RadiationAffect spermatogenesisRadiotherapy and chemotherapyTestosteroneTestisAdjuvant chemotherapyTesticular torsionFertilitySpermRegimensMaturationTesticleSeminiferousCryopreservationTumorGonadalToxicityPatientsSpermatozoaTestesReproductiveRecoverMolecularCancer treatmentsFailureTissueAbsenceDestroyPatientStem cellsTreatmentHealthStudySideHumanResearchShowsAdministration
Radiation5
- The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). (proteinlounge.com)
- Patients with associated pathologies: epididymo-orchitis, radiation or chemotherapy. (who.int)
- Cancer treatments, including chemotherapy and radiation can result in inferility. (ndhealthfacts.org)
- In that editorial, she discusses the potential benefits of combining chemotherapy drugs with radiation to treat women with cervical cancer. (asu.edu)
- At the time, healthcare professionals rarely treated cervical cancer by combining chemotherapy or radiation. (asu.edu)
Affect spermatogenesis1
- Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. (proteinlounge.com)
Radiotherapy and chemotherapy2
- Non-obstructive azoospermia may occur due to genetic factors, exposure to toxic substances, anticancer treatments such as radiotherapy and chemotherapy and testicular torsion. (jsurgmed.com)
- Non‐obstructive azoospermia may be congenital (present at birth), or acquired at a certain point in time during the male's life (testicular trauma, hormonal imbalance, illnesses such as the mumps and meningitis, radiotherapy and chemotherapy, use of certain medications or drugs, etc. (fertilityclinicspain.com)
Testosterone6
- Discussion Pretreatment with honey protect testis against chemotherapy and testicular IR injury, increase FSH and LH and testosterone and decrease the cellular damage and apoptosis. (greenmedinfo.com)
- This androgen-binding protein causes high local concentrations of testosterone near the sperm, an essential factor in the development of normal spermatogenesis. (medscape.com)
- Male childhood, adolescent and young adult cancer survivors treated with chemotherapy, or radiotherapy, or surgery involving reproductive organs have an increased risk of impaired spermatogenesis, testosterone deficiency and/or physical sexual dysfunction. (ighg.org)
- A decline in intratesticular testosterone levels has been highlighted in vitro in 35- to 49-day cultures of 5 d pp mouse testes, i.e. after the end of the first wave of spermatogenesis ( 9 ). (elifesciences.org)
- Bien entendu, rien ne vous empêche de recourir aux PCT en général, lutilisation de SERM ne provoque pas deffets secondaires supplémentaires et augmente très rapidement le taux de testostérone à un niveau supérieur à celui de base en stimulant lhypophyse, testosterone deficiency treatment. (apparelbyjae.com)
- These elements include somatic cells (such as Leydig cells, myoid cells, and Sertoli cells), extracellular matrix (ECM) components (including laminin, collagen type IV and collagen type I), as well as growth factors and hormones [including bFGF, glial cell-derived nerve factor, glial cellderived nerve factor (GDNF), and testosterone] that are capable of forming a complex microenvironment where spermatogenesis occurs (6). (ijfs.ir)
Testis1
- In an attempt to accelerate the maturation of the testes and facilitate the study of spermatogenesis, several research groups have grafted NHP testis tissue onto nude mice and successfully obtained mature sperm. (asianscientist.com)
Adjuvant chemotherapy2
- A comparison of the outcomes of neoadjuvant and adjuvant chemotherapy for clinical T2-T4aN0-N2M0 bladder cancer. (malereproduction.org)
- PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy. (cdc.gov)
Testicular torsion1
- Rare causes include orchitis due to mumps, testicular torsion, chemotherapy with alkylating drugs, and trauma. (msdmanuals.com)
Fertility6
- The loss of fertility in males and premature menopause in females are important and common long-term side effects of curative radio- and chemotherapy. (dsjuog.com)
- The frequency of fertility failure varies with the type, dose, duration of radio- and chemotherapy, and age of patient. (dsjuog.com)
- Pashootan N, Derogar P, Mohammadi S, Sadat Shirazi S R, Moharram T. The effect of chemotherapy drugs on male germ cells and fertility in men. (saremjrm.com)
- These data will provide cancer patients with better information, after recovery, regarding the risks of chemotherapy for their future fertility. (saremjrm.com)
- The aim of this study was to evaluate the effects and side complications of some chemotherapy drugs on fertility in men. (saremjrm.com)
- These results, published in Cell Research , could eventually lead to new techniques of preserving the fertility of cancer patients undergoing radiotherapy or chemotherapy. (asianscientist.com)
Sperm8
- Since in our study hGH had recovery effect on spermatogenesis cycle after treatment with MTX, and it can not have useful effect if only prescript in chemotherapy period than consequently hGH inducement is suitable for sperm health ability parameters after chemotherapy in patient. (ac.ir)
- Chemotherapy to treat cancer can kill stem cells in the testicles that make sperm. (newscientist.com)
- Before performing chemotherapy, cryopreservation should always be undertaken (freezing sperm in liquid nitrogen) because in some men permanent infertility can occur after chemotherapy. (uniklinik-freiburg.de)
- Non‐obstructive azoospermia is more serious, as it involves a defect in the process of sperm cell formation (spermatogenesis). (fertilityclinicspain.com)
- can impair spermatogenesis (the creation of sperm). (malefertility.com)
- Certain drugs used to treat hypertension, arthritis, and digestive disease, as well as chemotherapy drugs are associated with sperm production problems and infertility. (malefertility.com)
- can impair spermatogenesis (the creation of sperm).This occurs when impairment of the muscles or nerves of the bladder neck prohibit it from closing during ejaculation, allowing semen to flow backwards into the bladder. (malefertility.com)
- Systemic disease can cause a fever, infection, kidney disease or a metabolic disorder which can impair spermatogenesis (the process of creating sperm) . (malefertility.com)
Regimens1
- The harmful effects of chemotherapy on germ cells depend on many factors, including the initial parameters of semen, method of drug administration, the type and dose of chemotherapy regimens, and the stage of spermatogenesis at the time of drug administration. (saremjrm.com)
Maturation1
- Testicular failure includes absence of failure production and low production and maturation arrest during the process of spermatogenesis. (wikipedia.org)
Testicle1
- This almost always results in permanent spermatogenesis damage in that testicle. (uniklinik-freiburg.de)
Seminiferous2
- The seminiferous tubules were rated for their modified spermatogenesis index (SI) by Johnsons score. (greenmedinfo.com)
- In the best-case situation, SSCs could (recolonize the seminiferous tubules and) reinitiate spermatogenesis, resulting in mature spermatozoa. (iassist2012.org)
Cryopreservation1
- Relevant studies from the subject were identified with the keyphrases: cryopreservation, male potency preservation, (immature)testicular tissues, testicular cell suspension system, spermatogonial stem cell, gonadotoxicity, chemotherapy and radiotherapy. (iassist2012.org)
Tumor2
- In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
- After the procedure, depending on the stage of the tumor, chemotherapy, radiotherapy or a combination of these treatments are performed. (uniklinik-freiburg.de)
Gonadal4
- The relationship of gonadal activity and chemotherapy-induced gonadal damage. (dsjuog.com)
- Gonadal function following chemotherapy for childhood Hodgkin's disease. (dsjuog.com)
- Gonadal toxicity after combination chemotherapy for Hodgkin's disease. (dsjuog.com)
- Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. (jsurgmed.com)
Toxicity1
- Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)
Patients2
- Nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. (nih.gov)
- Human testisderived cells (hTCs) are suitable candidates for the initiation of in-vitro spermatogenesis for these types of patients. (ijfs.ir)
Spermatozoa1
- Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis. (harvard.edu)
Testes1
- Spermatogenesis is a vital developmental phenomenon in which the production of haploid male gametes from diploid spermatogonia occurs in mammalian testes. (ijfs.ir)
Reproductive1
- Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility. (greenmedinfo.com)
Recover1
- Anabolic steroid hormone abuse (such as for muscle building), which is associated with marked impairment of spermatogenesis that may recover once the drugs are stopped. (thenewjerseymaleinfertilitycenter.com)
Molecular1
- 2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules. (harvard.edu)
Cancer treatments1
- Unfortunately, clinical researches in humans are difficult because cancer treatments are often a combination of chemotherapy and radiotherapy. (saremjrm.com)
Failure1
- Other reasons for using donated eggs can be Premature Ovarian Failure or poor ovarian reserve after some operation, chemotherapy, genetic diseases, etc. (myivfanswers.com)
Tissue2
- Testicular tissue is very sensitive to chemotherapy and radiotherapy. (saremjrm.com)
- A complete in vitro spermatogenesis has been obtained from mouse prepubertal testicular tissue, although with low efficiency. (elifesciences.org)
Absence1
- 46,XX Male Syndrome, also known as sex reversal, typically involves an absence of spermatogenesis. (ndhealthfacts.org)
Destroy1
- Testicular Cancer can limit or destroy the ability for spermatogenesis. (malefertility.com)
Patient1
- Patient who shows alterations of the spermatogenesis and/or benign prostatic hyperplasia. (who.int)
Stem cells1
- As of 2004, several studies have shown that embryonic stem cells may restore the spermatogenesis and functional sperms in mouse and human, known as in vitro gametogenesis (IVG) (2-4). (ijfs.ir)
Treatment2
- We know that already from the variable responses to chemotherapy, radiotherapy, endocrine treatment and other immunotherapies. (innovations-report.com)
- On 15 April 1999, physician Gillian Thomas published the editorial "Improved Treatment for Cervical Cancer - Concurrent Chemotherapy and Radiotherapy," henceforth "Improved Treatment," in The New England Journal of Medicine. (asu.edu)
Health1
- Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds. (cdc.gov)
Study2
- Abstract: Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
- Steroid hormones being essential for the progression of spermatogenesis, the aim of this study was to investigate steroidogenesis and steroid signaling in organotypic cultures. (elifesciences.org)
Side1
- PMID: 29791311 Abstract Title: Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
Human1
- however, the most prevalent forms of human cancer respond poorly or not at all to chemotherapy. (doctorlib.info)
Research2
- His Chemotherapy research extends to Internal medicine, which is thematically connected. (research.com)
- His research combines Internal medicine and Chemotherapy. (research.com)
Shows1
- the surrounding testicular parenchyma is unremarkable and shows varying degrees of spermatogenesis. (testicularcancersociety.org)
Administration1
- The recommended starting dosage is 5 mg/m 2 , administered 1 to 3 hours prior to the administration of chemotherapy, then every 2 to 4 hours after chemotherapy, for a total of 4 to 6 doses per day. (nih.gov)