poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
Molecular characterization of proteins in detergent solutions. (wikidata.org)
CD1 molecules are cell-surface glycoproteins with strong structural similarities to major histocompatibility complex (MHC) class I molecules, and studies in humans and mice have demonstrated that CD1 proteins perform the unique role of presenting lipid antigens to T lymphocytes. (elsevierpure.com)
Presently almost no information is available on the oligosaccharide structure of the glycoproteins secreted from the methylotrophic yeast Hansenula polymorpha, a promising host for the production of recombinant proteins. (unboundmedicine.com)
The researchers wrote in the abstract of their article: "Different components of the cell membrane (i.e. proteins, glycoproteins and lipoproteins) may serve as adhesins and/or be toxic for the respiratory tract cells. (pigprogress.net)
Some animal proteins, for example, those in the LAT family (TC# 2.A.3.8) including ASUR4 (gbY12716) and SPRM1 (gbL25068) associate with a type 1 transmembrane glycoprotein that is essential for insertion or activity of the permease and forms a disulfide bridge with it. (tcdb.org)
The strong expression of ATP-gated P2X3 receptors by a subpopulation of sensory neurons indicates the important role of these membrane proteins in nociceptive signaling in health and disease, especially when the latter is accompanied by chronic pain syndromes. (gozmusic.org)
N-glycosylation plays an important role in the structure and function of membrane and secreted proteins. (cdc.gov)
Protein18
Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
CD47 belongs to the immunoglobulin superfamily [1] and partners with membrane integrins and also binds the ligands thrombospondin-1 ( TSP-1 ) and signal-regulatory protein alpha ( SIRPα ). (wikidoc.org)
The H4A3 monoclonal antibody specifically binds to CD107a which is also known as Lysosomal-associated membrane protein 1 (LAMP-1). (bdbiosciences.com)
Glycoprotein Ib (platelet), beta polypeptide ( GP1BB ) also known as CD42c ( C luster of D ifferentiation 42c ), is a protein that in humans is encoded by the GP1BB gene. (wikidoc.org)
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. (wikidoc.org)
Fibroblast activation protein (FAP) is a type II integral membrane glycoprotein belonging to the serine protease family. (imrpress.com)
The herpes simplex virus type 1 (HSV-1) glycoprotein N (gN/UL49.5) is a type I transmembrane protein conserved throughout the herpesvirus family. (mdpi.com)
1987). M glycoprotein As is the case with the N protein, the M glycoprotein of the various coronaviruses also exhibits different Mr values in polyacrylamide gels (see review by Siddell et al. (pdfroom.com)
These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
we report that in the developing embryonic mouse brain, the fluid in the lumen of the neural tube contains membrane particles carrying the stem cell marker prominin - 1 (CD133), a pentaspan membrane protein found on membrane protrusions of the apical surface of neuroepithelial cells. (biologists.com)
Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. (unige.ch)
A total of five major Open Reading Frames (ORF) were found in COVID-19: the ORF 1a/b region coding replicase and other enzymes, the spike or S protein ORF, M or membrane glycoprotein ORF, E or small membrane protein ORF and the N or nucleocapsid ORF ( fig. 1 )[ 5 ]. (ijpsonline.com)
Serine protease present on cell membrane, is used by SARS-CoV-2 for associating spike protein to enable its fusion with host cells[ 12 - 14 ]. (ijpsonline.com)
The spike glycoprotein sequence was retrieved from protein data bank (PDB) database. (ijpsonline.com)
The article shows how the virus interacts with a receptor on human cells, the EphA2 receptor, via a surface protein complex made of glycoproteins H and L (gH/gL). (pasteur.fr)
The ABCB4 gene (also known as MDR3 ) provides instructions for making a protein that helps move certain fats called phospholipids across the membranes of liver cells and release the phospholipids into a digestive fluid called bile. (medlineplus.gov)
Receptors4
Contagious human coronavirus (SARS-CoV-2) binds to the receptors of human host cells by transmembrane spike glycoprotein that makes homotrimers protruding from viral surface region[ 9 , 10 ]. (ijpsonline.com)
Spike glycoprotein has two subunits, S1-responsible for its binding to host cell membrane receptors and S2-responsible for the fusion of viral and host cellular membrane[ 8 , 11 ]. (ijpsonline.com)
Analysis of this HA gene shows that it is closely related to avian A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)
A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)
Lysosomal8
It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail exposed to the cytoplasm. (wikipedia.org)
Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. (bdbiosciences.com)
Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. (bdbiosciences.com)
Antigen5
The larger form of this antigen (185-255 kD) occurs in the developing nervous system and is present in membranes of nerve growth cones, as determined by analysis of a growth cone particle fraction. (rupress.org)
An immunochemical characterization of this antigen and of a smaller form (140 kD), sparsely present in the mature nervous system, has been described (Ellis, L., I. Wallis, E. Abreu, and K. H. Pfenninger, 1985, J. Cell. (rupress.org)
Based on the available data and research through clinical development, a vaccine antigen based on the E1E2 glycoprotein complex appears to be the best choice, but robust induction of humoral and cellular responses leading to virus neutralisation has not yet been achieved. (bvsalud.org)
Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (unige.ch)
We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema factor (EF), and their toxin complexes, lethal toxin and edema toxin in plasma, during the course of inhalation anthrax in 23 cynomolgus macaques. (cdc.gov)
Isolation and Characterization of Pepsin Solubilized Basement Membrane Collagens (Type 4) from Human Placenta, Bovine Kidney Cortices, and Bovine Lens Capsule 6. (edu.au)
Immunization Procedures, Isolation by Affinity Chromatography and Serological and Immunochemical Characterization of Collagen Specific Antibodies 12. (edu.au)
Molecular6
El càncer de pulmó de cèl·lula no petita (CPCNP) es pot definir a nivell molecular per les alteracions genètiques que es produeixen en múltiples oncogens, inclosos els reordenaments dels gens ALK i ROS1. (tesisenred.net)
Here, we report the molecular and cell-biological characterization. (biologists.com)
Here we report the molecular characterization of the chicken TLR7/8 loci which revealed an intact TLR7 gene and fragments of a TLR8-like gene with a 6-kilobase insertion containing chicken repeat 1 (CR1) retroviral-like insertion elements. (ox.ac.uk)
This project focused on the molecular and functional characterization of the SCFFBXO38 ubiquitin ligase. (nusl.cz)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
Receptor8
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. (openwetware.org)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (openwetware.org)
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. (google.com)
It is part of the Glycoprotein Ib-IX-V Receptor Complex (GPIb-V-IX) system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. (wikidoc.org)
Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. (unige.ch)
Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens. (ox.ac.uk)
Comprehensive characterization1
Toward a comprehensive characterization of a human cancer cell phosphoproteome. (unige.ch)
Platelet1
Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (bdbiosciences.com)
Specificity3
The main purpose of the two volumes on Immunochemistry of the Extracellular Matrix is to describe state of the art methods, which have been proven to provide antibody reagents of defined specificity to collagens as well as other glycoproteins found in association within connective tissue. (edu.au)
Gardas A, Kościelak J: Megaloglycolipids - unusually complex glycosphingolipids of human erythrocyte membrane with A, B, H and I blood group specificity. (hirszfeld.pl)
The hemagglutinin (HA) gene codes for one of the two surface glycoproteins and is central to species specificity because it is responsible for virus attachment and fusion with host cells. (cdc.gov)
Structural2
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. (ox.ac.uk)
We hope that detailed characterization of their epitopes and properties will facilitate the use of these renewable binders as structural and functional biology tools for TREM2 research. (ox.ac.uk)
Antibodies3
Biochemical characterization revealed that both antibodies detect the same 58-64-kDa glycoprotein anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. (uni-regensburg.de)
The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. (uni-regensburg.de)
Characterization of Tritrichomonas foetus antigens by use of monoclonal antibodies. (docksci.com)
Functional1
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. (lu.se)
19851
In addition, reviews have appeared which highlighted particularly interesting characteristics of the family, e.g. the replication strategy (Lai, 1986) and the glycoproteins (Sturman & Holmes, 1985). (pdfroom.com)
Ligands1
Despite its significant role, ligands and regulators of TREM2 activation, and the mechanisms governing TREM2-dependent responses and its cleavage from the membrane, remain poorly characterized. (ox.ac.uk)
Intracellular2
IEV is formed by wrapping of IMV with intracellular membranes, and is an intermediate between IMV and CEV/EEV that enables efficient virus dissemination to the cell surface on microtubules. (microbiologyresearch.org)
It is likely that intracellular and membrane-associated partners are crucial in determining the cellular response of CD47 signaling. (wikidoc.org)
Recombinant1
In this study, we analyze the size distribution and structure of N-linked oligosaccharides attached to the recombinant glycoprotein glucose oxidase (GOD) and the cell wall mannoproteins obtained from H. polymorpha. (unboundmedicine.com)
Purification1
Kamińska J, Glick MC, Koscielak J: Purification and characterization of GDP-L-Fuc: N-acetyl β-D-glucosaminide a1→6fucosyltransferase from human blood platelets. (hirszfeld.pl)
Human5
Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
Kościelak J, Plasek A, Górniak H, Gardas A, Gregor A: Structures of Fucose‐Containing Glycolipids with H and B Blood‐Group Activity and of Sialic Acid and Glucosamine‐Containing Glycolipid of Human‐Erythrocyte Membrane. (hirszfeld.pl)
Gardas A, Kościelak J: A, B and H Blood Group Specificities in Glycoprotein and Glycolipid Fractions of Human Erythrocyte Membrane. (hirszfeld.pl)
The characterization of exosomes, especially those derived from human stem cells, is a complex process. (resilielle.com)
Interacts1
CD47 interacts with several membrane integrins, most commonly integrin avb3. (wikidoc.org)
19871
1987) has revealed many interesting features of the M glycoprotein. (pdfroom.com)
Gene5
The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. (wikipedia.org)
Dissociation of progeny vaccinia virus from the cell membrane is regulated by a viral envelope glycoprotein: effect of a point mutation in the lectin homology domain of the A34R gene. (microbiologyresearch.org)
The utilisation of typing methods and complete or partial‐gene sequencing for M. hyo characterisation has increased in diagnostic laboratories as control and elimination strategies for this micro-organism are attempted worldwide. (pigprogress.net)
Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. (lu.se)
ABCB4 gene mutations that cause PFIC3 impair the movement of phospholipids across cell membranes, leading to a lack of phospholipids available to bind to bile acids. (medlineplus.gov)
Approaches1
In addition a tool determination be needed to iden- tify patients with P-glycoprotein over-expression in search any appositeness of healthy approaches aiming to bested transporter-mediated resistance. (rayart.lt)
Type2
Zdebska E, Musielak M, Jaeken J, Kościelak J: Band 3 glycoprotein and glycophorin A from erythrocytes of children with congenital disorder of glycosylation type-la are underglycosylated. (hirszfeld.pl)
In this report, we used mass spectrometry techniques to characterize and compare the N-glycosylation of the wild type (S-614D) or variant (S-614G) SARS-CoV-2 spike glycoproteins prepared under identical conditions. (cdc.gov)
Plasma1
Denis Corbeil Prominin - 1 /CD133 is a five-membrane-span glycoprotein that is thought to act as an organizer of plasma-membrane protrusions. (biologists.com)
Complex1
The pellicle complex of E. gracilis is composed of the cell membrane, the ridge and groove with the notch, four fibrils, and the subpellicular ER. (rupress.org)
Antiviral1
Any peptide that interrupts proteinprotein or viral proteinhost cell membrane interactions is potentially a novel antiviral drug and may be a useful tool for elucidating the mechanisms of viral entry. (cnr.it)
Deficient1
Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95. (lu.se)
Surface1
Computer predictions of its secondary structure have led to a model in which approximately 10~ of the N-terminal part of the molecule is exposed on the outer surface of the virus membrane (see references above and Rottier et al. (pdfroom.com)
Outer1
Salvage of polymeric PGN presumably requires the removal of peptides from PGN by an unknown amidase, concomitantly with the translocation of the polymer across the outer membrane. (karger.com)
Structure1
The antigenic structure of the HIV gp120 envelope glycoprotein. (openwetware.org)