Chagas disease. Medical search. Frequent questions

Chagas disease is common in Latin America, especially in poor, rural areas. (medlineplus.gov)
The disease affects about 8 million people in Latin America, of whom 30-40% either have or will develop cardiomyopathy, digestive megasyndromes, or both. (nih.gov)
Some 100 million (roughly 25% of the population of Latin America) are at risk of acquiring Chagas disease. (medscape.com)
Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy. (medscape.com)
Dogs Carry Kissing Bug Disease in Texas and Latin America. (medicinenet.com)
Chagas disease or American trypanosomiasis, caused by Trypanosoma cruzi , affects about 18 million people living mostly in Latin America. (sciencedaily.com)
Around 8 million people worldwide have Chagas disease, mostly in Latin America, and 11,000 people die of the disease each year, according to the WHO. (nih.gov)
Chagas kills more people in Latin America each year than any other parasitic disease, including malaria. (dndi.org)
Chagas disease is endemic to Latin America and efforts have been made to eradicate the triatomine insect in homes. (escardio.org)
Chagas disease infects an estimated 8 to 10 million people, mostly in Latin America, and kills some 12,000 people each year, making it the leading parasitic killer in the Americas, where it causes more deaths than malaria. (dndi.org)
Chagas' disease is endemic to Latin America, where some 6-7 million people are estimated to be infected. (eisai.com)
Though it is usually concentrated in rural rural areas of Latin America, large-scale population movements from rural areas to urban ones in Latin America and other regions in the world have increased the geographic distribution and the epidemiology of Chagas disease. (worldforgottenchildren.org)
There exists 300,000 US citizens who are infected with chagas disease, but the vast majority of these individuals contracted the disease while visiting Latin America, but at least 30 local infections have been discovered in the US. (bbpest.com)
Chagas disease remains a major cause of mortality in several countries of Latin America and has become a potential public health problem in non-endemic countries as a result of migration flows. (plos.org)
Chagas disease remains a major cause of morbidity and mortality in several countries of Latin America and has become a potential public health problem in countries where the disease is not endemic as a result of migration flows. (plos.org)
Chagas an endemic disease in Latin America, where thatched roofs and other forms of substandard housing provide nesting environments for the Chagas-transmitting "kissing bugs. (outbreaknewstoday.com)
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease and a health problem in Latin America. (fiocruz.br)

Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. (cdc.gov)
The disease was first described in 1909 by Brazilian physician Carlos Chagas, after whom it is named. (wikipedia.org)
Chagas disease, named after the Brazilian physician Dr Carlos Chagas who first described it in 1909, exists only in the western hemisphere. (medscape.com)
These insects can carry the protozoan Trypanosoma cruzi , the parasite isolated in 1909 by the Brazilian physician Carlos Chagas and are almost exclusively established inside human dwellings and/or peridomestic structures. (escardio.org)
This book presents and discusses the scientific achievements made since Dr. Carlos Chagas (1909) demonstrated the T. cruzi in the blood of a feverish child. (benthambooks.com)
Carlos Chagas discovered the disease over a century ago. (my-vaccine.com)

Diagnosis of early disease is by finding the parasite in the blood using a microscope or detecting its DNA by polymerase chain reaction. (wikipedia.org)
Chagas disease is caused by the Trypanosoma cruzi parasite. (medlineplus.gov)
Chagas' disease results from the bite of a triatomine bug infected by the parasite, Trypanosoma cruzi . (medicalnewstoday.com)
The acute phase of Chagas' disease occurs during the first couple of weeks to months after the infection starts while the parasite is circulating in the blood. (medicalnewstoday.com)
The parasite is a flagellated protozoan named Trypanosoma cruzi ( T. cruzi ) that can infect over 100 species of mammals and cause heart disease . (medicinenet.com)
Left untreated the disease can lead to cardiac and digestive disorders, as the parasite burrows into the heart, esophagus and colon tissue where it causes damage over time. (sciencedaily.com)
The current standard of care, the drug benznidazole, has significant activity against the parasite during the acute phase, but is less effective once the disease becomes chronic. (sciencedaily.com)
Chagas is caused by a parasite that is carried by mosquitoes and other insects. (nih.gov)
Parasite has a predilection for infection in muscle, so the primary presentation of Chagas disease is heart disease and sometimes gut disease. (drugdiscoverynews.com)
Although it sounds like a very unlikely set of occurrences - this bug biting you and pooping on you and this parasite getting into your bloodstream - it's actually an extraordinarily common and prevalent disease throughout the Americas. (drugdiscoverynews.com)
They get the disease from biting animals or humans, which are both the primary hosts in which the parasite reaches maturity. (escardio.org)
The Chagas parasite is primarily transmitted via the bite of the blood-sucking triatome bug, widely known as the 'kissing bug', which is often found in poor housing conditions. (dndi.org)
From now on, hope of an early cure for infection of the parasite that causes Chagas disease is a wonderful reality. (dndi.org)
Chagas' disease is caused by the parasite Trypanosoma cruzi , a species of flagellate trypanosomes that are transmitted to people via insects formally referred to as Reduviidae common to Latin American and Caribbean countries. (eisai.com)
Chagas disease is caused by the parasite Trypanosoma cruzi , which is transmitted to animals and people by an insect called a triatomine bug. (arkansas.gov)
Chagas disease is an infection, in which the necessary cause is a parasite called Trypanosoma cruzi . (biomedcentral.com)
Bob passed away in 2018 after receiving a heart that was infected with the parasite that causes Chagas disease. (propublica.org)
By the next day, doctors in Yale's intensive care unit found the culprit: The heart Naedele had received had been infected with a parasite that causes Chagas disease. (propublica.org)
Chagas disease is caused by a parasite called T. cruzi, which is transmitted via insects and found mainly in rural areas of Central America, South America and Mexico. (propublica.org)
Incompletely cured pre-existing diseases (except chronic Chagas) for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal - Acute Chagas'disease (During the acute phase, the parasite on a blood smear may be seen under a microscope. (bayer.com)
Genotype modifications resulting from transfer of minicircle sequence kDNA from the parasite into the host´s genome may explain the autoimmune pathogenesis of the disease. (benthambooks.com)
Chagas Disease prevention and control require further studies on the ecological conditions and environmental changes related to the complex epidemiological chain that links forty species of invertebrate transmitters of the protozoan parasite to over 1250 mammal species dwelling in various ecosystems throughout the American Continents. (benthambooks.com)
Caused by a parasite transmitted by blood-sucking "assassin bugs," Chagas' disease can lead to swollen lymph nodes and organ damage. (nih.gov)
Chagas is spread by the bite of an insect - the "assassin bug" - which infects people with a parasite. (enetmd.com)
And so they should: the parasite Trypanosoma cruzi that causes the disease hides inside the muscle fibres of the heart, the digestive system or peripheral nervous system, gradually damaging organs. (enetmd.com)
It is estimated that between 40,000 and 80,000 Latin Americans in Spain - mainly from Bolivia - have either the disease or the parasite. (enetmd.com)
Even though 70% of people with the Chagas parasite will never develop symptoms, they can still pass it on. (enetmd.com)
Factors like the age of the person when they got infected, the way the person acquired the disease or the strain of the T. cruzi parasite affects the severity and course of an individual's infection. (worldforgottenchildren.org)
The FDA defines Chagas disease as a parasitic infection caused by the Trypanosoma cruzi parasite. (benznidazoletablets.com)
3,4 Their feces contain the T cruzi parasite, which can cause Chagas disease when hosts scratch the bite and the feces enter their bloodstream. (benznidazoletablets.com)
Diagnosis of the disease in its acute form is relatively simple, as the parasite can be detected in peripheral blood smears, and symptoms are visible. (authorea.com)
The disease is caused by a parasite in feces of an insect named Trypanosoma Cruzi. (herbpathy.com)
New research shows that being infected by multiple strains of the parasite may stop the progression of the disease. (tulane.edu)
New research from Tulane University may shed light on how parasite strain diversity can impact Chagas disease progression and severity. (tulane.edu)
In a new study published in Microbiology Spectrum , Tulane researchers established a link between disease progression and parasite strain diversity. (tulane.edu)
Rhesus macaques naturally infected with T. cruzi were studied for two to three years, and researchers found that those infected with mixtures of multiple strains were able to better control the parasite and stop the progression of the disease, while those with a progressive form of the disease had fewer strains. (tulane.edu)
In a new study published in Microbiology Spectrum , Tulane researchers were able to establish a link between disease progression and parasite strain diversity. (greenhealthlive.com)

Chagas disease ( T. cruzi infection) is also referred to as American trypanosomiasis. (cdc.gov)
Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by Trypanosoma cruzi. (wikipedia.org)
Chagas disease, or American trypanosomiasis, is an illness that can cause serious heart and stomach problems. (medlineplus.gov)
Chagas disease (also known as American trypanosomiasis ) is a parasitic vector-borne disease. (medicinenet.com)
According to the World Health Organisation, Chagas disease (American trypanosomiasis) represents the third largest tropical disease burden after 1) malaria: 40 million people infected in numerous tropical and subtropical countries and 2) schistosomiasis, also referred to as snail fever: 30 million infected in Asia, Africa, and South America. (escardio.org)
This program appears to be designed to aid the physician in establishing a diagnosis of Chagas disease (also known as American trypanosomiasis). (nih.gov)
The evidence of natural infection by Trypanosoma cruzi in animals in which Chagas' disease (ChD) had not been previously described can contribute to a better understanding of many aspects of American trypanosomiasis. (scielo.br)

Chagas disease is a chronic, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi, and was discovered in 1909. (nih.gov)
A parasitic infection transmitted through an insect bite , the chronic form of Chagas results in devastating damage to the heart, cardiomyopathies, and often sudden death. (medscape.com)
Symptoms of Chagas' disease vary depending on whether the infection is in the acute or chronic phase of the disease. (medicalnewstoday.com)
Generally speaking, however, the symptoms of Chagas' disease primarily depend on whether someone is in the acute or chronic phase of the infection. (medicalnewstoday.com)
When the infection is acute, many people are unaware they have Chagas' disease because the symptoms can be so mild, varied, and similar to other common conditions. (medicalnewstoday.com)
People exhibiting signs and symptoms of Chagas' disease or any infection should seek medical attention to limit the chances of developing complications. (medicalnewstoday.com)
Both medications are almost 100% effective at curing the disease, according to the WHO, but only if a person takes them quickly after infection in the acute phase. (medicalnewstoday.com)
Trypanosoma cruzi Infection Prevalence and Bloodmeal Analysis in Triatomine Vectors of Chagas Disease From Rural Peridomestic Locations in Texas, 2013-2014. (medscape.com)
Some dogs may not develop any clinical symptoms until entering a chronic phase of the disease, which may be several years after initial infection. (medicinenet.com)
For more than 100 years before it was hit by the Zika virus, Brazil was battling Chagas disease, a vector-borne illness that is usually asymptomatic in the acute stage, but has deadly or debilitating health impacts long after infection - not unlike Zika. (nih.gov)
Chagas disease stems from a parasitic infection. (drugdiscoverynews.com)
For more than fifty years, the only drugs for Chagas disease, a parasitic infection that leads to deadly cardiac and gastrointestinal outcomes, have been difficult to get ahold of, plagued by unwanted side effects, and have not been very effective. (drugdiscoverynews.com)
A T. cruzi infection can lead to a life-threatening case of Chagas disease both in animals and humans. (drugdiscoverynews.com)
They are effective against the disease if given soon after infection and appear to be effective in the chronic asymptomatic phase of the disease. (dndi.org)
The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos R. J. Chagas. (medscape.com)
A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
Since Chagas' disease sometimes does not develop even after an infection, it is also known as the "silent disease. (eisai.com)
Immediately after infection, Chagas' disease can be diagnosed and treated with a high degree of success. (eisai.com)
The oral transmission of Chagas disease: an acute form of infection responsible for regional outbreaks. (ajtmh.org)
Seroprevalence of T. cruzi infection in blood donors and Chagas cardiomyopathy in patients from the coal mining region of Coahuila, Mexico. (nih.gov)
Chagas disease is an infection caused by the protozoa Trypanosoma cruzi , which is transmitted by the bite of a kissing bug (also called an assassin or Triatominae bug). (msdmanuals.com)
Fortunately, measures to control the spread of infection are reducing the number of Chagas cases. (msdmanuals.com)
Chagas disease is a neglected parasitic infection. (pasteur.fr)
A common parasitic roundworm infection, hookworm disease can be contracted by walking barefoot on soil contaminated by feces. (nih.gov)
Although this may lead to new modes of infection and increased transmission of insect-borne diseases, epidemiologists rarely consider the role of night lighting in their surveys. (nih.gov)
Despite a surprising lack of studies, existing evidence supports our hypothesis that artificial lighting leads to a higher risk of infection from vector-borne diseases. (nih.gov)
From 2001 to 2018, 5,184 cases of acute Chagas disease were found in Brazil, with the annual infection rate in Brazil being 0.16 per 100,000 inhabitants. (worldforgottenchildren.org)
People sick with Chagas disease are usually unaware of their infection, which makes it concerningly hard to detect and makes it more difficult to set up interventions. (worldforgottenchildren.org)
Because these symptoms are similar to other diseases, such as colds, people infected with Chagas disease are often unaware of their infection. (worldforgottenchildren.org)
Chagas disease can be treated effectively with benznidazole or nifurtimox if given soon after the infection is at the onset of the acute phase. (my-vaccine.com)
Chagas disease is an endemic infection throughout much of Mexico, Central America, and South America. (benznidazoletablets.com)
Chagas disease can only be diagnosed through analysis of a specific blood test to detect the presence of the parasitic infection. (benznidazoletablets.com)
We report a 24 year old female polar bear (Ursus maritimus) who contracted Chagas' infection at the Guadalajara Zoo, in Jalisco, México, and died of acute Chagas' carditis 15 days later. (scielo.br)
who contracted Chagas' infection at the Guadalajara Zoo, in Jalisco, México, and died of acute Chagas' carditis 15 days later. (scielo.br)
This patent application embodies use of synthetic peptides derived from Trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and Chagas disease. (utep.edu)
So you won't diagnose a soil-transmitted helminth infection the same way you would diagnose visceral leishmaniasis or Chagas disease. (asm.org)
While most infected patients remain asymptomatic, about 20-40 percent will develop chronic heart disease years or decades after infection, and about 5 percent will develop digestive disease. (tulane.edu)

As the disease progresses, the heart's ventricles become enlarged (dilated cardiomyopathy), which reduces its ability to pump blood. (wikipedia.org)
Patients with severe chronic disease usually die from sudden cardiac death or from heart failure associated with dilated cardiomyopathy . (medscape.com)

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. (medscape.com)
Approximately 10 million people are infected with Trypanosoma Cruzi , the etiological agent of Chagas disease. (escardio.org)
The World Health Organization (WHO) has estimated that 18 million people are infected with Trypanosoma cruzi , the causal agent of Chagas disease. (benthambooks.com)

What are the treatments for Chagas disease? (medlineplus.gov)
If you're trying to find new treatments for Chagas disease, you want a good marker of cure. (asm.org)

It is estimated that 6.5 million people, mostly in Mexico, Central America and South America, have Chagas disease as of 2019, resulting in approximately 9,490 annual deaths. (wikipedia.org)
The Centers for Disease Control (CDC) estimates that around 8 million people living in Central America, South America, and Mexico have Chagas' disease. (medicalnewstoday.com)
It is estimated that as many as 8 million people in Mexico, Central America, and South America have Chagas disease, most of whom do not know they are infected. (arkansas.gov)
It is estimated that 6.2 million people, mostly in Mexico, Central America and South America, have Chagas disease as of 2017, [1] [3] resulting in an estimated 7,900 deaths. (mdwiki.org)
Currently, Chagas disease is no longer restricted to the poor people in remote rural areas of South and Central America. (benthambooks.com)
The geographic distribution of the disease in South and Central America, and the epidemiological features, diagnostic tests, and causative agent of the disease are described. (nih.gov)

Chagas disease was first reported in Brazil in 1909 when it came to Brazilian physician Carlos Chagas's attention. (worldforgottenchildren.org)

It is important to note that, globally, only 1 in 10 people with Chagas' disease receive a proper diagnosis. (medicalnewstoday.com)
Evaluation of adult chronic Chagas' heart disease diagnosis by molecular and serological methods. (medscape.com)
But because the illness is mild in the acute stages, those infected are often unaware that they have Chagas and do not seek treatment or diagnosis. (nih.gov)
The process of getting a rare disease diagnosis can take several years. (nih.gov)
Development of a highly specific test system for the diagnosis of Chagas' disease (CD) was sought using Gp25, a surface glycoprotein recently isolated from Trypanosoma cruzi culture forms. (ajtmh.org)
The aim of this investigation was to review chronic Chagas disease diagnosis literature and to summarize results of ELISA and PCR performance. (biomedcentral.com)
Currently, PCR should not be used in clinical practice for chronic Chagas disease diagnosis and there is no PCR test commercially available for this purpose. (biomedcentral.com)
The definition of highly effective contraception will be left at the discretion of the investigator and will be in line with ICH ICH Topic M 3 (R2): Non-Clinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals - Male/female subject diagnosed with chronic Chagas' disease: Previous diagnosis of acute or chronic Chagas' disease by a health clinic prior to screening for the study. (bayer.com)
The diagnosis of chronic Chagas' disease may be made by clinical findings, supported by antibody titers if available. (bayer.com)
Biomarkers for the Diagnosis, Treatment Follow-Up, and Prediction of Cardiac Complications in Chagas Disease. (authorea.com)
It is important to note that a single test is not enough to confirm the disease, as a second serological test should confirm the diagnosis. (authorea.com)
In this work, we have searched scientific literature from the last years for mentions of novel biomarkers for diagnosis, treatment follow-up, and prediction of cardiac complications in Chagas disease in its chronic phase. (authorea.com)
If you look at sero-diagnosis, that can be a lot more specific, but at least in the context of Chagas disease, there's a lot of genetic variability with the parasites. (asm.org)

According to data from WHO, after several years of an asymptomatic period, most of those with the chronic form of Chagas develop cardiac symptoms. (medscape.com)
According to the World Health Organization (WHO), up to 30% of people with chronic Chagas' disease develop cardiac issues while 10% develop digestive or neurological issues. (medicalnewstoday.com)
Brain involvement in Chagas was long believed to be related to the illness' signature condition, cardiac disease. (nih.gov)
But Oliveira began looking for other explanations for Chagas-associated neurological disorders when he noticed that a considerable proportion of patients who have the disease without cardiac involvement still have a history of stroke. (nih.gov)
Oliveira and his team in Brazil, working with researchers at Harvard and Brown Universities in the U.S., have shown in NIH-funded studies that stroke occurs in Chagas patients independently of cardiomyopathy - an important finding because a Chagas serologic test is usually only ordered for stroke patients who are from endemic areas and have evidence of cardiac disease. (nih.gov)
This study aimed to assess the role of diastolic dysfunction, abnormal myocardial strain and elevated brain natriuretic peptide (BNP) in the early identification of cardiac involvement in Chagas disease. (plos.org)
Patients with significant non-cardiac diseases, other heart diseases and previous treatment with benznidazol were excluded. (plos.org)

Early infections are treatable with the medications benznidazole or nifurtimox, which usually cure the disease if given shortly after the person is infected, but become less effective the longer a person has had Chagas disease. (wikipedia.org)
The best treatment for people in the acute phase of Chagas' disease is antiparasitic medications, most commonly benznidazole and nifurtimox. (medicalnewstoday.com)
Benznidazole, one of the two drugs used to treat Chagas, is traditionally administered twice a day over a course of eight weeks, in line with PAHO and WHO recommendations and national guidelines. (infectioncontroltoday.com)
The trial was conducted in partnership with CEADES (Fundacion Ciencia y Estudios Aplicados para el Desarrollo en Salud y Medio Ambiente), ISGlobal, Japanese pharmaceutical company and manufacturer of fosravuconazole Eisai Co. Ltd., Argentinian pharmaceutical company manufacturer of benznidazole Elea and associated non-profit foundation FundaciÃ³n Mundo Sano, among others, and funded by the Global Health Innovative Technology Fund (GHIT). (infectioncontroltoday.com)
Background Benznidazole (BNZ) is safe and effective for the treatment of paediatric Chagas disease. (bmj.com)
Benznidazole Tablets are the first FDA-approved treatment for Chagas disease. (benznidazoletablets.com)
Benznidazole Tablets are indicated in pediatric patients 2 to 12 years of age for the treatment of Chagas disease caused by Trypanosoma cruzi . (benznidazoletablets.com)

Whether your dog stays outside for hours at a time or is primarily an inside dog, all dogs are at risk for Chagas disease, a potentially fatal disease that. (moderndogmagazine.com)

New drugs for Chagas disease are under development, and while experimental vaccines have been studied in animal models, a human vaccine has not been developed. (wikipedia.org)

Trypanosoma cruzi clonal diversity and the epidemiology of Chagas disease. (ajtmh.org)

The disease may also be spread through blood transfusion, organ transplantation, consuming food or drink contaminated with the parasites, and vertical transmission (from a mother to her baby). (wikipedia.org)
Rick Tarleton is an immunologist and parasitologist who has studied T. cruzi and Chagas disease at the University of Georgia for almost forty years, and he told me just how much damage these parasites can do. (drugdiscoverynews.com)
Suspected cases of acute Chagas are confirmed by detecting parasites in the blood through a microscope. (dndi.org)
Once the disease enters the chronic stage, parasites disappear from the peripheral blood, making it difficult to diagnose its presence using an ordinary blood test. (eisai.com)
This compound will have shown promising results against Leishmania or Trypanosoma cruzi, the parasites that cause leishmaniasis and Chagas disease, but may not yet be optimal for use as a future treatment. (pharmabiz.com)
The parasitic feces that are left on a human's face often make contact with mucous membranes or a small wound where the fecal parasites enter the bloodstream, causing chagas disease. (bbpest.com)
Kissing bugs are one of the primary transmitters of Chagas disease via T. cruzi parasites. (tulane.edu)
Chagas, a lesser-known and studied tropical disease, is caused by Trypanosoma cruzi parasites, which are transmitted by kissing bugs. (tulane.edu)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
See Centers for Disease Control and Prevention: Epidemiology & Risk Factors . (msdmanuals.com)

There are no vaccines or medicines to prevent Chagas disease. (medlineplus.gov)
Can you prevent Chagas disease in dogs? (medicinenet.com)

Who is more likely to develop Chagas disease? (medlineplus.gov)
1/3) will develop Chagas disease in the heart and digestive tract, where the immune system effector cells destroy target host cells. (benthambooks.com)

Up to 45% of people with chronic infections develop heart disease 10-30 years after the initial illness, which can lead to heart failure. (wikipedia.org)
Most chronic infections are asymptomatic, which is referred to as indeterminate chronic Chagas disease. (wikipedia.org)
In the southern United States, Chagas' disease infections rarely occur. (medicalnewstoday.com)
In the United States, Chagas disease is considered one of the neglected parasitic infections, a group of five parasitic diseases that have been targeted by CDC for public health action. (sciencedaily.com)
Most people with Chagas disease in the United States acquired their infections in endemic countries. (arkansas.gov)
Autochthonous cases of Chagas disease have been reported, occasionally, in the United States, where the zoonotic T. cruzi infections are widely spread below Parallel 42ºN. (benthambooks.com)
The multidisciplinary approaches used in the studies of Chagas disease, involving environmental sciences, zoology, epidemiology, parasitology, pathology, internal medicine, biochemistry and molecular biology, and genetics give the readers a balanced view about the role the scientific development have played in the prevention and control of the T. cruzi infections, and in the paliative treatment of the Chagas disease severe clinic manifestations. (benthambooks.com)
Studies have shown a rapid increase in records of Chagas disease infections before 2005, a slight drop in cases until 2009, before another increase in infections after 2009. (worldforgottenchildren.org)
All states where infections have been found are now monitoring the spread of the disease for public health purposes, except for Massachusetts, which stopped gathering data on chagas disease back in 2014. (bbpest.com)

Chagas disease has been targeted by the World Health Organization (WHO) for elimination but fewer than 10% of people with Chagas have been diagnosed and even fewer have been treated. (dndi.org)
In 2005 the World Health Organization recognised Chagas disease as one neglected tropical disease. (my-vaccine.com)
The International Federation of Associations of People Affected by Chagas Disease (FINDECHAGAS) celebrates this year, for the second time, the World Chagas Disease Day, which was approved by the World Health Organization (WHO) in 2019. (world-heart-federation.org)

The evolution of the disease in humans follows 3 stages. (medscape.com)
Kissing bugs in the United States: risk for vector-borne disease in humans. (medscape.com)
Chagas Disease in Dogs: Is It Transmissible to Humans? (medicinenet.com)
The development of Chagas disease in dogs is similar to the development of Chagas disease in humans. (medicinenet.com)
Studies have shown that more modern housing can drastically reduce the incidence of Chagas disease in humans because the vectors, reduviid bugs, do not live in most modern dwellings. (medicinenet.com)
Twenty to 30 years later, around a third of infected patients develop cardiomyopathy, the most common manifestation of Chagas in humans. (nih.gov)
Trypanosoma cruzi have been found in 150 species of animals that are an immense reservoir for the disease and 10 million infected humans. (escardio.org)
Chagas disease has been found both in triatomine bugs and humans in Arkansas. (arkansas.gov)
We believe that this is related not only to the simple attraction of traditional vectors to light sources but also to changes in the behavior of both humans and insects that result in new modes of disease transmission. (nih.gov)
Chagas disease is found mainly in endemic areas of 21 continental Latin American countries, where it is mostly transmitted when humans come into contact with faeces and/or urine of infected blood-sucking triatomine bugs (vector-borne transmission). (my-vaccine.com)

Estimating chagas disease prevalence and number of underdiagnosed, and undertreated individuals in Spain. (nih.gov)
Large-scale vector control programmes and screening of blood donors have reduced disease incidence and prevalence. (nih.gov)
The new paediatric dosage form has been granted registration from Brazil's National Health Surveillance Agency (ANVISA), and DND i is collaborating with LAFEPE to make the drug widely available, notably by working to register the drug in Argentina, Bolivia, Colombia, and Paraguay - priority countries where Chagas disease prevalence is high and treatment is urgently needed. (dndi.org)
We present three infectious vector-borne diseases-Chagas, leishmaniasis, and malaria-and discuss evidence that suggests that the use of artificial lighting results in behavioral changes among human populations and changes in the prevalence of vector species and in the modes of transmission. (nih.gov)

Chagas disease occurs in two stages: an acute stage, which develops one to two weeks after the insect bite, and a chronic stage, which develops over many years. (wikipedia.org)
Approximately 90% of transmission of Chagas disease occurs through an insect of certain species of triatoma within the reduviidae family, of which the triatoma infectans is the main vector (Fig. 1). (escardio.org)
Chagas disease emerged among the settlers after the triatomine insect-transmitter adapted to human domiciles, and its endemicity expanded exponentially in the XIX century. (benthambooks.com)
The major Amazon Basin tropical rain forest ecosystem, which was in the past considered Chagas disease-free, where new settlements, and ecosystem predation provide fertile conditions for the insect-vector to attack the human population, is now under epidemiologic surveillance for curtailing micro-epidemics detected in various counties. (benthambooks.com)
The nocturnal insect that spreads Chagas is widespread in the Americas. (enetmd.com)
This is the first clinical case report- spearheaded by San Francisco-based physician and Stanford Lecturer Dr. Eduardo Dolhun, MD, to evidence that commonly-used cardboard boxes provide ideal breeding environments for the disease-transmitting insect, thus facilitating their spread to non-endemic areas in the United States and beyond. (outbreaknewstoday.com)

Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease. (nih.gov)
Chagas Disease is the most lethal endemic infectious disease in the Western Hemisphere, having a devastating effect on Latin American populations. (benthambooks.com)
Cholera is an infectious, diarrheal, strictly human disease caused by bacteria from serogroups O1 and O139 of the species Vibrio cholerae. (pasteur.fr)
This highly contagious emerging infectious disease spreads by airborne transmission and surface contamination. (pasteur.fr)
An infectious disease carried by mosquitoes and caused by any of four related dengue viruses. (nih.gov)
A chronic infectious disease caused by mycobacteria, leprosy can lead to permanent damage to the skin, nerves, limbs, and eyes. (nih.gov)
Practically speaking, it means that physicians as far north as Canada should consider testing for this infectious disease once thought to belong exclusively to tropical climates. (outbreaknewstoday.com)
Outbreak News Today is an online blog magazine which focuses on news and information about infectious diseases and outbreaks. (outbreaknewstoday.com)
There's the disease part, of course-most of them are infectious. (asm.org)

What are the symptoms of Chagas disease? (medlineplus.gov)
If your dog exhibits symptoms of Chagas disease, your dog's vet can send blood tests that can be examined to diagnose the disease. (medicinenet.com)
Symptoms of Chagas' disease have acute and chronic stages. (eisai.com)

We reviewed the epidemiological evidence concerning the role of lighting in the spread of vector-borne diseases to encourage other researchers to consider it in future studies. (nih.gov)

This study will evaluate the bioequivalence as well as safety and tolerability of a novel 30 mg tablet of nifurtimox compared to the corresponding marketed 120 mg tablet in adult subjects suffering from chronic Chagas' disease when administered after a high-fat / high-calorie test meal. (bayer.com)

These included 1 case of acute Chagas myocarditis (ACM), hyperexcitability in 2 patients). (cdc.gov)
In our cohort, it was 15 percent of patients - not insignificant," noted Oliveira, who observed in his research that some Chagas patients develop cognitive impairment and brain atrophy, but do not have a stroke. (nih.gov)
They are continuing their studies to see if Chagas is an independent risk factor for cognitive impairment, and whether aspirin provides primary protection against stroke in high-risk Chagas patients. (nih.gov)
The acute phase may also occur due to reactivation of disease in patients with immunosuppressive states and in patients undergoing organ transplantation. (escardio.org)
Thousands of mothers with Chagas disease-infected babies will welcome this as more than just a pill', says Manuel Gutiérrez, President of the International Federation of Chagas Patients. (dndi.org)
A two-week treatment course for adult patients with chronic Chagas disease showed, when compared to placebo, similar efficacy and significantly fewer side effects than the standard treatment duration of eight weeks, according to the results of a clinical trial in Bolivia led by the Drugs for Neglected Diseases initiative (DNDi). (infectioncontroltoday.com)
Mental health support is available for patients and caregivers who are coping with the stress that can come with having a rare disease. (nih.gov)
Sera from patients with various clinical forms of chronic disease displayed similar levels of antibodies (Abs) to Gp25. (ajtmh.org)
Patients and methods Prospective cohort study of lactating women with Chagas disease treated with BNZ administered for 30 days. (bmj.com)
Usually Chagas patients die when they are between 30 and 45 years of age. (benthambooks.com)
We have to let people know that a treatment is available for Chagas disease, a treatment that in many patients works well," adds Navarro. (enetmd.com)
However, the benefits reduce the longer an infected person has the disease and in older patients. (my-vaccine.com)
Several patients are presented to illustrate various clinical features of the disease in both its acute and chronic phases. (nih.gov)
Half of patients in the undetermined form had impaired relaxation patterns, whereas half of patients with ECG abnormalities suggestive of Chagas cardiomyopathy had normal diastolic function. (plos.org)
In conclusion, the combination of diastolic function and BNP measurement adds important information that could help to better stratify patients with Chagas disease. (plos.org)
In addition, BNP levels identify patients with diastolic dysfunction and Chagas disease with high specificity. (plos.org)
The results reported in this study could help to early diagnose myocardial involvement and better stratify patients with Chagas disease. (plos.org)
And so now you have this catch-22 situation where the treatments work best at a time point where patients are unaware of their disease. (asm.org)
Treating Chagas patients is challenging because the disease progression is unpredictable, resulting in 14,000 deaths annually. (tulane.edu)

Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ, or from the pregnant parent to the baby during pregnancy. (medlineplus.gov)
Once a rural disease only, blood transfusion has also become a vector of transmission, one not easily screened for in developing countries. (medscape.com)
Due to potential transmission of Chagas disease through blood transfusion, the United States of America, Spain and other non Latin American countries also screen blood donors for Chagas disease [ 20 , 21 ]. (biomedcentral.com)
In addition to the public usually interested in neglected diseases, human and veterinarian hospital blood-bank health workers, world travelers, and policy-makers, the emergence of Chagas disease worldwide has become of great interest of the general public, particularly in the last five years, after the alert was given by Health Authorities in various countries, concerning its acquisition by blood transfusion and congenitally. (benthambooks.com)
Preventative measures in regions where Chagas disease is found but not endemic, like the United States, must include control strategies that focus on preventing transmission from blood transfusion, organ transplantation, consumption of uncooked food contaminated with feces from infected triatomine bugs and congenital (mother-to-baby) transmission. (worldforgottenchildren.org)
Unfortunately this screening is not so strict in some countries, so blood transfusion carries a higher risk of acquiring diseases such as hepatitis B or C, HIV /AIDS, or syphilis. (diagnose-me.com)

But little is known about these initial insults to the system, and the course of the disease is usually hidden much like the asymptomatic indeterminate stage of Chagas disease. (medscape.com)
The acute phase of the disease lasts 4-8 weeks and is usually asymptomatic although a distinctive swelling of the eye, referred to as Ramona's sign that may develop at the beginning of the 1-2 week incubation period in the first days after the bite. (escardio.org)

The disease affects more than 150 types of animals. (wikipedia.org)
However, over decades with the disease, approximately 30-40% of people develop organ dysfunction (determinate chronic Chagas disease), which most often affects the heart or digestive system. (wikipedia.org)
Also common in chronic Chagas disease is damage to the digestive system, which affects 10-21% of people. (wikipedia.org)
According to the WHO, the disease is endemic in 21 countries and affects 16 to 18 million people. (medscape.com)
Chagas disease affects an estimated six million people globally and can lead to irreversible damage to vital organs, and death. (infectioncontroltoday.com)
Chagas disease affects people in Mexico and Central and South America, mainly in rural areas where poverty is widespread. (msdmanuals.com)
Alzheimer's disease is a neurodegenerative disease that mainly affects memory but also has an impact on other cognitive functions, for example those related to language, reasoning and learning. (pasteur.fr)
Avian influenza is a viral disease that affects birds, with a very high mortality rate in farmed birds such as chickens and geese. (pasteur.fr)
In the Americas, the disease affects 6 million people in 21 countries, with approximately 30,000 new cases each year. (tulane.edu)

Now, by using a naturally infected nonhuman primate model, researchers have identified a new compound that may be the best hope yet for treating Chagas disease. (drugdiscoverynews.com)
Resveratrol may be helpful in treating Chagas Disease when it's affected the body internally such as the heart! (herbpathy.com)

Drugs for Neglected Diseases initiative (DNDi) and four pharmaceutical firms, Eisai Co Ltd, Shionogi & Co Ltd, Takeda Pharmaceutical Ltd, and AstraZeneca plc have announced the start of a ground-breaking initiative to accelerate and cut the cost of early stage drug discovery for two of the world's most neglected diseases of leishmaniasis and Chagas. (pharmabiz.com)
The 'Neglected Tropical Diseases Drug Discovery Booster' consortium, through a carefully engineered modus operandi, will circumvent early stage commercial barriers between the four pharmaceutical participants, allowing DNDi, for the first time, to search millions of unique compounds simultaneously, in the hunt for new treatment leads for leishmaniasis and Chagas disease. (pharmabiz.com)
Any progress or successful new treatment for leishmaniasis or Chagas disease resulting from the Drug Discovery Booster will be attributed to the collective effort of all partners, which have also agreed that no intellectual property barriers will be imposed to a new treatment if successful. (pharmabiz.com)
A parasitic disease transmitted by infected sand flies, leishmaniasis can cause skin ulcers or lesions and swelling of the spleen and liver. (nih.gov)

The four companies will then search their own full collections of high-quality chemical compounds for similar and potentially better molecules, and will select and send the most promising to DNDi, which will then have them screened for potential effectiveness against these two deadly parasitic diseases. (pharmabiz.com)
5,6 The reference diagnostic laboratory for parasitic diseases at the CDC can offer assistance. (benznidazoletablets.com)

In rare cases (less than 1-5%), infected individuals develop severe acute disease, which can involve inflammation of the heart muscle, fluid accumulation around the heart, and inflammation of the brain and surrounding tissues, and may be life-threatening. (wikipedia.org)
While we have drugs to treat this disease, the drugs themselves can have severe side effects, and if people don't get the drugs soon after they're infected, the treatment is not very effective. (drugdiscoverynews.com)
However, the current treatment can cause severe side effects, which has often discouraged some people from seeking treatment and healthcare workers from recommending it,' said Joaquim Gascon, a principal investigator in the trial and the director of the Chagas Initiative at ISGlobal. (infectioncontroltoday.com)
Botulism is a severe neurological disease caused by a highly potent toxin produced by Clostridium botulinum bacteria. (pasteur.fr)
The disease often causes only mild symptoms (or no symptoms at all), but in cases of high worm infestation, ascariasis can lead to severe abdominal pain, vomiting, restlessness, and sometimes death. (nih.gov)
In persons who are immune compromised, including persons with HIV /AIDS, Chagas disease can be severe. (diagnose-me.com)
The problem is that Chagas is better treated before severe symptoms occur. (asm.org)

The most frequent clinical CD manifestation is the chronic indeterminate form (CIF), and the effect of physical exercises on disease progression remains unknown. (fiocruz.br)

Lent H, Wygodzinsky P. Revision of the Triatominae (Hemiptera, Reduviidae), and their significance as vectors of Chagas' disease. (medscape.com)
The vectors of Chagas. (medscape.com)
In central and South America, individuals are exposed more often to reduviid bugs because these vectors of disease like to live in thatching used to make roofing over huts where people live. (medicinenet.com)
This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which the nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)
In various triatomine species vectors of Chagas disease (Triatominae, Reduviidae), a delay in the molt of a small proportion of individuals has been observed, and from an evolutionary ecology approach, we propose the hypothesis that the developmental delay is an adaptation to environmental stochasticity through a spreading of risk (bet-hedging) diapause strategy. (unlp.edu.ar)

Treatment of Chagas disease in dogs is mainly symptomatic. (medicinenet.com)
The efficacy shown in these T. cruzi murine studies suggests that nitrile-containing cruzipain inhibitors show promise as a viable approach for a safe and effective treatment of Chagas disease," write the researchers. (sciencedaily.com)
Chagas can be treated successfully in the early phase, but there is no treatment in the chronic phase," he said. (nih.gov)
But now, scientists may have discovered a new compound that could be a game-changer for Chagas disease treatment, and they did it with the help of a few of these bug-eating monkeys down in Texas. (drugdiscoverynews.com)
There is currently no approved treatment for chronic Chagas disease and there are currently no vaccines in use. (escardio.org)
This new tablet means easier-to-administer and safer treatment of Chagas disease in infants and young children under the age of two, as they will receive accurate dosage. (dndi.org)
We believe treatment can spare people with Chagas the risk of a lifetime of debilitating complications associated with the disease. (infectioncontroltoday.com)
This could change the paradigm for Chagas treatment, by improving adherence and encouraging wider adoption by the medical community,' said Dr Faustino Torrico, president of CEADES Foundation, Bolivia, and a principal investigator in the trial. (infectioncontroltoday.com)
These results bring new hope for people living with this silent disease and could change the reality of access to treatment in endemic countries. (infectioncontroltoday.com)
With a much simpler treatment regimen, there is no excuse for not treating people with Chagas disease,' said Dr. Sergio Sosa Estani, head of the Chagas Clinical Program at DNDi. (infectioncontroltoday.com)
When these symptoms appear, they cannot be treated with anti-Chagas' disease therapeutics, calling for specialized treatment. (eisai.com)
Treatment for this disease include administering a chemotherapeutic agent anthelmintic to eliminate the agent and symptomatic treatment to deal with emerging symptoms. (eisai.com)
Conclusions The limited transference of BNZ into breast milk and the reassuring normal clinical evaluation of the breastfed babies suggest that maternal BNZ treatment for Chagas disease during breast feeding is unlikely to present a risk for the breastfed infant. (bmj.com)
This study is a necessary step for the development of an age appropriate pediatric oral dosage form for the treatment of Chagas' disease in endemic countries according to the recommendations provided by current international guidelines (EMA Guideline on Clinical Development of Medicinal Products, EMA Note for Guidance on Oral Dosage Forms). (bayer.com)
Institut Pasteur research teams are working on the prevention and treatment of some fifty diseases. (pasteur.fr)
Although more than 1 billion people are sick with NTDs and require treatment, major efforts to eradicate and treat those diseases are nonexistent for the most part. (worldforgottenchildren.org)
As an immune system enhancer, astragalus root may also be a promising treatment for HIV and for autoimmune diseases such as lupus. (diagnose-me.com)
With conditions like Chagas disease, the treatment would be only when people present with Chagas disease. (asm.org)

DNDi will now continue to work with national programmes, partners and ministries of health of endemic countries to confirm these results and encourage necessary steps to register the new regimen and turn this breakthrough discovery into a reality for people affected by the disease. (infectioncontroltoday.com)
DNDi continues to work on pre-clinical and clinical research to discover, develop, and test new drugs and drug combinations to treat Chagas. (infectioncontroltoday.com)
This experimental approach to radically modernize drug development for neglected diseases is the result of a decade of growing partnerships with pharmaceutical companies', said Dr Bernard Pécoul, executive director of DNDi. (pharmabiz.com)
To identify promising new compounds for neglected diseases, DNDi has worked bilaterally with a range of pharmaceutical partners, searching through segments of their vast compound libraries, and testing them against infected cells. (pharmabiz.com)

In the past three decades, the control and management of Chagas disease has undergone several improvements. (nih.gov)
The chronic phase of Chagas' disease can last for decades or even a lifetime. (medicalnewstoday.com)
In Zika, this manifests as microcephaly in infants, and in Chagas, it occurs over decades in adults. (nih.gov)
In the following decades the endemic Chagas disease in Argentina was reported by Salvador Mazza. (benthambooks.com)
In the last decades the epidemiological pattern of the disease changed from a rural to a mostly urban disease, mainly due to population mobility and emigration. (my-vaccine.com)
Most infected people then enter into the chronic phase of the disease, which can go undetected for decades. (benznidazoletablets.com)
Since the 1980s, researchers have proposed that different strains could be associated with different disease outcomes due to the parasite's genetic diversity, but decades of research failed to uncover clear associations," said lead study author Eric Dumonteil , PhD, associate professor of tropical medicine at Tulane University School of Public Health and Tropical Medicine. (tulane.edu)
Since the 1980s, researchers have proposed that different strains could be associated with different disease outcomes due to the parasite's genetic diversity, but decades of research failed to uncover clear associations. (greenhealthlive.com)

Screening blood donors for Chagas disease is of much concern in all Latin American countries. (biomedcentral.com)

As people typically show no symptoms for many years, most are unaware they have Chagas. (dndi.org)

The spread of Chagas disease, a potentially fatal parasitic disease transmitted by the triatomine bug, colloquially known as the "kissing bug," has been linked to corrugated cardboard boxes, according to new findings published in the American Journal of Tropical Medicine and Hygiene . (outbreaknewstoday.com)

To date, in the United States, there have been no reports of dog to vector (reduviid bug) and then to human transmission of Chagas disease. (medicinenet.com)
That's Michael Levy, an epidemiologist who studies Chagas disease transmission at the University of Pennsylvania. (drugdiscoverynews.com)
In Chagas disease-endemic areas, the main way is through vectorborne transmission. (arkansas.gov)
That's why preventing transmission from mother to child is a key challenge, according to Dr Miriam Navarro, a researcher from Mundo Sano, an organisation in Spain that helps to control and eliminate neglected diseases. (enetmd.com)
It is believed that infected immigrants brought the disease into southern states, but after the disease was found in Massachusetts, experts believe that local transmission cases are now occurring in the US. (bbpest.com)

This article will explain what Chagas' disease symptoms are, including the differences between the acute and chronic phases. (medicalnewstoday.com)
There are two phases of Chagas disease: the acute phase and the chronic phase. (sciencedaily.com)
Chagas disease presents itself in 2 phases. (my-vaccine.com)
Diastolic dysfunction and elevated brain natriuretic peptide levels are present in different cardiomyopathies and in advanced phases of Chagas disease. (plos.org)

2023) Intra-host Trypanosoma cruzi strain dynamics shape disease progression: the missing link in Chagas disease pathogenesis. (greenhealthlive.com)

On this basis, we report here a case of acute Chagas' heart disease in a polar bear ( Ursus maritimus ) which occurred at the Guadajalara zoo in the State of Jalisco, Mexico. (scielo.br)

Current situation and perspectives regarding human Chagas disease in midwestern of the state of Minas Gerais, Brazil. (medscape.com)
Funding for Chagas research from the National Institute of Neurological Disorders and Stroke (NINDS) , through Fogarty's Global Brain Disorders Research program , has allowed Brazil to make strides against the disease by training scientists in field epidemiology, neuroimaging techniques and other research skills. (nih.gov)

The most common long-term manifestation is heart disease, which occurs in 14-45% of people with chronic Chagas disease. (wikipedia.org)
Chagas disease occurs in three stages. (msdmanuals.com)

Chagas disease is classified as a neglected tropical disease. (wikipedia.org)

Effects of immunosuppression and benzonidazole on Trypanosoma cruzi parasitism during experimental acute Chagas' disease. (nih.gov)
Trypanosoma cruzi e Doença de Chagas. (ajtmh.org)

Additionally, the public tends to focus more on diseases that kill, such as malaria. (worldforgottenchildren.org)

To eliminate the disease, we need a new drug for both chronic stages of the disease that is safe, efficacious, and adapted to the field. (dndi.org)
But in the early stages there are few or no symptoms, so getting the word out about the disease is essential. (enetmd.com)

The disease can cause very serious complications if it is not diagnosed and treated early. (world-heart-federation.org)

Chronic disease is diagnosed by finding antibodies for T. cruzi in the blood. (wikipedia.org)
When used in chronic disease, medication may delay or prevent the development of end-stage symptoms. (wikipedia.org)
Anemia caused by chronic disease, such as HIV /AIDS, Crohn's disease, and rheumatoid arthritis. (diagnose-me.com)

One project leads to another, everything is intertwined," said Dr. Jamary Oliveira-Filho of the Federal University of Bahia, one of the lead researchers on NIH-supported clinical trials and studies investigating the links between Chagas and stroke. (nih.gov)
The clinical information currently available comes from the experiences of people who were infected with Chagas disease through contact with triatomines as children. (worldforgottenchildren.org)
There's so many things we don't know about Chagas disease and there's so many needs-clinical needs-that intersect with that. (asm.org)

Chemotherapeutic agent can be administered not only during the acute stage but also during the early chronic stage, when disease has not appeared in the heart or digestive systems. (eisai.com)

After two years of the government health programme "Argentina justa, Argentina sin Chagas" (Fair Argentina, Chagas-Free Argentina) the fight against the endemic disease of that name is weakening, according to experts. (ipsnews.net)

People with Chagas heart disease often experience heart palpitations, and sometimes fainting, due to irregular heart function. (wikipedia.org)
By electrocardiogram, people with Chagas heart disease most frequently have arrhythmias. (wikipedia.org)
In many cases the first sign of Chagas heart disease is heart failure, thromboembolism, or chest pain associated with abnormalities in the microvasculature. (wikipedia.org)
Although treatments aiding the failing organs can help preserve life, many established heart failure treatments have a lower success rate in Chagas disease. (medscape.com)
If we can identify a biomarker for Chagas inflammation that we can block or change, we could decrease or eliminate the chances that people who get Chagas as children will have strokes, heart disease or intestinal problems later in life, and the financial and moral burdens that come with caring for someone with a long-term illness. (nih.gov)
Up to a third of people with Chagas will suffer heart damage that becomes evident only many years later and can lead to progressive heart failure or sudden death. (dndi.org)
Bob Naedele died after receiving a heart from a donor with Chagas disease. (propublica.org)

Most people with the disease are poor, and most do not realize they are infected. (wikipedia.org)
Washington, DC - Mysterious, implacable, and deadly, Chagas disease remains a threat to an estimated 100 million people across the Americas. (medscape.com)
The WHO estimates that 6-7 million people worldwide have Chagas' disease. (medicalnewstoday.com)
We aim to deliver new, safer, more affordable and effective treatments for people affected by Chagas disease. (dndi.org)
The advanced chronic stage is when 30-40% of people with Chagas experience symptoms. (dndi.org)
Death resulting from Chagas disease occurred in an estimated 10,000 people in the year 2008. (escardio.org)
Chagas' disease is caused by metacyclic trypanosomes of T. cruzi transmitted to people and animals via Reduviidae. (eisai.com)
Chagas disease is not transmitted from person-to-person like a cold or the flu or through casual contact with infected people or animals. (arkansas.gov)
This disease is endemic in Latin American countries and approximately 15 million people are estimated to be infected [ 1 ]. (biomedcentral.com)
In endemic regions, field studies show mortality rates due to Chagas disease may be as high as 0.56%, with approximately 100.000 people dying from the disease per year. (benthambooks.com)
Current research verifies the symptomatology of stress and other aspects related to resilience in people suffering from chronic Chagas Disease (CD). (bvsalud.org)
Dr Navarro runs the awareness campaign Madres comprometidas con la enfermedad de Chagas (Mothers against Chagas disease), to get as many people diagnosed as possible. (enetmd.com)
People affected by Chagas disease ask the international community for comprehensive care for this neglected disease that celebrates its World Day. (world-heart-federation.org)
Faced with the difficulties that the COVID-19 has imposed on humanity, people affected by Chagas, as well as other neglected diseases, have been perceived to be more vulnerable, both because of our state of health and exposure to the new pandemic. (world-heart-federation.org)
Although the COVID-19 pandemic has not facilitated the visibility of the actual condition of people affected by Chagas, we must remember that we are among those who suffer from one of the most neglected diseases on Earth, according to WHO. (world-heart-federation.org)
For all these reasons, advances in the care of people with Chagas disease will not be achieved through a single action or only the biomedical component, but by integrating all the necessary actions (intersectoral and interdisciplinary) so that we may no longer be underserved. (world-heart-federation.org)
Fatigue can be one of the most debilitating symptoms experienced by people with HIV disease, as well as one of the most under-reported and under-recognized aspects. (diagnose-me.com)

Results 12 lactating women with chronic Chagas disease were enrolled (median age 28.5 years, range 20-34). (bmj.com)

Anatomy1

Organisms18

Diseases18

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology1

Phenomena and Processes9

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture1

Humanities1

Information Science1

Named Groups4

Health Care18

Geographicals20

Latin America17

Carlos Chagas6

Parasite37

American Trypanosomiasis7

Infection37

Dilated cardiomyopathy2

Agent of Chagas disease3

Treatments for Chagas disease2

Central America6

19091

Diagnosis13

Cardiac7

Benznidazole7

Risk for Chagas disease1

Drugs for Chagas disease1

Epidemiology of Chagas disease1

Parasites8

Centers3

Prevent Chagas disease2

Develop Chagas disease2

Infections9

World Health Organ3

Humans10

Prevalence4

Insect6

Infectious9

Symptoms of Chagas3

Vector-borne1

Nifurtimox1

Patients19

Blood transfusion6

Asymptomatic2

Affects9

Treating Chagas2

Leishmaniasis4

Parasitic Diseases2

Severe7

Indeterminate1

Vectors5

Treatment18

DNDi4

Decades8

Donors1

Unaware1

Triatomine bug1

Transmission5

Phases4

20231

Case of acute1

Brazil2

Occurs2

Classified as a neglected tropical disease1

Trypanosoma Cruzi2

Malaria1

Stages2

Complications1

Chronic disease3

Clinical3

Digestive1

Endemic disease1

Heart7

People17

Median age1