• Introduction: In the United States, autologous hematopoietic cell transplantation (autoHCT) has fallen out of favor over chemotherapy consolidation for non-high-risk acute myeloid leukemia (AML) when allogeneic hematopoietic cell transplantation (alloHCT) is unfeasible, which is common in racial minorities because of donor registry under-representation and socioeconomic challenges. (elsevierpure.com)
  • In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
  • High-dose chemotherapy with autologous stem-cell rescue (HDC/ASCT) is the best salvage therapy for patients with aggressive B-cell lymphomas. (cun.es)
  • Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
  • OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
  • We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients. (northwestern.edu)
  • Patients underwent dose-intense immune suppression and autologous haemopoietic stem-cell (CD34) infusion. (northwestern.edu)
  • Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
  • The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
  • Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
  • Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
  • Prophylactic platelet transfusion for haemorrhage after chemotherapy and stem cell transplantation. (ox.ac.uk)
  • OBJECTIVES: To determine the optimal use of platelet transfusion for the prevention of haemorrhage (prophylactic platelet transfusion) in patients with haematological malignancies undergoing chemotherapy or stem cell transplantation. (ox.ac.uk)
  • SELECTION CRITERIA: Randomised controlled trials involving transfusions of platelet concentrates, prepared either from individual units of whole blood or by apheresis, and given prophylactically to prevent bleeding in patients with haematological malignancies and receiving treatment with chemotherapy and/or stem cell transplantation. (ox.ac.uk)
  • High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
  • Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
  • High dose intravenous melphalan and autologous stem cell transplantation was developed for the treatment of AL amyloidosis in the early 1990s and was prompted by its success in multiple myeloma. (medthority.com)
  • These guidelines provide a comprehensive assessment of eligibility criteria, stem cell collection and mobilisation strategies and regimens, risk-adapted melphalan dosing, role for induction and consolidation therapies, specific supportive care management, long-term outcome with respect to survival, haematologic response and relapse and organ responses following stem cell transplantation. (medthority.com)
  • These guidelines are developed by the experts in the field on behalf of the stem cell transplant working group of the International Society of Amyloidosis (ISA) and European Haematology Association (EHA). (medthority.com)
  • Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation. (blogspot.com)
  • Background/Aim: High-dose chemotherapy (HDCT) and stem cell transplantation (SCT) have been established as the standard of care in patients with relapsed germ cell tumours (GCTs). (herts.ac.uk)
  • High-dose chemotherapy with autologous stem cell transplantation is infrequently also used. (sciencedaily.com)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • Advancing stem cell and gonadal tissue transplantation therapies for infertility. (upmc.com)
  • Research suggests that while treatments such as intensive chemotherapy and allogeneic stem cell transplantation may be curative for younger people, they are less likely to be effective in older individuals. (medicalnewstoday.com)
  • Consequently, we proceeded with salvage chemotherapy followed by autologous stem cell transplantation. (karger.com)
  • The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
  • However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
  • She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
  • Even after stem-cell transplantation and intensive chemotherapy, the prognosis of RR-ALL remains grave. (nih.gov)
  • Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
  • The acute leukemias are aggressive malignancies that originate in a hematopoietic stem cell and are rapidly fatal without immediate treatment. (hematology.org)
  • Others can be cured with stem cell transplantation. (hematology.org)
  • High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. (uni-koeln.de)
  • Bone marrow or stem cell transplantation may be used in younger people with advanced or high-risk CLL. (medlineplus.gov)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • The stem cell mobilization result was poor. (cdc.gov)
  • The aim of this population-based study was to describe the magnitude and panorama of late effects among patients treated with or without high-dose chemotherapy with autologous stem cell transplantation (HD-ASCT). (lu.se)
  • Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such as ruxolitinib , fedratinib , or pacritnib, may decrease symptoms and stem cell transplantation may be curative. (msdmanuals.com)
  • Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
  • Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
  • Haematopoeitic stem cell transplant (HSCT) recipients - from day of admission (~day -7) to day +35. (who.int)
  • However, an alternative is to perform bone marrow or stem cell tx (transplantation). (lu.se)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • Patients and Methods: We identified adults with favorable or intermediate cytogenetic risk AML in first complete remission after induction at Montefiore Medical Center from 1999 to 2015, and analyzed 81 patients who received consolidation with ≥2 cycles of chemotherapy, of whom 28 received autoHCT. (elsevierpure.com)
  • She was treated with the DeAngelis chemotherapy protocol and achieved a complete remission. (karger.com)
  • Be able to state the approximate success rate of chemotherapy for AML (rate of complete remission with induction chemotherapy and cure rate). (hematology.org)
  • Allogeneic transplantation was performed in five patients, two of whom achieved complete remission despite residual or refractory disease. (oncotarget.com)
  • Autologous transplantation consolidation for non-high-risk acute myeloid leukemia is less frequently used, yet not fully abandoned. (elsevierpure.com)
  • Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes too many immature white blood cells called myeloblasts. (medicalnewstoday.com)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • Acute lymphoblastic leukemia (ALL) typically responds better when treated with multiagent chemotherapy in the pediatric and young adolescent populations. (nih.gov)
  • In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
  • A significant portion of patients with acute myelogenous leukemia (AML) can now be cured with chemotherapy. (hematology.org)
  • Rapidly progressive, chemotherapy-incurable acute leukemia Overview of Leukemia develops in about 30% of patients. (msdmanuals.com)
  • AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
  • There were no statistically significant differences between the groups with regards to mortality, remission rates, number of participants with severe bleeding events or red cell transfusion requirements. (ox.ac.uk)
  • This initial treatment aims to clear as many leukemia cells as possible in the blood and bone marrow and to induce remission. (medicalnewstoday.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • Their disease had been refractory (defined as less than partial response) to one (18 patients) or two (24 patients) regimens of neoadjuvant chemotherapy. (elsevierpure.com)
  • Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
  • In a systematic review that compared the effectiveness of these regimens, Amarasena et al concluded that platinum-based chemotherapy regimens did not provide a statistically significant benefit over non-platinum-based agents in survival or overall tumor response. (medscape.com)
  • The investigators suggested that non-platinum-based chemotherapy regimens may have a better risk-benefit profile. (medscape.com)
  • Scholars@Duke publication: Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. (duke.edu)
  • Doctors use this treatment regimen to eliminate leukemia cells and bring blood counts back to normal. (medicalnewstoday.com)
  • The current mobilization regimen with granulocyte colony-stimulating factor (G-CSF), alone or in combination with chemotherapy, still fails in 10-25% of patients. (uni-koeln.de)
  • Several chemotherapy combinations are active in SCLC, but usually a platinum-containing regimen is chosen. (medscape.com)
  • Guidelines for high dose chemotherapy and stem cel. (medthority.com)
  • The role of high-dose chemotherapy (HDCT) in patients with refractory breast cancer is not well established. (elsevierpure.com)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Radiation therapy uses high-energy rays to kill or shrink cancer cells. (hopkinsmedicine.org)
  • The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
  • The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
  • Other risk factors include radiation therapy, chemotherapy, and organ transplantation. (wikipedia.org)
  • Radiation is directed at the tumor from a source outside the body to kill the cancer cells. (epnet.com)
  • Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
  • They are removed from circulating blood before chemotherapy or radiation treatment. (epnet.com)
  • For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
  • TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
  • Chemotherapy uses anticancer drugs to kill cancer cells. (hopkinsmedicine.org)
  • AML cancer cells, or "blasts," are bigger than normal white blood cells, which makes it harder for them to pass through tiny blood vessels. (medicalnewstoday.com)
  • Chimeric antigen receptor-modified T cells (CAR-T) and engineered T cells are used to target cancer cells. (nih.gov)
  • Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
  • Cancer occurs when cells in the body divide out of control or order. (epnet.com)
  • Chemotherapy involves the use of drugs to kill cancer cells. (epnet.com)
  • They will kill mostly cancer cells. (epnet.com)
  • They interfere with the division of cancer cells and can slow tumor growth. (epnet.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cancer patients undergoing chemotherapy may be particularly vulnerable to medical errors, as their care often requires use of high-risk medications and must be closely coordinated between multiple physicians. (ahrq.gov)
  • Chronic lymphocytic leukemia (CLL) is cancer of a type of white blood cells called lymphocytes. (medlineplus.gov)
  • Cancer cells spread through the blood and bone marrow. (medlineplus.gov)
  • Tests that look at changes in the DNA inside the cancer cells may also be done. (medlineplus.gov)
  • Small cell lung cancer (SCLC) is characterized by rapid growth and early dissemination. (medscape.com)
  • See Small Cell Lung Cancer Treatment Protocols for summarized information. (medscape.com)
  • Investigating the effect of medicinal cannabis on the symptoms and side effects of chemotherapy in people with cancer. (who.int)
  • However, results with this therapy in peripheral T-cell lymphoma (PTCL) are not well defined. (cun.es)
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • Waldenström's macroglobulinemia is a slow-growing form of non-Hodgkin lymphoma that originates in white blood cells known as B lymphocytes. (sciencedaily.com)
  • Named for Dr. Thomas Hodgkin, the physician who first recognized the condition, Hodgkin lymphoma develops when white blood cells (lymphocytes) undergo abnormal changes that cause them to grow and divide at a very rapid pace, sometimes spreading beyond the lymphatic system. (moffitt.org)
  • We report a case of primary large B cell-type pituitary lymphoma in a 47-year-old immunocompetent female who presented with headache and cranial nerve palsy. (karger.com)
  • Liu JK, Sayama C, Chin SS, Couldwell WT: Extranodal NK/T-cell lymphoma presenting as a pituitary mass. (karger.com)
  • Aho R, Ecfor T: Pathogenesis of primary central nervous lymphoma: invasion of malignant lymphoid cells into and within the brain parenchyma. (karger.com)
  • Fleming WH, Murphy PR, Murphy LJ, Hatton TW, Matusik RJ, Friesen NG: Human growth hormone induces and maintains cmyc gene expression in Nb2 lymphoma cells. (karger.com)
  • 3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
  • Several factors hinder the identification of risk factors for central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL), including the retrospective nature of most studies, the relatively low frequency of CNS relapse in DLBCL, and the heterogeneity of CNS prophylaxis methods used in these studies. (haematologica.org)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare mature T-cell malignancy first described in Japan in 1977 [ 1 ]. (oncotarget.com)
  • Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
  • Studies on late effects in patients with mantle cell lymphoma (MCL) are becoming increasingly important as survival is improving, and novel targeted drugs are being introduced. (lu.se)
  • Adult T‐cell leukaemia/lymphoma in Brazil: A rare disease or rarely diagnosed? (bvsalud.org)
  • Adult T-cell leukaemia/lymphoma (ATL), caused by human risk of 4% (Iwanaga et al. (bvsalud.org)
  • ATL, Adult T-cell leukaemia/lymphoma. (bvsalud.org)
  • Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
  • People who undergo intensive chemotherapy may need to stay in the hospital for 3-5 weeks . (medicalnewstoday.com)
  • We compared autoHCT consolidation outcomes with chemotherapy alone in a minority-rich cohort in the Bronx. (elsevierpure.com)
  • We compared outcomes of consolidation strategies in a minority-rich cohort in the Bronx with limited access to allogeneic transplantation. (elsevierpure.com)
  • Autologous transplantation conferred relapse-free and overall survival benefit over chemotherapy consolidation alone, the current standard in the United States, and it might constitute a valuable option for ethnic/racial minorities. (elsevierpure.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
  • The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)
  • Gut distress determined by the Mucositis Daily Questionnaire (MDQ) for up to 3 cycles of chemotherapy and calculated as area under the curve and adjusted per cycle (AUC MDQ/cycle) [The MDQ is assessed daily for the duration of each treatment cycle up to a maximum of 3 full cycles. (who.int)
  • The safety profile of KEYTRUDA in combination with chemotherapy in this study was consistent with previously reported studies. (merck.com)
  • Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
  • The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)
  • See a sickle cell disease or hematology specialist to explore your treatment options and ways to manage your pain. (medlineplus.gov)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
  • Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • Salvage treatment results with HDC/ASCT in PTCL are similar to those found in corresponding aggressive B-cell lymphomas. (cun.es)
  • A randomized controlled trial, incorporating a GA and comparing age-adapted HCT-ASCT treatment with conventional chemotherapy is needed. (biomedcentral.com)
  • The primary objective is to demonstrate that intensified chemotherapy followed by consolidating HCT-ASCT is superior to conventional chemotherapy with rituximab, MTX, procarbazine (R-MP) followed by maintenance with procarbazine in terms of progression free survival (PFS). (biomedcentral.com)
  • Peripheral blood lymphocytes were analysed by flow cytometry, ELISA, and T-cell-receptor spectratyping before and after transplantation. (northwestern.edu)
  • Peripheral blood progenitor cells and/or bone marrow were infused on day 0. (duke.edu)
  • Describe the predominant cell types seen in the peripheral blood and/or bone marrow in each of the four major categories of leukemia (AML, ALL, CML, CLL). (hematology.org)
  • 20x10(6)/mu l peripheral CD34+ cells after mobilization but prior to apheresis. (uni-koeln.de)
  • Analysis of peripheral nerve regeneration after transection on the model of rat caudal nerve using tubulization and mesenchymal stem cells. (sav.sk)
  • It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
  • Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)
  • If you are receiving Nivestym because you are also receiving chemotherapy, your dose of Nivestym should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. (drugs.com)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • A number of randomized trials have tried to answer questions concerning the superiority of combination over single-agent chemotherapy, the number of drugs to be used in combination, and dose intensity. (medscape.com)
  • The mutation causes the cells to produce a distorted protein, which switches on the IRAK complex pathway, leading to activation of NF-kB, a protein that is essential for the growth and survival of Waldenström's tumor cells," Treon comments. (sciencedaily.com)
  • There was no difference in survival between patients who received chemotherapy alone versus chemotherapy with antiviral agents. (oncotarget.com)
  • Nonrandomized trials of combination chemotherapy have shown superior response rates and survival compared with single-agent chemotherapy. (medscape.com)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • Nivestym (filgrastim-aafi) is a recombinant human granulocyte colony-stimulating factor biosimilar to Neupogen indicated for the treatment of neutropenia associated with chemotherapy and related conditions. (drugs.com)
  • T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Reprogramming is a promising treatment, which redifferentiates T-induced pluripotent stem cells (T-IPSCs) into naïve and cytotoxic T cells or dedifferentiates within their own lineage [ 13 ]. (hindawi.com)
  • These cells are then replaced after treatment. (epnet.com)
  • This involves giving chemotherapy in cycles followed by a period of rest in between to allow the body to recover. (medicalnewstoday.com)
  • We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
  • In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
  • Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
  • T-cell lymphotropic virus type 1 (HTLV-1) infection has a expected to develop ATL. (bvsalud.org)