• Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)
  • A subclass of clathrin assembly proteins that occur as monomers. (lookformedical.com)
  • The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
  • A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
  • Proteins are composed of long chains of amino acids that fold on themselves to form three-dimensional structures. (elifesciences.org)
  • Different light chains are responsible for two diseases with diametrically opposite mesangial alterations: Light chain deposition disease which results in the expansion of the mesangium due to accumulation of matrix proteins not present in the normal mesangium and AL (light chain-associated) amyloidosis where the native mesangial matrix is replaced by fibrils (amyloid). (heraldopenaccess.us)
  • Normal light chains are small molecular weight proteins that are filtered through the peripheral capillary walls and are delivered to the proximal tubules where they are catabolized by endosomal activity in the apical portions of the tubules and their amino acids are then returned to the circulation. (heraldopenaccess.us)
  • Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. (lookformedical.com)
  • Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. (nih.gov)
  • The physicochemical and conformational characteristics of the abnormal light chains are primarily responsible for the downstream events affecting the mesangial milieu. (heraldopenaccess.us)
  • Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene. (wikipedia.org)
  • The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
  • Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
  • This gene belongs to the HLA class I heavy chain paralogues. (nih.gov)
  • The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)
  • They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. (lookformedical.com)
  • It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. (nih.gov)
  • Mesangial injury represents a crucial event in the pathogenesis of light chain-associated glomerulopathies in patients with plasma cell dyscrasias. (heraldopenaccess.us)
  • Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples. (nih.gov)
  • Dr. Greene studies the role of molecular chaperones and their co-factors in the formation of vesicular compartments from clathrin-coated pits in the cellular membrane during endocytosis. (nih.gov)
  • Despite numerous advances in the identification of the molecular machinery for clathrin-mediated budding at the plasma membrane, the mechanistic details of this process remain incomplete. (rupress.org)