Chemotherapy patients abnormalities drug induced. Medical search. Frequent questions

Tagrisso (osimertinib) is a kinase inhibitor indicated for the treatment of patients with metastatic epidermal growth factor receptor ( EGFR ) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR TKI therapy. (rxlist.com)
TAGRISSO is indicated for the first-line treatment of adult patients with metastatic NSCLC whose tumors have EGFR exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
TAGRISSO is indicated for the treatment of adult patients with metastatic EGFR T790M mutationpositive NSCLC, as detected by an FDA-approved test, whose disease has progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
In combination with docetaxel for the treatment of patients with HER2-positive metastatic breast cancer (MBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. (empr.com)
Patients can either be chemotherapy-naive or have received platinum-based chemotherapy for locally advanced or metastatic disease. (dana-farber.org)
3. Patients with documented evidence of metastatic CRPC who have had at least one line of systemic therapy for metastatic CRPC (either chemotherapy or an novel hormonal agents [NHA]) or for whom no alternative approved therapy is available. (astrazenecaclinicaltrials.com)

Decreased production of neutrophils is associated with deficiencies of vitamin B12 and folic acid, aplastic anemia, tumors, drugs, metabolic disease, nutritional deficiency and immune mechanisms. (wikipedia.org)
TAGRISSO is indicated as adjuvant therapy after tumor resection in adult patients with non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
In a retrospective survey, including 9144 patients, mostly with solid tumors in advanced stages, the probability of developing CHF increased with increasing cumulative doses of Epirubicin Hydrochloride Injection (Figure 5). (recallguide.org)
Furthermore, tumors cells can induce surrounding normal tissue cells to alter the overall microenvironment by secreting growth factors or proteases, or by suppressing immune response signals. (atcc.org)
Extending these promising findings to solid tumors faces substantial hurdles from drug uptake to clinical trial design. (aacrjournals.org)
In retrospect, the fact that cancer was viewed as a genetic disease for so long was likely an artifact of focus and technology: Chromosomal changes began to be detectable before we understood epigenetics at a molecular level, and the early focus on familial cancer and rapidly induced viral tumors favored the discovery of mutational carcinogenesis, which has largely colored our views over the past three decades ( 3, 4 ). (aacrjournals.org)
Hanahan and his colleagues have been exploring in preclinical studies whether drug combinations that target distinct growth-promoting properties of tumors might work synergistically to stall or reverse disease progression. (technologynetworks.com)
In this study, the researchers tested whether a drug aimed at an unrelated phenomenon, the abnormal blood vessels of tumors, used in combination with imipramine might further improve outcomes. (technologynetworks.com)

ELA2 mutation, GATA2 deficiency Barth syndrome Copper deficiency Vitamin B12 deficiency Pearson syndrome Some types of Hermansky-Pudlak syndrome Transient neutropenia: Typhoid Tuberculosis Chemotherapy Cytomegalovirus Influenza Human Immunodeficiency Virus Propylthiouracil Levamisole Penicillamine Trimethoprim/sulfamethoxazole Clozapine Valproate Vaccination Venetoclax Severe bacterial infections, especially in people with underlying hematological diseases or alcoholism, can deplete neutrophil reserves and lead to neutropenia. (wikipedia.org)
Increased neutropenia with other myelosuppressive chemotherapy. (empr.com)
hypersensitivity reactions, inj site reactions, exacerbation of chemotherapy-induced neutropenia. (empr.com)
Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
A dose-dependent, reversible leukopenia and/or neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin and represents the most common acute dose-limiting toxicity of this drug. (recallguide.org)
Leukopenia/neutropenia is usually transient, with WBC and neutrophil counts generally returning to normal values by Day 21 after drug administration. (recallguide.org)

The phenomenon of acquired drug resistance has been observed with various types of cancer therapeutics including chemotherapy, molecular-targeted anticancer drugs, and cancer immunotherapy. (atcc.org)
Bevacizumab is known to quasi-normalize leaky tumor blood vessels, whose abnormalities also compromise both chemotherapy and immunotherapy. (technologynetworks.com)
Any other chemotherapy, immunotherapy, immunosuppressant medication (other than corticosteroids) or anti-cancer agents within 3 weeks of the first dose of study treatment, except hormonal therapy with luteinising hormone-releasing hormone (LHRH) analogues for medical castration in patients with prostate cancer, which are permitted. (astrazenecaclinicaltrials.com)

In this case, the cancer cells gradually acquire specific genetic abnormalities or protein alterations that ultimately result in unresponsiveness to treatment and cancer relapse. (atcc.org)
It helps identify specific genetic abnormalities known to be associated with the disease. (askthenurseexpert.com)

The development of rickets as a complication of chemotherapy for the treatment of Wilms' tumor. (lvhn.org)
The extrinsic or receptor-dependent pathway is usually induced by members of the tumor necrosis factor (TNF) family of proteins, where a ligand binds to one of the death receptors that subsequently recruit the death-inducing signaling complex (DISC) and the apical caspase 8 (4,5). (eotp.org)
7 The genetic abnormalities and drug sensitivities of cells within the same tumor can vary widely, resulting in the survival and regrowth of a sub-population of tumor cells after a treatment that initially appears to be effective. (atcc.org)
3,4 In some cases, tumor cells can even acquire secondary genetic alterations during drug treatment. (atcc.org)
In this study, the anti-tumor activity of DEH on colorectal cancer was investigated through both the cell-derived xenograft (CDX) and patient-derived tumor xenograft (PDX) model. (biomedcentral.com)
Patient willingness and disease accessible to pre-treatment, on-treatment tumor, and progression biopsies (core biopsies). (dana-farber.org)
Researchers led by Ludwig Lausanne's Douglas Hanahan report in the current issue of Cancer Cell how the drugs used in the combination-an antidepressant, an immune checkpoint blockade antibody and a mouse analog of a cancer therapy that by themselves provide no survival benefit against GBM-synergize to unleash potently therapeutic immune responses against the tumor. (technologynetworks.com)
Diabetic patients are under direct tumor. (underwoodaccounting.com)
The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor barrier. (biomedcentral.com)
This permits the selective entry of small conventional chemotherapy drugs or contrast agents into malignant glioma tumor tissue[ 5 ]. (biomedcentral.com)
Even though the inherent leakiness of the BBTB does allow for the selective transvascular passage of small conventional chemotherapy drugs, such as carboplatin, these drugs do not achieve sufficiently high concentrations within tumor tissue after systemic infusion[ 9 ]. (biomedcentral.com)

These activate both arousability and the testicular artery, a branch (which form the intrinsic back sacral spinous processes with patients as renal transplant vasculitits 190 penile surgery arteriovenous malformations vascular arterial compromise veno-occlusive dysfunction metabolic abnormalities, which can such as playing or graphic movies and magazines contributes to the pelvis and urinary continence and preoperative introduction chemotherapy followed by an inflammatory reaction. (ben.edu)
After diagnosis, first-line therapy with cisplatin/pemetrexed was initiated, but the patient developed renal dysfunction. (biomedcentral.com)
Actually some old drugs have been developed for new indications, such as aspirin for Arsenic trioxide has been used for the treatment of cancers and stroke, sildenafil (Viagra) for erection dysfunction and other disorders for more than 500 years in China [14]. (med-abstracts.com)
global ventricular dysfunction, regional wall motion abnormalities, and diastolic dysfunction with preserved ejection fraction may be seen 4 . (emdocs.net)
What Are Dearest Bee Neurolysin Treatments order levitra plus 400mg erectile dysfunction drugs at walmart. (wgc2010.sk)
Darker umber is many salutary to your wellness discount cialis sublingual 20mg on line what if erectile dysfunction drugs don't work. (wgc2010.sk)
Antineoplastic therapy is frequently complicated by the development of cardiotoxicity, either as the direct effects of chemotherapy on the heart, such as left ventricular dysfunction (LVD), heart failure (HF) or ischaemia, or as indirect effects due to haemodynamic changes, thrombotic events or hypertension. (touchoncology.com)
M any of the drugs which were developed to deal with erectile dysfunction act on the levels of these 5,6 mediators [url=https://archives.gov.pk/rx-pharmacy/buy-lasix-no-rx/] heart attack from weed lasix 100 mg buy generic online[/url]. (ehd.org)

However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. (nih.gov)
ALK-TKIs are more effective than cytotoxic chemotherapy, and long-term treatment with TKIs has been shown to prolong the overall survival of patients. (biomedcentral.com)

6 Following the initial demonstration of the important role for miR in human cancer, such as downregulation of miR-15a-miR-16-1 in chronic lymphocytic leukemia, 7 a number of cancers have been shown to exhibit distinct miR expression patterns related to various phenotypes with remarkable cytogenetic abnormalities. (nature.com)
Objectives Acute myeloid leukemia (AML) is classified in part by recurrent cytogenetic abnormalities, often detected by both fluorescent in situ hybridization (FISH) and karyotype. (medscape.com)
[ 1-3 ] Several well-known, recurrent cytogenetic abnormalities have prognostic significance. (medscape.com)
It is common practice for laboratories to use interphase fluorescence in situ hybridization (FISH) panels in conjunction with karyotyping for the detection of the most prognostically significant recurrent AML-associated cytogenetic abnormalities, both in diagnostic specimens and during follow-up to monitor response to therapy. (medscape.com)

or for adjuvant treatment of patients with HER2-positive EBC at high risk of recurrence. (empr.com)
6,8,9 Analysis of more than 45,000 cases of early-stage BC treated in woman >65 years old has shown that patients who received both trastuzumab and anthracycline had an absolute 23.8 % higher rate, and those treated with anthracycline chemotherapy alone has an absolute 2.1 % higher rate of HF or cardiomyopathy (CM) events over 3 years compared with patients who received no adjuvant chemotherapy or trastuzumab. (touchoncology.com)

Valproic acid (VPA) is a short-chain fatty acid that belongs to a relatively new class of agents used for anticancer therapy, the histone deacetylase inhibitors (HDAC-I). VPA has been used as an anticonvulsant and mood-stabilizing drug for decades. (eotp.org)
In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
Moreover, DEH induced strong cellular autophagy, which could be inhibited through autophagic inhibitors, with a rction in the DEH-induced inhibition of cell growth in colorectal cancer cells. (biomedcentral.com)
Subsequent anti-neoplastic therapy (including other ALK inhibitors or chemotherapy) after progression on alectinib is not permitted. (dana-farber.org)
Patients who have received prior treatment with checkpoint inhibitors are eligible. (dana-farber.org)
Anaplastic lymphoma kinase tyrosine kinase inhibitors are standard therapeutic agents prescribed for anaplastic lymphoma kinase-positive non-small cell lung cancer, and treatment with these agents has been shown to contribute to long-term survival in patients. (biomedcentral.com)
However, there is no consensus regarding the course of treatment after the onset of anaplastic lymphoma kinase tyrosine kinase inhibitors related drug-induced interstitial lung disease. (biomedcentral.com)
With the identification of gene abnormalities in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), effective ALK tyrosine kinase inhibitors (ALK-TKIs) have been developed for treatment. (biomedcentral.com)
Finally, the recently proposed new therapies employing bcl-2 inhibitors prompted the potential use of bax/bcl-2 ratio to identify patients putatively resistant to these molecules. (haematologica.org)

Early replacement therapy is recommended when proximal renal tubular abnormalities are detected to help prevent and control the severe metabolic bone disease associated with the Fanconi syndrome. (lvhn.org)
Vancomycin can cause hearing loss, especially in patients with renal insufficiency. (msdmanuals.com)
Ethacrynic acid and furosemide given IV have caused profound, permanent hearing loss in patients with renal failure who had been receiving aminoglycoside antibiotics. (msdmanuals.com)
This mechanism of action does not explain why, in the clinical setting, carboplatin dosing based on patient renal function over-estimates the carboplatin dose required for target carboplatin exposure. (biomedcentral.com)
Contributing factors include age over 65, concomitant drug use, renal insufficiency and anaemia. (gponline.com)
No dose adjustment is required, including in patients with severe renal impairment (creatinine clearance less than 30 mL/minute) (see sections 4.4 and 5.2). (who.int)
However, linezolid should be used with special caution in patients with severe renal insufficiency, and only when the anticipated benefit is considered to outweigh the theoretical risk, because the clinical significance of higher exposure (up to 10 fold) to the two primary metabolites of linezolid is unknown. (who.int)
Haemodialysis removes the primary metabolites of linezolid to some extent, but the concentrations of these metabolites are still very considerably higher after dialysis than those in patients with normal renal function or mild to moderate renal insufficiency. (who.int)
There is no experience of linezolid administration to patients undergoing continuous ambulatory peritoneal dialysis (CAPD) or alternative treatments for renal failure (other than haemodialysis). (who.int)

Hypersensitivity reactions, such as anaphylaxis, shortness of breath, hypotension, and urticaria, may occur in patients with known hypersensitivity to other selective 5-HT3 receptor antagonists. (nih.gov)
Important noninfectious causes include giant cell myocarditis, drug-induced hypersensitivity, and cardiac manifestations of systemic autoimmunity, such as sarcoidosis or systemic lupus erythematosus 5 . (emdocs.net)

By the early 1980's, ES and PNET were found to not only have similar features when examined under a microscope, but in greater than 95% of cases they also had an identical genetic abnormality called a translocation (Aurias 1984, Whang-Peng 1984, Burchill 2003). (sarcomahelp.org)
These tests provide crucial information about the subtype of AML and any genetic abnormalities present. (askthenurseexpert.com)
Examine the medical history in support of risk factors, such as Hispanic channel, preceding chemotherapy, and genetic abnormalities such as Down syndrome, Fanconi anemia, neurofibromatosis type I, Shwachman syndrome, Bloom syndrome, and familial monosomy 7. (wgc2010.sk)
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia. (cdc.gov)

We previously identified ethoxyquin (EQ) as a potent neuroprotective compound through a phenotypic screen against three neurotoxic drugs and demonstrated that it prevents development of peripheral neuropathy in paclitaxel and cisplatin models of chemotherapy-induced peripheral neuropathy (CIPN). (nature.com)
ZOFRAN® Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin [see Clinical Studies ]. (globalrph.com)

Anthracycline-induced cardiac toxicity may be manifested by early (or acute) or late (delayed) events. (recallguide.org)
Life-threatening CHF is the most severe form of anthracycline-induced cardiomyopathy. (recallguide.org)
Anthracycline-Induced cardiomyopathy: a placebo in these guidelines. (underwoodaccounting.com)

Intrinsic resistance is present before a therapy is administered, and it results in the inherent ability of cancer cells to survive at clinically relevant concentrations of a drug. (atcc.org)
Does not have any clinically significant gastrointestinal abnormalities, such as malabsorption syndrome or major resection of the stomach or small bowel that may alter absorption of the medication. (dana-farber.org)
In one study of 80 patients with clinically suspected myocarditis, an elevated troponin level was only 53% sensitive 6 . (emdocs.net)
8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)

For pediatric patients aged 6 months through 18 years, the intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see Clinical Studies , CLINICAL PHARMACOLOGY ]. (globalrph.com)
Since 1947, Dana-Farber's sole focus has been to provide expert cancer care and groundbreaking treatments for adult and pediatric patients. (dana-farber.org)

As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. (globalrph.com)
In patients in whom nausea and/or vomiting must be avoided postoperatively, ZOFRAN Injection is recommended even when the incidence of postoperative nausea and/or vomiting is low. (globalrph.com)
For patients who do not receive prophylactic ZOFRAN Injection and experience nausea and/or vomiting postoperatively, ZOFRAN Injection may be given to prevent further episodes [see Clinical Studies ]. (globalrph.com)
The recommended adult intravenous dosage of ZOFRAN is 4 mg undiluted administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes, immediately before induction of anesthesia, or postoperatively if the patient did not receive prophylactic antiemetics and experiences nausea and/or vomiting occurring within 2 hours after surgery. (globalrph.com)

The patient is a 62-year-old male with a history of ischemic cardiomyopathy, CAD s/p CABG, HFrEF s/p AICD, DM, HTN, and restrictive lung disease presenting with dyspnea, cough, and lower extremity swelling for several months. (emdocs.net)

Apoptosis can be induced via two main pathways: interference with mitochondrial function, also called the intrinsic pathway, or triggering of cell surface death receptors, also called the extrinsic pathway (2,3). (eotp.org)
Phosphorylation of PINK1 is not only required for the PINK1-mediated mitochondrial recruitment of Parkin but also induces its kinase activity toward Parkin. (sdbonline.org)

Although this brings a hope to identify drug resistance and detect the cancer's relapse at an early stage, the corresponding treatment solutions are not always available. (atcc.org)
Thereafter, lorlatinib was administered, which was continued without drug-induced interstitial lung disease relapse. (biomedcentral.com)
The appearance of paraneoplastic AN usually coincides with the presence of malignancy, but it can precede or follow the diagnosis of cancer and thus may signal a relapse in patients with a history of cancer. (medscape.com)
Lower maternal educational level was associated with increased frequency of mucositis, as were induction chemotherapy and maintenance chemotherapy after relapse. (bvsalud.org)

Ethoxyquin (EQ), a quinolone-based antioxidant, has demonstrated neuroprotective properties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in animal models of chemotherapy-induced peripheral neuropathy. (nature.com)

In terms of hematological malignancies, several successful drugs have been discovered and developed from old ones such as arsenic trioxide for acute promyelocytic leukemia and thalidomide for multiple myeloma. (med-abstracts.com)

It has been widely established that cancer is associated with epigenetic modification, which is reversible and becomes an attractive target for drug development. (frontiersin.org)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
In addition to acquiring somatic mutations associated with drug resistance, cancer cells may alter cell signaling pathway feedback loops or bypass certain drug target signaling pathways through epigenetic alterations to maintain activation of key cell proliferation and survival signals. (atcc.org)
The classic organ systems are influenced by ters DNA repair or causes genomic mutation theory of cancer no longer mechanistic events associated with instability, (4) induces epigenetic fully encompasses the mechanistic cancer induction. (who.int)
Although host susceptibility stress, (6) induces chronic inflam- benzene) that induce not only muta- factors have a modulating role in mation, (7) is immunosuppressive, tions but also a variety of epigenetic carcinogenesis and can affect un- (8) modulates receptor-mediated changes. (who.int)

Does not appear to interact with emetogenic cancer chemotherapies. (nih.gov)
The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. (globalrph.com)
The first dose is to be administered 30 minutes before the start of moderately to highly emetogenic chemotherapy. (globalrph.com)

3 , 4 The current therapy for ovarian cancer is debulking surgery followed by chemotherapy using carboplatin and paclitaxel (PTX). (nature.com)

For patients requiring more rapid initiation of anticoagulation, regimens starting with 5mg doses, or a single 10mg dose followed by 5mg doses, are often used. (gponline.com)

Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide. (lvhn.org)

Collectively, our studies strongly suggest that DEH might be a potential anticancer agent against colorectal cancer by activating ER stress-induced inhibition of autophagy. (biomedcentral.com)

Nonspecific cytotoxic drugs such as alkylating agents or purine analogs have commonly been used to induce apoptosis via the intrinsic pathway. (eotp.org)
Drug resistance in cancer comes in two forms: intrinsic resistance and acquired resistance. (atcc.org)
A poor initial response to the given treatment indicates that a patient may have intrinsic drug resistance. (atcc.org)

The prevention of diabetes-induced mtDNA deletions may be a potential mechanism of the neuroprotective effects of EQ in diabetic neuropathy. (nature.com)
Anticoagulation therapy is commonly used for primary and secondary prevention of venous thromboembolism, prevention of systemic embolism in patients with AF or mechanical heart valves, and for treatment of acute coronary syndromes. (gponline.com)
Anticoagulation may also be used in primary prevention of MI in high-risk patients, congestive cardiac failure, mitral stenosis in the absence of AF and acute cerebral ischaemic syndromes, although evidence in these areas is less convincing. (gponline.com)

Although conventional chest radiography is the first choice among imaging options for identifying patients with pulmonary manifestations of drug toxicity, limitations of the pattern approach often necessitate the use of other imaging techniques, in addition to clinical and laboratory assessments. (medscape.com)
Thus, in order to improve patient outcomes and address the growing economic burden of HF management, we as emergency physicians need to have a better understanding of the heterogeneity of the disease and the phenomena that precipitate its acute manifestations. (emdocs.net)
About 70% of patients with Sjogren's syndrome suffer from fatigue, and for a large proportion of patients, it is one of the most noticeable manifestations leading to disability. (mdpi.com)

The duration of tuberculosis treatment depends on the regimen chosen, the patient's clinical and radiographical responses, smear and culture results, and susceptibility of Mycobacterium tuberculosis isolates from the patient or the suspected source case. (who.int)

Lack of response to empiric antibiotic treatment and an imaging pattern of organizing pneumonia should raise suspicion of everolimus-induced pneumonitis in patients undergoing therapy with this drug. (medscape.com)
[ 9 ] Likewise, bilateral pleural effusion and extensive pulmonary interstitial prominence suggesting pulmonary fibrosis on CT scan in a patient presenting with dyspnea and dry cough may alert the clinician to pulmonary injury resulting from use of nitrofurantoin for treatment of an uncomplicated urinary tract infection. (medscape.com)
For decades, chemotherapy was considered to be the only approach in the treatment of patients with advanced or accelerated CLL. (eotp.org)
Neonatal treatment using hypervolemic hemodilution and induced arterial hypertension pah. (elastizell.com)
Patients who are to receive SoC SBRT as definitive treatment of Stage I/II lymph node-negative NSCLC and confirmed to meet all eligibility criteria will be randomized 1:1 to Durvalumab or placebo. (uchicagomedicine.org)
In addition, a study cohort with a sufficient number of patients harboring an EGFR mutation, will receive Osimertinib treatment after completion of SoC SBRT as definitive treatment of Stage I/II lymph node-negative NSCLC. (uchicagomedicine.org)
Patients should be carefully monitored during treatment for possible clinical complications due to myelosuppression. (recallguide.org)
4,5 Drug resistance in each case could involve one or more of these major mechanisms, depending on the class of drugs and therapeutic treatment strategies being employed. (atcc.org)
These mutations can give the cell the ability to withstand further treatment with that drug. (atcc.org)
Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). (ajnr.org)
Thirty-five days after treatment the patient experienced emotional lability, which was assumed to be a depressive syndrome. (ajnr.org)
Although all these symptoms resolved without treatment, 12 hours later the patient exhibited eye deviation to the right with horizontal nystagmus and right hemiparesis, but right Babinski response was not present. (ajnr.org)
This research study is studying a drug combination as a possible treatment for anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer. (dana-farber.org)
For the expansion cohort: Patients must have had disease progression on alectinib (including patients who received alectinib as first-line treatment). (dana-farber.org)
Patients must have recovered from treatment toxicities to ≤ Grade 1 or to their pretreatment levels except for adverse events (AEs) that in the investigator's judgment do not constitute a safety risk for the patient. (dana-farber.org)
Here, we present a case of successful lorlatinib treatment after the onset of drug-induced interstitial lung disease caused by alectinib. (biomedcentral.com)
Since alectinib can occasionally cause drug-induced interstitial lung disease, as in the present case, lorlatinib may be an option to continue treatment in patients without other treatment alternatives. (biomedcentral.com)
Because of its efficacy, lorlatinib is the standard treatment option for patients with ALK-positive NSCLC for whom one or more ALK-TKIs have failed. (biomedcentral.com)
They used a mouse analog of the human anti-VEGF antibody bevacizumab, which has been approved as a second line treatment for GBM, though not so much to extend survival as to provide relief to patients by alleviating the edema caused by the aberrant vasculature. (technologynetworks.com)
b.Pre/perimenopausal women with medically-induced menopause c.Male subjects must use a contraceptive method from screening until 1 year after the last dose of study treatment. (who.int)
In this review, we discussed the latest advancement in exploring old drugs for the treatment of hematological malignancies. (med-abstracts.com)
In this review, we countries, arsenic derivatives were once used for syphilis treatment discussed latest advancement in repositioning old drugs for hemato- [14]. (med-abstracts.com)
Rb, prednisone for patch-stage and the 2016 revision was of treatment is much chemo drugs to baseline pre-pet scan in united kingdom. (underwoodaccounting.com)
The following article summarises the recent data in the literature on the epidemiology and pathophysiology of cardiotoxicity induced by different target drugs, as well as strategies for patient management before, during and after antineoplastic treatment, early diagnosis of cardiovascular adverse events, with particular attention on the role of echocardiography. (touchoncology.com)
1 Simultaneously, with the improvement in the management of cancer patients and prolonged survival, cardiotoxicity has become increasingly important, as the adverse effects on the heart may create new challenges in the long-term management of the patients, reducing the effectiveness of treatment and survival, due to the appearance of comorbidities. (touchoncology.com)
Patients should use barrier contraception (ie, condoms) from the time of screening until 16 weeks after discontinuation of study treatment. (astrazenecaclinicaltrials.com)
Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment. (astrazenecaclinicaltrials.com)
TB389 trade name] is indicated in combination with other tuberculosis medicines for the treatment of drug- resistant tuberculosis caused by Mycobacterium tuberculosis . (who.int)
Typically, a total treatment duration of 18-20 months and a treatment duration of 15-17 months after culture conversion are suggested for most patients, with the duration being modified according to the patient's response to therapy. (who.int)
From the article: 'In a real-world setting of new and emerging targeted therapies, a study found that patients with acute myeloid leukemia (AML) had unmet needs that hindered their ability to receive genomic testing and treatment options, especially for older patients with AML. (cdc.gov)

The mechanistic data for all types of can be used to identify and organize fects (e.g. is able to induce genotox- ionizing radiation ( IARC, 2012f) are mechanistic information related to icity or affect similar pathways), but particularly informative with regard to cancer induction. (who.int)

Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)

Conventional chest radiography is usually an initial investigation for patients with pulmonary and/or cardiac symptoms and may be the only imaging required. (medscape.com)
Use with caution in patients with pre-existing arrhythmias or cardiac conduction disorders. (nih.gov)
Optics of vision it is important to assess the anxious patient for adverse neurologic out-come after cardiac or other ventricular wall production of tension. (elastizell.com)
Langer cj, mehta mp therapeutic advances in clotting factor needed x can be supported by current techniques use reflected sound to measure latency to sleep onset and to if patients are treated as a result of slowing of cardiac output to the fall in ph can also assist in developing countries and is the preferred study. (elastizell.com)
In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
Early cardiac toxicity of epirubicin consists mainly of sinus tachycardia and/or ECG abnormalities such as non-specific ST-T wave changes, but tachyarrhythmias, including premature ventricular contractions and ventricular tachycardia, bradycardia, as well as atrioventricular and bundle-branch block have also been reported. (recallguide.org)
In patients presenting with acute or fulminant myocarditis, an elevated cardiac troponin level can support the diagnosis, but a normal level does not exclude it. (emdocs.net)

Radiographic abnormalities and pharyngitis. (underwoodaccounting.com)

Early recognition is important because drug-induced lung disease can often be reversed if appropriate therapy is instituted soon after the onset of symptoms. (medscape.com)
The present work proposes the translation, cultural adaptation, and validation of two questionnaires for the Romanian context, namely the 'Profile of Fatigue and Discomfort-Sicca Symptoms Inventory' (PROFAD-SSI-SF) and 'Primary Sjogren's Syndrome-Quality of Life' (PSS-QoL), whose purpose is to assess quality of life and fatigue in patients with Sjogren's syndrome. (mdpi.com)
As many as 46% with patients with classic symptoms have negative venograms,[2] and as many as 50% of those with image-documented venous thrombosis lack specific symptoms. (medscape.com)

The major problem with all imaging techniques is that drug-related lung toxicity has a nonspecific appearance, and patterns similar to those of many interstitial lung diseases have been described. (medscape.com)
Alectinib was started after the onset of progressive disease, but it resulted in drug-induced interstitial lung disease, necessitating alternative treatments. (biomedcentral.com)
However, it is unclear whether lorlatinib can be used after discontinuation of another ALK-TKI owing to adverse events, for example, in cases of drug-induced interstitial lung disease (DILD). (biomedcentral.com)

panel, urinalysis, computed tomographic scan of the The patient remained unresponsive with fl accid head, and chest radiograph. (cdc.gov)

Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: contrast with interleukin-1. (wgc2010.sk)

Attended video-PSG excluded RBD showing REM sleep with atonia and without increased phasic EMG activity, and diagnosed with severe obstructive sleep apnea (OSA) with an apnea-hypopnea index of 30.1 demonstrating that the reported abnormal sleep behaviors occurred only during respiratory event-induced arousals. (go.jp)
The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)

5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. (medindia.net)
These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
1 Statistical data indicate that over 90% of the mortality of patients with cancer is related to drug resistance. (atcc.org)
Each year, thousands of patients from around the world come to Dana-Farber for their cancer care. (dana-farber.org)
Some commonly used cancer drugs, such as the anthracyclines, are known to be cardiotoxic. (ajmc.com)
7 While several cardiovascular toxicity studies have been conducted in adult cancer patients, far fewer have been conducted in pediatric cancer patients. (ajmc.com)
Primary lung cancer was suspected, and the patient was directed to the Department of Respiratory Medicine on the same day that he was admitted to the Otolaryngology Department. (biomedcentral.com)
A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM). (technologynetworks.com)
Our investigation illustrates the great potential of drug repurposing for cancer therapy," said Hanahan, distinguished scholar at the Ludwig Institute for Cancer Research Lausanne Branch. (technologynetworks.com)
We've shown here that three extensively characterized drugs already in use in the clinic can be newly combined to lift the tumor's immunosuppressive barrier and induce a therapeutic immune response that significantly extends survival in mouse models of GBM, a cancer that has so far evaded every therapy used to treat it. (technologynetworks.com)
In a patient presenting with AN, key features of the medical history should include age of onset, history of diabetes or hyperandrogenism, new medication (steroids, oral contraceptives, estrogen replacement) use, cancer risk assessment, and family history. (medscape.com)
The delicate balance between effective cancer therapy and the risk of secondary cardiovascular disease that could affect the gain of survival, requires a profound collaboration between oncologists and cardiologists, with the aim of creating a personalised therapy for the patient and their illness. (touchoncology.com)

Therapeutic anticoagulation is achieved in the majority of patients within a few weeks. (gponline.com)

Sixteen patients (ten with one or more intestinal fistula) developed abdominal wall dehiscence were included in this study. (who.int)

Gout pain management is largely limited to colchicine and nonsteroidal anti-inflammatory drugs. (bvsalud.org)
However, current mainstream medications for chronic pain, including opioids, antidepressants and non-steroid anti-inflammatory drugs are sometimes inefficient for chronic pain management and may cause side effects that limit long term usage. (bvsalud.org)
The common causes of acquired agranulocytosis including drugs (non-steroidal anti-inflammatory drugs, antiepileptics, antithyroid, and antibiotics) and viral infection. (wikipedia.org)

However, pediatric drug toxicity cannot be predicted based on observation of adult patients. (ajmc.com)

Busulfan toxicity causes drug-induced pulmonary damage after prolonged exposure, usually after 3-4 years of therapy. (medscape.com)
Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. (medscape.com)
However, arsenic exposure induces cardiovascular diseases, logical malignancies and the discovery strategies. (med-abstracts.com)

If use is unavoidable, closely monitor for adverse reactions and consider dose reduction of BCRP substrate drug (refer BCRP substrate prescribing information). (medscape.com)

Pulse oximeters make the most of a lightweight supply and lightweight sensor applied to the surface of a patientвЂ™s pores and skin to compare noninvasively the sunshine absorption of shifting blood (throughout arterial ?ow) with the light absorption of the nonmoving blood and tissue during arterial diastole (analogous to a reference pattern). (ehd.org)

HDAC-Is exert pleiotropic antitumor effects by inducing growth arrest, differentiation, and apoptosis, both in vitro and in vivo (12). (eotp.org)

The recommended dosage for granisetron hydrochloride injection is 10 mcg/kg administered intravenously within 30 minutes before initiation of chemotherapy, and only on the day(s) chemotherapy is given. (nih.gov)

Conclusions: Oral abnormalities were common in children receiving chemotherapy and mucositis was the most prevalent manifestation. (bvsalud.org)

Leukocyte count was within reference range of signal abnormality in cerebral hemispheres, thalamus, (10.8 × 103/mm3), with neutrophil (polymorphonuclear and midbrain. (cdc.gov)

The use of chemotherapy in CLL is limited, however, because of rapidly developing resistance and partial unresponsiveness of patients with p53 abnormalities (9,10). (eotp.org)

In malignant cells, HDACIs induce apoptosis SMIP004 by upregulation of proapoptotic and repression of antiapoptotic genes (14C16). (eotp.org)
Metabolically stable bradykinin B2 receptor agonists, methionine-lysine-bradykinin and labradimil, enhance the transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug. (biomedcentral.com)
The selectivity of the increase in drug delivery into the malignant glioma tissue, but not into normal brain tissue or skeletal muscle tissue, is due to the inherent porous nature of the BBTB of malignant glioma microvasculature. (biomedcentral.com)

Heparin-induced thrombocytopenia is an immune mediated reaction, which may be secondary to heparin and causing platelet aggregation. (gponline.com)

in particular, patients with rare diseases like spinal muscular atrophy and certain cancers such as chronic myelogenous leukemia may now be prescribed personalized medicine treatments that simply didn't exist a couple of decades ago. (cdc.gov)
For most patients with most diseases, though, the lofty promises have failed to materialize. (cdc.gov)

INTRODUCTION - The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on distinguishing these primary syndromes from other systemic disorders that can present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. (medilib.ir)
iii) Drug discovery is a complicated systemic engineering requiring ancient drugs. (med-abstracts.com)

POWV infection should be suspected in tick- exposed patients with viral encephalitis, the patient underwent a computed tomography angiogram of the head and neck. (cdc.gov)

This is usually performed between to have drug-induced erectile dysfunc- 18. (ben.edu)

Further analysis indicated that DEH also induced endoplasmic reticulum (ER) stress and subsequently stimulated autophagy through the activation of PERK/eIF2α and IRE1α/XBP-1 s/CHOP pathways. (biomedcentral.com)
2 However, even these new target drugs have been shown to have a cardiotoxic potential, especially when used as combination therapies, by inhibition of transduction pathways in normal or non-cancerous cells. (touchoncology.com)

Knockdown of PERK or IRE1α significantly decreased DEH-induced autophagy and retrieved cell viability in cells treated with DEH. (biomedcentral.com)
Previous studies in Hanahan's lab had shown that a generic "tricyclic" antidepressant, imipramine, could be used in combination with an anticoagulant drug to hyperactivate a process known as autophagy, in which cells cannibalize their own proteins and organelles for the nutrients required to sustain their growth. (technologynetworks.com)
Hyperactivation of autophagy by these drugs modestly extended survival of mice with GBM. (technologynetworks.com)

Chronic pain poses heavy burdens to the suffering patients, both physically and mentally. (bvsalud.org)
In some patients the disease can evolve into new onset, progressive, or chronic heart failure. (emdocs.net)
Bax/bcl-2 was 1.50 or over in 263 patients (52%) with chronic lymphocytic leukemia. (haematologica.org)

Coadministration of granisetron hydrochloride injection with drugs known to prolong the QT interval and/or are arrhythmogenic may result in clinical consequences. (nih.gov)
This toxicity appears to be dependent on the cumulative dose of Epirubicin Hydrochloride Injection and represents the cumulative dose-limiting toxicity of the drug. (recallguide.org)

In the subset of patients with a meniscal resection of less than 25, direct MR arthrography does not appear to exhibit a diagnos- tic advantage over conventional MR imaging. (forexinfolink.com)
In addition, because the probe size is much smaller than the resolution provided by the banding pattern in karyotype, FISH can detect cryptic abnormalities not revealed by conventional karyotype. (medscape.com)

Oral lesions were associated with the induction phase of chemotherapy. (bvsalud.org)

The abnormality underlying both acquired and congenital long QT syndromes is in the ionic current flow during repolarization, which affects the QT interval. (medscape.com)

Anatomy5

Organisms1

Diseases91

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment73

Phenomena and Processes16

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science2

Named Groups1

Health Care31

Metastatic6

Tumors8

Neutropenia6

Immunotherapy3

Specific genetic abnormalities2

Tumor11

Dysfunction8

Cytotoxic chemotherapy2

Cytogenetic abnormalities4

Adjuvant2

Inhibitors10

Renal9

Hypersensitivity2

Genetic4

Cisplatin2

Anthracycline-induced3

Clinically4

Pediatric patients2

Nausea4

Cardiomyopathy1

Mitochondrial2

Relapse4

Peripheral neuropathy1

Acute promyelo1

Epigenetic5

Emetogenic3

Paclitaxel1

Regimens1

Fanconi1

Stress-induced1

Intrinsic3

Prevention3

Manifestations3

Susceptibility1

Treatment30

Radiation1

Autonomic1

Cardiac7

Radiographic1

Symptoms3

Interstitial3

Chest radiograph1

Contrast1

Severe2

Cancer13

Therapeutic1

Intestinal1

Inflammatory3

Adult Patients1

Exposure3

Adverse1

Arterial1

Antitumor1

Initiation1

Conclusions1

Cerebral1

Unresponsiveness1

Malignant3

Immune1

Diseases2

Systemic2

Viral1

Erectile1

Pathways2

Autophagy3

Chronic3

Injection2

Conventional2

Induction1

Syndromes1