been found to be one of the disease-associated microglial (DAM) genes that are upregulated in the brain of AD and AD transgenic mouse models. (cornell.edu)

[ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)
Smelt AH, de Beer F. Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects. (medscape.com)
High cholesterol level, the major modifiable risk factor for heart disease, has both an environmental as well as a genetic component. (hindawi.com)
Microglia expressing apolipoprotein E4 (apoE4), a genetic risk factor for AD, produce greater amounts of 25-HC than apoE3-expressing microglia following treatment with LPS. (cornell.edu)
Here, two batches of large-scale literature-based disease-gene relation data (updated in 2017 and 2019, respectively) and gene expression data were integrated to study the possible association between OCD and ASD at the genetic level. (silverchair.com)
Our results support the possible complex genetic associations between OCD and ASD. (silverchair.com)

Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study. (gianlucatognon.com)
10 Apr 2020 Apoliprotein E (Apo E) is a protein that helps transport lipids (fats and cholesterol) in the blood. (web.app)
Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. (uchicago.edu)
In summary, the investigated polymorphisms were associated with diverse effects on the LDL particle size distribution, consistent with respect to protein function and proposed association with CHD risk. (ox.ac.uk)

The triglyceride/HDL-cholesterol ratio appears to be a useful marker of the risk of coronary artery disease ( 3 ). (docsopinion.com)

Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. (uchicago.edu)

The observed associations were further modulated by gene-gene and gene-environment interactions. (ox.ac.uk)

Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. (cdc.gov)

Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures. (uchicago.edu)

Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study. (cdc.gov)

Specifically, the thyroid hormone stimulates the hepatic de novo cholesterol synthesis by inducing the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase that catalyzes the conversion of HMG-CoA to mevalonate, the first step in the biosynthesis of cholesterol 7 . (hormones.gr)
Regulation of apolipoprotein E biosynthesis by cAMP and phorbol ester in rat ovarian granulosa cells. (uchicago.edu)

In the current study, we have examined the association of body shape phenotypes based on allometric indices with serum levels of oestradiol and testosterone and their binding proteins (SHBG and albumin) and have explored heterogeneity by BMI, separately in men and women from the UK Biobank cohort, defining in men subgroups according to age and in women subgroups according to menopausal status and use of hormone replacement therapy (HRT). (nature.com)
On the other hand, hyperthyroidism (both overt and subclinical) is accompanied by a decrease in serum levels of total, LDL and HDL cholesterol 6 . (hormones.gr)
Serum cholesterol profile were obtained from 224 women across perimenopausal stages. (gremjournal.com)
Serum paraoxonase: effect of the apolipoprotein composition of HDL and the acute phase response. (uchicago.edu)

Extrahepatic synthesis of apolipoprotein E. (uchicago.edu)

Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. (uchicago.edu)

Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science . (medscape.com)
Both apolipoprotein E and immune deficiency exacerbate neointimal hyperplasia after vascular injury in mice. (uchicago.edu)

Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. (nature.com)

Regulation by cell cholesterol. (uchicago.edu)

Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)

2023 American Medical Association. (jamanetwork.com)

Using data from UK Biobank, we have previously described the associations of body shape phenotypes based on ABSI and HI with allometric body-composition indices, which similarly to ABSI and HI normalise body composition measurements for weight and height 11 . (nature.com)

Recently, it has become more common to assess the amount of circulating lipoprotein particles, rather than the amount of cholesterol itself. (docsopinion.com)
Scientific data suggest that the number of LDL particles is a stronger risk factor than LDL cholesterol ( 2 ). (docsopinion.com)

Apolipoprotein E4 association with metabolic syndrome depends on body fatness. (cdc.gov)

Elevated LDL-cholesterol (LDL-C) levels are well-established to cause cardiovascular disease and several LDL-C-lowering therapies are clinically available to manage this vascular risk factor. (biomedcentral.com)
Recent studies show an association between elevated plasma LDL, a well-known cardiovascular risk factor, and a higher risk of AD, and considerable evidence suggests that high HDL levels are associated with reduced CAA and lower neuroinflammation. (biomedcentral.com)
The association between thyroid autoimmunity and lipoprotein (a) levels is controversial. (hormones.gr)
Levels of total and LDL cholesterol tend to increase as the thyroid function declines 3 . (hormones.gr)
Dietary interventions to lower the risk of heart disease commonly aim at reducing blood levels of cholesterol, LDL cholesterol in particular. (docsopinion.com)
Maintaining normal levels of cholesterol is essential for the Apolipoprotein E has been found in amyloid plaques in the cerebral cortex of patients with Alzheimer's disease as well as in other types of amyloid. (web.app)

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (jamanetwork.com)

Obesity, Apolipoprotein E e4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study. (cdc.gov)

The main lipoprotein abnormality related with MetS is low concentration of HDL cholesterol and hypertriglyceridemia. (biomedcentral.com)

Apolipoprotein E structural requirements for the formation of SDS-stable complexes with beta-amyloid-(1-40): the role of salt bridges. (uchicago.edu)

There is an urgent need to screen subjects with premature CAD and their relatives in India for the presence of FH, identify the mutations that lead to high cholesterol, and carry out cascade screening in the at-risk relatives. (hindawi.com)

However, some experts have concluded that carbohydrate restriction may be harmful because of the possible detrimental effects of increased LDL cholesterol ( 1 ). (docsopinion.com)

The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. (lookformedical.com)
Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures. (uchicago.edu)
Primary structure of guinea pig apolipoprotein E. (uchicago.edu)

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). (medscape.com)

We defined body shape using "a body shape index" (ABSI) and hip index (HI), which are independent of weight and height by design, and examined associations in multivariable generalised linear models for the UK Biobank cohort (179,902 men, 207,444 women). (nature.com)
Mixed-effects multivariable log-binomial regression models were used to assess associations between intubation status and demographic factors, gestational age, and underlying conditions, including hospital as a random effect to account for between-site heterogeneity. (cdc.gov)

Foods containing K2 in the Western diet are concentrated sources of calories, cholesterol and saturated fat, thus supplementation is advisable. (vitamindwiki.com)

SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides. (uchicago.edu)

Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (PubMed:16533059, PubMed:29505618, PubMed:24698129). (proteopedia.org)
Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. (uchicago.edu)
Rat granulosa cell apolipoprotein E secretion. (uchicago.edu)

Anatomy24

Organisms7

Diseases35

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology6

Phenomena and Processes43

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science3

Health Care7

APOE30

Polymorphism3

Allele5

APOB5

Alleles3

Atherosclerosis4

Variants4

Metabolism6

Lipoproteins5

Total cholesterol6

Lecithin cholesterol acy2

Genotypes1

Triglycerides3

Lipid6

Density lipoprotein6

Neurodegenerative diseases1

Genes3

Genetic6

Protein4

Triglyceride1

Autoantibodies1

Gene1

Coronary heart diseas1

Mediate1

Genotype1

Biosynthesis2

Serum4

Synthesis1

Receptors1

Mice2

Proteins1

Regulation1

Interaction1

20231

Phenotypes1

Particles2

Metabolic1

Levels6

Clinical1

Obesity1

Hypertriglyceridemia1

Role1

High cholesterol1

Carbohydrate1

Primary3

Adults1

Multivariable2

Calories1

Complex1

Cell3