Characterization gene transcription transcription factor pit 1. Medical search. Frequent questions

Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. (nature.com)
The mouse basal cell carcinomas and trichoblastoma-like tumors resemble human basal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, frequent loss of the normal remaining Ptch allele, and activation of hedgehog target gene transcription. (nature.com)
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. (nature.com)
PCR analysis of the P. falciparum dihydrofolate reductase and dihyropteroate synthase genes showed no mutations associated with clinical failure. (cdc.gov)
Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. (medscape.com)
The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
Further investigations are necessary to identify these mutations and understand how these AKR1C genes affect these important reproductive traits. (biomedcentral.com)

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikiversity.org)
Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)
The Hh gene family encodes a secreted protein that plays a critical regulatory role in the process of embryogenesis and environmental stabilization in adult tissues of invertebrates and vertebrates [ 44 ]. (regenmedres-journal.org)
The product of the Drosophila gene decapentaplegic ( dpp) encodes a TGFβ homolog that plays multiple roles during embryogenesis and the development of imaginal discs. (biologists.com)

However, it is now understood that Sotos syndrome is caused by a variety of molecular genetic alterations resulting in haploinsufficiency of the NSD1 gene at chromosome 5q35 and that Beckwith-Wiedemann syndrome is caused by heterogeneous abnormalities in the imprinting of a number of growth regulatory genes within chromosome 11p15 in the majority of cases. (e-apem.org)
Quantitative trait loci (QTL) for age of puberty, nipple number and ovulation rate have been identified in Meishan crosses on pig chromosome 10q (SSC10) near the telomere, which is homologous to human chromosome 10p15 and contains an aldo-keto reductase (AKR) gene cluster with at least six family members. (biomedcentral.com)
In the human, an aldo-keto reductase (AKR) gene family (AKR1C) has been identified near the telomere on chromosome 10p15 that contains at least six aldo-keto reductase family 1, member C genes [ 11 ]. (biomedcentral.com)
The homologous region on mouse chromosome 13 contains a cluster of eight or nine AKR1C genes [ 12 ]. (biomedcentral.com)

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy. (nih.gov)
The result of Southern blot indicated that there isonly one C23O gene in the genome of C-14-1. (researchgate.net)
The Bmuccr gene covers a 1.4 kb genome region and contains 3exons. (researchgate.net)
however, no molecular characterization and recombination tests based on the genome sequences of ASGV isolates from pears are lacking. (online-rpd.org)
Because of their location in the swine genome and their implication in reproductive physiology, this gene cluster was characterized and evaluated for effects on reproductive traits in swine. (biomedcentral.com)

Cloning and initial characterization of human epsin 3, a novel matrix-induced keratinocyte specific transcript. (nih.gov)
Characterization of Serum Immunoglobulin M of Grouper and CDNA Cloning of Its Heavy Chain. (sinica.edu.tw)

Screening the porcine CHORI-242 BAC library with a full-length AKR1C4 cDNA identified 7 positive clones and sample sequencing of 5 BAC clones revealed 5 distinct AKR1C genes ( AKR1CL2 and AKR1C1 through 4 ), which mapped to 126-128 cM on SSC10. (biomedcentral.com)

It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)

Plasmid stabilization/stability protein-encoding genes were observed in some plasmids but were not established for participating in plasmid segregation. (frontiersin.org)

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. (wikipedia.org)
Green, J., Leigh, I.M., Poulsom R., Quinn, A.G. Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. (nature.com)
During mammalian development a cilia driven leftwards flow of liquid leads to the left-sided expression of Nodal , which in turn activates asymmetric expression of the transcription factor Pitx2 . (biomedcentral.com)
A L-R expression screen identified the cytoskeletally-associated gene, actin binding lim protein 1 ( Ablim1 ), as asymmetrically expressed in both the node and left lateral plate mesoderm (LPM). (biomedcentral.com)
At the node, a previously unrecognised action of early nodal flow and Pkd2 activity, within the pit of the node, influences gene expression in a symmetric manner. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. (cancerindex.org)
Characterization of protein marker expression, tumorigenicity, and doxorubicin chemoresistance in two new canine mammary tumor cell lines. (sinica.edu.tw)
Comparison of cofilin-1 and Twist-1 protein expression in human non-small cell lung cancer tissues. (sinica.edu.tw)
Infection of bovine leukocytes by the apicomplexan parasite Theileria annulata results in alteration of host cell gene expression and stimulation of host cell proliferation. (lookformedical.com)
The validity of co-IP approaches can quickly deteriorate when forced expression of tagged proteins are used to investigate possible interactions, yet this approach, particularly when endogenous factors are assessed, can provide useful information about potential protein associations. (aacrjournals.org)
Expression and localization of vascular endothelial growth factor and angiopoietin-1 and their receptors FLT-1, FLK-1, and TIE-2 in bovine ovaries during follicular and luteal development. (mcmaster.ca)
DHH/PTC1 signaling triggers differentiation of Leydig cells by up-regulating Steroidogenic Factor 1 and expression of cytochrome P450 Side-Chain Cleavage enzyme located outside testicular cord [ 145 ]. (regenmedres-journal.org)
In epithelial cells, VEGF-A and VEGFR-1 expression was higher in tumor tissue compared to benign tissue. (cdk-receptor.com)
The tkv receptor is therefore involved in delimiting the expression domains of homeotic genes in the visceral mesoderm. (biologists.com)
These duplicated genes maintain a high degree of sequence similarity, but differ greatly in their substrate specificity and tissue expression patterns. (biomedcentral.com)
There is an urgent need to update the names of brain stem structures to be consistent with the discovery of rhomobomeric segmentation based on gene expression. (edu.au)
This essay recommends a new brain stem nomenclature based on developmental gene expression, progeny analysis, and fate mapping. (edu.au)

In the case of genes that are used to produce proteins, the RNA polymerase II holoenzyme that actually performs the transcription from the template strand needs to find chemical cues for attachment to the DNA and where to begin transcription. (wikiversity.org)
In situ detection of hedgehog target genes and immunohistology of Ptch +/- mouse BCC differentiation markers, hemidesmosomal proteins and Bcl2 protein. (nature.com)
Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. (lookformedical.com)
This involves purification of a specific protein from the pool of cellular proteins, followed by Western blotting of a suspected interacting protein ( 1 ). (aacrjournals.org)
The mitochondrial voltage-dependent GKT137831 research buy anion channel 1 (VDAC1) is involved in the release of apoptotic proteins with possible relevance in Selleck PCI-34051 Alzheimer's disease (AD) neuropathology. (cdk-receptor.com)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)

23(1): 393, 2023 Sep 26. (bvsalud.org)

Additionally, genes conferring virulence and antibiotic resistance were identified amongst the plasmids. (frontiersin.org)
Depending on the genes it carries, it could act as a fitness factor to the host, or serve as a virulence factor by transforming the host into a pathogen. (frontiersin.org)
Hence, the spread of virulence factors and antibiotic resistance properties caused by plasmids is possible, leading to a threat in public health. (frontiersin.org)

The "upstream regions of the human CYP11A and bovine CYP11B genes [have] a distal promoter in each gene. (wikiversity.org)

Once the holoenzyme is assembled and attached to the promoter, the transcription start site (TSS) is transcribed as the first nucleotide of the pre-messenger RNA. (wikiversity.org)

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone. (wikipedia.org)

2022 Nov 24;13(1):1-9. (leibniz-fmp.de)
2022 Sep 15:1-0. (leibniz-fmp.de)
As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)

The identification of genes involved in replication, segregation, toxin-antitoxin systems and conjugation, would aid the design of drugs to prevent the survival or transmission of plasmids carrying pathogenic properties. (frontiersin.org)
Incomplete placental implantation in preeclampsia is caused by angiogenic imbalance as one of pathogenic factors. (biomedcentral.com)

BACKGROUND: To identify the disease-causing gene in a Chinese family affected with congenital aniridia. (bvsalud.org)

This distal sequence is upstream of the gene. (wikiversity.org)
according to morphological, physiological and its 16S rRNA gene sequence. (researchgate.net)
Comparison of sequence data with the porcine BAC fingerprint map show that the cluster of genes resides in a 300 kb region. (biomedcentral.com)

Diagnose of preeclampsia is clinically established if there is an increased blood pressure more than 140/90 mmHg and proteinuria is more than 300 mg/24 h (dipstik +1) with or without edema. (biomedcentral.com)

We now describe the isolation of a further two genes (TashAT1 and TashAT3) that are very closely related to TashAT2. (lookformedical.com)

The impact is enhanced if coupled with the presence of functional genes for antibiotic resistance. (frontiersin.org)
This study aimed to discuss the main findings of HRQoL in patients with CD, focusing on the association between sociodemographic and lifestyle factors, echocardiographic and functional determinants, and the effect of non-invasive interventions on HRQoL. (scielo.br)
in the absence of functional tkv gene product, visceral mesoderm parasegment 7 cells fail to express Ultra-bithorax , but instead accumulate Antennapedia protein. (biologists.com)

All three TashAT genes are located together in a tight cluster, interspersed by two further small open reading frames, all facing head to tail. (lookformedical.com)

Seventy-eight patients with lung cancer and a follow-up time of 120 months are used to identify a set of gene markers and an independent cohort of 26 patients is used to evaluate the identified biomarkers. (biomedcentral.com)
Using the IMpRH 7000rad and IMNpRH2 12000rad radiation hybrid panels, these 5 genes mapped between microsatellite markers SWR67 and SW2067 . (biomedcentral.com)

supplied by OMIM] Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and PITX1. (wikipedia.org)
Pituitary PRL is controlled by the Pit-1 transcription factor and ultimately dopamine, extrapituitary PRL is controlled by a superdistal promoter and apparently unaffected by dopamine. (wikiversity.org)
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. (medscape.com)

A distal promoter in the S-phase has a role in the control of the human H1.2 histone gene transcription. (wikiversity.org)

Signaling pathways that are activated by intrinsic or extrinsic stimulation converge on the transcriptional factors and regulate phenotypic changes of cancer cells [ 9 ]. (biomedcentral.com)

also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene. (wikiversity.org)
was isolated from Guangdong, China, and further identified by the mitochondrial cytochrome oxidase subunit 1 ( COI ) gene. (biomedcentral.com)

Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)

Figure 1: Gross and histopathological findings. (nature.com)

In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)

Using cloned chicken β A -globin genes, either individually or within the natural chromosomal locus, enhancer-dependent transcription is achieved in vitro at a distance of 2 kb with developmentally staged erythroid extracts. (wikiversity.org)

Proliferative and cytoprotective roles for vascular endothelial growth factor in ovarian granulosa cells. (mcmaster.ca)
The vascular endothelial growth factor (VEGF) ligand and receptor family have been implicated in the growth and spread of prostate cancer via activation of the blood vasculature and lymphatic systems. (cdk-receptor.com)

Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. (medscape.com)
Hypogonadotropic hypogonadism in a female caused by an X-linked recessive mutation in the DAX1 gene. (medscape.com)
Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH). (medscape.com)

In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
CONCLUSIONS These results suggest that activation of VEGFR-1 by VEGF-A within the carcinoma, and activation of lymphatic endothelial cell VEGFR-3 by VEGF-D within the adjacent benign stroma may be important see more signaling mechanisms involved in the progression and subsequent metastatic spread of prostate cancer. (cdk-receptor.com)

The diagnosis of GHD is a multifaceted process requiring comprehensive clinical and auxologic assessment combined with biochemical testing of the GH-insulinlike growth factor (IGF) axis and radiologic evaluation. (medscape.com)
Primary lung cancer is very heterogeneous in its clinical presentation, histopathology, and treatment response [ 1 ]. (biomedcentral.com)
With thousands of clinical trials to date, gene therapy is a flourishing strategy with great promise for the treatment of diseases impacting the nervous system. (frontiersin.org)

Human homolog of patched, a candidate gene for the basal cell nevus syndrome. (nature.com)
Although the exact functions of the causing genes have not yet been completely understood, these overgrowth syndromes can be good models to clarify the complex basis of human growth and help to develop better-directed therapies in the future. (e-apem.org)
Human growth comes from a complex interplay of various factors including genetic backgrounds and environmental influences. (e-apem.org)
The external human WGBS data consists of 19 germ cells and pre-implantation embryonic tissues, 13 post-implantation embryonic and battlebit remastered undetected remove visual punch tissues, 37 cell lines, 59 non-blood normal primary tissues pubg wallhack free download normal adjacent tissues of tumors as well as disease-free samples, blood or blood component samples, 11 solid tumors and 50 blood malignancies Supplementary Table 1. (zharos.pt)
Review - Time for Radical Changes in Brain Stem Nomenclature - Applying the Lessons From Developmental Gene Patterns [1] "The traditional subdivision of the brain stem into midbrain , pons , and medulla oblongata is based purely on the external appearance of the human brain stem. (edu.au)

OBJECTIVES: Paired box gene 6 (PAX6) plays a major role in the regulation of embryonic development. (bvsalud.org)
Since phospho-VDAC and reduced HXKI levels favors a VDAC1 conformational state more prone to the release proapoptotic factors, regulation of the function of this channel may be a promising therapeutic approach to combat AD. (cdk-receptor.com)

A derivative that lacks this domain, while it cannot repress the endogenous fushi tarazu gene, can still reduce the activity of the fushi tarazu autoregulatory enhancer, suggesting that it competes with endogenous Fushi Tarazu for binding sites in vivo. (biologists.com)

Normal Fushi Tarazu target genes are affected as they are in fushi tarazu mutants. (biologists.com)

We used the provincial cancer registry data to calculate the cumulative incidence rates of esophageal and gastric cancers for each location through June 1, 2020, and used weighted partial Pearson correlation to compare the incidence rates with median urinary nitrate and sodium in each village or the city. (cdc.gov)

The already assembled RNA polymerase II holoenzyme attaches per appropriate cues and begins transcription at the designated TSS. (wikiversity.org)
To detect ASGV using reverse transcription polymerase chain reaction (RT-PCR), total RNA was extracted from one leaf from each tree using IQeasy, plus the plant RNA extraction Mini Kit (iNtRON, Seongnam, Korea) according to the manufacturer's recommendations. (online-rpd.org)

TPD1-like Gene as a Suitable Marker for Early Sex Determination in Date Palm (Phoenix dactylifera L. (mdpi.com)

A distal promoter is a distant (in numbers of nucleotides) portion of the promoter for a particular gene. (wikiversity.org)
an upstream region between -2.0 knts to -1.5 knts for a gene that can exist in a supercoiled conformation with this region to be actively transcribed is called a distal promoter . (wikiversity.org)
The distal promoters are located at −1.8 to −1.5 kb in the upstream region of the CYP11A gene and −1.5 to −1.1 kb in the upstream region of the CYP11B gene. (wikiversity.org)
There is a G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemohlobin. (wikiversity.org)
The distal promoter element ACACCC has a role regarding base substitution at position -88 in a beta-thalassemic globin gene. (wikiversity.org)
[16] However breast and other tissues may also express the Pit-1 promoter in addition to the distal promoter. (wikiversity.org)
Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)

In the fly, signals are regulated by a single Hh gene, while in mammals, Sonic (SHH), Indian (IHH), and Desert (DHH) hedgehog play different regulatory roles [ 37 , 148 ]. (regenmedres-journal.org)

The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis. (nature.com)
One such target gene is repressed by EFE even where Fushi Tarazu is not expressed, suggesting that the repression is active. (biologists.com)

Angiogenic substance, placental growth factor (PlGF) is considered to play its role. (biomedcentral.com)
Selection for growth rate and leanness in modern commercial pigs has resulted in a delay in the onset of puberty [ 1 ]. (biomedcentral.com)

METHODS The localization of VEGF-A, VEGF-C, VEGF-D, VEGF receptor (VEGFR)-1, VEGFR-2, and VEGFR-3 was examined in cancerous and adjacent benign prostate tissue from 52 subjects representing various grades of prostate cancer. (cdk-receptor.com)

We do not aim to provide an exhaustive analysis of all available techniques, but instead will highlight some of the most widely used methods for protein-protein assessment and will describe some recent advances in global protein-protein analyses that are enabling non-experts to identify interactomes of their favorite factor. (aacrjournals.org)
Although recent advances in treatment, myeloma remains an incurable disease [ 1 ]. (oncotarget.com)

A promoter is a region of DNA that facilitates the transcription of a particular gene. (wikiversity.org)
A promoter is on the template strand for the gene and near the gene in numbers of nucleotides (nts) along the DNA template strand. (wikiversity.org)
Usually, the promoter lies within the string of nucleotides between genes. (wikiversity.org)
These specific stimuli for a gene find a receptive portion within that gene's promoter. (wikiversity.org)

Among various conditions showing overgrowth, genetic overgrowth syndrome refers to a nonhormonally mediated overgrowth condition which can accompany increased height and/or head circumference, various degrees of mental retardation, or physical dysmorphisms in children 1) . (e-apem.org)
Gestational hypertension is defined as hypertension disease which occurs in pregnancy, consisting of: (1) gestational hypertension, (2) preeclampsia and eclampsia syndrome, (3) chronic hypertension which is worsened by preeclampsia, and (4) chronic hypertension. (biomedcentral.com)

METHODS: Treatment-naïve patients with genotype 1 chronic HCV were followed over a lifetime horizon from the third-party payer perspective. (cdc.gov)

Scientific Reports 11 (1), 2943. (upv.es)

The GPR54 gene as a regulator of puberty. (medscape.com)

Gene therapy viruses are non-replicating, but still hijack host cell machinery to express transgenes of interest in the nucleus. (frontiersin.org)
Recently, we described the characterisation of a parasite gene (TashAT2), whose polypeptide product bears AT hook DNA-binding motifs and may be transported from the parasite to the host nucleus. (lookformedical.com)

Active Notch signaling in MM cells induces the secretion of the key osteoclastogenic factor, RANKL, which can be boosted in the presence of stromal cells. (oncotarget.com)

IHH is a core factor in the morphogenesis of vertebrate skeleton. (regenmedres-journal.org)

These pits are the entry route for macromolecules bound by cell surface receptors. (lookformedical.com)

1. Principal Investigator, Establishing a new model of mechanosensory hair cell damage/regeneration (斑马鱼动感毛细胞损伤/再生新模型的建立), a NSFC regular (sustech.edu.cn)

Anatomy17

Organisms9

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes78

Disciplines and Occupations1

Information Science3

Mutations7

Encodes5

Chromosome4

Genome5

Cloning2

CDNA1

Homologous1

Protein-encod1

Expression18

Proteins6

20231

Virulence3

Bovine1

Nucleotide1

POU1F11

20223

Pathogenic2

Congenital1

Sequence3

Edema1

Isolation1

Functional3

Cluster1

Markers2

Pituitary3

Histone1

Transcriptional1

Differentiation1

Subunit2

Insulin resistance1

Findings1

Activates1

Locus1

Vascular endoth2

Mutation3

Mechanisms2

Clinical3

Human5

Regulation2

Endogenous1

Mutants1

20201

Polymerase2

Marker1

Distal7

Regulatory1

Target gene2

Growth2

VEGF1

Recent Advances2

Promoter4

Syndrome2

Genotype1

Scientific Reports1

Puberty1

Nucleus2

Secretion1

Vertebrate1

Receptors1

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