AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
MucinsGastric MucinsMucin-5BMucin-1Mucin-4Mucin-3Mucin-6Goblet CellsMucusSialomucinsGlycosylationAntigens, Tumor-Associated, CarbohydrateOligosaccharidesTracheaPeriodic Acid-Schiff ReactionCarbohydratesIntestinal MucosaCarbohydrate SequenceConjunctiva
GlycoproteinsGastric mucinMucusIntestinalGlycoproteinStructuralMUC17PurificationGeneFunctionalPolymericGenomicColonicSubunitsMuc6MoleculesRespiratoryGenesAberrantPreliminaryHumanStrainsBacteriaCellsRodentsTissueReceptorSurfaceIdentificationFluidHighlyStructureExpressionPreviouslyPropertiesLargeInitialLinearCurrent
Glycoproteins4
  • Gel-forming mucins are large high-molecular weight secreted O-glycoproteins responsible for the gel-properties of the mucus blanket. (ox.ac.uk)
  • In the biopharmaceutical industry, characterization of glycoproteins routinely involves carbohydrate analysis, and changes in protein glycosylation are often studied in cancer research to identify potential biomarkers. (thermofisher.com)
  • The upper layer of the colonic mucus is a niche for a subset of the microbiota which utilise the mucin glycoproteins as a nutrient source and mucin grazing by the microbiota appears to play a key role in maintaining barrier function as well as community stability. (biorxiv.org)
  • Composite diagram of proposed structures for typical branched oligosaccharides in human 223 and pig 219 gastric mucin glycoproteins showing the immunodeterminant blood group A and H (- - -) and I (‐ ‐ ‐) saccharide structures. (comprehensivephysiology.com)
Gastric mucin2
  • Some blood group A-active substances (secretor A saliva and hog gastric mucin A + H) have low potency to inhibit the agglutination. (karger.com)
  • w/v) hog gastric mucin (HGM) (Sigma-Aldrich), had been used to improve the development of mucolytic bacterias before inoculation on solid mass media. (woofahs.com)
Mucus2
  • The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. (wikipedia.org)
  • The high proteinase susceptibility of the linkage suggests that it might be a point of control for mucin size and thus mucus rheology. (silverchair.com)
Intestinal5
  • Here we describe the discovery and characterisation of endo-acting family 16 glycoside hydrolases (GH16s) from prominent mucin degrading gut bacteria that specifically target the oligosaccharide side chains of intestinal mucins from both animals and humans. (biorxiv.org)
  • The data suggest a new paradigm for mucin breakdown by the microbiota and the endo-mucinases provide a potential tool to explore changes that occur in mucin structure in intestinal disorders such as inflammatory bowel disease and colon cancer. (biorxiv.org)
  • Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O-glycosylated mucin domain to the intestinal lumen. (scilifelab.se)
  • A novel anaerobic, mesophilic, amino-acid-fermenting bacterium, specified strain CL-84T, was isolated from your swine intestinal tract on mucin-based press. (woofahs.com)
  • Intestinal differentiation marker proteins Villin, Mucin 2 and glycocalyx were expressed and distributed on the apical side of the colon. (daxiangbio.com)
Glycoprotein2
  • Like other mucins, MUC-4 is a high-molecular weight glycoprotein. (wikipedia.org)
  • Despite the importance of mucin breakdown for gut health, the mechanisms by which gut bacteria access this complex glycoprotein are not well understood. (biorxiv.org)
Structural2
  • Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme. (scilifelab.se)
  • Structural and Quantitative Characterization of Mucin-Type O -Glycans and the Identification of O -Glycosylation Sites in Bovine Submaxillary Mucin. (bvsalud.org)
MUC172
  • Characterization of human mucin MUC17. (nih.gov)
  • The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. (scilifelab.se)
Purification1
  • Extensive characterization including infrared and X-ray spectroscopy, thermogravimetric analysis, size, charge, surface area, and density captured the alteration in physicochemical properties as the material went through sequential purification. (cdc.gov)
Gene5
  • Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. (wikipedia.org)
  • Here we show that this mucin fraction is dominated (at least 96% of the total) by the low-charge glycoform of the MUC5B gene product. (silverchair.com)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
  • This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)
Functional1
  • MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
Polymeric2
Genomic1
  • The implementation of molecular and genomic characterization of CTCs could contribute to improve the treatment selection and thus, to move toward more personalized treatments. (amegroups.org)
Colonic1
  • CRF increases colonic mucin rat mast cell protease II and prostaglandin 2 (PGE2) release ion secretion. (biosemiotics2013.org)
Subunits1
  • The effect of reducing agents was as expected for other gel-forming mucins, i.e. reduced subunits or monomers of M r 3×10 6 ) were produced within 15 min of treatment. (silverchair.com)
Muc64
  • The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. (ox.ac.uk)
  • Among them, the mucin MUC6 has been less studied, particularly in rodents and no anti rodent-Muc6 antibody has been reported yet. (ox.ac.uk)
  • The rabbit anti-mouse Muc6 polyclonal antibody seems highly specific to the mouse mucin and will be useful to study pancreatic pathology in cystic fibrosis. (ox.ac.uk)
  • Utilization of complementary proteomic tools revealed that several of the proteins such as mucin 6 (MUC6), bile salt-activated lipase (CEL), and pyruvate kinase lysozyme M1/M2 with significant differential expression have strong association with pancreatic cancer. (nih.gov)
Molecules1
  • Currently, he is endlessly focused on the characterization of mucin molecules found on or associated with microvesicles (exosomes), as well as on their potential role as ligands in protein-protein and protein-carbohydrate interactions with endogenous receptors of the immune system. (bitesizebio.com)
Respiratory1
  • An initial rapid cleavage generated mucins ranging from M r = 4×10 6 to 30×10 6 that in the electron microscope appeared as polydisperse threads (500-3000 nm in length), similar to normal and other respiratory mucins that we have previously characterized. (silverchair.com)
Genes2
  • Conclusion: The current experiment revealed changes in expression level of mucin genes and lncRNAs in CRC and its different stages, showing that they can be considered as biomarkers for diagnosis of this cancer. (sabanciuniv.edu)
  • Abstract Background The genome bears an enormous category of genes and pseudogenes coding for Mucin-Associated Surface area Protein (MASPs). (roma2024.com)
Aberrant1
  • It is believed that dysfunction in the expression of mucins and aberrant expression of some lncRNAs are associated with the occurrence and development of CRC. (sabanciuniv.edu)
Preliminary1
  • We perform syntheses, characterization, and preliminary biophysical and biological analysis ourselves. (fu-berlin.de)
Human3
  • MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation. (wikipedia.org)
  • Five orthologous gel-forming mucins have been cloned in human and mouse. (ox.ac.uk)
  • Towards non-parametric diffusion-T1 characterization of crossing fibers in the human brain. (lu.se)
Strains1
  • Stress CL-84T was among eight strains isolated through the characterization of mucosa-associated and mucin-degrading micro-organisms in the swine digestive tract. (woofahs.com)
Bacteria2
  • Transmembrane mucins have previously been shown to play a role in the prevention of bacterial colonization by acting as sheddable decoys for encroaching bacteria. (scilifelab.se)
  • Mucin-degrading bacteria had been isolated on solid basal moderate supplemented with 1? (woofahs.com)
Cells3
  • When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
  • Our interests are mainly natural glyco receptors present on the cells and mucins for different biomedical applications. (fu-berlin.de)
  • This study will be carried out on the multiepitope characterization of potential T cells against the protein mechanism in breast cancer. (ui.ac.id)
Rodents1
  • 3. Mohebali M, Yaghoobi-Ershadi MR, Akhavan AA, Hajjaran H, Abaei MR. Characterization of Leishmania infection in rodents from endemic areas of the islamic republic of Iran. (ac.ir)
Tissue1
  • Multidimensional diffusion magnetic resonance imaging for characterization of tissue microstructure in breast cancer patients: A prospective pilot study. (lu.se)
Receptor2
  • The characterization of corticotropin releasing factor (CRF) and more recently the discovery of additional CRF-related ligands urocortin 1 urocortin 2 and urocortin 3 the cloning of two distinct CRF receptor subtypes 1 (CRF1) and 2 (CRF2) and the development of selective CRF receptor antagonists provided new insight to unravel the mechanisms of stress. (biosemiotics2013.org)
  • Proteins used in this study are Mucin-4, Phosphatase And Tensin Homolog, and Receptor tyrosine-protein kinase erbB-2. (ui.ac.id)
Surface3
  • These endo-acting O-glycanases display β1,4-glactosidase activity and in several cases are surface located indicating they are involved in the initial step in mucin breakdown. (biorxiv.org)
  • The carefully rinsed mucosal surface area of the pig caecum was scraped using a sterile microscope glide and inoculated into minimal moderate containing mucin. (woofahs.com)
  • Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)
Identification1
  • CTCs are present in the bloodstream at a very low concentration, thus their detection and characterization require highly sensitive and specific methods, which consist of a combination of enrichment (isolation) and detection (identification) strategies ( Table 1 ) and both steps are essential components of the identification process ( 19 ). (amegroups.org)
Fluid1
  • B) In nasal cavities, copious amounts of exudate are present comprising numerous degenerating and necrotic neutrophils, cellular debris, proteinaceous fluid, and strands of mucin. (cdc.gov)
Highly1
  • Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
Structure1
  • Mucins: structure, function, and associations with malignancy. (xenbase.org)
Expression1
  • Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
Previously1
  • We have previously noted that sequential extraction of an asthmatic mucous exudate with 6 M guanidinium chloride yielded a fraction of the mucins that were most resistant to solubilization and of high M r [Sheehan, Richardson, Fung, Howard and Thornton (1995) Am. J. Respir. (silverchair.com)
Properties2
  • As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
  • Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II. (buffalo.edu)
Large1
  • MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. (wikipedia.org)
Initial1
  • Just how many taxa might talk about this characteristic is normally unclear, but to your knowledge, this is actually the initial description of an associate from the phylum that may use mucin being a sole way to obtain carbon and energy. (woofahs.com)
Linear1
  • The results suggest that the MUC5B mucin is assembled, first into polydisperse linear threads, which are then linked together via a protein-mediated process. (silverchair.com)
Current1
  • The current model for mucin degradation involves exclusively exo-acting glycosidases that sequentially trim monosaccharides from the termini of the glycan chains to eventually allow access to the mucin peptide backbone by proteases. (biorxiv.org)